GO:0032480

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Name negative regulation of type I interferon production
Categary Process
Go Slim No
Go Link GO:0032480
Unique Molecular Interactions 57
Total Molecular Interactions 63
Total Single Events 331
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of type I interferon production. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of type I interferon production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
2 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
3 INT116771 Binding of MAVS and MRGPRX1 1 0.00 0.51 0.89
4 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57
5 INT69177 UBA7 Negative_regulation of Igk 1 0.00 0.15 0.54
6 INT69179 Binding of UBA7 and Adarb1 1 0.00 0.16 0.53
7 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
8 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
9 INT304281 IL8 Positive_regulation of TBK1 1 0.01 2.35 0.44
10 INT129293 OPRM1 Positive_regulation of Phosphorylation of IKBKE 1 0.05 0.28 0.35
11 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
12 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
13 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
14 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
15 INT343837 TICAM1 Positive_regulation of IRF3 1 0.03 0.19 0.19
16 INT306067 Binding of ADH5 and CYLD 1 0.02 3.13 0.19
17 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
18 INT343863 Binding of IRF1 and IRF3 1 0.03 0.12 0.17
19 INT346451 Positive_regulation of Binding of IFNA1 and DDX58 1 0.01 0.54 0.15
20 INT346450 Binding of IFNA1 and DDX58 1 0.01 0.54 0.15
21 INT290314 MAVS Positive_regulation of DDX58 1 0.06 0.63 0.13
22 INT263449 Binding of NFKBIA and TBK1 1 0.07 0.2 0.1
23 INT191757 ROS1 Positive_regulation of TBK1 1 0.00 0.6 0.08
24 INT346452 TLR3 Positive_regulation of TBK1 1 0.03 0.45 0.06
25 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
26 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
27 INT346456 TLR3 Positive_regulation of IKBKE 1 0.02 0.45 0.06
28 INT346449 TICAM1 Positive_regulation of TBK1 1 0.01 0.45 0.06
29 INT346454 TICAM1 Positive_regulation of IKBKE 1 0.01 0.45 0.06
30 INT346457 IRF3 Positive_regulation of IFNA1 1 0.03 0.56 0.05
31 INT200645 Binding of AKT1 and TBK1 1 0.02 0.43 0.04
32 INT333559 TBK1 Regulation of Phosphorylation of IRF3 1 0.17 0.35 0.04
33 INT333633 Thse Positive_regulation of Transcription of IRF3 1 0.00 1.13 0.03
34 INT263453 Binding of GRP and TBK1 1 0.00 0.07 0.03
35 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
36 INT346453 Binding of DDX58 and IFIH1 1 0.00 1.04 0.03
37 INT287480 Protein_catabolism of NFKBIB Positive_regulation of TBK1 1 0.01 0.6 0.03
38 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
39 INT333639 Tlr4 Positive_regulation of IRF3 1 0.31 0 0
40 INT333565 TRAM1 Regulation of Phosphorylation of IRF3 1 0.17 0.59 0
41 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
42 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
43 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
44 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0
45 INT333563 PRKCA Positive_regulation of Gene_expression of IRF3 1 0.05 0.06 0
46 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
47 INT333630 Tlr4 Regulation of Phosphorylation of IRF3 1 0.39 0.59 0
48 INT333637 Smpd1 Positive_regulation of IRF3 1 0.09 0.62 0
49 INT328780 Binding of TBK1 and Memo1 1 0.09 0.6 0
50 INT217314 IFNA1 Positive_regulation of MAVS 1 0.01 1.47 0
51 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
52 INT313687 Binding of BCR and IFIH1 1 0.09 0.23 0
53 INT265390 IFIH1 Positive_regulation of Regulation of IFNA1 1 0.00 0.08 0
54 INT333638 Positive_regulation of Tlr4 Positive_regulation of Localization of IRF3 1 0.29 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of type I interferon production. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of type I interferon production. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43
2 INT183467 Negative_regulation of TBK1 6 0.12 9.89 5.41
3 INT92335 Gene_expression of TBK1 11 0.28 8.98 3
4 INT97132 Negative_regulation of Positive_regulation of TBK1 5 0.08 6.54 2.76
5 INT183468 Localization of TBK1 6 0.32 4.35 2.36
6 INT99524 Gene_expression of IFIH1 34 0.64 23.38 2.24
7 INT258048 Regulation of TBK1 4 0.05 3.81 1.44
8 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
9 INT183790 Binding of TBK1 2 0.04 2.97 1.16
10 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
11 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89
12 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
13 INT263481 Regulation of Positive_regulation of TBK1 1 0.07 1.28 0.81
14 INT352771 Positive_regulation of Localization of TBK1 1 0.05 0.98 0.78
15 INT333595 Negative_regulation of Gene_expression of TBK1 2 0.12 0.91 0.67
16 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
17 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
18 INT129296 Phosphorylation of IKBKE 1 0.35 0.54 0.63
19 INT188775 Binding of IFIH1 11 0.16 12.4 0.61
20 INT69176 Binding of UBA7 1 0.01 0.14 0.53
21 INT200677 Transcription of TBK1 2 0.14 0.74 0.49
22 INT313688 Regulation of IFIH1 3 0.19 4.2 0.48
23 INT135612 Regulation of IKBKE 1 0.21 1.24 0.48
24 INT135614 Positive_regulation of IKBKE 1 0.23 1.26 0.47
25 INT263479 Positive_regulation of Transcription of TBK1 1 0.12 0.32 0.46
26 INT183470 Positive_regulation of Negative_regulation of TBK1 1 0.08 0.46 0.46
27 INT166728 Regulation of MAVS 1 0.32 0.15 0.44
28 INT346479 Positive_regulation of DDX58 1 0.06 5.3 0.42
29 INT47625 Negative_regulation of IFIH1 4 0.51 1.68 0.39
30 INT181179 Binding of CYLD 4 0.43 7.06 0.39
31 INT188776 Positive_regulation of IFIH1 10 0.23 9.93 0.35
32 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35
33 INT346492 Protein_catabolism of MAVS 1 0.06 1.74 0.31
34 INT152643 Positive_regulation of Gene_expression of IFIH1 5 0.42 5.2 0.28
35 INT112834 Regulation of Gene_expression of IFIH1 1 0.08 0.15 0.25
36 INT185452 Regulation of CYLD 6 0.40 6.09 0.21
37 INT333601 Phosphorylation of IRF3 6 0.73 2.09 0.19
38 INT346493 Binding of MAVS 1 0.03 0.54 0.15
39 INT307231 Positive_regulation of Gene_expression of CYLD 1 0.45 2.37 0.14
40 INT185449 Regulation of Regulation of CYLD 1 0.21 2.03 0.13
41 INT279781 Gene_expression of MAVS 4 0.15 3.51 0.12
42 INT333604 Localization of IRF3 1 0.71 2.75 0.12
43 INT304602 Negative_regulation of UBA7 1 0.01 1.37 0.11
44 INT307240 Localization of CYLD 3 0.72 3.09 0.1
45 INT333625 Positive_regulation of IRF3 7 0.61 3.49 0.09
46 INT185440 Negative_regulation of Negative_regulation of CYLD 1 0.20 1.02 0.08
47 INT333620 Transcription of IRF3 1 0.63 1.12 0.06
48 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05
49 INT333598 Gene_expression of IRF3 1 0.60 0.58 0.05
50 INT290325 Binding of DDX58 1 0.04 0.52 0.05
51 INT333591 Negative_regulation of Gene_expression of IRF3 1 0.38 0.53 0.05
52 INT307229 Phosphorylation of CYLD 1 0.73 1.02 0.05
53 INT213682 Positive_regulation of Gene_expression of TBK1 2 0.21 2.18 0.04
54 INT333622 Phosphorylation of TBK1 1 0.17 0.35 0.04
55 INT282949 Negative_regulation of Localization of UBA7 1 0.08 0.05 0.04
56 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
57 INT333607 Positive_regulation of Localization of IRF3 1 0.61 0.4 0.04
58 INT200681 Regulation of Transcription of TBK1 1 0.03 0.42 0.04
59 INT333618 Positive_regulation of Phosphorylation of IRF3 1 0.41 0.24 0.04
60 INT328278 Phosphorylation of IFIH1 2 0.08 1.27 0.03
61 INT333605 Regulation of Transcription of IRF3 1 0.40 0 0.03
62 INT282950 Regulation of UBA7 1 0.05 0.05 0.03
63 INT333608 Negative_regulation of IRF3 1 0.38 1.92 0.03
64 INT282951 Localization of UBA7 1 0.14 0.05 0.03
65 INT333597 Regulation of Positive_regulation of IRF3 1 0.54 0.35 0.03
66 INT346490 Phosphorylation of DDX58 1 0.07 1.03 0.03
67 INT217333 Positive_regulation of TNFAIP3 3 0.23 2.65 0
68 INT229890 Negative_regulation of Gene_expression of IFIH1 2 0.08 1.06 0
69 INT307235 Positive_regulation of Binding of CYLD 1 0.45 1.1 0
70 INT348456 Protein_catabolism of TNFAIP3 1 0.22 1.13 0
71 INT333615 Regulation of Gene_expression of IRF3 1 0.40 0 0
72 INT333624 Regulation of Phosphorylation of IRF3 1 0.40 0.59 0
73 INT348453 Positive_regulation of Positive_regulation of TNFAIP3 1 0.17 1.06 0
74 INT217332 Gene_expression of UBA7 1 0.34 0.78 0
75 INT175213 Negative_regulation of Binding of UBC 1 0.02 0.13 0
76 INT156902 Positive_regulation of UBC 1 0.49 0 0
77 INT320197 Positive_regulation of Transcription of IFIH1 1 0.08 0.15 0
78 INT333616 Regulation of IRF3 1 0.24 1.14 0
79 INT333623 Binding of IRF3 1 0.32 0 0
80 INT307244 Regulation of Gene_expression of CYLD 1 0.24 1.84 0
81 INT320196 Localization of IFIH1 1 0.12 0.72 0
82 INT327507 Negative_regulation of Localization of CYLD 1 0.05 0.58 0
83 INT320193 Transcription of IFIH1 1 0.11 0.15 0
84 INT175222 Binding of UBC 1 0.02 0.54 0
85 INT333603 Negative_regulation of Localization of IRF3 1 0.52 0 0
86 INT320195 Positive_regulation of Binding of IFIH1 1 0.08 1.08 0
87 INT307230 Regulation of Localization of CYLD 1 0.40 0.11 0
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