GO:0021938

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Name smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
Categary Process
Go Slim No
Go Link GO:0021938
Unique Molecular Interactions 102
Total Molecular Interactions 139
Total Single Events 650
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported for smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
2 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
3 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
4 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
5 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
6 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
7 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
8 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
9 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
10 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
11 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
12 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
13 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
14 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
15 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
16 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
17 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
18 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
19 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
20 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
21 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
22 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
23 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
24 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
25 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
26 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
27 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
28 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
29 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
30 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
31 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
32 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
33 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
34 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
35 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
36 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
37 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
38 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
39 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
40 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
41 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
42 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
43 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
44 INT333294 Binding of Zic2 and Gli1 1 0.03 0 0
45 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
46 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
47 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
48 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
49 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
50 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
51 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
52 INT289372 Negative_regulation of Gli1 Positive_regulation of cac 1 0.48 0.68 0
53 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
54 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
55 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
56 INT333293 Binding of Zic1 and Gli1 1 0.01 0 0
57 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
58 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
59 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
60 INT289373 Gli1 Positive_regulation of cac 1 0.52 0.68 0
61 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
62 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
63 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
64 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
65 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
66 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
67 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
68 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
69 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
70 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
71 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation. They are ordered first by their pain relevance and then by number of times they were reported in smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
2 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
3 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
4 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
5 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
6 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
7 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
8 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
9 INT119674 Localization of GLI2 6 0.52 2.84 0.99
10 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
11 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
12 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
13 INT270447 Binding of Smo 2 0.07 2.61 0.78
14 INT104840 Binding of GLI2 6 0.08 1.89 0.72
15 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
16 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
17 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
18 INT206484 Localization of Shh 2 0.75 1.14 0.46
19 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
20 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
21 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
22 INT356400 Transcription of Smo 1 0.02 0.05 0.3
23 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
24 INT24320 Localization of Gli1 6 0.77 0.63 0.29
25 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
26 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
27 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
28 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
29 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
30 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
31 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
32 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
33 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
34 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
35 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
36 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
37 INT149891 Negative_regulation of Gene_expression of Gli1 1 0.41 0.68 0.14
38 INT253190 Localization of Shh 2 0.77 1.06 0.13
39 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
40 INT270442 Transcription of Shh 1 0.53 0.25 0.09
41 INT24318 Regulation of Gene_expression of Gli1 1 0.23 0 0.09
42 INT213515 Binding of Shh 8 0.37 1.92 0.08
43 INT270453 Regulation of Shh 1 0.27 0.83 0.08
44 INT352606 Localization of Gli1 1 0.38 1.19 0.08
45 INT205973 Binding of SHH 3 0.35 1.03 0.07
46 INT165151 Negative_regulation of Positive_regulation of Gli1 1 0.50 0.09 0.07
47 INT256862 Regulation of Shh 1 0.25 0 0.07
48 INT345344 Regulation of SMO 1 0.23 1.07 0.06
49 INT290112 Positive_regulation of Gene_expression of Gli1 1 0.50 1.09 0.05
50 INT290114 Negative_regulation of Gene_expression of Gli1 1 0.31 1.09 0.05
51 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
52 INT262772 Binding of SMO 1 0.27 0.59 0.05
53 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
54 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
55 INT262777 Localization of SMO 1 0.59 0.6 0.04
56 INT352603 Negative_regulation of Localization of Gli1 1 0.18 0.6 0.04
57 INT270456 Positive_regulation of Gli1 1 0.02 0.62 0.04
58 INT352604 Regulation of Gli1 1 0.21 0.6 0.04
59 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
60 INT253181 Transcription of Shh 1 0.68 0.54 0.03
61 INT246011 Transcription of Gli1 2 0.29 0 0
62 INT252242 Gene_expression of Smo 1 0.01 0.23 0
63 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
64 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
65 INT24319 Positive_regulation of Localization of Gli1 1 0.66 0 0
66 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
67 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
68 INT205956 Localization of Smo 1 0.06 0.71 0
69 INT207369 Transcription of GLI2 1 0.05 0.08 0
70 INT290929 Binding of Shh 1 0.31 0.1 0
71 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
72 INT289370 Binding of Gli1 1 0.37 2.78 0
73 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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