GO:0032587

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Name ruffle membrane
Categary Component
Go Slim No
Go Link GO:0032587
Unique Molecular Interactions 344
Total Molecular Interactions 477
Total Single Events 3623
Pain Genes Associated 42

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ruffle membrane. They are ordered first by their pain relevance and then by number of times they were reported for ruffle membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
2 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
3 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
4 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
5 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11
6 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
7 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
8 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22
9 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
10 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
11 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
12 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
13 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
14 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
15 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
16 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
17 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
18 INT302119 Positive_regulation of Binding of Oprm1 and Ppp1r9b 1 0.02 0 0.77
19 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
20 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
21 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
22 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
23 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
24 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
25 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
26 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
27 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
28 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
29 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
30 INT354249 Binding of Mtap6 and Ppp1r9b 1 0.24 0.07 0.67
31 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
32 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
33 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
34 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
35 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
36 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
37 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
38 INT127663 IRF6 Positive_regulation of PDE4A 1 0.14 0.76 0.48
39 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
40 INT127664 Negative_regulation of PDE4A Negative_regulation of MMP9 1 0.37 0.76 0.48
41 INT127665 Negative_regulation of PDE4A Negative_regulation of Transcription of MMP9 1 0.37 0.76 0.48
42 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
43 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
44 INT92743 Binding of NF2 and LMOD1 1 0.00 0.08 0.46
45 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
46 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
47 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
48 INT52954 Binding of Pdpn and Flvcr2 1 0.05 0.42 0.41
49 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4
50 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
51 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
52 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
53 INT183645 Ppp1r14b Positive_regulation of Macf1 1 0.00 1.23 0.38
54 INT188427 IL6 Positive_regulation of Pdxp 1 0.00 0.84 0.38
55 INT183647 Dss1 Positive_regulation of Macf1 1 0.01 1.23 0.38
56 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 0.00 1.29 0.38
57 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37
58 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
59 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
60 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
61 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
62 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
63 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
64 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
65 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
66 INT337161 Binding of Diap1 and Iqgap1 1 0.29 0.78 0.28
67 INT221918 TRPV4 Positive_regulation of TRPM8 1 0.05 0 0.28
68 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27
69 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
70 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
71 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
72 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
73 INT193029 CHRM2 Positive_regulation of RHOA 1 0.01 0.12 0.24
74 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
75 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
76 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23
77 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
78 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
79 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
80 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
81 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
82 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
83 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
84 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
85 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 0.05 0.84 0.21
86 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
87 INT118435 HGF Positive_regulation of TRPV4 1 0.54 0.13 0.2
88 INT110745 Bphl Positive_regulation of Positive_regulation of Aif1 1 0.03 0.18 0.2
89 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
90 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
91 INT299113 Binding of INPP5K and GOPC 1 0.18 2.69 0.19
92 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
93 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
94 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
95 INT142227 Urb1 Regulation of Trpv4 1 0.02 0.1 0.17
96 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
97 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
98 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
99 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
100 INT226365 Negative_regulation of PDE4A Negative_regulation of Localization of IL5 1 0.05 0.18 0.16
101 INT143505 Aif1 Positive_regulation of CETN1 1 0.01 0.35 0.16
102 INT226382 Negative_regulation of PDE4A Negative_regulation of Localization of IL4 1 0.12 0.18 0.16
103 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
104 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
105 INT273171 PDE4A Regulation of IL8 1 0.05 0.53 0.15
106 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
107 INT263176 Binding of PDE4A and COPD 1 0.01 1 0.15
108 INT337164 Binding of DIAPH1 and Iqgap1 1 0.53 0.37 0.14
109 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
110 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
111 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
112 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
113 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
114 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
115 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
116 INT273185 PDE4A Regulation of Gene_expression of Mmp12 1 0.08 0.57 0.13
117 INT67619 Inpp5k Negative_regulation of Ptgs1 1 0.03 0.5 0.13
118 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
119 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
120 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
121 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
122 INT101310 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.04 0.19 0.12
123 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
124 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
125 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11
126 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
127 INT137672 Baa1 Positive_regulation of Trpv4 1 0.17 0 0.11
128 INT312212 Binding of ADAM12 and INPP5K 1 0.16 0.46 0.11
129 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
130 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
131 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1
132 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1
133 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
134 INT262255 Binding of APC and F2R 1 0.05 3 0.1
135 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
136 INT269592 MAPKAP1 Positive_regulation of Phosphorylation of CFL1 1 0.03 0 0.09
137 INT309724 Regulation of Binding of TYRP1 and TRPV4 1 0.01 0 0.09
138 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
139 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
140 INT309754 Binding of TYRP1 and TRPV4 1 0.02 0 0.09
141 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
142 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
143 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
144 INT238215 Binding of STAT3 and Bmx 1 0.12 0.63 0.08
145 INT309722 TRPV4 Positive_regulation of CA2 1 0.11 0 0.08
146 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
147 INT343865 IRF6 Positive_regulation of TIRAP 1 0.03 0.28 0.08
148 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
149 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
150 INT238207 Binding of Bmx and Sik1 1 0.01 0.43 0.07
151 INT61385 FANCB Negative_regulation of PLEK 1 0.42 0.13 0.07
152 INT231676 Binding of CD47 and ITGA5 1 0.02 0.08 0.07
153 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
154 INT196124 Trpm5 Negative_regulation of Trpv4 1 0.13 0.08 0.06
155 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
156 INT196134 Gopc Negative_regulation of Trpv4 1 0.07 0.08 0.06
157 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
158 INT196126 Gopc Negative_regulation of Gene_expression of Trpv4 1 0.15 0.08 0.06
159 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
160 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
161 INT196131 Trpm7 Negative_regulation of Trpv4 1 0.14 0.08 0.06
162 INT196130 Trpm5 Negative_regulation of Gene_expression of Trpv4 1 0.30 0.08 0.06
163 INT196129 Trpm7 Negative_regulation of Gene_expression of Trpv4 1 0.32 0.08 0.06
164 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05
165 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
166 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
167 INT238208 Sik1 Positive_regulation of Positive_regulation of Bmx 1 0.01 0 0.05
168 INT322130 Trpv1 Positive_regulation of Positive_regulation of Trpv4 1 0.15 0.1 0.05
169 INT326384 Slc9a3r2 Positive_regulation of Positive_regulation of Rhoa 1 0.03 0.16 0.05
170 INT333034 Trpv4 Positive_regulation of Localization of Car2 1 0.06 0 0.05
171 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
172 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05
173 INT312226 INPP5K Positive_regulation of IGFBP5 1 0.12 0.07 0.05
174 INT169403 Binding of TRPV1 and Trpv4 1 0.23 0.94 0.05
175 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05
176 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
177 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04
178 INT333032 Binding of Trpv4 and Gopc 1 0.05 0 0.04
179 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
180 INT263378 Trib3 Regulation of Bmx 1 0.00 0 0.04
181 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
182 INT344312 PDPN Positive_regulation of ITK 1 0.05 0.26 0.04
183 INT263379 Abl1 Regulation of Bmx 1 0.04 0 0.04
184 INT269584 Binding of CFL1 and ROCK1 1 0.03 0.05 0.03
185 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03
186 INT241253 Gene_expression of Trpv4 Positive_regulation of Gene_expression of Pkd2 1 0.52 0.29 0.03
187 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
188 INT238214 Bmx Positive_regulation of Phosphorylation of STAT3 1 0.13 0 0.03
189 INT333037 Binding of Agt and Trpv4 1 0.09 0 0.03
190 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
191 INT344317 PDPN Negative_regulation of VEGFA 1 0.08 0.67 0.03
192 INT238213 Positive_regulation of Bmx Positive_regulation of Phosphorylation of STAT3 1 0.12 0.16 0.03
193 INT344308 Positive_regulation of PDPN Negative_regulation of VEGFA 1 0.09 0.24 0.03
194 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
195 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0
196 INT312224 INPP5K Regulation of Negative_regulation of COL1A1 1 0.08 0 0
197 INT309744 Binding of GOPC and TRPV4 1 0.09 0 0
198 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
199 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
200 INT308131 PLEK Positive_regulation of F2 1 0.12 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ruffle membrane. They are ordered first by their pain relevance and then by number of times they were reported in ruffle membrane. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68
2 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
3 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
4 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59
5 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
6 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
7 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
8 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
9 INT18412 Binding of PLEK 49 0.47 17.82 10.72
10 INT3366 Localization of PLEK 44 0.78 15.83 9.55
11 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03
12 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
13 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
14 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
15 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
16 INT75684 Regulation of Aif1 32 0.47 8.03 7.89
17 INT79456 Gene_expression of PDE4A 35 0.77 19.42 7.42
18 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
19 INT79770 Regulation of Gene_expression of Aif1 13 0.45 5.28 6.82
20 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
21 INT142065 Phosphorylation of CFL1 8 0.78 0.87 6.3
22 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
23 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
24 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
25 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
26 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
27 INT127668 Positive_regulation of PDE4A 12 0.68 8.39 5.13
28 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
29 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05
30 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
31 INT52952 Binding of Pdpn 8 0.13 3.57 4.79
32 INT79767 Negative_regulation of Aif1 30 0.42 5.14 4.73
33 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
34 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
35 INT79768 Negative_regulation of Gene_expression of Aif1 8 0.58 5.15 4.52
36 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
37 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
38 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
39 INT63121 Binding of APC 29 0.41 23.02 3.8
40 INT142066 Positive_regulation of Phosphorylation of CFL1 5 0.48 0.24 3.73
41 INT57397 Binding of Aif1 15 0.28 4.06 3.49
42 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
43 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
44 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
45 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
46 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
47 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
48 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
49 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85
50 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
51 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
52 INT67618 Positive_regulation of Inpp5k 3 0.45 0.77 2.64
53 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
54 INT98557 Regulation of PDE4A 12 0.44 8.42 2.56
55 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
56 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
57 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
58 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
59 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
60 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
61 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
62 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
63 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
64 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
65 INT142064 Negative_regulation of Phosphorylation of CFL1 3 0.56 0.42 2.06
66 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
67 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
68 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
69 INT85348 Localization of RHOA 12 0.59 4.81 1.83
70 INT4188 Binding of NF2 7 0.46 3.52 1.79
71 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
72 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
73 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
74 INT3818 Regulation of Apc 13 0.39 12.52 1.68
75 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
76 INT23176 Gene_expression of Pdpn 6 0.75 4.06 1.65
77 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
78 INT335495 Regulation of Regulation of Aif1 5 0.21 1.22 1.51
79 INT141455 Negative_regulation of Inpp5k 2 0.36 1.09 1.51
80 INT77311 Localization of Aif1 10 0.75 4.21 1.5
81 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
82 INT79455 Positive_regulation of Gene_expression of PDE4A 3 0.67 2.07 1.5
83 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
84 INT220177 Binding of Apc 21 0.37 15.34 1.37
85 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
86 INT125296 Regulation of Inpp5k 1 0.22 0 1.32
87 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
88 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
89 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
90 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
91 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
92 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
93 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
94 INT209138 Negative_regulation of Negative_regulation of PDE4A 4 0.42 3.84 1.21
95 INT143846 Positive_regulation of INPP5K 5 0.40 6.4 1.17
96 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
97 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
98 INT354243 Negative_regulation of Ppp1r9b 1 0.28 0.28 1.12
99 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
100 INT272172 Regulation of Positive_regulation of Aif1 3 0.26 0 1.11
101 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
102 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08
103 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
104 INT136817 Negative_regulation of Positive_regulation of RHOA 8 0.57 0 1.04
105 INT139117 Negative_regulation of Gene_expression of PDE4A 4 0.42 2.28 1.02
106 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
107 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
108 INT78014 Negative_regulation of ITGA5 1 0.01 1.71 0.98
109 INT191478 Negative_regulation of Positive_regulation of Aif1 2 0.25 0.31 0.95
110 INT131824 Negative_regulation of RHOA 10 0.57 2.9 0.92
111 INT242134 Localization of Apc 8 0.74 4.83 0.88
112 INT127669 Regulation of Negative_regulation of PDE4A 4 0.45 2.74 0.88
113 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
114 INT263129 Positive_regulation of Negative_regulation of PDE4A 3 0.35 2.92 0.86
115 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
116 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
117 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
118 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83
119 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
120 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
121 INT102262 Localization of NF2 1 0.14 0.6 0.79
122 INT142083 Positive_regulation of AIF1 4 0.12 4.86 0.77
123 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
124 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
125 INT158547 Negative_regulation of Positive_regulation of Trpv4 2 0.57 0.47 0.77
126 INT139945 Transcription of Aif1 2 0.65 0.89 0.76
127 INT173338 Positive_regulation of Localization of RHOA 2 0.14 1.52 0.76
128 INT85347 Negative_regulation of Localization of RHOA 1 0.31 0 0.74
129 INT67252 Regulation of Pdpn 1 0.00 0.9 0.74
130 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
131 INT57062 Regulation of APC 24 0.58 14.3 0.7
132 INT263225 Positive_regulation of Positive_regulation of Trpv4 3 0.46 0.75 0.7
133 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
134 INT142063 Negative_regulation of CFL1 1 0.56 0 0.69
135 INT309322 Gene_expression of AIF1 7 0.14 2.64 0.68
136 INT156302 Positive_regulation of Phosphorylation of Trpv4 2 0.46 0.92 0.68
137 INT52951 Negative_regulation of Binding of Pdpn 1 0.16 0.63 0.66
138 INT218815 Localization of Ppp1r9b 1 0.47 1.2 0.65
139 INT156303 Regulation of Regulation of Trpv4 2 0.27 0.26 0.63
140 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
141 INT318499 Regulation of AIF1 2 0.03 4.89 0.6
142 INT131421 Localization of INPP5K 9 0.74 4.3 0.59
143 INT299115 Regulation of INPP5K 6 0.39 4.11 0.59
144 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
145 INT158548 Regulation of Gene_expression of Trpv4 3 0.61 1.03 0.57
146 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
147 INT142079 Negative_regulation of Positive_regulation of AIF1 1 0.00 1.01 0.57
148 INT125188 Negative_regulation of Transcription of Trpv4 3 0.42 0.44 0.56
149 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
150 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
151 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55
152 INT180422 Regulation of Gene_expression of Rhoa 2 0.39 0.6 0.55
153 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
154 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
155 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
156 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
157 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
158 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
159 INT175068 Localization of Ezr 1 0.19 0 0.5
160 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
161 INT284454 Binding of Tirap 4 0.26 2.07 0.49
162 INT209136 Regulation of Gene_expression of PDE4A 3 0.27 1.63 0.49
163 INT263224 Phosphorylation of Trpv4 2 0.76 0.73 0.49
164 INT137671 Negative_regulation of Positive_regulation of Trpv4 3 0.58 0.25 0.48
165 INT167897 Gene_expression of Ppp1r9b 3 0.58 0.32 0.48
166 INT167898 Negative_regulation of Gene_expression of Ppp1r9b 1 0.42 0.32 0.48
167 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
168 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
169 INT218809 Positive_regulation of Ppp1r9b 1 0.24 1.21 0.45
170 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
171 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
172 INT130966 Binding of EZR 2 0.36 0.24 0.41
173 INT103316 Localization of PDE4A 2 0.68 1.76 0.41
174 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
175 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39
176 INT183634 Positive_regulation of Macf1 2 0.13 6.25 0.38
177 INT324921 Regulation of Localization of Aif1 1 0.23 0.46 0.38
178 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
179 INT209137 Negative_regulation of Positive_regulation of PDE4A 1 0.42 0.8 0.37
180 INT354234 Regulation of Binding of Aif1 1 0.30 0.57 0.36
181 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
182 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
183 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
184 INT132881 Binding of INPP5K 7 0.48 4.35 0.33
185 INT118243 Transcription of APC 4 0.45 3.33 0.33
186 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
187 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
188 INT216610 Positive_regulation of Bmx 1 0.04 0.07 0.33
189 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
190 INT119907 Binding of Inpp5k 3 0.33 0.6 0.32
191 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
192 INT225667 Transcription of Apc 3 0.52 3.73 0.32
193 INT188420 Positive_regulation of Pdxp 1 0.04 0.8 0.32
194 INT183879 Binding of RHOA 6 0.34 2.1 0.31
195 INT195672 Localization of APC 7 0.74 3.76 0.3
196 INT257213 Binding of PDE4A 5 0.36 1.69 0.3
197 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
198 INT131822 Positive_regulation of Positive_regulation of RHOA 2 0.45 0.33 0.29
199 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
200 INT238163 Positive_regulation of Bmx 1 0.17 0.48 0.27
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