GO:0034236

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Name protein kinase A catalytic subunit binding
Categary Function
Go Slim No
Go Link GO:0034236
Unique Molecular Interactions 106
Total Molecular Interactions 121
Total Single Events 1610
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase A catalytic subunit binding. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase A catalytic subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
2 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
3 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
4 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
5 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
6 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
7 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
8 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
9 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
10 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
11 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
12 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
13 INT110384 Binding of Prkaca and Akap11 1 0.08 0.31 0.2
14 INT121583 Negative_regulation of GSK3A Negative_regulation of Gene_expression of GDF15 1 0.11 0.49 0.2
15 INT307453 Bdnf Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.16 0.18
16 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
17 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
18 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
19 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
20 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
21 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
22 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
23 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
24 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
25 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
26 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
27 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
28 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
29 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
30 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
31 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
32 INT307454 Prkcg Regulation of Phosphorylation of Gsk3a 1 0.04 0.13 0.05
33 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
34 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
35 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
36 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
37 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
38 INT307455 Gsk3a Regulation of Bdnf 1 0.06 0.09 0.04
39 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
40 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
41 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03
42 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
43 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03
44 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03
45 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
46 INT234975 Binding of Dsg3 and Negative_regulation of Gsk3a 1 0.03 0.3 0.03
47 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
48 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03
49 INT303079 Gsk3b Positive_regulation of Cebpg 1 0.08 0.16 0.03
50 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
51 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
52 INT192046 Negative_regulation of Binding of RYR2 and Cbx5 1 0.01 1.12 0
53 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
54 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0
55 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
56 INT307457 Negative_regulation of Pik3cb Positive_regulation of Gsk3a 1 0.06 0.08 0
57 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
58 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
59 INT268628 Mpz Positive_regulation of Phosphorylation of Gsk3b 1 0.25 0.43 0
60 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
61 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
62 INT268635 Mpz Positive_regulation of Gsk3b 1 0.17 0.43 0
63 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
64 INT192049 Negative_regulation of Binding of RYR2 and Cbx1 1 0.01 1.12 0
65 INT290809 Binding of Arntl and Gsk3b 1 0.20 0 0
66 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
67 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
68 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.07 0.53 0
69 INT192047 Binding of RYR2 and Cbx1 1 0.01 1.12 0
70 INT192043 Binding of RYR2 and Cbx5 1 0.01 1.12 0
71 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
72 INT307451 Fig4 Regulation of Phosphorylation of Gsk3a 1 0.01 0.06 0
73 INT192048 Binding of DSP and Ryr2 1 0.24 1.1 0
74 INT281610 Positive_regulation of Akt1 Positive_regulation of Gsk3b 1 0.02 0.12 0
75 INT276212 Binding of Akt1 and Gsk3a 1 0.11 0 0
76 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
77 INT268632 Mpz Regulation of Gsk3b 1 0.22 0 0
78 INT290806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
79 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
80 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0
81 INT192042 Binding of Jup and Ryr2 1 0.17 1.09 0
82 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
83 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
84 INT307452 Negative_regulation of Pik3cb Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase A catalytic subunit binding. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase A catalytic subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
2 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
3 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
4 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22
5 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
6 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
7 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61
8 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
9 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
10 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
11 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
12 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
13 INT92000 Gene_expression of Gsk3a 12 0.18 4.12 2.39
14 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
15 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
16 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57
17 INT163506 Binding of Gsk3a 4 0.32 1.41 1.31
18 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
19 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
20 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
21 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
22 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
23 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
24 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
25 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92
26 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
27 INT253938 Positive_regulation of Gsk3a 3 0.06 3.4 0.9
28 INT91995 Positive_regulation of Gsk3a 8 0.14 2.84 0.86
29 INT307469 Regulation of Gsk3a 4 0.09 1.12 0.83
30 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
31 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
32 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
33 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
34 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
35 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
36 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
37 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
38 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
39 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
40 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
41 INT151663 Regulation of Gsk3a 3 0.16 1.03 0.54
42 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
43 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
44 INT85759 Localization of Gsk3a 3 0.55 0.43 0.52
45 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
46 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
47 INT163507 Negative_regulation of Phosphorylation of Gsk3a 3 0.51 0.96 0.45
48 INT307472 Regulation of Negative_regulation of Gsk3a 2 0.05 0.83 0.45
49 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44
50 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
51 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
52 INT307464 Regulation of Phosphorylation of Gsk3a 1 0.12 0.42 0.43
53 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
54 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
55 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
56 INT151662 Negative_regulation of Gsk3a 3 0.15 0.55 0.37
57 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
58 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
59 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
60 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
61 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
62 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
63 INT120216 Regulation of RYR2 2 0.28 1.03 0.22
64 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
65 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
66 INT121586 Positive_regulation of GSK3A 2 0.23 0.86 0.2
67 INT121585 Negative_regulation of Positive_regulation of GSK3A 1 0.11 0.49 0.2
68 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
69 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
70 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11
71 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
72 INT165787 Positive_regulation of RYR2 2 0.23 1.3 0.11
73 INT289741 Phosphorylation of Gsk3a 1 0.24 0.45 0.11
74 INT91997 Regulation of Gene_expression of Gsk3a 1 0.03 0.56 0.1
75 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
76 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
77 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
78 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
79 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
80 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
81 INT307465 Positive_regulation of Positive_regulation of Gsk3a 1 0.10 0.24 0.07
82 INT307482 Regulation of Regulation of Gsk3a 1 0.05 0 0.07
83 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
84 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
85 INT192016 Localization of RYR2 5 0.25 4.18 0.05
86 INT192012 Binding of RYR2 2 0.30 3.61 0.05
87 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05
88 INT336062 Regulation of Localization of Gsk3b 1 0.03 0.48 0.04
89 INT192023 Negative_regulation of RYR2 1 0.15 1.86 0.04
90 INT225365 Binding of Sox9 2 0.28 0.48 0.03
91 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
92 INT322462 Transcription of Ryr2 1 0.55 0.47 0.03
93 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
94 INT245757 Localization of SOX9 4 0.62 0.8 0
95 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
96 INT268625 Regulation of Transcription of Gsk3b 2 0.15 0 0
97 INT219581 Binding of Ryr2 2 0.27 4.54 0
98 INT219567 Phosphorylation of Ryr2 2 0.62 0.22 0
99 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
100 INT219566 Localization of Ryr2 1 0.45 0.49 0
101 INT211943 Transcription of Sox9 1 0.50 0.3 0
102 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
103 INT268441 Regulation of Regulation of Gsk3b 1 0.07 0.72 0
104 INT258227 Positive_regulation of Regulation of GSK3A 1 0.15 0 0
105 INT322886 Transcription of Sox9 1 0.50 0.25 0
106 INT322461 Negative_regulation of Transcription of Ryr2 1 0.45 0 0
107 INT219582 Positive_regulation of Phosphorylation of Ryr2 1 0.30 0.22 0
108 INT260480 Transcription of Gsk3b 1 0.02 3.08 0
109 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
110 INT152449 Regulation of Protein_catabolism of Gsk3b 1 0.12 0.49 0
111 INT192020 Regulation of Localization of RYR2 1 0.15 0.27 0
112 INT258225 Regulation of GSK3A 1 0.09 0 0
113 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
114 INT307476 Negative_regulation of Gene_expression of Gsk3a 1 0.09 0.06 0
115 INT152451 Regulation of Gene_expression of Gsk3b 1 0.12 0.57 0
116 INT245765 Binding of SOX9 1 0.31 0.87 0
117 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
118 INT152448 Protein_catabolism of Gsk3b 1 0.28 0.49 0
119 INT297204 Regulation of Ryr2 1 0.08 0.3 0
120 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
121 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
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