GO:0031941

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Name filamentous actin
Categary Component
Go Slim No
Go Link GO:0031941
Unique Molecular Interactions 49
Total Molecular Interactions 61
Total Single Events 279
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for filamentous actin. They are ordered first by their pain relevance and then by number of times they were reported for filamentous actin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
3 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
4 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
5 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
6 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
7 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
8 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
9 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
10 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
11 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
12 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
13 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
14 INT177661 Binding of Trib3 and Myo1f 1 0.00 0.54 0.24
15 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
16 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
17 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
18 INT27814 CD2AP Positive_regulation of PADI1 1 0.19 0.06 0.11
19 INT27815 Regulation of CD2AP Positive_regulation of PADI1 1 0.11 0.06 0.11
20 INT42067 Rln1 Positive_regulation of Phosphorylation of Myo1f 1 0.11 0.1 0.1
21 INT215245 Binding of Myo1f and Chd7 1 0.00 0.64 0.1
22 INT42066 Rln1 Regulation of Phosphorylation of Myo1f 1 0.05 0.07 0.07
23 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
24 INT194688 PAK1 Positive_regulation of GADD45A 1 0.11 0 0.05
25 INT215240 Binding of Myo1f and Racgap1 1 0.01 0.77 0.04
26 INT194707 RAC1 Positive_regulation of PAK1 1 0.01 0 0.03
27 INT194738 Binding of PAK1 and RAC1 1 0.01 0 0.03
28 INT219352 CDK5 Negative_regulation of PAK1 1 0.22 0.72 0.03
29 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
30 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
31 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
32 INT303406 Binding of NPAT and Myo1f 1 0.06 0 0
33 INT225898 Positive_regulation of RAC1 Positive_regulation of PAK1 1 0.01 0.08 0
34 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
35 INT339107 Binding of BCS1L and PAK1 1 0.01 0.08 0
36 INT101591 Binding of RAC1 and RAC3 1 0.13 0.52 0
37 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
38 INT232595 Binding of BRCA1 and HEPACAM 1 0.02 0.89 0
39 INT322259 Binding of Hcm and Tpm1 1 0.10 0.85 0
40 INT355221 Binding of Espn and Ocln 1 0.01 0 0
41 INT353436 Rock1 Positive_regulation of Myo1f 1 0.02 0.23 0
42 INT219354 FGFR1 Positive_regulation of Gene_expression of PAK1 1 0.10 0.55 0
43 INT259091 Binding of BRCA1 and LMO4 1 0.24 0.74 0
44 INT355223 Binding of Espn and Tjp2 1 0.01 0 0
45 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0
46 INT303396 Binding of Laptm5 and Myo1f 1 0.00 0 0
47 INT303390 Binding of Jag1 and Myo1f 1 0.07 0 0
48 INT225888 AKT1 Positive_regulation of PAK1 1 0.01 0.08 0
49 INT303395 Positive_regulation of Binding of Jag1 and Myo1f 1 0.07 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for filamentous actin. They are ordered first by their pain relevance and then by number of times they were reported in filamentous actin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
2 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
3 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
4 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
5 INT42140 Gene_expression of Myo1f 7 0.19 2.45 2.27
6 INT42065 Phosphorylation of Myo1f 13 0.38 2.05 1.71
7 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
8 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
9 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
10 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
11 INT42138 Binding of Myo1f 5 0.10 1.49 1.03
12 INT125903 Gene_expression of Espn 2 0.06 0.77 0.94
13 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
14 INT276176 Negative_regulation of Myo1f 4 0.12 1.85 0.71
15 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
16 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
17 INT42139 Regulation of Myo1f 3 0.14 0.64 0.49
18 INT276175 Positive_regulation of Transcription of Myo1f 1 0.10 1.03 0.47
19 INT276194 Positive_regulation of Gene_expression of Myo1f 1 0.14 1.03 0.47
20 INT276190 Transcription of Myo1f 1 0.11 1.02 0.46
21 INT276191 Negative_regulation of Binding of Myo1f 1 0.09 0.05 0.46
22 INT230517 Localization of Myo1f 2 0.15 1.38 0.44
23 INT144907 Gene_expression of RAC3 2 0.53 0.57 0.43
24 INT167432 Binding of MYO1C 1 0.19 0.67 0.41
25 INT35501 Positive_regulation of Myo1f 5 0.69 1.73 0.39
26 INT27819 Gene_expression of CD2AP 2 0.25 0.09 0.37
27 INT66251 Negative_regulation of Phosphorylation of Myo1f 1 0.20 0 0.35
28 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
29 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
30 INT203636 Positive_regulation of CD2AP 4 0.13 1.27 0.28
31 INT169689 Localization of CD2AP 2 0.73 0.05 0.24
32 INT139301 Regulation of Espn 1 0.02 0.38 0.24
33 INT276203 Negative_regulation of Gene_expression of Myo1f 1 0.09 0.38 0.23
34 INT195576 Binding of Myo1f 6 0.06 2.79 0.21
35 INT219361 Gene_expression of PAK1 1 0.75 2.91 0.21
36 INT113855 Regulation of Phosphorylation of Espn 1 0.04 0.06 0.2
37 INT113856 Phosphorylation of Espn 1 0.08 0.06 0.2
38 INT113857 Positive_regulation of Phosphorylation of Espn 1 0.06 0.06 0.2
39 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
40 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
41 INT276193 Regulation of Negative_regulation of Myo1f 1 0.09 0.38 0.14
42 INT219368 Negative_regulation of PAK1 1 0.42 1.11 0.13
43 INT219376 Positive_regulation of PAK1 1 0.67 4.84 0.11
44 INT193893 Gene_expression of Tpm1 5 0.65 1.65 0.09
45 INT208274 Negative_regulation of Espn 1 0.03 0.66 0.08
46 INT286583 Localization of PKD2 1 0.35 0.17 0.06
47 INT261879 Binding of PKD2 3 0.13 2.59 0.05
48 INT226169 Positive_regulation of Gene_expression of Tpm1 2 0.49 1.17 0.05
49 INT265312 Gene_expression of Myo1f 3 0.10 1.44 0.04
50 INT195575 Localization of Myo1f 2 0.12 0.28 0.03
51 INT219373 Positive_regulation of Phosphorylation of PAK1 1 0.48 0.69 0.03
52 INT344009 Negative_regulation of Localization of BRCA1 1 0.30 0.18 0.03
53 INT272938 Negative_regulation of Myo1f 1 0.03 1.06 0.03
54 INT219367 Phosphorylation of PAK1 1 0.79 0.69 0.03
55 INT219356 Regulation of Phosphorylation of PAK1 1 0.44 0.7 0.03
56 INT203637 Binding of CD2AP 1 0.04 0.57 0.03
57 INT219363 Localization of PAK1 3 0.72 1.14 0
58 INT259116 Transcription of BRCA1 3 0.44 3.77 0
59 INT241245 Negative_regulation of PKD2 2 0.42 2.35 0
60 INT119064 Regulation of Gene_expression of BRCA1 1 0.53 0.05 0
61 INT303355 Positive_regulation of Localization of Myo1f 1 0.10 0.22 0
62 INT193842 Negative_regulation of Tpm1 1 0.09 0 0
63 INT303375 Positive_regulation of Myo1f 1 0.08 0.22 0
64 INT292413 Negative_regulation of Binding of Myo1f 1 0.00 0.88 0
65 INT219371 Positive_regulation of Gene_expression of PAK1 1 0.67 0.62 0
66 INT353415 Phosphorylation of Myo1f 1 0.08 0.61 0
67 INT232493 Negative_regulation of Positive_regulation of PKD2 1 0.23 0.61 0
68 INT169690 Negative_regulation of Localization of CD2AP 1 0.41 0 0
69 INT105331 Positive_regulation of RAC3 1 0.05 0.41 0
70 INT261878 Negative_regulation of Binding of PKD2 1 0.14 0.6 0
71 INT219362 Transcription of PAK1 1 0.51 0.61 0
72 INT353421 Positive_regulation of Phosphorylation of Myo1f 1 0.05 0.5 0
73 INT219380 Regulation of Transcription of PAK1 1 0.26 0.61 0
74 INT303350 Regulation of Myo1f 1 0.09 0.26 0
75 INT232491 Positive_regulation of PKD2 1 0.27 0.56 0
76 INT221271 Negative_regulation of Binding of BRCA1 1 0.28 0.93 0
77 INT320718 Positive_regulation of Positive_regulation of CD2AP 1 0.08 0.55 0
78 INT219369 Positive_regulation of Localization of PAK1 1 0.48 0.61 0
79 INT334189 Regulation of Binding of BRCA1 1 0.13 0.8 0
80 INT248559 Positive_regulation of Tpm1 1 0.13 0.07 0
81 INT287856 Positive_regulation of Positive_regulation of Myo1f 1 0.03 0.11 0
82 INT234188 Positive_regulation of Localization of BRCA1 1 0.42 0.68 0
83 INT303365 Protein_catabolism of Myo1f 1 0.10 0.29 0
84 INT219364 Regulation of PAK1 1 0.60 0.61 0
85 INT219379 Regulation of Gene_expression of PAK1 1 0.44 0.71 0
86 INT241408 Binding of Dpysl3 1 0.05 0 0
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