GO:0042629

From wiki-pain
Revision as of 08:35, 22 January 2013 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Name mast cell granule
Categary Component
Go Slim No
Go Link GO:0042629
Unique Molecular Interactions 114
Total Molecular Interactions 182
Total Single Events 1901
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mast cell granule. They are ordered first by their pain relevance and then by number of times they were reported for mast cell granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
2 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51
3 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
4 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 0.52 0.27 1.57
5 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46
6 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
7 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28
8 INT31773 Pdyn Positive_regulation of Nppa 1 0.12 0.13 1.27
9 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
10 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
11 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
12 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95
13 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95
14 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95
15 INT182193 Binding of CXCR2 and CXCL5 1 0.30 1.25 0.94
16 INT182197 Binding of CXCR2 and CCL16 1 0.00 1.24 0.94
17 INT62956 CXCR2 Positive_regulation of IL8 1 0.30 0 0.88
18 INT201945 Binding of CXCR1 and CXCR2 3 0.14 0.84 0.8
19 INT107810 Sst Positive_regulation of Localization of Nppa 1 0.42 0.14 0.77
20 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76
21 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72
22 INT83957 Binding of Cxcr2 and Cxcl2 1 0.33 0.97 0.7
23 INT318738 Binding of CXCR2 and CXCL6 1 0.32 1.39 0.67
24 INT102863 Prkaca Regulation of Srgn 1 0.50 0.05 0.64
25 INT16412 Nppa Negative_regulation of Localization of LH 2 0.41 0.29 0.62
26 INT147049 CB Positive_regulation of Nppa 1 0.02 1.01 0.6
27 INT174452 Binding of Cxcr2 and Cxcr3 1 0.31 1.23 0.58
28 INT101216 Pnoc Positive_regulation of Localization of Nppa 1 0.68 0.09 0.57
29 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
30 INT107814 Nppa Positive_regulation of Positive_regulation of Sst 1 0.42 0.16 0.55
31 INT16643 Nppa Regulation of Rabep2 1 0.13 0.07 0.55
32 INT99789 Cxcl10 Positive_regulation of Cxcr2 1 0.53 0.28 0.46
33 INT99790 Ifng Positive_regulation of Cxcr2 1 0.12 0.28 0.46
34 INT16413 Nppa Regulation of Localization of LH 1 0.43 0.76 0.45
35 INT253996 Binding of Cxcr2 and Cxcr4 1 0.18 0.81 0.44
36 INT25430 Gtf3a Regulation of Nppa 1 0.24 0.57 0.43
37 INT303858 DDR1 Positive_regulation of CXCR2 1 0.11 1.5 0.42
38 INT79486 Nppa Negative_regulation of NA 1 0.03 1.83 0.41
39 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
40 INT32698 Nppa Regulation of Oxt 1 0.57 0.35 0.35
41 INT32699 Nppa Regulation of Avp 1 0.28 0.35 0.35
42 INT239540 Binding of CXCR2 and MYC 1 0.15 0.09 0.33
43 INT244234 Cxcr2 Positive_regulation of Cxcr1 1 0.16 0.08 0.32
44 INT239558 Binding of CXCR2 and Hopx 1 0.06 0.44 0.31
45 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
46 INT30706 Nppa Positive_regulation of Localization of AVP 1 0.78 0.45 0.3
47 INT239537 CXCR2 Regulation of MYC 1 0.15 0.05 0.29
48 INT137166 IL8 Positive_regulation of CXCR2 1 0.24 0.28 0.27
49 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27
50 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26
51 INT20587 Nppa Positive_regulation of Gfra1 1 0.02 0.32 0.26
52 INT339287 Binding of Cxcr2 and Cxcl1 1 0.29 0.48 0.24
53 INT32636 Slc12a3 Regulation of Localization of Nppa 1 0.00 0.41 0.23
54 INT170158 NPPA Positive_regulation of Gene_expression of NPPB 1 0.13 0.91 0.23
55 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
56 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22
57 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22
58 INT239536 Binding of CXCR2 and NCOR2 1 0.00 0 0.2
59 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
60 INT32700 Nppa Negative_regulation of Oxt 1 0.40 0.16 0.19
61 INT32696 Nppa Negative_regulation of Avp 1 0.45 0.16 0.19
62 INT32697 Nppa Negative_regulation of Gene_expression of Oxt 1 0.40 0.16 0.19
63 INT32494 Nppa Negative_regulation of Localization of Avp 1 0.28 1.16 0.18
64 INT322965 Binding of IL8 and Cxcr2 1 0.28 0.51 0.18
65 INT273792 Cxcr2 Positive_regulation of Nfasc 1 0.08 0.29 0.17
66 INT183697 Ducm1 Positive_regulation of Gene_expression of Cxcr2 1 0.05 0.2 0.16
67 INT26367 POMC Regulation of Localization of NPPA 1 0.28 0.29 0.16
68 INT30705 Nppa Negative_regulation of Localization of AVP 1 0.48 0.22 0.15
69 INT7296 Binding of HCLS1 and NPPA 1 0.02 1.65 0.15
70 INT56181 sch Regulation of Positive_regulation of Nppa 1 0.07 0.08 0.14
71 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
72 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
73 INT71755 Nppa Regulation of Localization of Alb 1 0.25 1.29 0.11
74 INT7302 Binding of NPPA and Nppa 1 0.13 1.25 0.11
75 INT42154 NPPA Regulation of Gene_expression of TUBA4A 1 0.04 0.68 0.1
76 INT5627 Tfpi Positive_regulation of Localization of Nppa 1 0.31 0.07 0.1
77 INT42153 NPPA Regulation of TUBA4A 1 0.04 0.68 0.1
78 INT5626 Tfpi Positive_regulation of Transcription of Nppa 1 0.31 0.07 0.1
79 INT248185 Binding of Cxcr2 and DRGX 1 0.01 0 0.09
80 INT7295 HCLS1 Positive_regulation of NPPA 1 0.02 0.44 0.09
81 INT9086 Binding of Nppa and Nppb 1 0.35 0.19 0.08
82 INT208937 Nfkb1 Positive_regulation of Gene_expression of Nppa 1 0.04 0.38 0.08
83 INT50079 Binding of NPPA and SLC12A1 1 0.01 0.42 0.07
84 INT183701 Negative_regulation of Cxcr2 Negative_regulation of Ducm1 1 0.03 0.45 0.07
85 INT51719 Nppa Regulation of Regulation of Pomc 1 0.14 0.1 0.07
86 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
87 INT16414 Nppa Regulation of Nppb 1 0.24 0.26 0.05
88 INT222512 Nppa Positive_regulation of Localization of LH 1 0.02 0 0.05
89 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
90 INT329015 Binding of APCS and SRGN 1 0.08 1.14 0.04
91 INT239402 Binding of NPPA and ASAP1 1 0.19 1.24 0.04
92 INT158391 Oxt Positive_regulation of Localization of Nppa 2 0.27 0.64 0.03
93 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
94 INT325586 Nppa Positive_regulation of Prkg1 1 0.28 0.16 0.03
95 INT177671 Vmn1r51 Positive_regulation of Localization of Nppa 1 0.01 0.24 0.03
96 INT253085 NPPA Positive_regulation of INS 1 0.32 0 0
97 INT325589 Nppa Regulation of Cacna1c 1 0.05 0 0
98 INT14790 Nppa Regulation of Edn3 1 0.45 0.7 0
99 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0
100 INT14792 Edn3 Regulation of Nppa 1 0.17 0.17 0
101 INT239401 FIG4 Regulation of NPPA 1 0.17 2.24 0
102 INT325587 Binding of Ang and Nppa 1 0.21 0.24 0
103 INT354619 AR Positive_regulation of Gene_expression of Nppa 1 0.00 0.38 0
104 INT165146 Kiss1 Regulation of Nppa 1 0.42 0 0
105 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0
106 INT325597 Nppa Regulation of Gopc 1 0.15 0 0
107 INT325605 Pls1 Regulation of Nppa 1 0.00 0 0
108 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
109 INT11122 Nppa Negative_regulation of Thop1 1 0.20 0.4 0
110 INT325588 Nppa Regulation of Localization of Rgs2 1 0.32 0 0
111 INT325604 Nppa Regulation of Car2 1 0.23 0 0
112 INT325584 Binding of Olfml3 and Nppa 1 0.01 0.1 0
113 INT325611 Nppa Regulation of Gene_expression of Car2 1 0.20 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mast cell granule. They are ordered first by their pain relevance and then by number of times they were reported in mast cell granule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5617 Localization of Nppa 266 0.81 83.51 83.89
2 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33
3 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45
4 INT6196 Regulation of Nppa 83 0.62 30.31 30.18
5 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72
6 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31
7 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11
8 INT5618 Regulation of Localization of Nppa 36 0.62 13.42 17.46
9 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82
10 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96
11 INT7132 Localization of NPPA 53 0.81 19.79 10.86
12 INT16356 Regulation of NPPA 33 0.62 13.24 9.53
13 INT123382 Gene_expression of Cxcr2 12 0.69 4.62 8.62
14 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65
15 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24
16 INT6210 Binding of Nppa 39 0.47 14.35 7.21
17 INT15156 Positive_regulation of Localization of NPPA 21 0.70 8.61 6.97
18 INT6565 Positive_regulation of Positive_regulation of Nppa 14 0.70 4.04 6.76
19 INT62958 Positive_regulation of CXCR2 14 0.59 8.61 4.92
20 INT99785 Positive_regulation of Cxcr2 10 0.53 8.03 4.89
21 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76
22 INT5624 Transcription of Nppa 19 0.69 8.52 4.72
23 INT102855 Negative_regulation of Srgn 8 0.57 0.91 4.63
24 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41
25 INT73434 Negative_regulation of Nppa 8 0.35 3.86 4.31
26 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98
27 INT6193 Regulation of Gene_expression of Nppa 6 0.45 2.02 2.93
28 INT28640 Positive_regulation of Gene_expression of CXCR2 8 0.69 5.51 2.91
29 INT123384 Binding of Cxcr2 4 0.33 1.33 2.81
30 INT162380 Negative_regulation of CXCR2 11 0.57 6.98 2.76
31 INT208588 Binding of CXCR2 11 0.48 6.43 2.68
32 INT102856 Positive_regulation of Srgn 7 0.61 1.27 2.54
33 INT20498 Negative_regulation of Positive_regulation of Nppa 9 0.59 4.5 2.43
34 INT25461 Negative_regulation of Regulation of Nppa 2 0.43 0.22 1.97
35 INT182243 Regulation of CXCR2 4 0.39 2.59 1.94
36 INT26370 Positive_regulation of Positive_regulation of NPPA 4 0.60 0.67 1.87
37 INT102857 Phosphorylation of Srgn 1 0.72 0.26 1.71
38 INT15155 Regulation of Localization of NPPA 8 0.62 2.67 1.65
39 INT89849 Regulation of Srgn 6 0.30 0.93 1.59
40 INT11057 Protein_catabolism of Nppa 11 0.94 3.34 1.47
41 INT73432 Gene_expression of Nppa 32 0.59 21.04 1.39
42 INT102852 Negative_regulation of Phosphorylation of Srgn 1 0.52 0.17 1.32
43 INT102853 Positive_regulation of Phosphorylation of Srgn 1 0.61 0.17 1.31
44 INT99788 Regulation of Cxcr2 3 0.41 2.25 1.27
45 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19
46 INT174435 Transcription of Cxcr2 1 0.53 2.16 1.19
47 INT99779 Positive_regulation of Positive_regulation of Cxcr2 2 0.46 1.62 1.13
48 INT150854 Negative_regulation of Cxcr2 7 0.54 4.12 1.06
49 INT89853 Gene_expression of Srgn 12 0.44 1.13 1
50 INT16371 Positive_regulation of Gene_expression of NPPA 7 0.45 3.62 0.96
51 INT182220 Regulation of Positive_regulation of CXCR2 2 0.39 1.29 0.91
52 INT28641 Regulation of Gene_expression of CXCR2 1 0.45 1.9 0.91
53 INT147880 Regulation of SRGN 28 0.33 13.99 0.9
54 INT29759 Negative_regulation of Negative_regulation of Nppa 3 0.58 1.5 0.9
55 INT15587 Protein_catabolism of NPPA 4 0.71 1.55 0.87
56 INT134099 Negative_regulation of Gene_expression of CXCR2 1 0.04 0.81 0.87
57 INT174431 Positive_regulation of Transcription of Cxcr2 1 0.36 1.44 0.83
58 INT16587 Regulation of Negative_regulation of Nppa 3 0.53 0.84 0.82
59 INT174416 Negative_regulation of Gene_expression of Cxcr2 2 0.33 2.06 0.82
60 INT7297 Binding of NPPA 8 0.45 5.33 0.79
61 INT16537 Regulation of Positive_regulation of Nppa 2 0.45 1.44 0.76
62 INT5621 Positive_regulation of Transcription of Nppa 5 0.50 4.97 0.74
63 INT99776 Positive_regulation of Gene_expression of Cxcr2 2 0.64 1.7 0.74
64 INT54167 Negative_regulation of Positive_regulation of NPPA 4 0.42 1.26 0.63
65 INT109081 Localization of Nppa 9 0.59 2.72 0.61
66 INT51718 Positive_regulation of Negative_regulation of Nppa 3 0.47 0.79 0.57
67 INT110319 Positive_regulation of SRGN 10 0.40 6.2 0.56
68 INT99786 Localization of Cxcr2 2 0.69 0.86 0.56
69 INT7293 Negative_regulation of Binding of Nppa 5 0.43 1.4 0.55
70 INT239556 Positive_regulation of Phosphorylation of CXCR2 1 0.18 0.11 0.53
71 INT277204 Positive_regulation of Binding of Cxcr2 1 0.39 1.37 0.53
72 INT239544 Phosphorylation of CXCR2 1 0.29 0.1 0.53
73 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52
74 INT183375 Binding of Nppa 14 0.38 8.95 0.51
75 INT182214 Transcription of CXCR2 1 0.59 0.45 0.47
76 INT5625 Regulation of Transcription of Nppa 2 0.26 0.29 0.46
77 INT99783 Positive_regulation of Localization of Cxcr2 1 0.46 0.22 0.45
78 INT6563 Positive_regulation of Regulation of Nppa 1 0.33 0.44 0.41
79 INT32533 Negative_regulation of Gene_expression of Nppa 2 0.32 1.93 0.38
80 INT133819 Localization of CXCR2 3 0.61 1.64 0.37
81 INT183684 Regulation of Gene_expression of Cxcr2 1 0.57 1.42 0.37
82 INT59593 Regulation of Gene_expression of NPPA 2 0.41 2.51 0.36
83 INT306349 Transcription of SRGN 1 0.20 2.36 0.36
84 INT17158 Regulation of Protein_catabolism of Nppa 1 0.24 0.1 0.28
85 INT248175 Positive_regulation of Cxcr2 1 0.35 0 0.27
86 INT16358 Positive_regulation of Negative_regulation of NPPA 2 0.41 0.83 0.21
87 INT141306 Binding of Srgn 1 0.30 0.23 0.21
88 INT92135 Positive_regulation of Transcription of NPPA 1 0.03 1.17 0.2
89 INT236282 Transcription of Nppa 2 0.29 0.93 0.19
90 INT92134 Transcription of NPPA 1 0.04 1.15 0.19
91 INT89851 Localization of Srgn 1 0.58 0.15 0.18
92 INT89850 Positive_regulation of Localization of Srgn 1 0.36 0.15 0.18
93 INT84554 Regulation of Regulation of Nppa 1 0.27 0.39 0.18
94 INT11058 Positive_regulation of Protein_catabolism of Nppa 1 0.37 0.53 0.17
95 INT89857 Regulation of Gene_expression of Srgn 1 0.20 0.17 0.17
96 INT183377 Positive_regulation of Nppa 7 0.38 1.46 0.16
97 INT153077 Positive_regulation of Gene_expression of Nppa 9 0.40 5.07 0.13
98 INT242739 Positive_regulation of Binding of Nppa 1 0.40 1.48 0.09
99 INT280055 Positive_regulation of Gene_expression of SRGN 5 0.42 2.49 0.08
100 INT290410 Negative_regulation of Transcription of Nppa 1 0.18 0.38 0.07
101 INT7300 Negative_regulation of Binding of NPPA 1 0.38 0.83 0.07
102 INT11120 Negative_regulation of Gene_expression of NPPA 2 0.39 1.45 0.06
103 INT305399 Positive_regulation of Positive_regulation of SRGN 1 0.37 0.13 0.06
104 INT21280 Negative_regulation of Localization of NPPA 1 0.23 0 0.06
105 INT248176 Localization of Cxcr2 1 0.52 0 0.06
106 INT290420 Negative_regulation of Positive_regulation of Nppa 2 0.32 0.37 0.05
107 INT242742 Negative_regulation of Gene_expression of Nppa 2 0.34 1.29 0.05
108 INT325564 Positive_regulation of Positive_regulation of Nppa 1 0.38 0.08 0.05
109 INT325464 Localization of SRGN 1 0.01 0.73 0.05
110 INT177342 Negative_regulation of SRGN 15 0.28 5.66 0.04
111 INT306350 Negative_regulation of Transcription of SRGN 1 0.12 0.5 0.04
112 INT329018 Binding of SRGN 1 0.23 1.21 0.03
113 INT306348 Regulation of Transcription of SRGN 1 0.08 0.52 0.03
114 INT329019 Negative_regulation of Binding of SRGN 1 0.28 1.22 0.03
115 INT306351 Regulation of Regulation of SRGN 1 0.13 0.51 0.03
116 INT292857 Regulation of Nppa 3 0.30 1.56 0
117 INT230773 Negative_regulation of Gene_expression of SRGN 2 0.16 1.19 0
118 INT315664 Negative_regulation of Gene_expression of Srgn 2 0.16 0.46 0
119 INT230772 Regulation of Negative_regulation of SRGN 1 0.17 0.13 0
120 INT177343 Negative_regulation of Negative_regulation of SRGN 1 0.07 1.13 0
121 INT253087 Positive_regulation of Binding of NPPA 1 0.40 0.05 0
122 INT230771 Negative_regulation of Positive_regulation of SRGN 1 0.19 0.36 0
123 INT315667 Positive_regulation of Transcription of Srgn 1 0.12 0.17 0
124 INT325552 Negative_regulation of Negative_regulation of Nppa 1 0.32 0.64 0
125 INT315663 Transcription of Srgn 1 0.17 0.17 0
126 INT315666 Positive_regulation of Gene_expression of Srgn 1 0.12 0.26 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox