GO:0017076

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Name purine nucleotide binding
Categary Function
Go Slim No
Go Link GO:0017076
Unique Molecular Interactions 65
Total Molecular Interactions 90
Total Single Events 612
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for purine nucleotide binding. They are ordered first by their pain relevance and then by number of times they were reported for purine nucleotide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
2 INT63407 Binding of Oprl1 and Pck1 1 0.40 0 1.29
3 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
4 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
5 INT111194 Binding of NEUROD1 and Pck1 1 0.39 0 0.75
6 INT15221 RRM1 Regulation of Localization of VIP 1 0.12 0.08 0.74
7 INT15222 RRM1 Regulation of VIP 1 0.12 0.08 0.74
8 INT321300 Ins1 Negative_regulation of Pck1 1 0.09 0.52 0.59
9 INT66660 Pck1 Positive_regulation of Localization of Ptprg 1 0.07 0 0.4
10 INT321292 Fig4 Negative_regulation of Pck1 1 0.10 0.33 0.39
11 INT21286 Binding of Oprd1 and Pck1 1 0.08 0 0.34
12 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33
13 INT311263 RENBP Regulation of TNF 1 0.01 1.59 0.33
14 INT34449 Binding of Ca2 and Pck1 1 0.17 0.18 0.33
15 INT311266 RENBP Regulation of IL6 1 0.02 1.59 0.32
16 INT178910 Ins1 Negative_regulation of Gene_expression of Pck1 1 0.04 0.34 0.31
17 INT229332 BAS Negative_regulation of Pck1 1 0.01 0.2 0.28
18 INT170560 Binding of Renbp and Narf 1 0.01 1.69 0.27
19 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26
20 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 0.01 0 0.26
21 INT311268 RENBP Regulation of Gene_expression of IL8 1 0.02 1.05 0.24
22 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22
23 INT112205 Pck1 Regulation of Rab38 1 0.00 0 0.2
24 INT33141 Pck1 Regulation of Npr1 1 0.00 0.17 0.16
25 INT279102 Renbp Regulation of Hand1 1 0.02 0.27 0.14
26 INT311262 RENBP Regulation of Regulation of TNF 1 0.02 0.33 0.13
27 INT305287 Renbp Regulation of FRTS 1 0.02 0.06 0.13
28 INT216486 Pck1 Regulation of Gene_expression of Ca2 1 0.05 0.19 0.13
29 INT299158 Binding of Lgals3 and Renbp 1 0.00 0.64 0.11
30 INT311267 RENBP Regulation of Gene_expression of TNF 1 0.02 0.54 0.09
31 INT321298 Rxfp2 Regulation of Pck1 1 0.10 0.07 0.09
32 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09
33 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
34 INT301641 Irs2 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08
35 INT306241 Ins1 Negative_regulation of Gene_expression of PCK1 1 0.00 0.91 0.08
36 INT270682 Binding of OLR1 and RENBP 1 0.00 0.76 0.08
37 INT34450 Pck1 Regulation of Binding of Trh 1 0.15 0 0.07
38 INT262190 Foxo1 Positive_regulation of Pck1 1 0.04 0.15 0.06
39 INT172832 Binding of ROS1 and Renbp 1 0.00 0.83 0.03
40 INT240875 Gene_expression of Sod1 Negative_regulation of Gene_expression of Pck1 1 0.33 0.27 0.03
41 INT342936 Renbp Positive_regulation of Ros1 1 0.02 1.56 0.03
42 INT240876 Gene_expression of Sod1 Negative_regulation of Pck1 1 0.33 0.27 0.03
43 INT228592 Pck1 Regulation of Positive_regulation of Gck 1 0.02 0.05 0
44 INT353551 Pck1 Regulation of SLC17A5 1 0.00 0 0
45 INT353549 Pck1 Regulation of Gene_expression of Gpt 1 0.00 0 0
46 INT216488 Binding of Gin1 and Pck1 1 0.00 0 0
47 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0
48 INT308132 Binding of RRM1 and F2 1 0.01 0 0
49 INT270683 Binding of OXA1L and RENBP 1 0.00 0 0
50 INT279101 Binding of Hand1 and Renbp 1 0.02 0 0
51 INT245730 RENBP Regulation of DISC1 1 0.01 0.58 0
52 INT335048 PPARA Regulation of PCK1 1 0.16 0.26 0
53 INT353191 Renbp Regulation of Gene_expression of Yif1 1 0.00 0.55 0
54 INT353550 Pck1 Regulation of Gpt 1 0.00 0 0
55 INT266395 Renbp Positive_regulation of Ager 1 0.00 0.31 0
56 INT240942 Ins1 Regulation of Transcription of Pck1 1 0.08 0.73 0
57 INT323492 Ins1 Regulation of Gene_expression of Pck1 1 0.08 0.16 0
58 INT266409 Binding of ALB and Renbp 1 0.00 1.41 0
59 INT104528 Binding of FSCN1 and Pck1 1 0.01 0 0
60 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0
61 INT339045 Binding of RENBP and SNRNP70 1 0.01 0.38 0
62 INT339049 Binding of PITX2 and RENBP 1 0.00 0.27 0
63 INT279100 Regulation of Binding of Hand1 and Renbp 1 0.01 0 0
64 INT339046 Binding of RENBP and SUGT1 1 0.00 0.38 0
65 INT170561 Renbp Regulation of Narf 1 0.01 3.86 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for purine nucleotide binding. They are ordered first by their pain relevance and then by number of times they were reported in purine nucleotide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12717 Binding of Pck1 85 0.47 12.49 54.81
2 INT7663 Positive_regulation of Pck1 15 0.67 3.05 8.63
3 INT29142 Positive_regulation of Binding of Pck1 10 0.67 1.48 7.6
4 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48
5 INT25193 Negative_regulation of Pck1 20 0.57 5.66 6.05
6 INT86799 Gene_expression of Pck1 20 0.65 6.22 5.8
7 INT34441 Negative_regulation of Binding of Pck1 6 0.42 0.76 3.8
8 INT181922 Binding of RENBP 16 0.36 13.92 3.71
9 INT12843 Regulation of Pck1 13 0.60 3.46 3.18
10 INT64748 Regulation of Binding of Pck1 4 0.44 0.45 3.15
11 INT53707 Negative_regulation of RRM1 4 0.59 0.44 2.87
12 INT130633 Negative_regulation of Gene_expression of Pck1 6 0.37 3.19 2.48
13 INT86797 Regulation of Gene_expression of Pck1 6 0.44 1.12 2.36
14 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68
15 INT178909 Transcription of Pck1 4 0.56 2.09 1.4
16 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38
17 INT98020 Gene_expression of PCK1 4 0.53 1.21 1.37
18 INT197143 Positive_regulation of Renbp 15 0.33 9.41 1.31
19 INT99532 Positive_regulation of PCK1 2 0.25 1.19 1.25
20 INT45553 Negative_regulation of PCK1 3 0.43 0.73 1.17
21 INT99530 Negative_regulation of Gene_expression of PCK1 1 0.05 0.54 1.17
22 INT99533 Negative_regulation of Positive_regulation of PCK1 1 0.05 0.54 1.17
23 INT99531 Positive_regulation of Gene_expression of PCK1 1 0.05 0.54 1.16
24 INT88568 Positive_regulation of RRM1 4 0.41 1.81 1.14
25 INT108246 Regulation of Renbp 5 0.21 4.66 1.12
26 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04
27 INT21284 Localization of Pck1 3 0.30 0.63 1
28 INT42552 Negative_regulation of Protein_catabolism of Pck1 1 0.14 0 0.94
29 INT42553 Protein_catabolism of Pck1 1 0.21 0 0.93
30 INT321350 Negative_regulation of Transcription of Pck1 1 0.28 1.04 0.91
31 INT130632 Positive_regulation of Gene_expression of Pck1 2 0.37 0.59 0.88
32 INT170546 Gene_expression of Renbp 15 0.32 14.33 0.72
33 INT187050 Localization of RENBP 8 0.35 6.92 0.61
34 INT219793 Negative_regulation of Renbp 5 0.13 3.42 0.61
35 INT174106 Binding of Renbp 18 0.24 15.82 0.58
36 INT25168 Phosphorylation of Pck1 1 0.79 0.53 0.56
37 INT205619 Regulation of Renbp 6 0.17 1.91 0.55
38 INT235515 Positive_regulation of Gene_expression of Renbp 5 0.24 5.19 0.54
39 INT229276 Negative_regulation of Pck1 4 0.54 4.56 0.51
40 INT170554 Binding of Renbp 17 0.17 12.36 0.45
41 INT112204 Negative_regulation of Negative_regulation of Pck1 2 0.32 0.76 0.43
42 INT21182 Negative_regulation of Regulation of Pck1 1 0.41 0.08 0.43
43 INT149747 Negative_regulation of Positive_regulation of Pck1 2 0.42 1.46 0.4
44 INT211361 Regulation of RENBP 5 0.08 2.8 0.38
45 INT240924 Transcription of Pck1 7 0.66 3.6 0.37
46 INT321323 Regulation of Regulation of Pck1 1 0.30 0.35 0.36
47 INT229284 Positive_regulation of Pck1 6 0.43 1.24 0.35
48 INT274774 Regulation of RRM1 2 0.16 0.07 0.27
49 INT199354 Gene_expression of Pck1 13 0.72 5.57 0.26
50 INT308129 Positive_regulation of Positive_regulation of RRM1 2 0.04 0.82 0.24
51 INT184652 Binding of RRM1 5 0.22 0.55 0.23
52 INT234683 Protein_catabolism of Renbp 2 0.26 0.33 0.21
53 INT205617 Negative_regulation of Positive_regulation of Renbp 1 0.16 1.04 0.21
54 INT236560 Negative_regulation of Gene_expression of Pck1 4 0.54 1.67 0.2
55 INT187051 Positive_regulation of Gene_expression of RENBP 3 0.09 2.04 0.18
56 INT98021 Regulation of PCK1 2 0.31 0.07 0.16
57 INT184651 Gene_expression of RRM1 6 0.48 3.46 0.15
58 INT342932 Positive_regulation of Gene_expression of Renbp 2 0.10 1.09 0.15
59 INT184649 Localization of RRM1 3 0.07 1.08 0.13
60 INT192591 Protein_catabolism of RENBP 1 0.02 0.94 0.12
61 INT315821 Regulation of Transcription of RRM1 1 0.21 0.67 0.1
62 INT235508 Localization of Renbp 3 0.36 2.02 0.09
63 INT315817 Transcription of RRM1 2 0.42 0.67 0.09
64 INT342933 Negative_regulation of Gene_expression of Renbp 4 0.09 2.42 0.08
65 INT240937 Negative_regulation of Transcription of Pck1 3 0.39 0.32 0.08
66 INT301567 Positive_regulation of Transcription of Pck1 1 0.14 0.64 0.08
67 INT184647 Regulation of Localization of RRM1 1 0.04 0.07 0.07
68 INT330353 Positive_regulation of Gene_expression of RRM1 1 0.04 1.01 0.06
69 INT330365 Positive_regulation of Localization of RRM1 1 0.04 1.01 0.06
70 INT262588 Negative_regulation of Binding of Renbp 3 0.02 2.64 0.05
71 INT321426 Negative_regulation of Gene_expression of RENBP 1 0.03 0.81 0.05
72 INT236569 Positive_regulation of Gene_expression of Pck1 4 0.64 1.88 0.03
73 INT262587 Protein_catabolism of Renbp 1 0.02 0.44 0.03
74 INT165692 Negative_regulation of RENBP 7 0.20 1.7 0
75 INT199330 Regulation of Pck1 3 0.57 3.12 0
76 INT219794 Regulation of Gene_expression of Renbp 2 0.08 0.2 0
77 INT199341 Localization of Pck1 2 0.65 1.29 0
78 INT216497 Positive_regulation of Localization of Pck1 1 0.12 0 0
79 INT310442 Gene_expression of POLA1 1 0.30 0.97 0
80 INT262590 Positive_regulation of Positive_regulation of Renbp 1 0.01 0.82 0
81 INT238796 Regulation of Gene_expression of Renbp 1 0.03 1.27 0
82 INT240835 Regulation of Gene_expression of Pck1 1 0.47 0.59 0
83 INT240854 Positive_regulation of Regulation of Pck1 1 0.36 0.59 0
84 INT320323 Negative_regulation of Transcription of RRM1 1 0.25 0 0
85 INT310440 Positive_regulation of POLA1 1 0.18 0.09 0
86 INT219796 Localization of Renbp 1 0.13 0.2 0
87 INT262585 Negative_regulation of Renbp 1 0.01 1.08 0
88 INT296403 Regulation of Positive_regulation of Renbp 1 0.03 1.31 0
89 INT240926 Regulation of Transcription of Pck1 1 0.42 1.34 0
90 INT255453 Positive_regulation of Binding of RENBP 1 0.09 1.47 0
91 INT310439 Regulation of POLA1 1 0.24 2.21 0
92 INT262591 Transcription of Renbp 1 0.02 0.8 0
93 INT310443 Negative_regulation of POLA1 1 0.16 0.31 0
94 INT353180 Transcription of Renbp 1 0.12 0 0
95 INT305283 Phosphorylation of Renbp 1 0.24 0.06 0
96 INT342927 Positive_regulation of Binding of Renbp 1 0.09 1.14 0
97 INT240936 Regulation of Negative_regulation of Pck1 1 0.36 0.47 0
98 INT240925 Binding of Pck1 1 0.34 0.78 0
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