GO:0035408

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Name histone H3-T6 phosphorylation
Categary Process
Go Slim No
Go Link GO:0035408
Unique Molecular Interactions 180
Total Molecular Interactions 201
Total Single Events 1267
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone H3-T6 phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for histone H3-T6 phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
3 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
4 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
5 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
6 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
7 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
8 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
9 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
10 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
11 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
12 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
13 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
14 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
15 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
16 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
17 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
18 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
19 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
20 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
21 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
22 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
23 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
24 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
25 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
26 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
27 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
28 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
29 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
30 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
31 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
32 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
33 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
34 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
35 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
36 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
37 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
38 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
39 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
40 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
41 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
42 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
43 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
44 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
45 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
46 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
47 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
48 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
49 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
50 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
51 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
52 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
53 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
54 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
55 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
56 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
57 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
58 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
59 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
60 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
61 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
62 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
63 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
64 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
65 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
66 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
67 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
68 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
69 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
70 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
71 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
72 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
73 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
74 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
75 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
76 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
77 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41
78 INT189689 CHKB Negative_regulation of Positive_regulation of PRKCA 1 0.11 0 0.4
79 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
80 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
81 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
82 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39
83 INT306693 Prkca Regulation of Positive_regulation of Nav1 1 0.10 0.06 0.39
84 INT244046 Binding of Gabrg1 and Prkca 1 0.06 0 0.39
85 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
86 INT272726 Mdk Regulation of Negative_regulation of Prkca 1 0.00 0 0.38
87 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
88 INT193034 PRKCA Regulation of Positive_regulation of CDK20 1 0.05 0.15 0.37
89 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
90 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37
91 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36
92 INT268110 PRKCA Positive_regulation of Phosphorylation of SNAP25 1 0.32 0.11 0.35
93 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35
94 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
95 INT171679 PPY Regulation of PRKCA 1 0.08 0.33 0.33
96 INT171677 PRKCA Regulation of CISD1 1 0.00 0 0.33
97 INT207631 Hspg2 Positive_regulation of Gene_expression of Prkca 1 0.03 0.08 0.31
98 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
99 INT307215 Negative_regulation of Prkca Negative_regulation of Ppara 1 0.09 0.21 0.3
100 INT296473 Prkca Regulation of Serac1 1 0.00 0.14 0.3
101 INT185144 Prkca Positive_regulation of Snrpd1 1 0.00 0.16 0.29
102 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 0.03 0 0.29
103 INT137684 Binding of Cyp27b1 and Prkca 1 0.02 0 0.29
104 INT207634 Prkca Negative_regulation of Positive_regulation of Mapk1 1 0.08 0.1 0.28
105 INT221236 Ros1 Positive_regulation of Localization of Prkca 1 0.01 0.15 0.27
106 INT338039 F2 Positive_regulation of Positive_regulation of Prkca 1 0.04 0.52 0.27
107 INT196880 Binding of Ly6 and Prkca 1 0.01 0.18 0.25
108 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
109 INT207641 Positive_regulation of Prkca Positive_regulation of Mapk1 1 0.08 0.09 0.24
110 INT189692 INSRR Positive_regulation of PRKCA 1 0.00 0 0.24
111 INT189693 CHKB Positive_regulation of PRKCA 1 0.11 0 0.24
112 INT356098 Prkca Regulation of Prkaca 1 0.01 0.11 0.24
113 INT189700 CHKB Negative_regulation of PRKCA 1 0.11 0 0.24
114 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
115 INT139050 Negative_regulation of AR Negative_regulation of Phosphorylation of PRKCB 1 0.02 0.34 0.23
116 INT207632 Prkca Positive_regulation of Phosphorylation of Mapk1 1 0.08 0 0.23
117 INT335462 IGHE Regulation of Positive_regulation of PRKCA 1 0.07 0 0.23
118 INT341779 DBT Positive_regulation of PRKCA 1 0.02 0 0.22
119 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22
120 INT173357 Gnaq Positive_regulation of PRKCA 1 0.01 0 0.22
121 INT239236 Prkca Regulation of CYBB 1 0.00 0.98 0.2
122 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
123 INT226720 Binding of Prkca and Il27ra 1 0.00 0.52 0.2
124 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
125 INT226756 Positive_regulation of Binding of Prkca and Il27ra 1 0.00 0.52 0.2
126 INT226738 Binding of Cd4 and Prkca 1 0.02 0.52 0.2
127 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2
128 INT338043 F2 Positive_regulation of Localization of Prkca 1 0.04 0.1 0.2
129 INT106630 Binding of GRK5 and PRKCA 1 0.16 0.82 0.19
130 INT226727 Positive_regulation of Prkca Positive_regulation of Protein_catabolism of Cd4 1 0.03 0.46 0.19
131 INT226761 Prkca Positive_regulation of Protein_catabolism of Cd4 1 0.03 0.45 0.19
132 INT191890 Pbsn Negative_regulation of Binding of Prkca 1 0.03 0.29 0.18
133 INT191881 Pbsn Negative_regulation of Prkca 1 0.03 0.29 0.18
134 INT328923 Car2 Positive_regulation of Prkca 1 0.00 0 0.18
135 INT193081 PRKCA Positive_regulation of Ppp1r14a 1 0.01 0.13 0.18
136 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
137 INT266899 Binding of Prkca and Plat 1 0.02 0.57 0.17
138 INT112133 Gast Positive_regulation of Prkca 1 0.18 0.13 0.16
139 INT269330 DYNC1I2 Negative_regulation of PRKCA 1 0.03 0 0.15
140 INT269326 PRKCA Positive_regulation of Localization of TMPO 1 0.01 0 0.13
141 INT269336 PRKCA Regulation of Localization of TMPO 1 0.01 0.12 0.13
142 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
143 INT269335 PRKG1 Positive_regulation of Gene_expression of PRKCA 1 0.14 0 0.12
144 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12
145 INT228455 Ins1 Positive_regulation of Prkca 1 0.02 0.98 0.12
146 INT338054 Par2 Positive_regulation of Localization of Prkca 1 0.06 0 0.11
147 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08
148 INT269334 Regulation of PRKCA Regulation of ZAK 1 0.02 0 0.07
149 INT269328 PRKCA Regulation of ZAK 1 0.02 0 0.07
150 INT272734 Prkaca Positive_regulation of Gene_expression of Prkca 1 0.00 0 0.06
151 INT191893 Pbsn Regulation of Gene_expression of Prkca 1 0.03 0.13 0.05
152 INT245369 Gpm6a Negative_regulation of Phosphorylation of Prkca 1 0.20 0.08 0.05
153 INT191891 Prkca Regulation of Gene_expression of Mapk3 1 0.03 0.13 0.05
154 INT261647 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of BDKRB1 1 0.04 0.6 0.04
155 INT261649 Positive_regulation of PRKCA Positive_regulation of BDKRB1 1 0.04 0.59 0.04
156 INT172912 CYP4A11 Regulation of Prkca 1 0.00 0.05 0.04
157 INT231845 Pcdh8 Positive_regulation of Prkca 1 0.00 0 0.04
158 INT350347 Negative_regulation of Prkca Negative_regulation of Chrm1 1 0.08 0 0.03
159 INT295479 PRKCA Positive_regulation of MAP2K1 1 0.14 0.35 0.03
160 INT350346 Negative_regulation of Prkca Negative_regulation of Negative_regulation of Chrm1 1 0.08 0 0.03
161 INT350341 Negative_regulation of Prkca Negative_regulation of Localization of Chrm1 1 0.08 0 0.03
162 INT213039 Hdl1 Positive_regulation of Prkca 1 0.10 0.98 0.03
163 INT295858 Prkca Positive_regulation of Gtf3a 1 0.00 0 0
164 INT249184 PRKCA Regulation of CYBB 1 0.09 0 0
165 INT333567 PRKCA Positive_regulation of Phosphorylation of TRAM1 1 0.02 0 0
166 INT97566 CPOX Positive_regulation of Gene_expression of PRKCA 1 0.06 0.07 0
167 INT333563 PRKCA Positive_regulation of Gene_expression of IRF3 1 0.05 0.06 0
168 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0
169 INT97091 HSPG2 Regulation of PRKCA 1 0.04 0 0
170 INT232574 ROS1 Positive_regulation of PRKCA 1 0.13 0.69 0
171 INT295856 Binding of Prkca and Srsf1 1 0.10 0 0
172 INT286651 OLR1 Positive_regulation of PRKCA 1 0.14 0.5 0
173 INT311375 Phosphorylation of Prkca Positive_regulation of Celf1 1 0.04 0.1 0
174 INT295855 Prkca Positive_regulation of Akt1 1 0.02 0 0
175 INT326058 Negative_regulation of PRKCA Negative_regulation of APOA1 1 0.15 0.32 0
176 INT169485 Dbi Regulation of Prkca 1 0.02 0.08 0
177 INT249189 CA2 Regulation of PRKCA 1 0.04 0 0
178 INT249196 Positive_regulation of PRKCA Positive_regulation of TRPC3 1 0.08 0 0
179 INT102623 Negative_regulation of PRKCA Negative_regulation of Gene_expression of CPOX 1 0.09 0.12 0
180 INT72214 Positive_regulation of PRKCA Regulation of OPRM1 1 0.17 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone H3-T6 phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in histone H3-T6 phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
2 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
3 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
4 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
5 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
6 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
7 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
8 INT117527 Binding of Prkca 25 0.48 6.43 21.05
9 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
10 INT79458 Localization of Prkca 30 0.81 11.13 15.78
11 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
12 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
13 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
14 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
15 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
16 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
17 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
18 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
19 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
20 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
21 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
22 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
23 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
24 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
25 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
26 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
27 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
28 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
29 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
30 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
31 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
32 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
33 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
34 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
35 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
36 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
37 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
38 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
39 INT79569 Protein_catabolism of PRKCA 3 1.00 0.44 1.78
40 INT97571 Positive_regulation of Gene_expression of PRKCA 13 0.43 1.61 1.7
41 INT52713 Regulation of Negative_regulation of PRKCA 5 0.36 1.23 1.41
42 INT220763 Regulation of Phosphorylation of PRKCA 3 0.29 0.84 1.22
43 INT317485 Regulation of Binding of Prkca 1 0.17 0.17 0.87
44 INT79568 Regulation of Protein_catabolism of PRKCA 1 0.45 0.1 0.76
45 INT85349 Negative_regulation of Localization of PRKCA 1 0.09 0 0.74
46 INT82366 Positive_regulation of Protein_catabolism of PRKCA 1 0.49 0 0.73
47 INT94211 Positive_regulation of Negative_regulation of Prkca 1 0.43 0 0.67
48 INT79459 Protein_catabolism of Prkca 2 1.00 0.09 0.6
49 INT76855 Negative_regulation of Gene_expression of PRKCA 4 0.30 1.8 0.36
50 INT139053 Phosphorylation of PRKCB 1 0.04 0.32 0.23
51 INT139051 Positive_regulation of Phosphorylation of PRKCB 1 0.02 0.33 0.23
52 INT139054 Negative_regulation of Phosphorylation of PRKCB 1 0.02 0.33 0.23
53 INT144005 Negative_regulation of PRKCB 2 0.28 0.2 0.19
54 INT341785 Regulation of Localization of PRKCA 1 0.08 0 0.19
55 INT76856 Negative_regulation of Transcription of PRKCA 1 0.30 0.08 0.13
56 INT76859 Transcription of PRKCA 1 0.49 0.08 0.13
57 INT227120 Transcription of Prkca 2 0.59 0.51 0.1
58 INT269369 Regulation of Gene_expression of PRKCA 1 0.12 0 0.1
59 INT144004 Positive_regulation of PRKCB 1 0.45 0 0.1
60 INT144003 Gene_expression of PRKCB 1 0.39 0 0.08
61 INT97092 Positive_regulation of Negative_regulation of PRKCA 2 0.27 0.31 0
62 INT185445 Binding of PRKCB 1 0.23 0.99 0
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