GO:0016004

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Name phospholipase activator activity
Categary Function
Go Slim No
Go Link GO:0016004
Unique Molecular Interactions 74
Total Molecular Interactions 136
Total Single Events 1095
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phospholipase activator activity. They are ordered first by their pain relevance and then by number of times they were reported for phospholipase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
3 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
4 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
5 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
6 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
7 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
8 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
9 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03
10 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
11 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
12 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
13 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
14 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
15 INT120018 VEGFA Positive_regulation of CCL3 1 0.01 1 0.7
16 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
17 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7
18 INT297307 Negative_regulation of Binding of Ccr1 and Ccl3 1 0.27 0.73 0.67
19 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
20 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
21 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
22 INT254637 Bdkrb2 Regulation of Gene_expression of Ccl5 1 0.17 1.22 0.56
23 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
24 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
25 INT181447 Ccl3 Positive_regulation of Csf2 1 0.06 1.89 0.45
26 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39
27 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39
28 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
29 INT187219 Vip Negative_regulation of Gene_expression of Ccl3 1 0.32 0.65 0.35
30 INT325221 Il13 Regulation of Ccl3 1 0.08 0.17 0.32
31 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
32 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29
33 INT181446 Csf2 Positive_regulation of Ccl3 1 0.05 0.81 0.29
34 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
35 INT237088 Binding of Cxcl9 and Ccl5 1 0.29 1.51 0.26
36 INT246438 Ccl5 Positive_regulation of Gene_expression of Cd79a 1 0.13 0.83 0.26
37 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26
38 INT237087 Binding of Cxcl9 and Ccl3 1 0.30 1.51 0.26
39 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
40 INT252815 Binding of CCL5 and TNF 1 0.02 0.75 0.25
41 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
42 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
43 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
44 INT295713 PTGER2 Positive_regulation of Regulation of CCL5 1 0.01 0.82 0.21
45 INT170995 Binding of IFNA1 and Positive_regulation of Localization of CCL5 1 0.03 0.34 0.19
46 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
47 INT244243 Regulation of Binding of IL8 and Ccl3 1 0.04 0.05 0.18
48 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
49 INT244241 Binding of IL8 and Ccl3 1 0.05 0.05 0.18
50 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18
51 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
52 INT244242 Negative_regulation of Binding of IL8 and Ccl3 1 0.06 0.05 0.18
53 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
54 INT244235 Binding of Cxcl1 and Ccl3 1 0.14 0.23 0.17
55 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17
56 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
57 INT221019 ELANE Positive_regulation of CCL3 1 0.00 0.24 0.15
58 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
59 INT171295 CXCL10 Positive_regulation of CCL5 1 0.04 0.06 0.12
60 INT213415 Binding of CCL8 and SET 1 0.11 0.17 0.1
61 INT294444 KLK4 Negative_regulation of CCL3 1 0.00 0 0.1
62 INT186767 Ccl11 Regulation of Ccl5 1 0.01 0 0.07
63 INT171297 TNF Positive_regulation of Localization of CCL5 1 0.17 0.66 0.07
64 INT186766 Il5 Regulation of Ccl5 1 0.01 0 0.07
65 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06
66 INT246436 Ccl5 Regulation of Aif1 1 0.01 0.67 0.06
67 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04
68 INT247774 Binding of Ccl5 and Ccrl2 1 0.14 0.29 0.04
69 INT171279 IL6 Positive_regulation of CCL5 1 0.04 0.38 0.04
70 INT171301 TNF Positive_regulation of CCL5 1 0.16 0.38 0.04
71 INT247766 Binding of Ccl2 and Ccl5 1 0.14 0.28 0.04
72 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0
73 INT127690 TNF Positive_regulation of Regulation of CCL5 1 0.33 0.17 0
74 INT171282 TNFSF12 Positive_regulation of Gene_expression of CCL5 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phospholipase activator activity. They are ordered first by their pain relevance and then by number of times they were reported in phospholipase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
2 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
3 INT78901 Localization of CCL5 67 0.78 40.79 20.59
4 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
5 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
6 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
7 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
8 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
9 INT128364 Positive_regulation of Ccl3 20 0.70 23.96 10.65
10 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
11 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
12 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
13 INT153271 Localization of Ccl3 7 0.81 11.29 7.14
14 INT181348 Localization of Ccl5 24 0.65 19.55 6.8
15 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86
16 INT181363 Regulation of Ccl5 16 0.46 13.65 5.09
17 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96
18 INT82887 Positive_regulation of Ccl5 10 0.40 3.4 4.91
19 INT176614 Positive_regulation of Gene_expression of Ccl5 20 0.59 16.2 4.81
20 INT166878 Regulation of Ccl3 9 0.44 8.21 4.81
21 INT153269 Binding of Ccl3 10 0.48 8.87 4.69
22 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67
23 INT181042 Binding of Ccl5 18 0.41 9.34 4.51
24 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26
25 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15
26 INT144083 Positive_regulation of Gene_expression of Ccl3 10 0.50 8.16 3.81
27 INT103281 Transcription of CCL5 10 0.67 5.95 3.7
28 INT89592 Localization of Ccl5 10 0.61 7.65 3.62
29 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59
30 INT181357 Negative_regulation of Ccl3 12 0.59 13.09 3.38
31 INT124123 Positive_regulation of Localization of CCL5 12 0.67 7 3.37
32 INT181418 Regulation of Gene_expression of Ccl5 11 0.52 9.86 3.37
33 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17
34 INT78898 Regulation of Gene_expression of CCL5 9 0.42 5.7 3.11
35 INT115617 Binding of Ccl5 5 0.33 0.58 3.11
36 INT194661 Binding of CCL5 9 0.46 6.07 2.73
37 INT71681 Positive_regulation of Gene_expression of CCL3 8 0.54 8.21 2.41
38 INT295676 Localization of CCL8 3 0.49 6.05 2.11
39 INT115616 Positive_regulation of Binding of Ccl5 3 0.25 0.59 2.04
40 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9
41 INT120014 Transcription of CCL3 5 0.69 3.03 1.82
42 INT194660 Positive_regulation of Binding of CCL5 1 0.42 2.74 1.72
43 INT78896 Negative_regulation of Localization of CCL5 8 0.57 2.43 1.59
44 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51
45 INT115895 Phosphorylation of Ccl5 1 0.55 0 1.31
46 INT65699 Localization of CCL3 7 0.78 2.56 1.25
47 INT123828 Regulation of CCL3 3 0.60 0.79 1.25
48 INT153267 Negative_regulation of Binding of Ccl3 2 0.43 2.06 1.14
49 INT149554 Transcription of Ccl5 2 0.59 0.55 1.14
50 INT115893 Negative_regulation of Binding of Ccl5 1 0.37 0 1.14
51 INT181410 Regulation of Gene_expression of Ccl3 2 0.33 3.52 1.06
52 INT166880 Negative_regulation of Gene_expression of Ccl3 1 0.57 0.81 1.01
53 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01
54 INT181351 Transcription of Ccl5 5 0.64 2.19 0.9
55 INT202174 Negative_regulation of CCL3 2 0.26 1.77 0.9
56 INT103285 Regulation of Localization of CCL5 3 0.44 1.11 0.89
57 INT79235 Binding of CCL3 3 0.36 2.2 0.88
58 INT149555 Negative_regulation of Positive_regulation of Ccl5 1 0.15 0 0.88
59 INT153272 Positive_regulation of Localization of Ccl3 2 0.50 2.02 0.79
60 INT168999 Positive_regulation of CCL8 1 0.39 0.89 0.79
61 INT181390 Negative_regulation of Positive_regulation of Ccl5 2 0.31 2.31 0.77
62 INT120013 Negative_regulation of Transcription of CCL3 1 0.41 1 0.72
63 INT153270 Positive_regulation of Binding of Ccl3 1 0.47 1.44 0.69
64 INT115897 Positive_regulation of Phosphorylation of Ccl5 1 0.41 0 0.66
65 INT181349 Positive_regulation of Localization of Ccl5 2 0.37 0.89 0.62
66 INT128360 Negative_regulation of Positive_regulation of Ccl3 2 0.41 1.86 0.55
67 INT194225 Positive_regulation of Positive_regulation of Ccl5 1 0.07 1.13 0.55
68 INT221040 Negative_regulation of Gene_expression of CCL3 2 0.20 1.19 0.53
69 INT194658 Positive_regulation of Transcription of CCL5 1 0.45 0.68 0.44
70 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43
71 INT171037 Gene_expression of CCL8 2 0.45 0.42 0.42
72 INT268760 Positive_regulation of Binding of Ccl5 1 0.13 0.91 0.39
73 INT322698 Protein_catabolism of Ccl5 1 0.49 0.33 0.38
74 INT319431 Positive_regulation of Localization of CCL8 1 0.33 3.69 0.35
75 INT195733 Phosphorylation of CCL5 2 0.10 1.04 0.33
76 INT79236 Positive_regulation of Positive_regulation of CCL3 1 0.49 1.22 0.28
77 INT103283 Negative_regulation of Transcription of CCL5 1 0.50 0.28 0.27
78 INT322710 Positive_regulation of Transcription of Ccl5 1 0.43 0.56 0.26
79 INT301314 Regulation of Binding of CCL3 1 0.04 0 0.24
80 INT181399 Transcription of Ccl3 2 0.60 0.41 0.22
81 INT282377 Regulation of Positive_regulation of CCL5 1 0.05 1.12 0.22
82 INT329819 Phosphorylation of CCL3 1 0.23 0.61 0.17
83 INT285899 Positive_regulation of Localization of CCL3 1 0.12 1.08 0.17
84 INT312718 Protein_catabolism of CCL3 1 0.31 0.44 0.16
85 INT89593 Negative_regulation of Localization of Ccl5 1 0.03 0.46 0.15
86 INT233838 Regulation of Binding of Ccl5 1 0.21 1 0.15
87 INT195730 Negative_regulation of Binding of CCL5 1 0.05 0.51 0.13
88 INT246434 Negative_regulation of Negative_regulation of Ccl5 1 0.40 1.72 0.09
89 INT189478 Regulation of Transcription of Ccl5 1 0.38 0.63 0
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