GO:0035197

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Name siRNA binding
Categary Function
Go Slim No
Go Link GO:0035197
Unique Molecular Interactions 70
Total Molecular Interactions 79
Total Single Events 755
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for siRNA binding. They are ordered first by their pain relevance and then by number of times they were reported for siRNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
2 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
3 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
4 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
5 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
6 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
7 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
8 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
9 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
10 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
11 INT804 Aap Negative_regulation of MBD2 1 0.01 0 0.57
12 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
13 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
14 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
15 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
16 INT1066 Gm5720 Positive_regulation of MBD2 1 0.00 0.73 0.42
17 INT178218 IFNA1 Regulation of Tlr7 1 0.04 0.87 0.37
18 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
19 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
20 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
21 INT137160 TLR7 Positive_regulation of Gene_expression of CXCR3 1 0.35 0.34 0.32
22 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29
23 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29
24 INT137169 Binding of TLR5 and TLR7 1 0.25 0.33 0.29
25 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
26 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27
27 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
28 INT47600 Ccno Regulation of MBD2 1 0.00 0.22 0.24
29 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
30 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
31 INT260437 Positive_regulation of Tlr7 Positive_regulation of Positive_regulation of Il12a 1 0.03 0.27 0.21
32 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21
33 INT260441 Negative_regulation of Tlr7 Negative_regulation of Positive_regulation of IFNA1 1 0.05 0.96 0.21
34 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2
35 INT329068 Tlr9 Positive_regulation of Localization of IFNA1 1 0.03 1.54 0.19
36 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
37 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
38 INT87092 Binding of PPP4C and MBD2 1 0.05 0 0.16
39 INT333271 Tlr9 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
40 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
41 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
42 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
43 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11
44 INT286683 Gopc Positive_regulation of MBD2 1 0.01 1.07 0.11
45 INT190246 TARBP2 Positive_regulation of PKLR 1 0.01 0.41 0.1
46 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
47 INT294773 IRF6 Positive_regulation of TLR9 1 0.06 0.17 0.1
48 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
49 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08
50 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
51 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05
52 INT190247 TARBP2 Negative_regulation of PKLR 1 0.01 0.2 0.05
53 INT290165 Tlr9 Positive_regulation of Gene_expression of IFNA1 1 0.10 1.2 0.04
54 INT290161 Tlr9 Positive_regulation of Gene_expression of Pdc 1 0.21 1.2 0.04
55 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04
56 INT290313 Binding of MYD88 and TLR7 1 0.03 0.1 0.03
57 INT225644 Binding of TARBP2 and Acp5 1 0.04 0.15 0
58 INT225613 TARBP2 Positive_regulation of Prkdc 1 0.00 0 0
59 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0
60 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0
61 INT225643 Binding of TARBP2 and Acsl1 1 0.00 0 0
62 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
63 INT225634 Binding of TARBP2 and MED23 1 0.04 0.15 0
64 INT324814 Binding of Ighm and Tlr9 1 0.06 0.17 0
65 INT225618 TARBP2 Positive_regulation of gr 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for siRNA binding. They are ordered first by their pain relevance and then by number of times they were reported in siRNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
2 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31
3 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
4 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
5 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49
6 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
7 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
8 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
9 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
10 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
11 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
12 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
13 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
14 INT204524 Binding of TLR9 17 0.43 11.69 2.76
15 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21
16 INT38374 Regulation of MBD2 8 0.10 0.72 2.09
17 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
18 INT188678 Binding of Tlr7 14 0.32 6.6 1.89
19 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
20 INT178188 Positive_regulation of Tlr7 12 0.40 6.33 1.77
21 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
22 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
23 INT174689 Gene_expression of Tlr7 11 0.67 8.24 1.56
24 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
25 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
26 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
27 INT219159 Positive_regulation of TLR7 8 0.55 2.37 1.32
28 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
29 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
30 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
31 INT22946 Gene_expression of MBD2 4 0.25 0.26 0.98
32 INT120599 Binding of Tlr7 2 0.27 2.16 0.96
33 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
34 INT280014 Binding of TLR7 4 0.14 3.52 0.76
35 INT288495 Gene_expression of Tlr7 3 0.50 2.83 0.76
36 INT294787 Localization of TLR9 2 0.67 2.35 0.75
37 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
38 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
39 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
40 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
41 INT280463 Binding of Mecp2 3 0.37 4 0.63
42 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
43 INT178202 Regulation of Tlr7 2 0.34 1.69 0.59
44 INT260425 Positive_regulation of Gene_expression of Tlr7 3 0.39 2.88 0.53
45 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
46 INT288490 Binding of Tlr9 1 0.25 1.88 0.51
47 INT285448 Positive_regulation of Gene_expression of TLR7 4 0.61 2.58 0.5
48 INT245223 Negative_regulation of Gene_expression of TLR7 3 0.37 2.81 0.5
49 INT8053 Regulation of Negative_regulation of MBD2 1 0.16 0 0.5
50 INT188677 Positive_regulation of Positive_regulation of Tlr9 2 0.29 1.22 0.49
51 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
52 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
53 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
54 INT260427 Negative_regulation of Tlr7 2 0.33 1.42 0.42
55 INT178171 Localization of Tlr7 1 0.51 0.53 0.41
56 INT204533 Regulation of Gene_expression of TLR9 8 0.55 2.81 0.4
57 INT219171 Negative_regulation of Positive_regulation of TLR9 1 0.18 1.3 0.39
58 INT219182 Negative_regulation of Positive_regulation of TLR7 1 0.24 1.3 0.39
59 INT182134 Transcription of TLR9 2 0.72 1.21 0.37
60 INT284455 Regulation of Gene_expression of Tlr9 1 0.30 1.19 0.37
61 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
62 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
63 INT329061 Positive_regulation of Tlr9 1 0.47 2.05 0.29
64 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
65 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28
66 INT204528 Negative_regulation of Gene_expression of TLR9 5 0.52 4.47 0.27
67 INT236357 Negative_regulation of Positive_regulation of Tlr9 2 0.33 3.1 0.27
68 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
69 INT219175 Localization of TLR7 2 0.49 1.32 0.25
70 INT204531 Negative_regulation of TLR9 1 0.43 1.29 0.25
71 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
72 INT245222 Regulation of TLR7 2 0.39 1.52 0.19
73 INT41148 Binding of MBD2 1 0.18 0 0.17
74 INT350779 Positive_regulation of Positive_regulation of TLR9 1 0.08 0.8 0.15
75 INT204527 Regulation of TLR9 7 0.40 2.88 0.12
76 INT120600 Positive_regulation of Binding of Tlr7 1 0.04 0.17 0.12
77 INT260428 Regulation of Gene_expression of Tlr7 1 0.25 1.01 0.12
78 INT151569 Transcription of Tlr9 3 0.69 0.75 0.11
79 INT151566 Positive_regulation of Transcription of Tlr9 2 0.47 0.67 0.11
80 INT188681 Positive_regulation of Binding of Tlr7 1 0.17 0 0.11
81 INT46899 Negative_regulation of Positive_regulation of MBD2 1 0.00 0 0.1
82 INT27567 Positive_regulation of Gene_expression of MBD2 1 0.01 0 0.09
83 INT280012 Positive_regulation of Binding of TLR7 1 0.18 1.11 0.09
84 INT280015 Positive_regulation of Binding of TLR9 1 0.12 1.11 0.09
85 INT47659 Localization of MBD2 2 0.70 0.72 0.08
86 INT322026 Positive_regulation of Positive_regulation of TLR7 1 0.40 0.06 0.08
87 INT120535 Positive_regulation of Negative_regulation of MBD2 1 0.01 0.22 0.07
88 INT288492 Negative_regulation of Gene_expression of Tlr7 1 0.32 0.63 0.04
89 INT204526 Positive_regulation of Transcription of TLR9 1 0.50 0.06 0.03
90 INT324758 Negative_regulation of Positive_regulation of Tlr7 1 0.21 0.22 0.03
91 INT294790 Regulation of Localization of TLR9 1 0.40 0 0
92 INT285438 Regulation of Regulation of TLR9 1 0.40 0 0
93 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
94 INT110559 Positive_regulation of Tlr7 1 0.04 0.19 0
95 INT161253 Regulation of Gene_expression of Tlr9 1 0.09 0.18 0
96 INT320939 Transcription of Mecp2 1 0.69 0.2 0
97 INT328132 Regulation of Mecp2 1 0.40 1 0
98 INT324755 Positive_regulation of Binding of Tlr9 1 0.26 0.17 0
99 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
100 INT161254 Regulation of Tlr9 1 0.09 0.18 0
101 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
102 INT225465 Transcription of TARBP2 1 0.08 0.13 0
103 INT225458 Phosphorylation of TARBP2 1 0.09 0 0
104 INT329056 Positive_regulation of Gene_expression of Tlr9 1 0.43 0.09 0
105 INT151568 Negative_regulation of Transcription of Tlr9 1 0.41 0.08 0
106 INT225459 Binding of TARBP2 1 0.05 0 0
107 INT225461 Negative_regulation of TARBP2 1 0.06 0 0
108 INT341498 Negative_regulation of Gene_expression of Tlr9 1 0.11 0.38 0
109 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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