GO:0030676

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Name Rac guanyl-nucleotide exchange factor activity
Categary Function
Go Slim No
Go Link GO:0030676
Unique Molecular Interactions 20
Total Molecular Interactions 20
Total Single Events 127
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rac guanyl-nucleotide exchange factor activity. They are ordered first by their pain relevance and then by number of times they were reported for Rac guanyl-nucleotide exchange factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
2 INT287062 Gopc Positive_regulation of Positive_regulation of Vav1 1 0.18 0.15 0
3 INT194716 Positive_regulation of Binding of VAV1 and ZAP70 1 0.04 0 0
4 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0
5 INT338194 Regulation of VAV3 Regulation of AR 1 0.31 0.49 0
6 INT199110 Vav1 Positive_regulation of Binding of Sergef 1 0.04 0.23 0
7 INT194711 LAT Positive_regulation of Binding of VAV1 1 0.03 0 0
8 INT294412 Binding of Vav2 and Vav3 1 0.41 0.65 0
9 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
10 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
11 INT287061 Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.14 0.15 0
12 INT288827 Binding of Rasgrf2 and Vav1 1 0.40 0.37 0
13 INT194692 Binding of VAV1 and LAT 1 0.02 0 0
14 INT228115 Gene_expression of Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.16 0.26 0
15 INT338187 VAV3 Regulation of CDCP1 1 0.00 1.47 0
16 INT194687 Binding of VAV1 and ZAP70 1 0.03 0 0
17 INT287075 Positive_regulation of Vav1 Positive_regulation of Gene_expression of Prdm1 1 0.14 0.15 0
18 INT194734 ZAP70 Positive_regulation of Binding of VAV1 1 0.05 0 0
19 INT338185 VAV3 Regulation of Positive_regulation of AR 1 0.19 0.49 0
20 INT338193 VAV3 Regulation of AR 1 0.31 0.49 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rac guanyl-nucleotide exchange factor activity. They are ordered first by their pain relevance and then by number of times they were reported in Rac guanyl-nucleotide exchange factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT194779 Binding of VAV1 2 0.14 1.62 0.36
2 INT199072 Negative_regulation of Vav1 2 0.58 9.64 0.07
3 INT270629 Gene_expression of Vav3 3 0.78 9.71 0.06
4 INT294404 Transcription of Vav3 1 0.53 0 0.06
5 INT184012 Protein_catabolism of Vav1 1 0.96 0.34 0.05
6 INT184064 Regulation of Protein_catabolism of Vav1 1 0.26 0.34 0.05
7 INT338241 Positive_regulation of VAV3 1 0.56 1.28 0.04
8 INT199080 Localization of Vav1 2 0.66 1.74 0.03
9 INT338258 Binding of VAV3 1 0.39 0.86 0.03
10 INT194792 Regulation of Phosphorylation of VAV1 1 0.09 0 0.03
11 INT199101 Positive_regulation of Localization of Vav1 1 0.18 0.34 0.03
12 INT194796 Phosphorylation of VAV1 1 0.17 0 0.03
13 INT228104 Gene_expression of Vav1 13 0.77 12.18 0
14 INT287041 Binding of Vav1 6 0.37 3.4 0
15 INT199095 Phosphorylation of Vav1 3 0.42 0.6 0
16 INT287052 Positive_regulation of Vav1 2 0.50 3.51 0
17 INT294407 Positive_regulation of Negative_regulation of Vav3 1 0.50 0.73 0
18 INT338234 Localization of VAV3 1 0.61 0.38 0
19 INT288812 Regulation of Gene_expression of Vav1 1 0.45 3.41 0
20 INT338248 Negative_regulation of Gene_expression of VAV3 1 0.48 2.92 0
21 INT199088 Positive_regulation of Phosphorylation of Vav1 1 0.18 0.25 0
22 INT294409 Regulation of Vav3 1 0.45 1.42 0
23 INT338235 Negative_regulation of VAV3 1 0.48 0.38 0
24 INT294397 Regulation of Binding of Vav3 1 0.45 0.87 0
25 INT288819 Negative_regulation of Transcription of Vav1 1 0.42 1.23 0
26 INT338236 Gene_expression of VAV3 1 0.63 8.45 0
27 INT288804 Transcription of Vav1 1 0.68 3.37 0
28 INT288803 Positive_regulation of Gene_expression of Vav1 1 0.50 1.05 0
29 INT294403 Localization of Vav3 1 0.80 0.96 0
30 INT338243 Positive_regulation of Gene_expression of VAV3 1 0.41 1.9 0
31 INT194795 Positive_regulation of Phosphorylation of VAV1 1 0.11 0 0
32 INT294402 Binding of Vav3 1 0.48 2.43 0
33 INT288814 Regulation of Vav1 1 0.12 1.12 0
34 INT294399 Negative_regulation of Vav3 1 0.59 1.59 0
35 INT338250 Positive_regulation of VAV1 1 0.13 0.38 0
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