GO:0030318

Name melanocyte differentiation Categary Process Go Slim No Go Link GO:0030318

Unique Molecular Interactions 458 Total Molecular Interactions 669 Total Single Events 4877 Pain Genes Associated 29

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for melanocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported for melanocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT104977	MITF Regulation of Gene_expression of MC1R	1	0.69	0.91	3.71
2	INT103669	Hps4 Positive_regulation of Mors1	1	0.01	0	2.7
3	INT110525	Binding of MC1R and OCA2	1	0.41	1.08	1.97
4	INT65025	Binding of Oprm1 and Hps4	1	0.01	0	1.93
5	INT43447	Binding of H3 and Hps4	1	0.07	0	1.82
6	INT156008	Bcl2 Regulation of Localization of Aifm1	1	0.17	1.92	1.47
7	INT104975	MITF Regulation of Transcription of PRSS1	1	0.68	0.35	1.46
8	INT104972	MITF Regulation of Transcription of TYR	1	0.20	0.35	1.45
9	INT145930	ecs Positive_regulation of Gene_expression of Bcl2	1	0.01	2.06	1.34
10	INT107567	Hps4 Positive_regulation of Localization of Il1b	1	0.01	0.09	1.08
11	INT172757	Rnpep Positive_regulation of Hps4	1	0.00	0	1.08
12	INT107564	Hps4 Regulation of Localization of Il1b	1	0.01	0.1	1.07
13	INT69874	POMC Negative_regulation of TYRP1	1	0.13	0	1.07
14	INT69871	ASIP Negative_regulation of TYRP1	1	0.36	0	1.07
15	INT243494	Binding of Vta1 and LOC308670	1	0.01	0.06	1.06
16	INT107566	Penk Regulation of Hps4	1	0.00	0.1	1.04
17	INT107565	Hps4 Regulation of Mtr	1	0.00	0.1	1.04
18	INT142202	FL Positive_regulation of Bcl2	1	0.05	0.39	0.99
19	INT38579	Binding of POMC and Hps4	1	0.00	0.32	0.99
20	INT54972	Binding of EDNRA and EDNRB	7	0.52	3.31	0.97
21	INT302309	Hps4 Positive_regulation of Cia1	1	0.01	1.34	0.95
22	INT112765	Binding of Nfkb1 and Bcl2	1	0.00	1.37	0.91
23	INT166634	Binding of Bcl2 and Becn1	1	0.20	0.5	0.86
24	INT150864	RYBP Positive_regulation of Positive_regulation of Bcl2	1	0.01	0.66	0.86
25	INT140985	Gli3 Regulation of Ihh	1	0.29	0.85	0.85
26	INT128701	Ednra Regulation of EDNRB	1	0.17	0.58	0.84
27	INT53377	Binding of Edn1 and Edn3	1	0.39	0	0.81
28	INT266108	Binding of COMT and HPS1	1	0.23	1.21	0.74
29	INT218935	Cyp3a23/3a1 Regulation of Bcl2	1	0.00	1.08	0.74
30	INT104974	MITF Positive_regulation of MC1R	1	0.52	0.16	0.74
31	INT314203	Nos2 Positive_regulation of Gli3	1	0.19	1.27	0.73
32	INT63557	Binding of Edn1 and Edn3	1	0.23	0.63	0.7
33	INT68561	Binding of Gli3 and Ust	1	0.01	0.68	0.68
34	INT278827	Binding of EDN1 and EDNRB	3	0.17	2.7	0.67
35	INT153921	Positive_regulation of Adra2a Regulation of Ednrb	1	0.01	0	0.66
36	INT110526	OCA2 Regulation of MC1R	1	0.49	0.43	0.65
37	INT296785	Tlr9 Regulation of Bcl2	1	0.19	0.76	0.65
38	INT30130	Binding of TYRP1 and Gast	1	0.06	0.09	0.63
39	INT79210	Hps4 Negative_regulation of Mme	1	0.00	0	0.62
40	INT37034	PLAT Positive_regulation of PLDN	1	0.08	0.15	0.58
41	INT278824	Positive_regulation of Binding of EDNRA and EDNRB	1	0.12	1.65	0.53
42	INT130157	Pomc Regulation of Gene_expression of Ednrb	1	0.14	0	0.52
43	INT127337	Crh Regulation of LOC308670	1	0.01	0	0.51
44	INT278825	Positive_regulation of Binding of EDN1 and EDNRB	3	0.16	1.24	0.49
45	INT47226	Asap1 Regulation of Hps4	1	0.10	0.18	0.49
46	INT94024	Binding of EDN1 and EDN3	1	0.27	0	0.49
47	INT94018	Binding of EDN2 and EDN3	1	0.19	0	0.48
48	INT237154	LGALS4 Positive_regulation of KIT	1	0.10	1.99	0.47
49	INT302839	MIR15A Negative_regulation of Bcl2	1	0.15	1.41	0.47
50	INT32662	Hps1 Negative_regulation of Localization of CGB	1	0.00	0	0.46
51	INT238639	Cd86 Negative_regulation of Negative_regulation of Bcl2	1	0.01	0.97	0.46
52	INT335594	Myo5a Regulation of Hmmr	1	0.00	0.39	0.45
53	INT112772	Binding of Bcl2 and SGSM3	1	0.02	0.69	0.45
54	INT116609	Lnpep Negative_regulation of Bcl2	1	0.05	0.62	0.43
55	INT321046	Anpep Regulation of Negative_regulation of Hps4	1	0.02	0.25	0.43
56	INT116606	Lnpep Regulation of Gene_expression of Bcl2	1	0.07	0.62	0.43
57	INT116607	Lnpep Negative_regulation of Gene_expression of Bcl2	1	0.10	0.62	0.43
58	INT309143	Dlat Positive_regulation of Bcl2	1	0.06	1.04	0.42
59	INT309152	Dlat Positive_regulation of Gene_expression of Bcl2	1	0.04	1.05	0.42
60	INT31794	Hps6 Positive_regulation of Th	1	0.03	0	0.38
61	INT235878	Creb1 Positive_regulation of Gene_expression of Bcl2	1	0.05	0.17	0.38
62	INT152315	Ifng Regulation of Ednrb	1	0.19	0.22	0.36
63	INT152313	Il18 Regulation of Ednrb	1	0.30	0.22	0.36
64	INT227943	Binding of Vip and Mlph	1	0.01	0.33	0.36
65	INT155062	Csf2 Positive_regulation of Transcription of Bcl2	1	0.31	2.91	0.36
66	INT201068	Binding of Edn1 and Ednrb	2	0.18	1.23	0.35
67	INT269962	Bcl2 Negative_regulation of Bcl2l11	1	0.15	2.14	0.34
68	INT155060	Stat3 Negative_regulation of Bcl2	1	0.21	3.7	0.33
69	INT201484	Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb	1	0.34	0.96	0.32
70	INT99843	Edn3 Negative_regulation of Localization of Ren	1	0.25	0.42	0.31
71	INT284137	EDNRB Regulation of EDNRA	1	0.07	0.09	0.3
72	INT242398	Cyp19a1 Positive_regulation of Bcl2	1	0.00	1.28	0.3
73	INT59682	Hps6 Positive_regulation of Binding of Chrna7	1	0.02	0	0.29
74	INT218928	Cyp3a23/3a1 Regulation of Transcription of Bcl2	1	0.00	0.56	0.28
75	INT260837	NRP2 Negative_regulation of Negative_regulation of Bcl2	1	0.00	0.9	0.28
76	INT54639	Edn3 Negative_regulation of Edn2	1	0.00	0	0.28
77	INT172905	Binding of Bad and Bcl2	3	0.08	6.46	0.27
78	INT172465	Binding of Rab27a and Rab27b	2	0.41	1.71	0.27
79	INT293900	TYRP1 Regulation of IGKC	1	0.01	0.11	0.27
80	INT72820	EDN3 Positive_regulation of Avp	1	0.31	0.64	0.27
81	INT272157	Gh1 Negative_regulation of Bcl2	1	0.23	1.2	0.26
82	INT71643	Binding of HLA-A and TYRP1	1	0.24	0.36	0.26
83	INT272158	Gh1 Regulation of Bcl2	1	0.15	1.2	0.26
84	INT213804	Binding of Mitf and Tfeb	1	0.24	0.81	0.24
85	INT260840	NRP2 Positive_regulation of Gene_expression of Bcl2	1	0.00	0.85	0.24
86	INT37033	PLAT Negative_regulation of PLDN	1	0.08	0.07	0.23
87	INT284139	EDNRB Positive_regulation of Gene_expression of EDNRA	1	0.12	0.45	0.22
88	INT237201	Cd3e Positive_regulation of KIT	1	0.03	0	0.21
89	INT323346	Positive_regulation of Tyrp1 Positive_regulation of Positive_regulation of Gpr35	1	0.11	0.76	0.21
90	INT57964	Myo5a Regulation of Negative_regulation of Cyp1a1	1	0.00	0.1	0.2
91	INT313799	Binding of HLA-B and TYRP1	1	0.01	0.54	0.18
92	INT249962	Binding of KIT and KITLG	6	0.19	3.69	0.17
93	INT178092	EDN3 Positive_regulation of PTK2	1	0.01	1.02	0.17
94	INT285026	Bak1 Regulation of Bcl2	1	0.09	0.71	0.17
95	INT285022	Regulation of Bak1 Regulation of Bcl2	1	0.09	0.71	0.17
96	INT349475	Regulation of Bax Regulation of Bcl2	1	0.07	1.35	0.17
97	INT285024	Bcl2 Regulation of Bak1	1	0.09	0.71	0.17
98	INT229203	Binding of Bcl2 and Cyp2c11	1	0.36	1.2	0.17
99	INT155068	Csf2 Negative_regulation of Bcl2	1	0.12	1.88	0.17
100	INT94017	Binding of EDN3 and INSRR	1	0.03	0	0.16
101	INT266101	Binding of HPS1 and SH2B2	1	0.17	0.67	0.16
102	INT264276	Binding of Ednrb and P2rx1	1	0.00	0.17	0.16
103	INT94014	Positive_regulation of Binding of EDN1 and EDN3	1	0.36	0	0.16
104	INT94023	Positive_regulation of Binding of EDN2 and EDN3	1	0.25	0	0.16
105	INT94019	Positive_regulation of Binding of EDN3 and INSRR	1	0.04	0	0.16
106	INT213817	Phosphorylation of Tfe3 Positive_regulation of Mitf	1	0.22	1.22	0.15
107	INT292750	Akt1 Positive_regulation of Bcl2	1	0.01	1.67	0.15
108	INT213800	Kit Positive_regulation of Mitf	1	0.30	1.24	0.15
109	INT349476	Bax Regulation of Bcl2	1	0.07	1.33	0.15
110	INT213807	Mitf Positive_regulation of Spg21	1	0.05	1.2	0.15
111	INT293901	Positive_regulation of TYRP1 Regulation of IGKC	1	0.02	0.06	0.15
112	INT139538	Binding of CD34 and KIT	2	0.39	2.73	0.14
113	INT243524	Positive_regulation of Binding of NTF3 and SOX10	1	0.01	0.54	0.14
114	INT243525	Binding of NTF3 and SOX10	1	0.01	0.54	0.14
115	INT89940	Ednrb Positive_regulation of Positive_regulation of TNF	1	0.01	0.09	0.14
116	INT162776	TYRP1 Regulation of Kcnq2	1	0.24	0.14	0.14
117	INT72818	Edn3 Negative_regulation of Avp	1	0.08	0.34	0.14
118	INT72819	Regulation of EDN3 Positive_regulation of Avp	1	0.28	0.32	0.13
119	INT309139	Edc4 Positive_regulation of Bcl2	1	0.03	0.12	0.13
120	INT268083	Ido1 Negative_regulation of Tyrp1	1	0.22	0	0.13
121	INT89939	Ednrb Regulation of Gene_expression of TNF	1	0.00	0.09	0.13
122	INT309142	Edc4 Regulation of Bcl2	1	0.02	0.12	0.13
123	INT246016	Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2	1	0.03	1.07	0.13
124	INT246017	Timp1 Negative_regulation of Gene_expression of Bcl2	1	0.03	1.07	0.13
125	INT172899	Binding of Bcl2 and Bcl2l1	3	0.02	5.54	0.12
126	INT305194	Bcl2 Positive_regulation of Epo	1	0.06	0.29	0.12
127	INT222507	Igf1 Positive_regulation of Localization of Edn3	1	0.05	0	0.11
128	INT273063	Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2	1	0.01	0.72	0.11
129	INT334871	Binding of Mpz and Sox10	1	0.13	0	0.11
130	INT334862	Positive_regulation of Binding of Mpz and Sox10	1	0.17	0	0.11
131	INT221684	Binding of Bcl2 and FRTS	1	0.01	1.19	0.11
132	INT284140	Binding of EDNRB and PAH	1	0.08	0.1	0.1
133	INT309724	Regulation of Binding of TYRP1 and TRPV4	1	0.01	0	0.09
134	INT275183	Bad Positive_regulation of Gene_expression of Bcl2	1	0.08	0.63	0.09
135	INT294637	Bcl2a1a Positive_regulation of Gene_expression of Bcl2	1	0.15	0.97	0.09
136	INT309754	Binding of TYRP1 and TRPV4	1	0.02	0	0.09
137	INT279707	Positive_regulation of AGTR1 Regulation of TYRP1	1	0.00	0	0.09
138	INT204300	Bcl2 Negative_regulation of Positive_regulation of Bak1	1	0.02	1.13	0.09
139	INT178072	Gene_expression of EDNRB Positive_regulation of EDN3	1	0.05	1.11	0.08
140	INT238628	Mef2c Regulation of Gene_expression of Arc	1	0.09	0.16	0.08
141	INT181584	Binding of EDNRB and Edn1	1	0.46	0.85	0.08
142	INT137632	Rasa1 Regulation of Ednrb	1	0.05	0	0.08
143	INT238625	Mef2c Regulation of Gene_expression of Syngap1	1	0.10	0.16	0.08
144	INT94653	Tyrp1 Positive_regulation of Positive_regulation of Tyr	1	0.39	0	0.08
145	INT178100	Gene_expression of EDNRB Positive_regulation of EDN1	1	0.17	1.11	0.08
146	INT244640	AGK Negative_regulation of KIT	1	0.00	0.69	0.08
147	INT232897	Binding of Rab27a and SAMSN1	1	0.00	0.73	0.08
148	INT350908	Binding of Bcl2 and Twist1	1	0.04	1.9	0.08
149	INT268087	Binding of Tyrp1 and Gpr35	1	0.02	0	0.08
150	INT201456	Hmox1 Positive_regulation of Gene_expression of Bcl2	1	0.06	0.74	0.08
151	INT204299	Bcl2 Negative_regulation of Localization of Aifm1	1	0.06	1.22	0.07
152	INT178093	EDN3 Positive_regulation of Gene_expression of EDNRB	1	0.05	1.01	0.07
153	INT192907	Edn1 Positive_regulation of Ednrb	1	0.10	0.35	0.07
154	INT57965	Myo5a Negative_regulation of Cyp2e1	1	0.01	0.09	0.07
155	INT178096	EDN1 Positive_regulation of Gene_expression of EDNRB	1	0.17	1.01	0.07
156	INT297733	Cbr1 Regulation of Gene_expression of Bcl2	1	0.05	0.94	0.07
157	INT313807	Binding of TYRP1 and YOD1	1	0.00	0.49	0.06
158	INT237197	KIT Positive_regulation of LPT	1	0.00	0.15	0.06
159	INT309726	Binding of CALM1 and TYRP1	1	0.00	0	0.05
160	INT341375	Sod2 Regulation of Bcl2	1	0.08	1.96	0.05
161	INT309730	Binding of CALM3 and TYRP1	1	0.01	0	0.05
162	INT190824	Binding of Cl and Bcl2	1	0.02	1.4	0.05
163	INT292089	Binding of KIT and TXK	1	0.02	1.54	0.04
164	INT333252	Positive_regulation of Binding of Bcl2 and Mcl1	1	0.03	0.88	0.04
165	INT292090	Negative_regulation of Binding of KIT and TXK	1	0.02	1.54	0.04
166	INT268664	Ptger2 Positive_regulation of Bcl2	1	0.02	0.9	0.04
167	INT306513	EDN3 Positive_regulation of EDNRB	1	0.14	0.98	0.04
168	INT333245	Binding of Bcl2 and Bcl2l11	1	0.03	0.87	0.04
169	INT268666	Ptger2 Positive_regulation of Gene_expression of Bcl2	1	0.02	0.9	0.04
170	INT215244	Binding of Racgap1 and Mlph	1	0.04	0.76	0.04
171	INT268085	Tdo2 Regulation of Gene_expression of Tyrp1	1	0.25	0.09	0.04
172	INT306514	EDN1 Positive_regulation of EDNRB	1	0.11	0.98	0.04
173	INT350905	Binding of Bcl2 and Pcsk4	1	0.03	0.96	0.04
174	INT268084	Tdo2 Positive_regulation of Tyrp1	1	0.26	0.09	0.04
175	INT333253	Binding of Bcl2 and Mcl1	1	0.02	2.14	0.04
176	INT250025	Map3k1 Positive_regulation of Regulation of Bcl2	1	0.01	1.1	0.04
177	INT246450	Lta Positive_regulation of Ednrb	1	0.00	0	0.04
178	INT172902	Binding of Bax and Bcl2	5	0.30	3.19	0.03
179	INT288538	Il2 Positive_regulation of Gene_expression of Bcl2	1	0.04	1.96	0.03
180	INT266105	SH2B2 Positive_regulation of Gene_expression of HPS1	1	0.24	0.62	0.03
181	INT337727	ADAMTS2 Positive_regulation of Gene_expression of KIT	1	0.02	0	0.03
182	INT213422	MITF Negative_regulation of PROC	1	0.00	0.52	0.03
183	INT334867	Binding of C4b and Sox10	1	0.04	0	0.03
184	INT330875	PLDN Negative_regulation of Gene_expression of Ache	1	0.01	0.85	0.03
185	INT256228	EDNRB Positive_regulation of EDN1	1	0.26	0.62	0.03
186	INT101159	Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT	1	0.31	0.96	0.03
187	INT239225	Binding of Edn1 and Ednrb	1	0.02	0.36	0.03
188	INT334872	Positive_regulation of Binding of C4b and Sox10	1	0.04	0	0.03
189	INT229204	Olr1254 Negative_regulation of Gene_expression of Bcl2	1	0.02	0.18	0.03
190	INT239228	Regulation of Binding of Edn1 and Ednrb	1	0.02	0.37	0.03
191	INT333259	Bcl2 Regulation of Bax	1	0.03	0.32	0.03
192	INT290437	Gene_expression of Mef2c Negative_regulation of Upf1	1	0.02	0.25	0.03
193	INT334864	Positive_regulation of Binding of Nfatc1 and Sox10	1	0.04	0	0.03
194	INT172894	Negative_regulation of Lox Negative_regulation of Gene_expression of Bcl2	1	0.03	1.12	0.03
195	INT220445	Bcl2 Negative_regulation of Positive_regulation of Casp9	1	0.01	1.37	0.03
196	INT334873	Binding of Nfatc1 and Sox10	1	0.02	0	0.03
197	INT239224	Positive_regulation of Binding of Edn1 and Ednrb	1	0.02	0.37	0.03
198	INT333262	Bcl2 Regulation of Bak1	1	0.04	0.31	0.03
199	INT282995	Binding of Bcl2 and Becn1	21	0.03	9.8	0
200	INT283013	Binding of Bak1 and Bcl2	4	0.06	1.03	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for melanocyte differentiation. They are ordered first by their pain relevance and then by number of times they were reported in melanocyte differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT82650	Gene_expression of Bcl2	312	0.78	211.71	55.03
2	INT77307	Gene_expression of Bcl2	399	0.77	319.77	38
3	INT93734	Positive_regulation of Gene_expression of Bcl2	76	0.70	61.95	18.46
4	INT86673	Positive_regulation of Bcl2	77	0.70	57.74	17.37
5	INT32648	Gene_expression of Tyrp1	80	0.66	17.9	16.59
6	INT30440	Gene_expression of Hps4	15	0.29	2.39	15.31
7	INT18430	Positive_regulation of Hps4	14	0.24	0.81	14.82
8	INT80222	Negative_regulation of Bcl2	82	0.58	69.16	13.18
9	INT81640	Positive_regulation of Gene_expression of Bcl2	106	0.69	84.58	11.63
10	INT30236	Negative_regulation of Hps4	8	0.15	1.03	11.4
11	INT85631	Positive_regulation of Tyrp1	40	0.64	18.73	10.84
12	INT55014	Positive_regulation of Ednrb	31	0.70	16.61	9.68
13	INT18429	Localization of Hps4	8	0.31	1.23	9.01
14	INT69264	Gene_expression of KIT	207	0.78	179.41	8.95
15	INT86672	Negative_regulation of Bcl2	50	0.53	34.16	8.37
16	INT80220	Positive_regulation of Bcl2	71	0.58	57.73	7.86
17	INT77306	Negative_regulation of Gene_expression of Bcl2	46	0.58	38.05	7.71
18	INT43441	Binding of Hps4	7	0.24	0.46	7.43
19	INT91445	Regulation of Bcl2	50	0.56	38.8	7.41
20	INT104979	Gene_expression of MITF	51	0.62	54.83	6.91
21	INT31911	Regulation of Hps4	5	0.19	2.16	6.83
22	INT93101	Regulation of Gene_expression of Bcl2	26	0.62	18.45	6.71
23	INT78178	Gene_expression of Ednrb	21	0.75	7.1	6.37
24	INT49027	Gene_expression of TYRP1	35	0.75	9.81	6.06
25	INT119523	Gene_expression of EDNRB	32	0.75	26.47	5.75
26	INT100422	Negative_regulation of Gene_expression of Bcl2	46	0.58	28.86	5.7
27	INT114993	Binding of Myo5a	15	0.30	11.46	5.48
28	INT68591	Regulation of TYRP1	14	0.44	3.93	5.05
29	INT68559	Negative_regulation of Gli3	5	0.37	4.56	4.93
30	INT29519	Gene_expression of Ednrb	8	0.66	1.99	4.55
31	INT92133	Negative_regulation of Ednrb	8	0.42	1.7	4.44
32	INT101957	Transcription of Bcl2	30	0.69	16.57	4.3
33	INT152312	Positive_regulation of Ednrb	7	0.49	1.46	4.04
34	INT105882	Phosphorylation of Bcl2	11	0.59	8.15	3.73
35	INT142501	Transcription of Tyrp1	4	0.18	2.09	3.71
36	INT5782	Gene_expression of Edn3	17	0.67	3.38	3.65
37	INT18073	Positive_regulation of TYRP1	11	0.67	1.98	3.36
38	INT148892	Binding of HPS1	13	0.37	19.21	3.35
39	INT84222	Regulation of Ednrb	4	0.45	2.24	3.25
40	INT81642	Regulation of Gene_expression of Bcl2	20	0.44	16.93	3.19
41	INT160251	Gene_expression of Myo5a	48	0.63	37.14	3.16
42	INT64234	Regulation of Bcl2	41	0.54	31.88	3.16
43	INT16729	Positive_regulation of LOC308670	10	0.65	1.63	3.11
44	INT55033	Localization of Edn3	7	0.80	1.4	3.05
45	INT105884	Binding of Bcl2	19	0.35	15.67	3
46	INT30437	Negative_regulation of Gene_expression of Hps4	1	0.03	0	2.74
47	INT47503	Gene_expression of HPS1	12	0.58	7.96	2.7
48	INT83073	Negative_regulation of Tyrp1	10	0.23	4.4	2.65
49	INT128774	Regulation of Gene_expression of Ednrb	3	0.46	1	2.56
50	INT30040	Negative_regulation of TYRP1	11	0.51	2.72	2.54
51	INT178291	Gene_expression of Hps1	26	0.67	8.2	2.52
52	INT126581	Positive_regulation of Gli3	6	0.35	1.59	2.48
53	INT37341	Regulation of Tyrp1	4	0.29	4.53	2.42
54	INT147349	Localization of Bcl2	13	0.65	7.83	2.31
55	INT142677	Negative_regulation of Positive_regulation of Bcl2	4	0.36	3.09	2.24
56	INT266121	Transcription of HPS1	1	0.50	7.79	2.19
57	INT85085	Positive_regulation of KIT	36	0.53	30.08	2.17
58	INT78177	Negative_regulation of Gene_expression of Ednrb	4	0.41	1.04	2.16
59	INT109327	Negative_regulation of KIT	42	0.57	43.2	2.15
60	INT86671	Negative_regulation of Positive_regulation of Bcl2	6	0.57	3.83	2.03
61	INT126374	Gene_expression of Gli3	6	0.77	3.67	2.02
62	INT101108	Localization of Bcl2	16	0.72	11.68	1.86
63	INT105883	Positive_regulation of Phosphorylation of Bcl2	8	0.32	5.67	1.86
64	INT178130	Binding of EDNRB	12	0.36	6.18	1.84
65	INT280889	Gene_expression of Sox10	19	0.72	3.45	1.78
66	INT201475	Negative_regulation of Positive_regulation of Ednrb	6	0.42	3.74	1.66
67	INT101958	Positive_regulation of Transcription of Bcl2	4	0.50	2.22	1.65
68	INT30037	Binding of TYRP1	9	0.36	0.45	1.6
69	INT139514	Localization of EDNRB	7	0.73	4.63	1.52
70	INT172752	Protein_catabolism of Hps4	2	0.16	0.22	1.51
71	INT217825	Regulation of Gene_expression of MITF	3	0.00	5.2	1.47
72	INT30439	Positive_regulation of Gene_expression of Hps4	1	0.02	0	1.47
73	INT145177	Positive_regulation of Gene_expression of Tyrp1	5	0.30	3.31	1.46
74	INT140245	Binding of Gli3	3	0.36	2.65	1.46
75	INT114298	Positive_regulation of Gene_expression of Ednrb	4	0.36	0.79	1.42
76	INT62425	Regulation of Gene_expression of Tyrp1	7	0.29	1.44	1.41
77	INT323338	Positive_regulation of Positive_regulation of Tyrp1	2	0.13	1.53	1.4
78	INT60772	Negative_regulation of Ednrb	8	0.41	4.56	1.39
79	INT311241	Transcription of Myo5a	1	0.50	1.61	1.37
80	INT162196	Binding of Tyrp1	2	0.31	0.69	1.35
81	INT101107	Positive_regulation of Localization of Bcl2	3	0.48	3.13	1.28
82	INT153757	Positive_regulation of Mitf	10	0.46	8.38	1.22
83	INT32660	Regulation of Hps1	8	0.16	2.3	1.21
84	INT16730	Negative_regulation of LOC308670	2	0.08	0.19	1.21
85	INT40736	Regulation of LOC308670	3	0.02	0.2	1.18
86	INT172855	Binding of Bcl2	37	0.32	23.41	1.09
87	INT24020	Positive_regulation of HPS1	6	0.44	6.14	1.08
88	INT24019	Negative_regulation of HPS1	7	0.37	7.94	1.04
89	INT90898	Negative_regulation of Rab27a	5	0.43	1.99	1.04
90	INT133842	Binding of SOX10	3	0.38	5.79	1.02
91	INT38737	Localization of TYRP1	2	0.68	0.5	0.97
92	INT78181	Negative_regulation of EDNRB	6	0.57	4.46	0.95
93	INT227935	Gene_expression of Mlph	4	0.08	0.51	0.94
94	INT139515	Positive_regulation of EDNRB	15	0.67	10.35	0.93
95	INT192785	Regulation of Myo5a	4	0.05	9.05	0.93
96	INT243533	Positive_regulation of SOX10	1	0.35	3.93	0.92
97	INT58928	Gene_expression of OCA2	6	0.65	2.04	0.9
98	INT49024	Transcription of TYRP1	3	0.66	0.96	0.9
99	INT167588	Localization of HPS1	3	0.65	1.24	0.9
100	INT151115	Regulation of Regulation of Bcl2	4	0.21	4.12	0.88
101	INT277586	Negative_regulation of Mef2c	36	0.59	11.03	0.86
102	INT44800	Negative_regulation of Positive_regulation of Hps4	1	0.16	0	0.85
103	INT6243	Regulation of Edn3	2	0.35	0.2	0.83
104	INT17916	Gene_expression of LOC308670	4	0.02	1.62	0.81
105	INT133841	Gene_expression of SOX10	18	0.67	9.96	0.8
106	INT178127	Positive_regulation of Gene_expression of EDNRB	7	0.51	5.24	0.78
107	INT57958	Positive_regulation of Myo5a	9	0.41	7.52	0.77
108	INT124844	Regulation of Positive_regulation of Bcl2	3	0.43	2.55	0.75
109	INT61122	Regulation of Regulation of Edn3	1	0.35	0.2	0.75
110	INT90899	Gene_expression of Rab27a	49	0.78	26.71	0.74
111	INT155392	Negative_regulation of Negative_regulation of Bcl2	3	0.21	1.64	0.74
112	INT178293	Positive_regulation of Gene_expression of Hps1	4	0.19	1.79	0.73
113	INT134444	Positive_regulation of Binding of Bcl2	3	0.47	2.67	0.72
114	INT30038	Negative_regulation of Binding of TYRP1	1	0.42	0	0.72
115	INT155704	Positive_regulation of MITF	10	0.45	7.51	0.7
116	INT63556	Binding of Edn3	1	0.24	0.63	0.7
117	INT68560	Regulation of Gli3	3	0.18	1.51	0.68
118	INT202361	Gene_expression of Mef2c	28	0.78	5.53	0.67
119	INT50061	Negative_regulation of Edn3	4	0.58	0.77	0.65
120	INT139513	Negative_regulation of Localization of EDNRB	2	0.41	0	0.62
121	INT204254	Localization of KIT	8	0.73	6.78	0.61
122	INT222005	Regulation of HPS1	2	0.33	3.3	0.6
123	INT114299	Transcription of Ednrb	2	0.19	0.32	0.59
124	INT129783	Positive_regulation of Gene_expression of KIT	16	0.50	18.12	0.58
125	INT213774	Positive_regulation of Positive_regulation of Mitf	1	0.31	1.53	0.58
126	INT217804	Negative_regulation of MITF	19	0.01	19.95	0.57
127	INT217823	Positive_regulation of Gene_expression of MITF	8	0.01	7.1	0.55
128	INT126213	Regulation of Gene_expression of TYRP1	2	0.44	0.51	0.55
129	INT11358	Gene_expression of PLDN	2	0.11	1.16	0.55
130	INT135062	Transcription of Gli3	1	0.05	0	0.52
131	INT144696	Regulation of Transcription of Bcl2	5	0.44	2.96	0.51
132	INT178286	Positive_regulation of Hps1	9	0.61	3.86	0.5
133	INT90897	Regulation of Rab27a	6	0.45	3.28	0.5
134	INT134445	Positive_regulation of Positive_regulation of Bcl2	3	0.47	2.43	0.49
135	INT221676	Protein_catabolism of Bcl2	4	0.24	2.77	0.48
136	INT243538	Regulation of SOX10	1	0.31	3.27	0.48
137	INT128376	Binding of KIT	26	0.48	14.24	0.47
138	INT186998	Negative_regulation of Gene_expression of KIT	20	0.43	16.77	0.46
139	INT153758	Binding of Mitf	5	0.47	2.5	0.46
140	INT230623	Negative_regulation of SOX10	2	0.36	0.46	0.46
141	INT204052	Transcription of Bcl2	5	0.51	3.25	0.45
142	INT100005	Binding of MITF	7	0.47	6.93	0.44
143	INT55370	Positive_regulation of Localization of Edn3	2	0.47	1.13	0.44
144	INT220424	Positive_regulation of Negative_regulation of Bcl2	2	0.14	1.81	0.44
145	INT201478	Regulation of Positive_regulation of Ednrb	1	0.35	0.68	0.44
146	INT92195	Negative_regulation of Edn3	3	0.43	1.92	0.43
147	INT61455	Negative_regulation of Gene_expression of LOC308670	1	0.01	0.09	0.43
148	INT19601	Localization of Hps6	2	0.31	0.36	0.4
149	INT131106	Positive_regulation of Positive_regulation of Ednrb	1	0.15	0.91	0.4
150	INT97450	Gene_expression of Mitf	36	0.75	17.22	0.39
151	INT168066	Transcription of Edn3	1	0.38	0.87	0.38
152	INT155724	Negative_regulation of Transcription of Bcl2	6	0.53	2.35	0.37
153	INT8664	Positive_regulation of EDN3	2	0.38	0	0.37
154	INT217807	Regulation of MITF	20	0.00	18.57	0.36
155	INT195574	Localization of Myo5a	4	0.34	1.1	0.36
156	INT201476	Positive_regulation of Negative_regulation of Ednrb	1	0.49	0.62	0.36
157	INT129487	Negative_regulation of EDN3	1	0.38	0.35	0.35
158	INT323718	Localization of MITF	1	0.01	0.6	0.35
159	INT37038	Positive_regulation of PLDN	1	0.10	0.07	0.34
160	INT238560	Regulation of Mef2c	9	0.45	2.12	0.33
161	INT86133	Binding of Hps1	7	0.48	1.7	0.33
162	INT32661	Localization of Hps1	2	0.12	0	0.33
163	INT268126	Phosphorylation of OCA2	1	0.02	1.07	0.33
164	INT37039	Regulation of PLDN	2	0.05	0.95	0.32
165	INT53375	Binding of Edn3	1	0.36	0	0.32
166	INT131110	Localization of EDN3	1	0.03	0.74	0.31
167	INT131109	Positive_regulation of Localization of EDN3	1	0.02	0.76	0.31
168	INT114527	Positive_regulation of Regulation of TYRP1	1	0.45	0.43	0.3
169	INT16366	Gene_expression of Edn3	4	0.49	1.35	0.29
170	INT350971	Negative_regulation of Binding of EDNRB	1	0.13	0.86	0.29
171	INT19600	Binding of Hps6	1	0.46	0	0.27
172	INT53212	Negative_regulation of RAB27A	4	0.57	2.46	0.26
173	INT139512	Positive_regulation of Localization of EDNRB	3	0.37	0.69	0.26
174	INT135061	Protein_catabolism of Gli3	1	0.04	0	0.25
175	INT124944	Regulation of KIT	15	0.60	11.84	0.24
176	INT292743	Negative_regulation of Binding of Bcl2	1	0.05	1.97	0.24
177	INT234614	Phosphorylation of KIT	6	0.78	4.85	0.23
178	INT192957	Transcription of KIT	5	0.69	2.19	0.23
179	INT131612	Negative_regulation of Mitf	3	0.56	3.91	0.23
180	INT285003	Positive_regulation of Regulation of Bcl2	1	0.46	0.68	0.23
181	INT91597	Negative_regulation of Positive_regulation of TYRP1	1	0.41	0.09	0.23
182	INT237188	Negative_regulation of Localization of KIT	1	0.08	0	0.22
183	INT148891	Positive_regulation of Binding of HPS1	1	0.07	0.37	0.22
184	INT108563	Negative_regulation of Regulation of Bcl2	1	0.32	0.74	0.22
185	INT8665	Positive_regulation of Positive_regulation of EDN3	1	0.38	0	0.22
186	INT172442	Binding of Rab27a	3	0.37	1.5	0.21
187	INT202355	Transcription of Mef2c	3	0.69	0.6	0.21
188	INT240411	Negative_regulation of Binding of Myo5a	1	0.09	0.97	0.21
189	INT136228	Phosphorylation of TYRP1	1	0.80	0.17	0.21
190	INT321011	Negative_regulation of Protein_catabolism of Hps4	1	0.09	0	0.2
191	INT196100	Localization of Tyrp1	3	0.36	0	0.19
192	INT129672	Positive_regulation of Rab27a	2	0.69	2.72	0.19
193	INT53376	Positive_regulation of Regulation of Edn3	1	0.48	0	0.19
194	INT135060	Negative_regulation of Transcription of Gli3	1	0.03	0	0.19
195	INT248543	Positive_regulation of Mef2c	7	0.69	2.82	0.18
196	INT53373	Regulation of Edn3	2	0.45	1.38	0.18
197	INT55013	Localization of Ednrb	2	0.16	0.98	0.18
198	INT220426	Regulation of Negative_regulation of Bcl2	1	0.05	0.81	0.18
199	INT279733	Regulation of Regulation of TYRP1	1	0.01	0	0.18
200	INT274098	Regulation of EDNRB	1	0.33	2.41	0.18