GO:0030260

Name entry into host cell Categary Process Go Slim No Go Link GO:0030260

Unique Molecular Interactions 119 Total Molecular Interactions 200 Total Single Events 1760 Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for entry into host cell. They are ordered first by their pain relevance and then by number of times they were reported for entry into host cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT121651	Binding of CXCL12 and CXCR4	13	0.48	17.61	3.52
2	INT182635	Binding of CCR5 and CCL5	2	0.09	4.19	3
3	INT187175	Binding of BSG and PPIA	1	0.14	2.23	1.64
4	INT241750	Binding of CD4 and ITIH4	14	0.18	5.72	1.53
5	INT174508	Binding of CD4 and HLA-B	1	0.14	4.68	1.53
6	INT106248	Binding of CCR5 and YY1	1	0.54	0.19	0.98
7	INT182190	Binding of IL8 and CXCR4	1	0.26	1.25	0.95
8	INT182210	Binding of CXCR4 and CXCL13	1	0.32	1.25	0.95
9	INT182205	Binding of CXCL5 and CXCR4	1	0.29	1.24	0.94
10	INT182195	Binding of CXCL1 and CXCR4	1	0.13	1.25	0.94
11	INT128652	ITIH4 Regulation of Gene_expression of CCR5	1	0.36	1.46	0.93
12	INT226340	Binding of CD4 and IFNA1	3	0.03	3.84	0.85
13	INT174509	Binding of CD4 and CD28	1	0.26	1.68	0.84
14	INT205120	Binding of CD4 and CD8A	3	0.15	2.83	0.72
15	INT182201	Binding of CXCR5 and CXCR4	1	0.36	1.15	0.72
16	INT182202	Binding of CXCR2 and CXCR4	1	0.31	1.15	0.72
17	INT239538	Binding of CXCR4 and CALCRL	1	0.00	0.35	0.71
18	INT254352	Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12	1	0.14	1.8	0.66
19	INT106247	Binding of CCR5 and CCL4	1	0.54	0.06	0.64
20	INT174500	Positive_regulation of Binding of CD4 and HLA-B	1	0.21	2.33	0.63
21	INT62299	Binding of CD4 and SGCG	1	0.39	1.23	0.51
22	INT251297	Binding of C2 and CD4	1	0.04	0.35	0.47
23	INT178664	Binding of CCR5 and TH1L	1	0.04	1.04	0.44
24	INT208461	Binding of CD4 and IL16	1	0.05	3.04	0.41
25	INT330515	TNFSF10 Regulation of Gene_expression of CD4	1	0.29	1.24	0.4
26	INT330518	TNFSF10 Regulation of CD4	1	0.29	1.24	0.4
27	INT117184	GOLPH3 Regulation of CXCR4	1	0.30	0.29	0.37
28	INT273172	Negative_regulation of PDE4A Negative_regulation of Localization of CD4	1	0.11	0.74	0.37
29	INT226350	MBTPS1 Negative_regulation of Gene_expression of CD4	1	0.03	0.61	0.37
30	INT226374	Negative_regulation of Binding of CD4 and IFNA1	1	0.03	0.66	0.37
31	INT117182	GOLPH3 Regulation of Binding of CXCR4	1	0.50	0.29	0.37
32	INT27030	HERPUD1 Regulation of CD4	1	0.41	0	0.34
33	INT188391	Binding of CD4 and HLA-DRB1	1	0.05	0.96	0.34
34	INT27037	HERPUD1 Regulation of Gene_expression of CD4	1	0.55	0	0.34
35	INT278693	ERAL1 Positive_regulation of CD4	1	0.05	1.1	0.31
36	INT278692	ERAL1 Positive_regulation of Positive_regulation of CD4	1	0.05	1.1	0.31
37	INT174499	Binding of CD4 and HLA-E	1	0.04	1.08	0.29
38	INT245072	PPARA Regulation of Gene_expression of CXCR4	1	0.07	0.68	0.26
39	INT194670	CREB1 Regulation of Gene_expression of CD4	1	0.05	0.07	0.25
40	INT330521	Binding of CD4 and TNFSF10	1	0.20	0.73	0.24
41	INT352081	Binding of CD4 and ADAM11	1	0.09	0.33	0.24
42	INT88310	ITIH4 Positive_regulation of CXCR4	2	0.27	1.98	0.23
43	INT241822	Binding of CD4 and HIVEP1	3	0.01	2.73	0.21
44	INT182634	Binding of CCR5 and MIP	2	0.39	1.29	0.2
45	INT252821	Binding of CD4 and IL12A	1	0.02	1.36	0.19
46	INT188570	Negative_regulation of IRF6 Positive_regulation of CD4	1	0.04	0.19	0.19
47	INT188573	IRF6 Positive_regulation of CD4	1	0.05	0.19	0.19
48	INT193787	Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53	1	0.03	0.71	0.19
49	INT274386	Binding of CD4 and ERVW-1	1	0.05	3.07	0.18
50	INT117183	Binding of CXCR4 and GOLPH3	1	0.53	0.27	0.16
51	INT88311	ITIH4 Positive_regulation of CCR5	1	0.49	1.57	0.16
52	INT188569	Binding of CD4 and TLR4	1	0.16	0.34	0.16
53	INT117191	Binding of CXCR4 and Coro1a	1	0.39	0.28	0.16
54	INT193779	Positive_regulation of ITIH4 Positive_regulation of CXCR4	1	0.19	0.83	0.15
55	INT291349	CXCR4 Positive_regulation of EPHB2	1	0.42	1.87	0.13
56	INT10731	NEUROD1 Regulation of CD4	1	0.42	1.3	0.12
57	INT10730	CD9 Regulation of CD4	1	0.42	1.3	0.12
58	INT251295	Binding of CD4 and Regulation of ITIH4	1	0.11	0.24	0.11
59	INT241748	CCR5 Regulation of CD4	1	0.21	0.39	0.11
60	INT189144	MTNR1B Positive_regulation of Gene_expression of CD4	1	0.01	0.35	0.11
61	INT294441	KLK4 Negative_regulation of CXCR4	1	0.01	0	0.1
62	INT333099	Localization of IL2 Negative_regulation of Negative_regulation of CD4	1	0.14	0.8	0.09
63	INT292632	CD4 Positive_regulation of Gene_expression of IL9	1	0.24	0	0.09
64	INT333094	HIVEP1 Regulation of CD4	1	0.00	0.22	0.09
65	INT182644	Binding of CXCR4 and Cxcr4	1	0.10	0.66	0.09
66	INT333089	CD4 Positive_regulation of ERVW-1	1	0.05	0.07	0.08
67	INT342288	Binding of CD4 and HFE	1	0.01	1.26	0.08
68	INT15953	Binding of CD4 and IgG2a	1	0.54	0.38	0.08
69	INT183768	Csf2 Regulation of CD4	1	0.37	0.52	0.08
70	INT333096	Binding of CD4 and IFN1@	1	0.12	0.17	0.07
71	INT333092	Binding of CD4 and IL2	1	0.01	0.17	0.07
72	INT166732	BATF Negative_regulation of PPIA	1	0.05	1.45	0.06
73	INT335715	Binding of FASLG and CD4	1	0.22	0.9	0.06
74	INT335714	Binding of FAS and CD4	1	0.38	0.9	0.06
75	INT333091	Localization of IFN1@ Negative_regulation of Negative_regulation of CD4	1	0.14	0.4	0.05
76	INT233303	Binding of CD4 and SRY	1	0.07	0.34	0.05
77	INT241751	Negative_regulation of Binding of CD4 and ITIH4	3	0.18	1.07	0.04
78	INT329102	Binding of CD4 and HLA-DQA2	2	0.04	0.92	0.04
79	INT241752	ITIH4 Negative_regulation of Binding of CXCR4	1	0.08	0.71	0.04
80	INT283464	Binding of CD4 and DLAT	1	0.07	0.69	0.04
81	INT251296	Binding of CCR5 and ITIH4	1	0.16	0.08	0.04
82	INT241749	ITIH4 Negative_regulation of Binding of CCR5	1	0.16	0.71	0.04
83	INT286968	Positive_regulation of STAT3 Regulation of Gene_expression of CD4	1	0.16	0.44	0.04
84	INT286962	IL2 Regulation of Gene_expression of CD4	1	0.01	0.45	0.04
85	INT212584	IFNA1 Regulation of Gene_expression of CD4	1	0.21	0.98	0.03
86	INT308540	CD4 Regulation of Localization of AGRP	1	0.39	0.85	0.03
87	INT183767	Csf2 Negative_regulation of Transcription of CCR5	1	0.17	0.92	0.03
88	INT245076	CXCR4 Regulation of Gene_expression of VEGFA	1	0.16	1.05	0.03
89	INT183769	Csf2 Negative_regulation of Transcription of CXCR4	1	0.48	0.92	0.03
90	INT183757	INCENP Negative_regulation of Transcription of CXCR4	1	0.01	0.93	0.03
91	INT221262	Binding of BRCA1 and CD4	1	0.22	0.81	0.03
92	INT183758	INCENP Negative_regulation of Transcription of CCR5	1	0.00	0.93	0.03
93	INT291357	CXCR4 Positive_regulation of AKT1	1	0.08	1.27	0.03
94	INT121650	Negative_regulation of Binding of CXCL12 and CXCR4	2	0.47	1.61	0
95	INT121652	Binding of CCR5 and CXCL12	1	0.33	0.2	0
96	INT245078	FGF2 Positive_regulation of CXCR4	1	0.07	1.36	0
97	INT326167	Binding of CD4 and Tmed8	1	0.47	0.29	0
98	INT245073	VEGFA Positive_regulation of CXCR4	1	0.27	5.09	0
99	INT260127	Binding of CD4 and Trav6-3	1	0.03	0	0
100	INT245074	Gene_expression of VHL Negative_regulation of Gene_expression of CXCR4	1	0.31	1.84	0
101	INT328477	Mkrn1 Positive_regulation of CCR5	1	0.01	0.69	0
102	INT121649	Binding of CD4 and CXCL12	1	0.29	0.2	0
103	INT343501	CD4 Regulation of ERVW-1	1	0.09	0.16	0
104	INT240420	Myo5a Positive_regulation of CD4	1	0.06	0.27	0
105	INT277809	Binding of CD4 and CD40LG	1	0.15	0	0
106	INT329101	Binding of CD4 and INCENP	1	0.01	0.11	0
107	INT343499	CD4 Regulation of HIVEP1	1	0.02	0.16	0
108	INT205121	Binding of CD4 and CD7	1	0.05	0.51	0
109	INT340516	CD4 Regulation of IL2	1	0.04	0.32	0
110	INT258911	Binding of CD4 and HLA-G	1	0.04	0.06	0
111	INT235494	SFTPA1 Positive_regulation of Positive_regulation of CD4	1	0.01	0	0
112	INT275190	Localization of CD4 Positive_regulation of Positive_regulation of LCK	1	0.10	0.99	0
113	INT188750	Binding of CD4 and ADC	1	0.16	0.93	0
114	INT336169	Binding of HIVEP1 and CXCR4	1	0.01	0.44	0
115	INT336168	Binding of CCR5 and HIVEP1	1	0.01	0.44	0
116	INT353129	Binding of CD4 and CXCR4	1	0.13	1.08	0
117	INT174502	HLA-B Regulation of CD4	1	0.13	0	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for entry into host cell. They are ordered first by their pain relevance and then by number of times they were reported in entry into host cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT13556	Gene_expression of CD4	367	0.78	230.82	41.74
2	INT88322	Gene_expression of CCR5	111	0.78	77.36	39.84
3	INT88318	Gene_expression of CXCR4	208	0.77	189.67	31.72
4	INT5328	Positive_regulation of CD4	191	0.69	133.43	21.31
5	INT89293	Positive_regulation of Gene_expression of CCR5	29	0.70	22.14	15
6	INT10709	Negative_regulation of CD4	106	0.59	95.6	14.89
7	INT36287	Binding of CD4	96	0.47	58.93	11.88
8	INT16404	Regulation of CD4	54	0.61	33.05	10.29
9	INT89292	Positive_regulation of CCR5	27	0.70	15.12	8.59
10	INT91758	Binding of CCR5	28	0.45	20.16	7.07
11	INT17049	Localization of CD4	57	0.75	35.33	6.89
12	INT117186	Positive_regulation of CXCR4	29	0.69	24.19	6.84
13	INT107315	Negative_regulation of CCR5	22	0.57	13.82	6.11
14	INT122653	Positive_regulation of Gene_expression of CD4	48	0.68	22.5	5.96
15	INT117189	Binding of CXCR4	34	0.37	24.27	5.81
16	INT113112	Negative_regulation of CXCR4	39	0.58	28.28	5.36
17	INT170528	Negative_regulation of Gene_expression of CD4	25	0.41	17.98	3.6
18	INT103674	Positive_regulation of Gene_expression of CXCR4	32	0.69	37.1	3.08
19	INT110233	Regulation of Gene_expression of CCR5	6	0.34	7.14	2.76
20	INT106433	Regulation of CCR5	11	0.59	6.93	2.75
21	INT232510	Negative_regulation of Gene_expression of CXCR4	18	0.58	20.27	2.54
22	INT113775	Negative_regulation of Gene_expression of CCR5	6	0.43	3.97	2.28
23	INT113111	Regulation of CXCR4	14	0.61	12.81	1.39
24	INT174486	Regulation of Gene_expression of CD4	12	0.36	6.09	1.39
25	INT193815	Regulation of Gene_expression of CXCR4	17	0.61	20.27	1.15
26	INT241757	Localization of CCR5	6	0.71	5.7	1.14
27	INT187188	Binding of PPIA	3	0.47	1.1	1.01
28	INT182211	Transcription of CXCR4	5	0.69	3.8	0.95
29	INT264171	Positive_regulation of Positive_regulation of CD4	5	0.49	4.74	0.94
30	INT189171	Positive_regulation of Localization of CD4	7	0.49	5.88	0.79
31	INT19218	Negative_regulation of Positive_regulation of CD4	9	0.41	9.21	0.69
32	INT202428	Positive_regulation of Binding of CD4	4	0.37	2.11	0.68
33	INT171946	Positive_regulation of Binding of CCR5	1	0.47	3.86	0.66
34	INT193811	Localization of CXCR4	6	0.75	7.68	0.58
35	INT202427	Negative_regulation of Localization of CD4	2	0.32	3.1	0.56
36	INT260124	Positive_regulation of Positive_regulation of CCR5	1	0.14	0.84	0.51
37	INT164518	Gene_expression of PPIA	7	0.75	3.92	0.5
38	INT202426	Transcription of CD4	6	0.69	3.96	0.49
39	INT260119	Regulation of Localization of CD4	2	0.44	1.61	0.46
40	INT260118	Regulation of Regulation of CD4	1	0.44	1.66	0.4
41	INT193814	Positive_regulation of Positive_regulation of CXCR4	2	0.38	3.08	0.39
42	INT287286	Positive_regulation of Binding of CXCR4	2	0.53	0.78	0.39
43	INT187184	Localization of PPIA	1	0.27	0.64	0.37
44	INT221044	Positive_regulation of Negative_regulation of CCR5	1	0.19	0.62	0.35
45	INT260110	Positive_regulation of Regulation of CD4	2	0.48	1.5	0.32
46	INT282775	Regulation of Positive_regulation of CD4	2	0.37	1.28	0.3
47	INT212592	Regulation of Binding of CD4	2	0.30	1.15	0.3
48	INT245085	Positive_regulation of Negative_regulation of CXCR4	1	0.47	1.7	0.23
49	INT204183	Negative_regulation of Negative_regulation of CD4	3	0.30	1.79	0.22
50	INT104449	Transcription of CCR5	4	0.53	2.73	0.21
51	INT296064	Positive_regulation of Transcription of CD4	1	0.28	0.11	0.21
52	INT107316	Negative_regulation of Positive_regulation of CCR5	2	0.41	1.96	0.17
53	INT166737	Positive_regulation of Gene_expression of PPIA	1	0.68	2.5	0.15
54	INT20433	Regulation of Phosphorylation of CD4	1	0.06	0	0.13
55	INT20434	Phosphorylation of CD4	2	0.61	0	0.12
56	INT241759	Negative_regulation of Binding of CCR5	2	0.41	0.94	0.11
57	INT203282	Negative_regulation of Binding of CD4	2	0.30	0.63	0.11
58	INT166739	Positive_regulation of PPIA	1	0.45	1.39	0.06
59	INT183764	Negative_regulation of Transcription of CXCR4	1	0.41	0.91	0.03
60	INT183763	Negative_regulation of Transcription of CCR5	1	0.15	0.92	0.03
61	INT245080	Regulation of Negative_regulation of CXCR4	1	0.45	0.78	0.03
62	INT273759	Positive_regulation of Negative_regulation of CD4	2	0.45	2.05	0
63	INT290522	Regulation of PPIA	1	0.04	0.18	0
64	INT291075	Regulation of Gene_expression of PPIA	1	0.31	0.35	0
65	INT322320	Transcription of PPIA	1	0.30	0.67	0
66	INT166738	Negative_regulation of PPIA	1	0.42	1.2	0