GO:0031694

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Name alpha-2A adrenergic receptor binding
Categary Function
Go Slim No
Go Link GO:0031694
Unique Molecular Interactions 78
Total Molecular Interactions 98
Total Single Events 910
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for alpha-2A adrenergic receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for alpha-2A adrenergic receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
2 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
3 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
4 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
5 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
6 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
7 INT56459 ADRA2C Positive_regulation of Localization of AHSP 1 0.23 0 0.78
8 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
9 INT33575 ADRB1 Positive_regulation of Localization of Ahsp 1 0.00 0.33 0.73
10 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
11 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
12 INT81832 Binding of ADRA2C and CRYGS 1 0.06 0 0.66
13 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
14 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
15 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
16 INT108020 Binding of Adrb1 and Clec4d 1 0.00 1.19 0.61
17 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
18 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
19 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
20 INT81331 ADRBK1 Regulation of OPRK1 1 0.03 0.09 0.48
21 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
22 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
23 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
24 INT132580 Binding of ADRA2C and Htr1a 1 0.41 0.27 0.45
25 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
26 INT145576 Binding of Adra2c and Hcn4 1 0.21 0.19 0.4
27 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
28 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
29 INT145574 Regulation of Binding of Adra2c and Hcn4 1 0.26 0.19 0.4
30 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
31 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
32 INT84602 Binding of Adrb1 and Avp 1 0.00 0 0.36
33 INT35981 Adrb1 Regulation of Localization of Prl 1 0.00 0 0.36
34 INT31713 Adra2c Regulation of Localization of Ins1 1 0.22 0.31 0.35
35 INT106397 Positive_regulation of OPRL1 Positive_regulation of ADRBK1 1 0.46 0.09 0.31
36 INT102976 Binding of ADRBK1 and Rbm39 1 0.00 0 0.31
37 INT116680 Binding of ADRBK1 and Oxtr 1 0.18 0.14 0.3
38 INT102955 OPRK1 Positive_regulation of Localization of ADRBK1 1 0.13 0 0.3
39 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 0.13 0 0.28
40 INT7850 Adra2c Regulation of Localization of Gcg 1 0.08 0 0.27
41 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27
42 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27
43 INT81833 Negative_regulation of Binding of ADRA2C and CRYGS 1 0.06 0 0.19
44 INT148397 Adra2c Regulation of Gnb3 1 0.12 0.08 0.19
45 INT71547 ADRA2C Positive_regulation of Localization of GCG 1 0.01 0.14 0.17
46 INT71548 ADRA2C Negative_regulation of Localization of INS 1 0.04 0.13 0.16
47 INT102975 ADRBK1 Regulation of Localization of Rbm39 1 0.00 0 0.15
48 INT81831 Positive_regulation of Binding of ADRA2C and CRYGS 1 0.07 0 0.14
49 INT102954 Binding of ADRBK1 and OPRK1 1 0.11 0 0.14
50 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
51 INT83831 Binding of PNMT and Adrb1 1 0.02 0 0.1
52 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
53 INT83832 Negative_regulation of Binding of PNMT and Adrb1 1 0.02 0 0.1
54 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
55 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
56 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
57 INT262704 Bace1 Positive_regulation of Aplp1 1 0.15 0.25 0.09
58 INT223039 Gene_expression of TFPI Positive_regulation of Gene_expression of ADRBK1 1 0.11 0 0.07
59 INT65410 Penk Positive_regulation of Uchl1 1 0.05 0.19 0.05
60 INT65415 Penk Positive_regulation of Binding of Uchl1 1 0.05 0.19 0.05
61 INT65413 Tac1 Positive_regulation of Uchl1 1 0.02 0.19 0.05
62 INT223041 Binding of ADRBK1 and TFPI 1 0.08 0 0.03
63 INT247856 Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 1 0.03
64 INT247853 Positive_regulation of Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 0.54 0
65 INT223037 SLURP1 Positive_regulation of Gene_expression of ADRBK1 1 0.02 0 0
66 INT303758 Binding of ADRB1 and IGHG3 1 0.06 0.09 0
67 INT240546 Binding of ADRB1 and INS 1 0.11 0.34 0
68 INT247848 Narfl Negative_regulation of Uchl1 1 0.03 0.74 0
69 INT323251 Binding of Isl1 and Uchl1 1 0.00 0.6 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for alpha-2A adrenergic receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in alpha-2A adrenergic receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
2 INT170 Negative_regulation of Adrb1 52 0.55 13.46 14.78
3 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41
4 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
5 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
6 INT59 Regulation of Adrb1 25 0.42 8.32 9.78
7 INT30247 Regulation of Adrb1 18 0.44 4.45 8.93
8 INT96 Binding of Adrb1 18 0.48 2.8 8.52
9 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
10 INT26115 Gene_expression of Adrb1 14 0.64 5.13 7.78
11 INT23992 Positive_regulation of Adrb1 25 0.56 4.01 7.62
12 INT5678 Gene_expression of ADRA2C 17 0.74 2.62 6.24
13 INT18443 Positive_regulation of ADRA2C 12 0.69 2.61 5.48
14 INT26940 Positive_regulation of Adra2c 9 0.49 2.21 5.27
15 INT5675 Gene_expression of Adra2c 7 0.75 1.25 4.58
16 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
17 INT465 Binding of Adrb1 14 0.35 3.04 4.07
18 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
19 INT13134 Binding of ADRA2C 11 0.46 0.73 3.86
20 INT277 Negative_regulation of Adra2c 8 0.43 1.89 3.42
21 INT18459 Regulation of Adra2c 6 0.45 0.42 3.4
22 INT36115 Transcription of Uchl1 7 0.60 3.24 3.25
23 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11
24 INT38760 Positive_regulation of Adra2c 3 0.39 1.82 3.04
25 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87
26 INT15265 Gene_expression of Adra2c 5 0.54 1.8 2.83
27 INT110503 Negative_regulation of ADRBK1 4 0.53 0.71 2.69
28 INT7848 Regulation of Adra2c 3 0.33 1.74 2.37
29 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33
30 INT4495 Gene_expression of Adrb1 7 0.66 2.43 2.29
31 INT94 Positive_regulation of Negative_regulation of Adrb1 4 0.46 0.97 2.16
32 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14
33 INT102970 Localization of ADRBK1 4 0.66 0.45 1.85
34 INT23884 Negative_regulation of Negative_regulation of Adrb1 7 0.38 2.3 1.83
35 INT101148 Gene_expression of UCHL1 20 0.70 9.61 1.8
36 INT32176 Negative_regulation of Negative_regulation of Adrb1 2 0.40 0.4 1.77
37 INT110026 Localization of Adrb1 4 0.72 1.56 1.71
38 INT1731 Localization of Adrb1 5 0.43 0.31 1.67
39 INT214123 Negative_regulation of Gene_expression of Uchl1 3 0.06 4.52 1.52
40 INT40907 Localization of Adra2c 3 0.71 0 1.46
41 INT40906 Negative_regulation of Localization of Adra2c 1 0.43 0 1.46
42 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4
43 INT38312 Positive_regulation of Gene_expression of Adrb1 2 0.07 0.22 1.33
44 INT26786 Positive_regulation of Uchl1 7 0.34 1.37 1.32
45 INT55318 Localization of ADRA2C 3 0.73 1.39 1.3
46 INT6519 Positive_regulation of Gene_expression of ADRA2C 3 0.44 0.71 1.1
47 INT106404 Positive_regulation of Positive_regulation of ADRBK1 2 0.41 0.31 1.08
48 INT76497 Transcription of Adra2c 2 0.21 0.08 1.07
49 INT140159 Regulation of Gene_expression of Adrb1 1 0.00 0.17 1.07
50 INT71031 Gene_expression of ADRB1 5 0.55 2.96 1.01
51 INT26012 Binding of Adra2c 2 0.48 0 1.01
52 INT33442 Regulation of ADRB1 2 0.04 0.38 0.98
53 INT12555 Binding of ADRB1 7 0.39 3.78 0.97
54 INT42420 Negative_regulation of Binding of Adrb1 2 0.58 0.8 0.97
55 INT31828 Transcription of Adrb1 2 0.27 0.18 0.94
56 INT33665 Positive_regulation of Gene_expression of Adra2c 1 0.50 0.43 0.89
57 INT65230 Negative_regulation of Adra2c 3 0.42 0.44 0.88
58 INT124538 Positive_regulation of Gene_expression of Adra2c 1 0.27 0.75 0.87
59 INT70724 Positive_regulation of Negative_regulation of ADRB1 1 0.38 0.2 0.86
60 INT123124 Positive_regulation of Gene_expression of Uchl1 1 0.49 0.54 0.84
61 INT101149 Positive_regulation of Gene_expression of UCHL1 1 0.02 1.22 0.84
62 INT123125 Positive_regulation of Positive_regulation of Uchl1 1 0.49 0.54 0.84
63 INT101146 Positive_regulation of Transcription of Uchl1 1 0.13 1.22 0.84
64 INT40928 Regulation of Binding of ADRA2C 1 0.43 0 0.82
65 INT101145 Transcription of Uchl1 1 0.18 1.17 0.82
66 INT1732 Positive_regulation of Localization of Adrb1 2 0.22 0.06 0.8
67 INT159728 Localization of Uchl1 2 0.73 0.54 0.8
68 INT14130 Regulation of ADRA2C 4 0.45 1.57 0.79
69 INT32751 Regulation of Positive_regulation of Adrb1 2 0.36 0.07 0.77
70 INT110117 Negative_regulation of Positive_regulation of Adra2c 1 0.12 0.33 0.77
71 INT110511 Regulation of ADRBK1 1 0.22 0.22 0.76
72 INT110505 Positive_regulation of Negative_regulation of ADRBK1 1 0.38 0.22 0.76
73 INT28057 Binding of Adra2c 4 0.36 0.25 0.75
74 INT55317 Transcription of ADRA2C 6 0.63 0.36 0.74
75 INT43481 Positive_regulation of ADRB1 3 0.19 1.36 0.68
76 INT95816 Regulation of Positive_regulation of Adra2c 2 0.28 0.66 0.68
77 INT134173 Binding of APLP1 4 0.37 2.41 0.67
78 INT243712 Positive_regulation of Gene_expression of Uchl1 4 0.21 2.68 0.61
79 INT24095 Protein_catabolism of Adrb1 2 0.10 0.59 0.61
80 INT83826 Negative_regulation of Binding of Adrb1 3 0.25 0.67 0.6
81 INT29256 Positive_regulation of Positive_regulation of ADRA2C 2 0.46 0.06 0.59
82 INT29111 Negative_regulation of Positive_regulation of Adrb1 1 0.37 0.14 0.58
83 INT126960 Phosphorylation of ADRBK1 2 0.66 0.06 0.52
84 INT18442 Negative_regulation of ADRA2C 2 0.49 0.61 0.51
85 INT116677 Binding of ADRBK1 6 0.44 0.65 0.5
86 INT42184 Positive_regulation of Binding of Adrb1 1 0.31 0.19 0.5
87 INT56662 Regulation of Protein_catabolism of Adrb1 1 0.05 0.27 0.5
88 INT56661 Positive_regulation of Protein_catabolism of Adrb1 1 0.06 0.27 0.49
89 INT293504 Regulation of Gene_expression of Uchl1 1 0.03 0.31 0.46
90 INT278 Positive_regulation of Negative_regulation of Adra2c 1 0.47 0.27 0.42
91 INT271483 Regulation of Regulation of Uchl1 1 0.01 0.58 0.41
92 INT202908 Binding of Uchl1 1 0.08 0.27 0.4
93 INT34999 Regulation of UCHL1 1 0.04 0 0.38
94 INT63924 Regulation of Binding of Adrb1 1 0.16 0.27 0.34
95 INT52207 Positive_regulation of Positive_regulation of Adrb1 1 0.09 0 0.33
96 INT69187 Regulation of Positive_regulation of Adrb1 1 0.25 0 0.33
97 INT26941 Localization of Adra2c 2 0.23 0 0.3
98 INT26939 Positive_regulation of Positive_regulation of Adra2c 1 0.16 0 0.3
99 INT43325 Regulation of Binding of ADRB1 1 0.37 0.36 0.3
100 INT26858 Regulation of Positive_regulation of ADRA2C 3 0.32 0.63 0.29
101 INT280583 Negative_regulation of Gene_expression of ADRB1 2 0.09 1.18 0.29
102 INT10857 Regulation of Negative_regulation of Adrb1 2 0.45 0.65 0.28
103 INT123126 Protein_catabolism of Uchl1 1 0.64 0.2 0.27
104 INT116676 Negative_regulation of Binding of ADRBK1 2 0.53 0.33 0.23
105 INT25814 Negative_regulation of Binding of ADRA2C 1 0.31 0.08 0.23
106 INT113433 Binding of UCHL1 3 0.47 1.84 0.22
107 INT134174 Gene_expression of APLP1 3 0.77 1.76 0.22
108 INT209146 Negative_regulation of Negative_regulation of ADRB1 1 0.31 0 0.21
109 INT18444 Positive_regulation of Negative_regulation of ADRA2C 1 0.42 0.61 0.19
110 INT306554 Regulation of Localization of ADRA2C 1 0.26 0.98 0.17
111 INT97050 Negative_regulation of Uchl1 2 0.22 2.28 0.14
112 INT180233 Negative_regulation of Negative_regulation of Uchl1 1 0.14 0.6 0.14
113 INT262674 Gene_expression of Aplp1 2 0.54 0.7 0.13
114 INT345349 Protein_catabolism of Uchl1 1 0.54 0.94 0.13
115 INT113434 Negative_regulation of Gene_expression of UCHL1 4 0.53 1.34 0.12
116 INT134170 Positive_regulation of APLP1 1 0.50 0.24 0.12
117 INT223056 Regulation of Gene_expression of ADRBK1 1 0.22 0 0.12
118 INT134172 Positive_regulation of Gene_expression of APLP1 1 0.50 0.26 0.12
119 INT40871 Regulation of Negative_regulation of Adrb1 1 0.24 0.32 0.1
120 INT44040 Negative_regulation of Gene_expression of Adrb1 1 0.35 0.34 0.09
121 INT113431 Negative_regulation of UCHL1 2 0.39 0.62 0.08
122 INT65408 Binding of Uchl1 2 0.30 0.95 0.08
123 INT262692 Positive_regulation of Gene_expression of Aplp1 1 0.31 0.24 0.08
124 INT45551 Regulation of Regulation of Adrb1 1 0.22 0.29 0.08
125 INT193837 Localization of Aplp1 2 0.45 1.85 0.06
126 INT113432 Regulation of Gene_expression of UCHL1 1 0.24 0.6 0.06
127 INT193853 Positive_regulation of Localization of Aplp1 1 0.25 0.81 0.06
128 INT356071 Negative_regulation of Aplp1 1 0.37 0.44 0.03
129 INT87516 Negative_regulation of Gene_expression of ADRA2C 1 0.41 0.1 0
130 INT303767 Localization of ADRB1 1 0.18 0.2 0
131 INT303766 Positive_regulation of Gene_expression of ADRB1 1 0.11 0.15 0
132 INT303768 Negative_regulation of Binding of ADRB1 1 0.09 0.5 0
133 INT247884 Negative_regulation of Gene_expression of Uchl1 1 0.21 1.22 0
134 INT223046 Positive_regulation of Localization of ADRBK1 1 0.24 0 0
135 INT247860 Regulation of Uchl1 1 0.14 1.46 0
136 INT220590 Binding of Aplp1 1 0.24 0.19 0
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