GO:0022857

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Name transmembrane transporter activity
Categary Function
Go Slim Yes
Go Link GO:0022857
Unique Molecular Interactions 56
Total Molecular Interactions 87
Total Single Events 819
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67
2 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
3 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
4 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
5 INT115811 Binding of Slc22a6 and Mtx1 1 0.02 0.17 0.65
6 INT115812 Binding of Slc22a8 and Mtx1 1 0.08 0.17 0.65
7 INT346412 Binding of Tesc and Sv2a 1 0.02 0.6 0.59
8 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
9 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
10 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
11 INT177981 Binding of RUNX1 and SLC22A4 1 0.08 1.04 0.5
12 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
13 INT264209 Binding of Igh-Lev and Sv2a 1 0.17 1.78 0.38
14 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
15 INT58305 AQP1 Regulation of Localization of TNF 1 0.10 0.16 0.22
16 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
17 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
18 INT55300 Slc2a1 Regulation of Gene_expression of Slc2a4 1 0.41 0.41 0.19
19 INT55295 Slc2a1 Regulation of Ins1 1 0.17 0.41 0.19
20 INT55296 Slc2a4 Regulation of Ins1 1 0.17 0.41 0.19
21 INT55299 Slc2a4 Regulation of Gene_expression of Slc2a1 1 0.41 0.41 0.19
22 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
23 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
24 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
25 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08
26 INT177255 Binding of SV2A and NR1H4 1 0.04 0 0.07
27 INT346415 Binding of Mns1 and Sv2a 1 0.03 0.14 0.07
28 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06
29 INT55297 Gene_expression of Slc2a4 Positive_regulation of Ins1 1 0.19 0.36 0.06
30 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
31 INT267046 Binding of SLC2A1 and SV2A 1 0.12 0 0.05
32 INT329219 Ins1 Positive_regulation of Gene_expression of Slc2a4 1 0.04 0.93 0.05
33 INT177288 Binding of CXADR and SV2A 1 0.32 0 0.04
34 INT352062 Binding of SV2A and Chrna7 1 0.00 0.7 0.04
35 INT346418 Sv2a Positive_regulation of Binding of Tesc 1 0.02 0.1 0.04
36 INT177275 Binding of CA2 and SV2A 1 0.30 0 0.04
37 INT352519 INS Positive_regulation of Localization of Slc2a4 1 0.07 0.97 0.03
38 INT346407 Negative_regulation of Binding of Tesc and Sv2a 1 0.02 0 0.03
39 INT323483 Slc2a2 Positive_regulation of Localization of Ins1 1 0.07 0.1 0.03
40 INT177258 SV2A Regulation of CXADR 1 0.63 0 0.03
41 INT255752 hs Positive_regulation of Phosphorylation of Slc2a4 1 0.08 1.32 0
42 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
43 INT177299 SV2A Regulation of FAUP1 1 0.02 0 0
44 INT233304 Binding of SRY and SLC22A8 1 0.34 0.93 0
45 INT177252 SV2A Positive_regulation of CYP2B6 1 0.45 0 0
46 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 0.03 0 0
47 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
48 INT177264 Positive_regulation of Binding of NCOA1 and SV2A 1 0.17 0 0
49 INT177271 Binding of NCOA1 and SV2A 1 0.17 0 0
50 INT98626 Aqp1 Positive_regulation of Aqp4 1 0.52 0 0
51 INT177256 SV2A Positive_regulation of ABCB1 1 0.38 0 0
52 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
53 INT219634 Binding of NLRP1 and Slc22a6 1 0.26 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane transporter activity. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane transporter activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
2 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
3 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
4 INT95099 Gene_expression of SLC22A8 14 0.67 1.59 5.14
5 INT95101 Binding of SLC22A8 6 0.48 0.75 5.07
6 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
7 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
8 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
9 INT95102 Localization of SLC22A8 3 0.75 0.69 4.24
10 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
11 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
12 INT134747 Gene_expression of SV2A 10 0.72 0.44 3.48
13 INT96304 Gene_expression of Slc22a8 9 0.66 0.63 3.12
14 INT104134 Binding of SLC22A6 3 0.34 0.52 2.75
15 INT129695 Binding of Sv2a 6 0.47 4.96 2.51
16 INT156373 Binding of Sv2a 4 0.39 1.54 2.3
17 INT19157 Gene_expression of SLC22A6 5 0.71 1.39 2.18
18 INT55291 Gene_expression of Slc2a1 20 0.68 11.46 2.16
19 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
20 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
21 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14
22 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
23 INT87779 Positive_regulation of Gja1 4 0.53 0.9 1.95
24 INT128030 Gene_expression of GJA1 23 0.75 7.81 1.88
25 INT87776 Positive_regulation of Phosphorylation of Gja1 3 0.62 0.71 1.86
26 INT346404 Gene_expression of Sv2a 1 0.72 3.2 1.62
27 INT230805 Localization of Slc2a4 23 0.46 11 1.48
28 INT62015 Gene_expression of Sv2a 3 0.30 0.99 1.45
29 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
30 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
31 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
32 INT92405 Negative_regulation of Slc22a6 2 0.47 1.52 1.34
33 INT90829 Negative_regulation of SLC22A6 3 0.40 0.75 1.22
34 INT115810 Negative_regulation of Slc22a8 3 0.41 0.27 1.18
35 INT55294 Gene_expression of Slc2a4 17 0.70 6.84 1.11
36 INT11934 Regulation of Sv2a 4 0.44 1.72 1.1
37 INT123213 Negative_regulation of SLC22A8 2 0.35 1.43 1.05
38 INT134822 Gene_expression of Gja1 18 0.72 4.2 1
39 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
40 INT108805 Binding of Slc22a8 3 0.18 0.44 0.97
41 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
42 INT90830 Localization of SLC22A6 3 0.69 0.86 0.89
43 INT177997 Regulation of SLC22A4 2 0.20 3.88 0.86
44 INT134748 Positive_regulation of SV2A 7 0.46 2.89 0.82
45 INT168284 Localization of Slc22a8 1 0.78 0.1 0.82
46 INT87777 Regulation of Gja1 1 0.62 0.76 0.81
47 INT112780 Positive_regulation of Slc2a1 6 0.46 1.85 0.78
48 INT81604 Transcription of SLC22A6 2 0.63 0.67 0.78
49 INT178004 Binding of SLC22A4 2 0.26 2.45 0.77
50 INT143306 Positive_regulation of Gja1 3 0.50 0.42 0.75
51 INT178116 Phosphorylation of GJA1 7 0.80 4.09 0.74
52 INT172412 Negative_regulation of SV2A 6 0.47 0.88 0.74
53 INT128402 Negative_regulation of Phosphorylation of Gja1 1 0.58 0.73 0.73
54 INT230808 Positive_regulation of Localization of Slc2a4 12 0.40 5.42 0.7
55 INT134744 Positive_regulation of Gene_expression of SV2A 1 0.50 0.08 0.69
56 INT152909 Regulation of Gene_expression of Gja1 1 0.61 0.46 0.69
57 INT87781 Regulation of Phosphorylation of Gja1 1 0.27 0 0.67
58 INT246207 Positive_regulation of GJA1 3 0.67 0.91 0.65
59 INT115809 Binding of Slc22a6 1 0.03 0.17 0.65
60 INT70515 Gene_expression of Slc22a6 7 0.78 1.26 0.63
61 INT177327 Localization of SV2A 6 0.69 0.08 0.62
62 INT172411 Regulation of SV2A 3 0.22 0.93 0.61
63 INT346381 Localization of Sv2a 1 0.69 1.12 0.61
64 INT346389 Negative_regulation of Sv2a 1 0.47 0.41 0.61
65 INT90831 Negative_regulation of Gene_expression of SLC22A6 1 0.40 0.39 0.58
66 INT215899 Negative_regulation of Gene_expression of Slc2a1 6 0.43 3.96 0.55
67 INT139780 Binding of AQP1 7 0.32 4.62 0.54
68 INT154837 Regulation of Gja1 2 0.45 1.42 0.53
69 INT55293 Positive_regulation of Gene_expression of Slc2a4 7 0.63 4.18 0.51
70 INT134820 Positive_regulation of Gene_expression of Gja1 3 0.64 0.84 0.49
71 INT87774 Binding of Gja1 2 0.48 0.19 0.48
72 INT329831 Positive_regulation of Positive_regulation of GJA1 1 0.49 0.58 0.48
73 INT55292 Positive_regulation of Gene_expression of Slc2a1 5 0.61 2.98 0.46
74 INT192937 Positive_regulation of Gene_expression of GJA1 4 0.67 0.4 0.44
75 INT19592 Localization of AQP1 4 0.81 1.09 0.44
76 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
77 INT168285 Negative_regulation of Localization of Slc22a8 1 0.36 0 0.44
78 INT177338 Binding of SV2A 21 0.44 1.14 0.42
79 INT95100 Transcription of SLC22A8 4 0.45 0.57 0.39
80 INT147225 Positive_regulation of Slc22a8 2 0.49 0 0.38
81 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
82 INT253118 Negative_regulation of Localization of Slc2a4 3 0.25 2.47 0.33
83 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
84 INT262284 Negative_regulation of Positive_regulation of Slc22a6 1 0.06 0.79 0.31
85 INT262299 Negative_regulation of Positive_regulation of SLC22A8 1 0.06 0.79 0.31
86 INT262283 Positive_regulation of Slc22a6 1 0.07 0.73 0.3
87 INT262300 Positive_regulation of SLC22A8 1 0.07 0.73 0.3
88 INT184526 Phosphorylation of Slc2a1 2 0.18 1.53 0.29
89 INT126820 Negative_regulation of Gene_expression of Slc22a6 2 0.26 0.85 0.26
90 INT262296 Negative_regulation of Transcription of SLC22A8 1 0.06 0.58 0.26
91 INT262292 Negative_regulation of Gene_expression of SLC22A8 1 0.06 0.58 0.26
92 INT346396 Positive_regulation of Gene_expression of Sv2a 1 0.43 1.09 0.26
93 INT262285 Negative_regulation of Transcription of Slc22a6 1 0.06 0.58 0.26
94 INT262286 Transcription of Slc22a6 1 0.09 0.58 0.26
95 INT128386 Transcription of Slc22a8 1 0.38 0 0.25
96 INT132951 Regulation of GJA1 2 0.57 0.79 0.24
97 INT247021 Binding of GJA1 6 0.47 0.91 0.23
98 INT126761 Negative_regulation of Gja1 1 0.33 0.08 0.22
99 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
100 INT231256 Regulation of Slc2a4 3 0.21 0.76 0.18
101 INT186146 Negative_regulation of GJA1 2 0.41 1.29 0.18
102 INT178124 Positive_regulation of Phosphorylation of GJA1 2 0.65 1.21 0.18
103 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
104 INT346382 Regulation of Sv2a 1 0.36 0 0.17
105 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
106 INT290795 Gene_expression of Slc2a2 3 0.44 1.22 0.16
107 INT209185 Regulation of Phosphorylation of GJA1 2 0.44 0.09 0.14
108 INT308623 Localization of Slc2a2 1 0.23 0.1 0.14
109 INT155667 Negative_regulation of Gene_expression of Gja1 3 0.42 1.16 0.1
110 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
111 INT159343 Positive_regulation of Localization of AQP1 1 0.11 0 0.1
112 INT236581 Regulation of Gene_expression of Slc2a4 3 0.36 0.5 0.09
113 INT209182 Regulation of Gene_expression of GJA1 1 0.57 0.09 0.09
114 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
115 INT346394 Regulation of Negative_regulation of Sv2a 1 0.36 0.16 0.08
116 INT352512 Regulation of Localization of Slc2a4 1 0.06 0.66 0.08
117 INT188177 Localization of GJA1 2 0.75 0.07 0.07
118 INT178132 Negative_regulation of Gene_expression of GJA1 2 0.35 0.84 0.07
119 INT11935 Positive_regulation of Sv2a 2 0.39 0.14 0.07
120 INT209187 Positive_regulation of Localization of GJA1 1 0.65 0.07 0.07
121 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
122 INT257689 Negative_regulation of Gja1 1 0.37 0.58 0.05
123 INT228786 Regulation of Gene_expression of Gja1 2 0.29 0.49 0.04
124 INT253095 Regulation of Gene_expression of Slc2a1 1 0.30 0.14 0.04
125 INT177310 Negative_regulation of Binding of SV2A 1 0.54 0 0.04
126 INT228802 Negative_regulation of Gene_expression of Gja1 4 0.37 0.87 0.03
127 INT215896 Binding of Slc2a1 2 0.36 0.42 0.03
128 INT216569 Localization of Gja1 2 0.36 0.35 0.03
129 INT185438 Gene_expression of SLC22A4 1 0.39 1.51 0.03
130 INT253101 Binding of Slc2a4 1 0.21 0 0.03
131 INT177311 Negative_regulation of Localization of SV2A 1 0.34 0 0.03
132 INT247813 Localization of Gja1 2 0.45 0.47 0
133 INT247793 Regulation of Localization of Gja1 2 0.17 0.47 0
134 INT262504 Positive_regulation of Aqp1 1 0.25 0.43 0
135 INT286264 Positive_regulation of Negative_regulation of AQP1 1 0.01 0.79 0
136 INT262513 Negative_regulation of Binding of Aqp1 1 0.23 0.64 0
137 INT209190 Negative_regulation of Negative_regulation of GJA1 1 0.40 0 0
138 INT268312 Negative_regulation of Negative_regulation of Slc2a4 1 0.26 0.31 0
139 INT317361 Negative_regulation of Gene_expression of Slc2a4 1 0.40 0.15 0
140 INT178112 Negative_regulation of Phosphorylation of GJA1 1 0.18 1.09 0
141 INT262514 Binding of Aqp1 1 0.20 0.64 0
142 INT58101 Negative_regulation of Sv2a 1 0.00 0 0
143 INT200582 Positive_regulation of Negative_regulation of SV2A 1 0.00 0.19 0
144 INT177329 Regulation of Localization of SV2A 1 0.42 0 0
145 INT336105 Positive_regulation of Slc2a4 1 0.39 0.63 0
146 INT160111 Localization of Slc22a6 1 0.68 0 0
147 INT177330 Positive_regulation of Binding of SV2A 1 0.64 0 0
148 INT215898 Regulation of Slc2a1 1 0.20 0.47 0
149 INT268302 Negative_regulation of Slc2a4 1 0.26 0.31 0
150 INT299193 Transcription of Aqp1 1 0.56 0.62 0
151 INT262511 Positive_regulation of Gene_expression of Aqp1 1 0.37 1.78 0
152 INT327782 Regulation of Gene_expression of AQP1 1 0.36 1.63 0
153 INT126821 Negative_regulation of Gene_expression of Slc22a8 1 0.17 0.27 0
154 INT262512 Localization of Aqp1 1 0.40 0.7 0
155 INT255722 Phosphorylation of Slc2a4 1 0.46 1.3 0
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