GO:0019885

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Name antigen processing and presentation of endogenous peptide antigen via MHC class I
Categary Process
Go Slim No
Go Link GO:0019885
Unique Molecular Interactions 42
Total Molecular Interactions 52
Total Single Events 330
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for antigen processing and presentation of endogenous peptide antigen via MHC class I. They are ordered first by their pain relevance and then by number of times they were reported for antigen processing and presentation of endogenous peptide antigen via MHC class I. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
2 INT163946 Binding of ERAP1 and Il23r 1 0.23 0.56 0.72
3 INT160711 Binding of KIR3DL1 and ERAP1 1 0.15 0.71 0.71
4 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
5 INT132267 Binding of SGCG and Tap1 1 0.05 0.24 0.18
6 INT317243 Npy Positive_regulation of Tap2 1 0.08 0 0.1
7 INT317260 Pyy Positive_regulation of Tap2 1 0.09 0 0.1
8 INT54095 ERAP1 Regulation of Protein_catabolism of Fgg 1 0.00 0 0.09
9 INT317257 Binding of Tap2 and Pyy 1 0.06 0 0.05
10 INT317242 Binding of Tap2 and Npy 1 0.05 0 0.05
11 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04
12 INT225027 Binding of TAPBP and TRERF1 1 0.33 0 0.04
13 INT336765 Binding of FLT1 and ERAP2 1 0.30 0.58 0.03
14 INT92381 Binding of HLA-B and Tap1 1 0.01 0 0
15 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
16 INT189115 Binding of Esr1 and Tap1 1 0.07 0.05 0
17 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0
18 INT336764 ERAP2 Regulation of Gene_expression of HLA-E 1 0.24 0 0
19 INT189117 TAP1 Positive_regulation of Tap1 1 0.44 0.45 0
20 INT336780 Ighmbp2 Regulation of ERAP2 1 0.02 0.15 0
21 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
22 INT250952 Binding of TAP1 and USO1 1 0.02 0 0
23 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0
24 INT189109 Tap1 Regulation of Tap2 1 0.27 0.29 0
25 INT159710 Binding of Tap1 and ERAP1 1 0.04 0.11 0
26 INT152402 Binding of Il1a and ERAP1 1 0.00 0.06 0
27 INT336762 Negative_regulation of ERAP2 Negative_regulation of HLA-E 1 0.23 0.31 0
28 INT336781 Negative_regulation of ERAP2 Negative_regulation of Atp8a1 1 0.48 0.31 0
29 INT189104 Negative_regulation of Binding of Esr1 and Tap1 1 0.08 0.06 0
30 INT189107 Binding of Atp8a1 and Tap1 1 0.39 0 0
31 INT189113 Gene_expression of Tap1 Positive_regulation of Gene_expression of H2-D1 1 0.05 0.47 0
32 INT189103 Binding of Tap1 and Tap2 1 0.21 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for antigen processing and presentation of endogenous peptide antigen via MHC class I. They are ordered first by their pain relevance and then by number of times they were reported in antigen processing and presentation of endogenous peptide antigen via MHC class I. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT101140 Negative_regulation of Tap1 7 0.50 9.08 17.46
2 INT159709 Binding of ERAP1 12 0.47 3.42 2.91
3 INT96273 Binding of TAP1 4 0.37 4.27 2.67
4 INT93753 Positive_regulation of Tap2 1 0.57 1.31 2.21
5 INT189092 Gene_expression of Tap1 56 0.76 14.09 1.33
6 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09
7 INT79115 Binding of Tap1 12 0.47 4.21 0.95
8 INT122101 Negative_regulation of Tap2 4 0.25 0.36 0.82
9 INT145747 Regulation of ERAP1 1 0.25 0.19 0.76
10 INT140449 Positive_regulation of Tap1 5 0.68 1.84 0.74
11 INT132528 Gene_expression of TAPBP 17 0.65 5.93 0.69
12 INT78257 Transcription of Tap2 1 0.28 0.59 0.62
13 INT154643 Negative_regulation of ERAP1 1 0.11 0.69 0.58
14 INT11458 Binding of Tap2 3 0.39 2.51 0.57
15 INT9688 Localization of Tap1 3 0.73 0.96 0.57
16 INT78254 Gene_expression of Tap2 4 0.54 2.59 0.56
17 INT139674 Regulation of TAPBP 2 0.44 1.34 0.46
18 INT78256 Regulation of Gene_expression of Tap2 2 0.28 0.38 0.32
19 INT143502 Regulation of Tap1 2 0.40 0.75 0.29
20 INT160070 Binding of ERAP2 2 0.37 1.54 0.23
21 INT117251 Positive_regulation of Localization of TAPBP 1 0.40 0.8 0.22
22 INT111912 Negative_regulation of TAP1 1 0.04 0.41 0.22
23 INT117250 Localization of TAPBP 1 0.61 0.8 0.22
24 INT336768 Gene_expression of ERAP2 1 0.78 2.82 0.19
25 INT132529 Binding of TAPBP 8 0.47 1.43 0.18
26 INT243261 Gene_expression of TAP1 1 0.05 0.1 0.1
27 INT336779 Localization of ERAP2 1 0.75 0.84 0.09
28 INT243262 Localization of TAP1 1 0.06 0.09 0.09
29 INT4418 Positive_regulation of ERAP1 4 0.45 1.21 0.08
30 INT219617 Negative_regulation of Positive_regulation of Tap1 1 0.27 1.03 0.07
31 INT172369 Negative_regulation of Gene_expression of TAPBP 1 0.09 0.25 0.07
32 INT336771 Negative_regulation of ERAP2 1 0.43 2.12 0.05
33 INT181175 Negative_regulation of TAPBP 1 0.35 0.81 0.05
34 INT336770 Regulation of Localization of ERAP2 1 0.45 0.42 0.04
35 INT189097 Positive_regulation of Gene_expression of Tap1 18 0.68 2.67 0
36 INT159707 Gene_expression of ERAP1 4 0.66 0.69 0
37 INT189089 Regulation of Binding of Tap1 1 0.38 0 0
38 INT335230 Positive_regulation of TAP1 1 0.01 0.07 0
39 INT336776 Positive_regulation of Transcription of ERAP2 1 0.47 0.14 0
40 INT163945 Positive_regulation of Gene_expression of ERAP1 1 0.26 0.09 0
41 INT336775 Transcription of ERAP2 1 0.72 0.65 0
42 INT132530 Positive_regulation of Binding of TAPBP 1 0.67 0.08 0
43 INT336778 Phosphorylation of ERAP2 1 0.63 0 0
44 INT336777 Regulation of Gene_expression of ERAP2 1 0.61 0.41 0
45 INT336767 Negative_regulation of Transcription of ERAP2 1 0.43 0.14 0
46 INT336772 Regulation of ERAP2 1 0.61 0.76 0
47 INT189094 Positive_regulation of Gene_expression of Tap2 1 0.37 0.14 0
48 INT189099 Localization of Tap2 1 0.39 0.33 0
49 INT189091 Regulation of Gene_expression of Tap1 1 0.44 0.18 0
50 INT189098 Transcription of Tap1 1 0.67 0.32 0
51 INT243348 Regulation of TAP1 1 0.05 0.08 0
52 INT189095 Negative_regulation of Gene_expression of Tap1 1 0.36 0.22 0
53 INT189090 Negative_regulation of Localization of Tap1 1 0.42 0.38 0
54 INT132527 Positive_regulation of Gene_expression of TAPBP 1 0.49 0.84 0
55 INT336774 Protein_catabolism of ERAP2 1 0.44 0.1 0
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