GO:0033256

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Name I-kappaB/NF-kappaB complex
Categary Component
Go Slim No
Go Link GO:0033256
Unique Molecular Interactions 155
Total Molecular Interactions 225
Total Single Events 1186
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for I-kappaB/NF-kappaB complex. They are ordered first by their pain relevance and then by number of times they were reported for I-kappaB/NF-kappaB complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
2 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
3 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
4 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
5 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
6 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
7 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
8 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
9 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
10 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
11 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
12 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
13 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
14 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
15 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
16 INT129034 Nfkbia Positive_regulation of Nfkb1 1 0.02 0.67 0.89
17 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
18 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
19 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
20 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
21 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
22 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
23 INT146463 TNFSF10 Positive_regulation of NFKB1 2 0.08 2.45 0.71
24 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
25 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
26 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7
27 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
28 INT160119 EPO Regulation of Gene_expression of NFKB1 1 0.02 0.2 0.64
29 INT120851 NFKB1 Positive_regulation of Localization of TNF 3 0.04 2.05 0.62
30 INT66207 Positive_regulation of TNF Positive_regulation of NFKB1 1 0.42 0.08 0.61
31 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
32 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
33 INT147071 NFKB1 Regulation of Gene_expression of PTGES 1 0.36 0.35 0.57
34 INT113548 NFKB1 Regulation of Localization of PLAU 1 0.26 1.93 0.55
35 INT156246 NFKB1 Regulation of Gene_expression of TNF 1 0.17 0.35 0.54
36 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
37 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
38 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
39 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
40 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
41 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
42 INT135588 Positive_regulation of IKBKE Positive_regulation of NFKB1 1 0.18 1.29 0.48
43 INT135587 IKBKE Positive_regulation of NFKB1 1 0.18 1.28 0.48
44 INT191948 NFKB1 Regulation of Gene_expression of NOS2 1 0.38 1 0.47
45 INT106073 IL1B Positive_regulation of Positive_regulation of NFKB1 1 0.41 0.7 0.47
46 INT87934 Phosphorylation of Nfkbia Positive_regulation of Nfkb1 1 0.02 0.1 0.45
47 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
48 INT87936 Nfkbia Positive_regulation of Nfkb1 1 0.03 0.1 0.44
49 INT103128 Positive_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.07 0.73 0.43
50 INT107699 IL1B Positive_regulation of Localization of NFKB1 1 0.03 0.13 0.41
51 INT84516 NFKB1 Positive_regulation of Gene_expression of TF 1 0.10 0.09 0.41
52 INT103131 Positive_regulation of NFKB1 Regulation of Gene_expression of IL8 1 0.27 0.68 0.4
53 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
54 INT103795 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0.47 0.37
55 INT107705 DCSTAMP Positive_regulation of Localization of NFKB1 1 0.07 0.07 0.36
56 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35
57 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35
58 INT83347 GSR Negative_regulation of NFKB1 1 0.25 0.72 0.33
59 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
60 INT144251 TNF Positive_regulation of Gene_expression of NFKB1 1 0.43 0.65 0.3
61 INT80029 Binding of FAS and Positive_regulation of NFKB1 1 0.34 0.92 0.3
62 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
63 INT166789 HRAS Regulation of Positive_regulation of NFKB1 1 0.05 0.31 0.3
64 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3
65 INT113558 Negative_regulation of NFKB1 Negative_regulation of Localization of PLAU 1 0.41 0.97 0.29
66 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28
67 INT144237 Negative_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.06 0.72 0.28
68 INT80873 Positive_regulation of Nfkb1 Positive_regulation of Protein_catabolism of Nfkbia 2 0.01 0.58 0.27
69 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
70 INT144239 CTSG Regulation of Positive_regulation of NFKB1 1 0.00 0.67 0.27
71 INT56071 NFKB1 Positive_regulation of Gene_expression of IL1B 1 0.36 0.4 0.27
72 INT108878 ZNF236 Regulation of Protein_catabolism of Nfkbia 1 0.00 0.38 0.26
73 INT125514 Positive_regulation of PRKDC Positive_regulation of Positive_regulation of NFKB1 1 0.07 0.44 0.26
74 INT108880 ZNF236 Regulation of Gene_expression of Nfkbia 1 0.00 0.38 0.26
75 INT108877 ZNF236 Regulation of Phosphorylation of Nfkbia 1 0.00 0.38 0.26
76 INT108881 ZNF236 Regulation of Transcription of Nfkbia 1 0.00 0.36 0.26
77 INT125512 Gene_expression of NFKB1 Positive_regulation of GDF15 1 0.32 0.42 0.25
78 INT321224 TLR4 Positive_regulation of NFKB1 1 0.04 1.02 0.25
79 INT120849 PRL Positive_regulation of NFKB1 1 0.07 0.49 0.25
80 INT321223 CXCR1 Positive_regulation of NFKB1 1 0.00 1.02 0.25
81 INT321222 Binding of NFKB1 and NFKBIZ 1 0.02 1.11 0.24
82 INT125518 Binding of NFKB1 and GDF15 1 0.33 0.41 0.24
83 INT125519 Regulation of PLAT Positive_regulation of NFKB1 1 0.07 0.44 0.24
84 INT143950 Negative_regulation of NFKB1 Positive_regulation of Gene_expression of RELA 1 0.45 0.46 0.23
85 INT144238 TNF Positive_regulation of Protein_catabolism of NFKB1 1 0.40 0.35 0.22
86 INT144241 CGA Negative_regulation of Phosphorylation of NFKBIA 1 0.10 0.34 0.22
87 INT144244 TNF Positive_regulation of Protein_catabolism of NFKBIA 1 0.28 0.34 0.22
88 INT144253 TNF Positive_regulation of Phosphorylation of NFKBIA 1 0.39 0.34 0.22
89 INT144247 CGA Positive_regulation of Protein_catabolism of NFKBIA 1 0.11 0.34 0.22
90 INT144243 CGA Positive_regulation of Phosphorylation of NFKBIA 1 0.11 0.34 0.22
91 INT104838 Binding of NFKB1 and IGKV2OR2-1 1 0.01 0 0.22
92 INT55164 Binding of NFKB1 and WRAP53 1 0.02 0.11 0.19
93 INT159788 Tnf Positive_regulation of Phosphorylation of Nfkbia 1 0.01 0.39 0.19
94 INT102805 NFKB1 Regulation of TCEAL1 1 0.25 0.77 0.17
95 INT116442 CD8B Negative_regulation of Positive_regulation of NFKB1 1 0.02 0 0.17
96 INT144252 CGA Positive_regulation of Positive_regulation of NFKB1 1 0.17 0.38 0.17
97 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
98 INT116443 LY9 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0 0.17
99 INT102806 NFKB1 Regulation of Gene_expression of TCEAL1 1 0.25 0.77 0.17
100 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
101 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
102 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16
103 INT350013 ARID1B Regulation of Positive_regulation of NFKB1 1 0.00 1.77 0.16
104 INT296078 Binding of NFKB1 and Gtf3a 1 0.00 1.18 0.16
105 INT104832 Binding of IL10 and NFKB1 1 0.15 0 0.15
106 INT139822 ZNF833P Negative_regulation of Transcription of NFKB1 1 0.03 0.11 0.15
107 INT61360 Regulation of TNF Positive_regulation of NFKB1 2 0.21 1.34 0.14
108 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14
109 INT214480 SELPLG Negative_regulation of Positive_regulation of NFKB1 1 0.00 0.6 0.14
110 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14
111 INT139791 PRSS53 Negative_regulation of NFKB1 1 0.09 0.71 0.13
112 INT128281 Binding of JUND and NFKB1 1 0.36 0.39 0.13
113 INT306262 NFKB1 Positive_regulation of Transcription of PTGS2 1 0.42 0.31 0.12
114 INT139790 PRSS53 Negative_regulation of Phosphorylation of NFKBIA 1 0.01 0.9 0.11
115 INT306265 Binding of NFKB1 and NFKBIA 1 0.21 0.48 0.11
116 INT147073 NFKB1 Regulation of PTGS2 1 0.37 0 0.11
117 INT147072 NFKB1 Regulation of PTGES 1 0.36 0 0.11
118 INT139789 TNFAIP8 Positive_regulation of Phosphorylation of NFKBIA 1 0.02 0.89 0.11
119 INT139788 TNFAIP8 Positive_regulation of NFKBIA 1 0.01 0.88 0.11
120 INT139784 PRSS53 Negative_regulation of Positive_regulation of NFKB1 1 0.09 0.9 0.11
121 INT139785 TNFAIP8 Positive_regulation of Positive_regulation of NFKB1 1 0.19 0.89 0.11
122 INT294681 Tlr4 Positive_regulation of Positive_regulation of NFKB1 1 0.02 0.27 0.1
123 INT263449 Binding of NFKBIA and TBK1 1 0.07 0.2 0.1
124 INT263450 NFKB2 Positive_regulation of Protein_catabolism of NFKBIA 1 0.17 0.17 0.09
125 INT208218 NFKB1 Regulation of IRF6 1 0.01 0.07 0.07
126 INT312645 Binding of DNAJA3 and Musk 1 0.08 0.96 0.07
127 INT161532 Tlr4 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.76 0.03
128 INT161531 Nfkbia Regulation of Gene_expression of Tlr4 1 0.01 0.75 0.03
129 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
130 INT161534 Tlr4 Positive_regulation of Phosphorylation of Nfkbia 1 0.00 0.77 0.03
131 INT139004 Mtpn Regulation of NFKB1 1 0.33 0.55 0
132 INT103286 Negative_regulation of IRF6 Positive_regulation of NFKB1 1 0.18 0 0
133 INT103287 IRF6 Positive_regulation of NFKB1 1 0.19 0 0
134 INT165509 CYBB Regulation of Gene_expression of NFKB1 1 0.02 0 0
135 INT156450 ANGPTL5 Positive_regulation of Positive_regulation of NFKB1 1 0.03 0 0
136 INT155918 NFKB1 Positive_regulation of Gene_expression of TNF 1 0.34 0 0
137 INT155173 NFKB1 Regulation of Gene_expression of NOS1 1 0.12 0.08 0
138 INT150957 STK16 Positive_regulation of Positive_regulation of NFKB1 1 0.04 0.08 0
139 INT312642 DNAJA3 Positive_regulation of Musk 1 0.08 0.37 0
140 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0
141 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
142 INT315070 Binding of IL8 and NFKB1 1 0.26 0.34 0
143 INT165510 HSPG2 Negative_regulation of Gene_expression of NFKB1 1 0.01 0.06 0
144 INT335513 EDIL3 Regulation of NFKB1 1 0.26 0.2 0
145 INT170589 NFKB1 Regulation of Gene_expression of ICAM1 1 0.27 0 0
146 INT156451 Negative_regulation of NFKB1 Negative_regulation of Gene_expression of ANGPTL5 1 0.03 0 0
147 INT292152 Binding of NFKB1 and REL 1 0.03 0.4 0
148 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
149 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
150 INT164909 IL33 Positive_regulation of Phosphorylation of NFKBIA 1 0.53 0.05 0
151 INT164070 AKT1 Positive_regulation of NFKB1 1 0.32 0.09 0
152 INT164071 AKT1 Regulation of Positive_regulation of NFKB1 1 0.17 0.09 0
153 INT155917 NFKB1 Positive_regulation of Gene_expression of IL6 1 0.29 0 0
154 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for I-kappaB/NF-kappaB complex. They are ordered first by their pain relevance and then by number of times they were reported in I-kappaB/NF-kappaB complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
2 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
3 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
4 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
5 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
6 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
7 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
8 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
9 INT81538 Phosphorylation of Nfkbia 27 0.62 8.86 10.49
10 INT80872 Protein_catabolism of Nfkbia 28 0.92 10.56 8.62
11 INT95297 Gene_expression of Nfkbia 14 0.68 7.61 8.24
12 INT81532 Negative_regulation of Protein_catabolism of Nfkbia 21 0.54 8.92 7.38
13 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
14 INT81541 Negative_regulation of Nfkbia 12 0.51 5.73 6.79
15 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
16 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39
17 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31
18 INT81535 Negative_regulation of Phosphorylation of Nfkbia 15 0.44 5.74 5.18
19 INT66211 Positive_regulation of Localization of NFKB1 20 0.68 8.18 5.01
20 INT131253 Positive_regulation of Gene_expression of Nfkbia 4 0.41 3.28 4.71
21 INT81543 Positive_regulation of Phosphorylation of Nfkbia 7 0.37 2.51 4.1
22 INT108868 Transcription of Nfkbia 2 0.57 2.91 4.03
23 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94
24 INT56075 Transcription of NFKB1 13 0.71 9.03 3.83
25 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66
26 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63
27 INT139801 Phosphorylation of NFKB1 9 0.66 5.2 3.13
28 INT93401 Positive_regulation of Protein_catabolism of Nfkbia 11 0.46 3.89 2.7
29 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
30 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
31 INT108869 Localization of Nfkbia 5 0.56 1.04 2.63
32 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
33 INT71305 Regulation of Gene_expression of NFKB1 9 0.61 5.41 2.44
34 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
35 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
36 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
37 INT151269 Positive_regulation of Localization of Nfkbia 1 0.37 0 1.86
38 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83
39 INT76608 Regulation of Negative_regulation of NFKB1 1 0.33 0.53 1.75
40 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69
41 INT165446 Positive_regulation of Phosphorylation of NFKB1 3 0.56 1.88 1.66
42 INT47972 Positive_regulation of Protein_catabolism of NFKBIA 5 0.46 2.09 1.53
43 INT66214 Regulation of Binding of NFKB1 2 0.35 0.55 1.28
44 INT131254 Positive_regulation of Transcription of Nfkbia 1 0.36 0.99 1.28
45 INT166013 Positive_regulation of Gene_expression of NFKBIA 2 0.32 1.15 1.2
46 INT129726 Regulation of Nfkbia 2 0.06 1.63 1.05
47 INT107971 Regulation of NFKBIA 3 0.24 2.03 1.04
48 INT81542 Regulation of Protein_catabolism of Nfkbia 2 0.04 0.43 1.02
49 INT81540 Positive_regulation of Nfkbia 4 0.22 1.37 0.92
50 INT88600 Positive_regulation of Binding of NFKB1 9 0.59 2.1 0.88
51 INT76609 Regulation of Regulation of NFKB1 2 0.20 0.97 0.79
52 INT56073 Positive_regulation of Transcription of NFKB1 4 0.46 1.88 0.77
53 INT95298 Negative_regulation of Gene_expression of Nfkbia 2 0.38 0.62 0.71
54 INT81533 Negative_regulation of Negative_regulation of Nfkbia 1 0.04 0.36 0.7
55 INT166019 Regulation of Gene_expression of NFKBIA 1 0.05 0.64 0.65
56 INT56074 Negative_regulation of Transcription of NFKB1 3 0.58 1.53 0.64
57 INT122004 Negative_regulation of Phosphorylation of NFKBIA 3 0.41 1.59 0.58
58 INT263482 Positive_regulation of Transcription of NFKBIA 1 0.39 0.61 0.57
59 INT25362 Binding of NFKBIA 4 0.26 2.52 0.55
60 INT107106 Positive_regulation of Negative_regulation of NFKB1 1 0.33 1.26 0.54
61 INT232453 Negative_regulation of DNAJA3 1 0.41 0 0.54
62 INT166794 Regulation of Localization of NFKB1 2 0.36 0.49 0.38
63 INT166795 Regulation of Phosphorylation of NFKB1 1 0.36 0.49 0.38
64 INT132627 Binding of Nfkbia 1 0.03 0.41 0.31
65 INT56079 Negative_regulation of Transcription of NFKBIA 1 0.05 0.54 0.26
66 INT108867 Regulation of Transcription of Nfkbia 1 0.00 0.36 0.25
67 INT143955 Negative_regulation of Negative_regulation of NFKB1 1 0.35 0.48 0.2
68 INT151129 Negative_regulation of Localization of Nfkbia 1 0.30 0.31 0.19
69 INT154558 Regulation of Phosphorylation of Nfkbia 1 0.00 0.33 0.17
70 INT139798 Positive_regulation of Phosphorylation of NFKBIA 1 0.04 0.88 0.11
71 INT312616 Binding of DNAJA3 1 0.07 0.58 0.07
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