GO:0042588

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Name zymogen granule
Categary Component
Go Slim No
Go Link GO:0042588
Unique Molecular Interactions 49
Total Molecular Interactions 55
Total Single Events 790
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for zymogen granule. They are ordered first by their pain relevance and then by number of times they were reported for zymogen granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
2 INT317559 Binding of Hint1 and Pla2g4a 1 0.01 0.06 0.94
3 INT270218 P2rx3 Positive_regulation of Pla2g4a 1 0.34 0.63 0.85
4 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77
5 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77
6 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
7 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64
8 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
9 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 0.00 1.59 0.5
10 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4
11 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
12 INT324830 Hspd1 Positive_regulation of IFNA1 1 0.04 0.46 0.3
13 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
14 INT324835 Hspd1 Positive_regulation of Gene_expression of IFNA1 1 0.15 0.31 0.23
15 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
16 INT146744 Binding of NR3C1 and PLA2G4A 1 0.26 0.25 0.15
17 INT231838 Pcdh8 Regulation of Cel 1 0.00 0.39 0.15
18 INT231846 Pcdh8 Negative_regulation of Positive_regulation of Cel 1 0.00 0.91 0.14
19 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
20 INT324804 Binding of Hspd1 and Tlr4 1 0.14 0.36 0.13
21 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
22 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
23 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
24 INT246535 Binding of Cel and Mag 1 0.01 7.26 0.1
25 INT327557 Pla2g4a Positive_regulation of Phosphorylation of Ptgs2 1 0.14 1.03 0.1
26 INT327559 Pla2g4a Positive_regulation of Gene_expression of Ptgs2 1 0.14 1 0.09
27 INT197776 Pla2g10 Regulation of Pla2g4a 1 0.18 0.61 0.08
28 INT234606 Tlr4 Positive_regulation of Transcription of PLA2G4A 1 0.57 0 0.06
29 INT231834 Trip12 Positive_regulation of Positive_regulation of Cel 1 0.00 0.75 0.05
30 INT276951 Hspd1 Positive_regulation of Il10 1 0.05 0.75 0.04
31 INT329015 Binding of APCS and SRGN 1 0.08 1.14 0.04
32 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
33 INT276949 Hspd1 Positive_regulation of Gene_expression of Socs3 1 0.15 0.71 0.04
34 INT276977 Hspd1 Positive_regulation of Gene_expression of Il13 1 0.07 0.75 0.04
35 INT276956 Hspd1 Positive_regulation of Il13 1 0.07 0.75 0.04
36 INT276954 Hspd1 Positive_regulation of Stat3 1 0.31 0.65 0.04
37 INT249199 CA2 Positive_regulation of PLA2G4A 1 0.15 0 0.04
38 INT276967 Hspd1 Regulation of Gene_expression of Socs3 1 0.14 0.71 0.04
39 INT195837 Tlr4 Positive_regulation of Pla2g4a 1 0.01 0.44 0.03
40 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03
41 INT276970 Hspd1 Positive_regulation of Gene_expression of Il10 1 0.10 0.69 0.03
42 INT350792 Binding of Hspd1 and Lsr1 1 0.00 0.25 0
43 INT320632 Ptger2 Regulation of Gene_expression of Hspd1 1 0.00 0.41 0
44 INT249179 PLA2G4A Regulation of CYBB 1 0.18 0 0
45 INT146131 Binding of Gnrh1 and Hspd1 1 0.02 0.88 0
46 INT249191 CYBB Positive_regulation of PLA2G4A 1 0.20 0 0
47 INT249187 Binding of CYBB and PLA2G4A 1 0.14 0 0
48 INT246536 Mag Regulation of Gene_expression of Cel 1 0.01 1.28 0
49 INT350796 Binding of CEBPB and Hspd1 1 0.00 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for zymogen granule. They are ordered first by their pain relevance and then by number of times they were reported in zymogen granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
2 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
3 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
4 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
5 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
6 INT102855 Negative_regulation of Srgn 8 0.57 0.91 4.63
7 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09
8 INT162125 Gene_expression of Pla2g4a 4 0.54 7.69 3.75
9 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
10 INT175442 Gene_expression of Cel 22 0.34 21.36 3.33
11 INT270224 Positive_regulation of Positive_regulation of Pla2g4a 1 0.62 6.63 3.22
12 INT53813 Positive_regulation of Cel 20 0.58 19.39 3.05
13 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89
14 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58
15 INT102856 Positive_regulation of Srgn 7 0.61 1.27 2.54
16 INT270235 Negative_regulation of Phosphorylation of Pla2g4a 1 0.39 3.4 2.34
17 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3
18 INT152076 Negative_regulation of Pla2g4a 3 0.55 3.22 2.21
19 INT86814 Transcription of Pla2g4a 4 0.49 2.35 2.14
20 INT195828 Positive_regulation of Phosphorylation of Pla2g4a 3 0.45 5.05 2.12
21 INT102857 Phosphorylation of Srgn 1 0.72 0.26 1.71
22 INT89849 Regulation of Srgn 6 0.30 0.93 1.59
23 INT91773 Positive_regulation of PLA2G4A 10 0.50 4.4 1.54
24 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52
25 INT270223 Negative_regulation of Localization of Pla2g4a 1 0.39 1.83 1.5
26 INT53775 Gene_expression of Hspd1 21 0.78 31.25 1.38
27 INT268619 Phosphorylation of Pla2g4a 5 0.69 2.14 1.36
28 INT102852 Negative_regulation of Phosphorylation of Srgn 1 0.52 0.17 1.32
29 INT102853 Positive_regulation of Phosphorylation of Srgn 1 0.61 0.17 1.31
30 INT11415 Negative_regulation of Cel 5 0.38 5.67 1.29
31 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23
32 INT73176 Positive_regulation of Hspd1 5 0.35 3.96 1.22
33 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19
34 INT86812 Negative_regulation of Transcription of Pla2g4a 1 0.13 0.49 1.18
35 INT64863 Localization of PLA2G4A 9 0.44 3.33 1.07
36 INT195832 Regulation of Phosphorylation of Pla2g4a 3 0.34 2.91 1.02
37 INT162126 Positive_regulation of Gene_expression of Pla2g4a 4 0.42 2.52 1.01
38 INT89853 Gene_expression of Srgn 12 0.44 1.13 1
39 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96
40 INT86816 Negative_regulation of Gene_expression of Pla2g4a 3 0.50 2.27 0.93
41 INT270236 Regulation of Localization of Pla2g4a 1 0.24 1.68 0.93
42 INT270231 Regulation of Positive_regulation of Pla2g4a 1 0.24 1.92 0.92
43 INT147880 Regulation of SRGN 28 0.33 13.99 0.9
44 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9
45 INT168990 Positive_regulation of Positive_regulation of Pla2g4a 2 0.43 2.14 0.86
46 INT77928 Binding of Pla2g4a 3 0.10 2.5 0.84
47 INT270226 Negative_regulation of Positive_regulation of Pla2g4a 1 0.38 2.34 0.84
48 INT146746 Transcription of PLA2G4A 3 0.69 1.03 0.8
49 INT322101 Localization of Cel 2 0.29 1.11 0.76
50 INT188347 Localization of Hspd1 2 0.41 4.53 0.71
51 INT113400 Positive_regulation of Transcription of Pla2g4a 1 0.08 0.96 0.7
52 INT175450 Positive_regulation of Gene_expression of Cel 4 0.25 2.69 0.68
53 INT308475 Regulation of Positive_regulation of Pla2g4a 1 0.09 1.14 0.67
54 INT116838 Regulation of Gene_expression of Hspd1 1 0.18 0.19 0.62
55 INT53774 Positive_regulation of Gene_expression of Hspd1 7 0.70 6.99 0.6
56 INT183163 Positive_regulation of Positive_regulation of Cel 9 0.31 11.55 0.58
57 INT110319 Positive_regulation of SRGN 10 0.40 6.2 0.56
58 INT231823 Negative_regulation of Positive_regulation of Cel 2 0.17 2.34 0.56
59 INT270227 Positive_regulation of Localization of Pla2g4a 1 0.45 1.31 0.56
60 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55
61 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52
62 INT76858 Binding of PLA2G4A 4 0.30 1.22 0.52
63 INT53778 Regulation of Gene_expression of Hspd1 2 0.58 3.61 0.52
64 INT207614 Binding of Hspd1 4 0.18 1.16 0.5
65 INT270229 Binding of Pla2g4a 1 0.29 1.23 0.45
66 INT53811 Regulation of Cel 4 0.23 2.1 0.43
67 INT100082 Negative_regulation of Hspd1 3 0.54 1.91 0.42
68 INT228731 Negative_regulation of Gene_expression of Cel 2 0.17 1.12 0.41
69 INT248153 Phosphorylation of PLA2G4A 1 0.20 0.65 0.38
70 INT126173 Negative_regulation of Regulation of Pla2g4a 1 0.40 1.01 0.37
71 INT306349 Transcription of SRGN 1 0.20 2.36 0.36
72 INT126174 Positive_regulation of Regulation of Pla2g4a 1 0.37 1.03 0.34
73 INT205894 Regulation of Gene_expression of Pla2g4a 3 0.52 1.9 0.33
74 INT146747 Negative_regulation of Gene_expression of PLA2G4A 1 0.43 0.66 0.33
75 INT53814 Regulation of Positive_regulation of Cel 2 0.23 0.45 0.29
76 INT324772 Positive_regulation of Gene_expression of Hspd1 1 0.49 0.41 0.29
77 INT126171 Negative_regulation of Positive_regulation of Pla2g4a 1 0.39 0.91 0.27
78 INT175459 Binding of Cel 2 0.11 6.62 0.24
79 INT312523 Negative_regulation of Phosphorylation of Pla2g4a 1 0.16 0.68 0.22
80 INT141306 Binding of Srgn 1 0.30 0.23 0.21
81 INT312522 Positive_regulation of Phosphorylation of Pla2g4a 1 0.14 0.68 0.21
82 INT89851 Localization of Srgn 1 0.58 0.15 0.18
83 INT89850 Positive_regulation of Localization of Srgn 1 0.36 0.15 0.18
84 INT207611 Regulation of Hspd1 1 0.20 0.19 0.17
85 INT146748 Positive_regulation of Transcription of PLA2G4A 1 0.50 0.22 0.17
86 INT89857 Regulation of Gene_expression of Srgn 1 0.20 0.17 0.17
87 INT195826 Negative_regulation of Gene_expression of Pla2g4a 1 0.28 1.38 0.15
88 INT195829 Regulation of Pla2g4a 1 0.20 2.54 0.15
89 INT175454 Positive_regulation of Binding of Cel 1 0.15 0.92 0.14
90 INT84395 Protein_catabolism of Pla2g4a 1 0.02 0.41 0.12
91 INT53777 Negative_regulation of Positive_regulation of Hspd1 1 0.59 0.58 0.12
92 INT109025 Negative_regulation of Hspd1 2 0.55 1.48 0.1
93 INT109020 Positive_regulation of Negative_regulation of Hspd1 1 0.39 0.76 0.1
94 INT280055 Positive_regulation of Gene_expression of SRGN 5 0.42 2.49 0.08
95 INT305399 Positive_regulation of Positive_regulation of SRGN 1 0.37 0.13 0.06
96 INT253445 Positive_regulation of Binding of Pla2g4a 1 0.12 0.91 0.06
97 INT221986 Localization of Hspd1 1 0.52 1.8 0.06
98 INT325464 Localization of SRGN 1 0.01 0.73 0.05
99 INT177342 Negative_regulation of SRGN 15 0.28 5.66 0.04
100 INT258395 Positive_regulation of Positive_regulation of Hspd1 5 0.25 2.79 0.04
101 INT306350 Negative_regulation of Transcription of SRGN 1 0.12 0.5 0.04
102 INT269823 Transcription of Hspd1 1 0.30 1.66 0.04
103 INT249275 Positive_regulation of Localization of PLA2G4A 1 0.25 0 0.04
104 INT329018 Binding of SRGN 1 0.23 1.21 0.03
105 INT306348 Regulation of Transcription of SRGN 1 0.08 0.52 0.03
106 INT329019 Negative_regulation of Binding of SRGN 1 0.28 1.22 0.03
107 INT306351 Regulation of Regulation of SRGN 1 0.13 0.51 0.03
108 INT143410 Regulation of Localization of PLA2G4A 2 0.34 0 0
109 INT230773 Negative_regulation of Gene_expression of SRGN 2 0.16 1.19 0
110 INT315664 Negative_regulation of Gene_expression of Srgn 2 0.16 0.46 0
111 INT230477 Binding of Hspd1 2 0.34 1.09 0
112 INT195830 Regulation of Regulation of Pla2g4a 1 0.20 0.62 0
113 INT238790 Regulation of Gene_expression of Cel 1 0.07 1.27 0
114 INT230772 Regulation of Negative_regulation of SRGN 1 0.17 0.13 0
115 INT320629 Regulation of Hspd1 1 0.58 0.68 0
116 INT276945 Negative_regulation of Positive_regulation of Hspd1 1 0.22 0.9 0
117 INT177343 Negative_regulation of Negative_regulation of SRGN 1 0.07 1.13 0
118 INT230771 Negative_regulation of Positive_regulation of SRGN 1 0.19 0.36 0
119 INT337080 Positive_regulation of Localization of Pla2g4a 1 0.18 1 0
120 INT315667 Positive_regulation of Transcription of Srgn 1 0.12 0.17 0
121 INT320630 Negative_regulation of Gene_expression of Hspd1 1 0.55 1.3 0
122 INT315663 Transcription of Srgn 1 0.17 0.17 0
123 INT315666 Positive_regulation of Gene_expression of Srgn 1 0.12 0.26 0
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