GO:0032795

Name heterotrimeric G-protein binding Categary Function Go Slim No Go Link GO:0032795

Unique Molecular Interactions 95 Total Molecular Interactions 132 Total Single Events 1221 Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heterotrimeric G-protein binding. They are ordered first by their pain relevance and then by number of times they were reported for heterotrimeric G-protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT123451	Binding of YY1 and Adra2a	1	0.37	0	2.98
2	INT25708	Oprl1 Positive_regulation of Adra2a	1	0.25	0.15	2.63
3	INT18786	Binding of Adra2a and Nisch	2	0.19	0	1.7
4	INT141907	F2r Regulation of Plat	1	0.46	0	1.59
5	INT352269	Binding of Jund and Adora1	1	0.15	1.2	1.25
6	INT181490	Tryptase Positive_regulation of F2rl1	1	0.13	1.83	1.21
7	INT207116	F2 Positive_regulation of F2r	5	0.12	2.16	1.16
8	INT215648	Binding of Adora1 and Gabrd	1	0.03	0.06	1.16
9	INT338053	F2r Positive_regulation of Localization of Calca	1	0.06	0.47	1.15
10	INT156238	Binding of F2rl1 and Tnfsf14	1	0.08	2.85	1.08
11	INT41175	Adra2a Regulation of Th	1	0.59	0	1.04
12	INT162319	Positive_regulation of F2rl1 Positive_regulation of Il1b	1	0.46	1.6	1.04
13	INT63543	Binding of Adra2a and Serpini1	1	0.13	0	1
14	INT127263	Adra2a Regulation of Gene_expression of Jun	1	0.07	1.1	0.95
15	INT258170	Binding of Adora1 and Ppap2a	1	0.05	0.26	0.94
16	INT215650	Binding of Adora1 and Drd1a	2	0.39	0.54	0.92
17	INT207149	Binding of F2r and Par2	1	0.17	1.64	0.92
18	INT28921	Adra2a Positive_regulation of Localization of Prl	1	0.24	0	0.9
19	INT43796	Binding of CDS1 and Adra2a	1	0.06	0	0.86
20	INT215646	Binding of Adora1 and P2rx2	1	0.13	0.51	0.85
21	INT156239	Tnfsf14 Positive_regulation of F2rl1	1	0.09	2.4	0.81
22	INT60102	Adora1 Regulation of Localization of Calca	1	0.46	0	0.79
23	INT63544	Adra2a Regulation of Nisch	1	0.18	0	0.79
24	INT262582	F2rl1 Regulation of Positive_regulation of Prkca	1	0.03	0.58	0.78
25	INT110130	NR3C1 Regulation of ADORA1	1	0.04	0.73	0.77
26	INT262562	F2rl1 Regulation of Trpv1	1	0.12	0.58	0.77
27	INT108611	Adra2a Regulation of Gene_expression of Nos1	1	0.10	0	0.75
28	INT84283	Binding of Adra2a and Htr1f	1	0.16	0.15	0.74
29	INT338057	Positive_regulation of F2r Positive_regulation of Localization of Calca	1	0.05	0.28	0.71
30	INT20688	Adra2a Regulation of Localization of Gh1	1	0.26	0.37	0.7
31	INT81968	Binding of PLEK and Adra2a	1	0.07	0.1	0.7
32	INT132152	Adra2a Regulation of Localization of Abat	1	0.03	0	0.66
33	INT153921	Positive_regulation of Adra2a Regulation of Ednrb	1	0.01	0	0.66
34	INT215647	Adora1 Positive_regulation of Kcnj5	1	0.00	0	0.62
35	INT17187	Binding of Adra2a and Fabp6	1	0.16	0.69	0.61
36	INT17186	Positive_regulation of Binding of Adra2a and Fabp6	1	0.21	0.69	0.61
37	INT41250	Binding of Adra2a and Eef1a1	1	0.06	0.4	0.56
38	INT311256	Nt5e Positive_regulation of Positive_regulation of Adora1	1	0.49	0.19	0.54
39	INT338038	Gopc Regulation of Gene_expression of F2r	1	0.08	0	0.52
40	INT338045	F2r Regulation of Localization of Calca	1	0.03	0.05	0.52
41	INT327806	Binding of ADORA1 and ADORA2A	1	0.06	0.18	0.49
42	INT7851	Man2a2 Positive_regulation of Adra2a	1	0.13	0	0.49
43	INT146113	Binding of Adra2a and Lrp1	1	0.01	1.07	0.48
44	INT233527	Tlr4 Positive_regulation of ADORA1	1	0.00	0.45	0.47
45	INT26448	Adra2a Regulation of Positive_regulation of Npy	1	0.06	0	0.46
46	INT312813	Binding of F2rl1 and Tpsab1	1	0.01	0.26	0.46
47	INT86380	Adra2a Regulation of Gene_expression of Tnf	1	0.15	0.79	0.44
48	INT165724	Bdkrb1 Positive_regulation of Adora1	1	0.24	1.65	0.43
49	INT56576	Adra2a Positive_regulation of Localization of Gnrh1	1	0.44	0	0.43
50	INT55395	Binding of Htr1a and Adra2a	1	0.42	0	0.43
51	INT156234	Tnfsf14 Positive_regulation of Transcription of F2rl1	1	0.09	1.26	0.42
52	INT215651	Binding of Adora1 and Cpa1	1	0.00	0	0.42
53	INT338059	Nrtn Positive_regulation of Gene_expression of F2r	1	0.12	0.45	0.41
54	INT34987	Adra2a Positive_regulation of Localization of Gnrhr	1	0.43	0	0.4
55	INT156237	Binding of F2r and Tnfsf14	1	0.02	1.14	0.4
56	INT156233	Positive_regulation of Tnfsf14 Positive_regulation of F2rl1	1	0.09	1.15	0.4
57	INT134167	Binding of ADRA2A and APLP1	1	0.09	0.64	0.39
58	INT150333	4930519F16Rik Positive_regulation of F2rl1	1	0.00	0.67	0.38
59	INT70656	Adra2a Regulation of Gene_expression of Npy	1	0.23	0	0.38
60	INT156235	Tnfsf14 Positive_regulation of F2r	1	0.03	1.03	0.35
61	INT67030	Negative_regulation of Adra2a Negative_regulation of Etf1	1	0.00	0.64	0.33
62	INT67028	Adra2a Negative_regulation of Nts	1	0.06	0.64	0.33
63	INT67029	Adra2a Negative_regulation of Etf1	1	0.00	0.64	0.33
64	INT31182	Adra2a Regulation of Localization of Gh	1	0.01	0.35	0.32
65	INT215645	Binding of Adora1 and Kcnj5	1	0.00	0.08	0.29
66	INT215653	Binding of Adora1 and Adora3	1	0.39	0.07	0.27
67	INT95061	Binding of Adra2a and ADHD1	1	0.02	0.8	0.27
68	INT42635	Adra2a Positive_regulation of epi	1	0.00	0	0.26
69	INT215652	Binding of Adora1 and Npy1r	1	0.39	0.22	0.24
70	INT55641	Binding of CHRM1 and Adra2a	1	0.00	0	0.24
71	INT183247	ADA Negative_regulation of ADORA1	1	0.01	0	0.23
72	INT32735	ADRA2A Regulation of RTCA	1	0.07	0	0.22
73	INT338042	F2r Positive_regulation of Localization of Prkca	1	0.06	0.1	0.2
74	INT207151	PLA2G6 Positive_regulation of Localization of F2rl1	1	0.16	0.73	0.18
75	INT207147	Pla2g1b Positive_regulation of Localization of F2rl1	1	0.03	0.73	0.18
76	INT195115	Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r	1	0.17	1.67	0.18
77	INT195114	Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r	1	0.38	1.67	0.18
78	INT207144	F2r Positive_regulation of Pawr	1	0.14	0.51	0.16
79	INT293712	Binding of Adra2a and Atl1	1	0.06	0.83	0.15
80	INT207117	Binding of VEGFA and F2r	1	0.02	0.56	0.15
81	INT338040	Ctsg Positive_regulation of F2r	1	0.29	0	0.15
82	INT338052	F2r Positive_regulation of F2rl3	1	0.12	0	0.15
83	INT249322	Positive_regulation of Adora1 Regulation of Rit2	1	0.10	0	0.14
84	INT103425	Binding of Adra2a and Cyth2	1	0.00	0	0.14
85	INT109082	Adra2a Regulation of Nppa	1	0.21	0.56	0.14
86	INT249321	Positive_regulation of Adora1 Regulation of Preb	1	0.20	0.09	0.12
87	INT338041	F2r Positive_regulation of Pard3	1	0.15	0.05	0.11
88	INT17394	Adra2a Positive_regulation of GNAI1	1	0.02	0.37	0.1
89	INT346526	Binding of ADORA1 and PTH1R	1	0.01	0	0.1
90	INT66171	Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt	1	0.38	0	0.08
91	INT66166	Negative_regulation of Binding of Pnmt and Adra2a	1	0.38	0	0.07
92	INT66167	Negative_regulation of Pnmt Negative_regulation of Adra2a	1	0.38	0	0.07
93	INT66172	Binding of Pnmt and Adra2a	1	0.33	0	0.07
94	INT338047	Binding of F2r and Pard3	1	0.11	0	0
95	INT66168	Pde2a Negative_regulation of Adra2a	1	0.04	0	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heterotrimeric G-protein binding. They are ordered first by their pain relevance and then by number of times they were reported in heterotrimeric G-protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT7059	Regulation of Adra2a	89	0.62	18.24	48.43
2	INT7608	Positive_regulation of Adra2a	66	0.70	17.81	35.15
3	INT40160	Positive_regulation of Adora1	74	0.70	26.36	33.03
4	INT7779	Negative_regulation of Adra2a	47	0.58	9.45	28
5	INT7717	Positive_regulation of Adra2a	62	0.70	17.68	27.32
6	INT8248	Binding of Adra2a	43	0.48	6.72	22.17
7	INT3030	Gene_expression of Adra2a	37	0.68	5.58	19.76
8	INT14114	Binding of Adra2a	30	0.48	4.24	18.53
9	INT118512	Gene_expression of F2r	33	0.63	26.56	18.26
10	INT12875	Regulation of Adra2a	26	0.45	7.51	17.35
11	INT5674	Gene_expression of Adra2a	34	0.77	6.14	15.13
12	INT25872	Positive_regulation of Adora1	19	0.69	4.9	15.01
13	INT104674	Positive_regulation of F2rl1	35	0.65	27.76	14.16
14	INT19155	Binding of Adora1	25	0.47	6.41	10.72
15	INT12455	Negative_regulation of Adra2a	30	0.54	5.63	10.14
16	INT114406	Gene_expression of Adora1	28	0.72	6.83	9.13
17	INT117497	Positive_regulation of F2r	18	0.57	14.45	8.13
18	INT9350	Regulation of ADORA1	9	0.12	1.53	7.79
19	INT101699	Regulation of Adora1	14	0.61	3.7	7.59
20	INT6576	Localization of Adra2a	11	0.71	1.49	7.18
21	INT40159	Negative_regulation of Adora1	13	0.51	3.51	7.13
22	INT76197	Positive_regulation of ADORA1	7	0.59	5.06	7
23	INT9167	Binding of Adora1	6	0.40	0.53	6.9
24	INT76255	Gene_expression of ADORA1	11	0.78	2.51	6.85
25	INT21138	Binding of ADRA2A	16	0.48	5.57	6.8
26	INT13650	Positive_regulation of Gene_expression of Adra2a	6	0.50	0.69	4.94
27	INT7716	Positive_regulation of Positive_regulation of Adra2a	9	0.68	0.8	4.69
28	INT65527	Positive_regulation of Positive_regulation of Adora1	4	0.46	0.67	3.71
29	INT215604	Localization of Adora1	10	0.78	1.47	3.49
30	INT101477	Binding of ADORA1	8	0.31	0.42	3.07
31	INT17389	Negative_regulation of Positive_regulation of Adra2a	6	0.58	0.99	3.06
32	INT7931	Positive_regulation of Protein_catabolism of Adra2a	1	0.70	0	2.9
33	INT31923	Positive_regulation of Positive_regulation of Adra2a	7	0.44	1.88	2.89
34	INT54178	Regulation of Adora1	5	0.39	0.29	2.85
35	INT215608	Negative_regulation of Binding of Adora1	5	0.41	1.35	2.73
36	INT31451	Negative_regulation of Gene_expression of Adra2a	4	0.43	1.03	2.72
37	INT215601	Regulation of Positive_regulation of Adora1	9	0.60	1.74	2.66
38	INT82653	Regulation of F2r	8	0.36	3.78	2.62
39	INT111017	Regulation of F2rl1	3	0.22	0	2.61
40	INT215599	Positive_regulation of Positive_regulation of Adora1	7	0.47	2.29	2.58
41	INT114020	Gene_expression of Adora1	2	0.33	4.24	2.55
42	INT43212	Regulation of Gene_expression of Adra2a	4	0.45	0.24	2.48
43	INT12456	Negative_regulation of Positive_regulation of Adra2a	4	0.37	1.35	2.42
44	INT111016	Gene_expression of F2rl1	11	0.73	3.58	2.37
45	INT114433	Positive_regulation of Positive_regulation of F2rl1	4	0.49	3.5	2.29
46	INT53587	Positive_regulation of Binding of Adra2a	1	0.12	0	2.26
47	INT82652	Negative_regulation of F2r	4	0.37	3.5	2.19
48	INT215611	Negative_regulation of Positive_regulation of Adora1	6	0.43	1.18	2.16
49	INT34196	Regulation of Binding of Adra2a	2	0.45	0	2.12
50	INT31262	Positive_regulation of Binding of Adra2a	4	0.10	1.02	2.04
51	INT111018	Binding of F2rl1	5	0.30	3.11	2.02
52	INT23426	Regulation of ADRA2A	8	0.48	1.81	1.88
53	INT32558	Negative_regulation of ADORA1	5	0.12	2.77	1.86
54	INT124556	Negative_regulation of Positive_regulation of Adora1	3	0.51	1.2	1.81
55	INT168519	Positive_regulation of Gene_expression of Adora1	4	0.61	0.75	1.75
56	INT29763	Negative_regulation of Adora1	3	0.42	0	1.64
57	INT156231	Binding of F2r	9	0.23	3.78	1.57
58	INT43327	Positive_regulation of ADRA2A	3	0.46	1.54	1.53
59	INT7780	Positive_regulation of Negative_regulation of Adra2a	2	0.50	0.09	1.48
60	INT7932	Protein_catabolism of Adra2a	1	1.00	0	1.44
61	INT241721	Positive_regulation of Transcription of Adora1	3	0.50	1.39	1.41
62	INT53632	Regulation of Negative_regulation of Adra2a	1	0.23	0.08	1.41
63	INT29262	Negative_regulation of Binding of Adra2a	4	0.40	0.25	1.37
64	INT95815	Regulation of Positive_regulation of Adra2a	4	0.45	1.45	1.32
65	INT241737	Transcription of Adora1	3	0.72	0.89	1.32
66	INT7847	Positive_regulation of Localization of Adra2a	2	0.40	0.22	1.28
67	INT117498	Regulation of Positive_regulation of F2r	1	0.18	0.91	1.24
68	INT79489	Transcription of Adra2a	2	0.61	2.38	1.22
69	INT338033	Localization of F2r	1	0.41	0.62	1.2
70	INT76254	Positive_regulation of Positive_regulation of ADORA1	2	0.43	1.27	1.14
71	INT12976	Negative_regulation of ADRA2A	4	0.50	0.16	1.01
72	INT20687	Positive_regulation of Regulation of Adra2a	1	0.35	1.07	0.95
73	INT195105	Negative_regulation of Gene_expression of F2r	3	0.37	1.41	0.91
74	INT18801	Negative_regulation of Negative_regulation of Adra2a	2	0.43	0	0.91
75	INT215606	Positive_regulation of Localization of Adora1	3	0.49	0.44	0.87
76	INT92880	Localization of ADORA1	2	0.80	0.09	0.84
77	INT195099	Positive_regulation of Gene_expression of F2r	7	0.57	5.31	0.78
78	INT14770	Localization of Adra2a	2	0.60	0.1	0.78
79	INT18836	Localization of ADRA2A	2	0.38	0.33	0.76
80	INT113512	Regulation of Gene_expression of ADORA1	1	0.11	0.19	0.73
81	INT11102	Negative_regulation of Regulation of Adra2a	2	0.42	1.5	0.71
82	INT7609	Regulation of Positive_regulation of Adra2a	3	0.32	0.59	0.66
83	INT54183	Regulation of Positive_regulation of Adora1	1	0.17	0	0.65
84	INT215607	Positive_regulation of Negative_regulation of Adora1	1	0.45	0	0.63
85	INT207089	Regulation of Negative_regulation of F2r	1	0.17	1.49	0.62
86	INT297831	Protein_catabolism of F2rl1	2	0.10	0.5	0.6
87	INT82128	Negative_regulation of Transcription of Adra2a	1	0.18	1.32	0.55
88	INT59394	Regulation of Regulation of Adra2a	1	0.17	0	0.55
89	INT31363	Positive_regulation of Regulation of Adra2a	1	0.04	0	0.55
90	INT30428	Positive_regulation of Binding of ADRA2A	1	0.34	0.59	0.53
91	INT216748	Regulation of Localization of ADORA1	1	0.07	0.09	0.53
92	INT338026	Regulation of Localization of F2r	1	0.25	0.05	0.52
93	INT279525	Negative_regulation of Transcription of Adora1	1	0.43	0.26	0.51
94	INT77904	Negative_regulation of Gene_expression of Adra2a	2	0.43	0.87	0.5
95	INT249309	Regulation of Gene_expression of Adora1	6	0.39	0.51	0.49
96	INT41146	Negative_regulation of Localization of Adra2a	1	0.37	0.1	0.49
97	INT215600	Regulation of Binding of Adora1	1	0.08	0.09	0.48
98	INT111019	Negative_regulation of Binding of F2rl1	1	0.35	0	0.48
99	INT29102	Transcription of ADRA2A	2	0.27	0.83	0.46
100	INT156226	Transcription of F2rl1	1	0.23	1.25	0.41
101	INT156230	Positive_regulation of Binding of F2rl1	1	0.21	1.11	0.4
102	INT33171	Positive_regulation of Negative_regulation of Adra2a	1	0.39	0	0.4
103	INT279524	Protein_catabolism of Adora1	1	0.88	0.34	0.38
104	INT279523	Positive_regulation of Protein_catabolism of Adora1	1	0.50	0.34	0.38
105	INT29100	Negative_regulation of Binding of ADRA2A	1	0.19	0.84	0.37
106	INT29101	Positive_regulation of Transcription of ADRA2A	1	0.19	0.76	0.32
107	INT92881	Transcription of ADORA1	1	0.69	0	0.31
108	INT224100	Regulation of Negative_regulation of ADORA1	1	0.01	0.05	0.3
109	INT13453	Regulation of Negative_regulation of Adra2a	2	0.27	0.49	0.28
110	INT134176	Gene_expression of ADRA2A	4	0.58	1.45	0.25
111	INT195091	Negative_regulation of Positive_regulation of F2r	1	0.48	1.69	0.25
112	INT25928	Positive_regulation of Negative_regulation of ADRA2A	1	0.05	0	0.23
113	INT186700	Localization of Adora1	1	0.23	0	0.23
114	INT195112	Positive_regulation of Positive_regulation of F2r	1	0.41	0.97	0.18
115	INT207129	Localization of F2rl1	1	0.22	0.72	0.18
116	INT249313	Negative_regulation of Gene_expression of Adora1	1	0.37	0	0.14
117	INT127623	Protein_catabolism of ADORA1	1	0.49	0.19	0.14
118	INT207087	Negative_regulation of Binding of F2r	1	0.27	0.06	0.14
119	INT134177	Positive_regulation of Gene_expression of ADRA2A	1	0.10	0.26	0.12
120	INT134178	Positive_regulation of Regulation of ADRA2A	1	0.10	0.24	0.12
121	INT145503	Protein_catabolism of F2r	1	0.66	0.46	0.07
122	INT195082	Regulation of Gene_expression of F2r	1	0.37	0.67	0.07
123	INT241720	Regulation of Transcription of Adora1	1	0.40	0.27	0.07
124	INT210662	Transcription of Adra2a	1	0.01	0.09	0
125	INT338031	Transcription of F2r	1	0.39	0	0
126	INT149028	Positive_regulation of Gene_expression of F2rl1	1	0.43	0	0
127	INT149032	Regulation of Gene_expression of F2rl1	1	0.23	0	0