GO:0043122

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Name regulation of I-kappaB kinase/NF-kappaB cascade
Categary Process
Go Slim No
Go Link GO:0043122
Unique Molecular Interactions 1448
Total Molecular Interactions 2069
Total Single Events 18541
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported for regulation of I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
3 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
4 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
6 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
7 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
8 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
9 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
10 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
11 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
12 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
13 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
14 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
15 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
16 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
17 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
18 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
19 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
20 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
21 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
22 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
23 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
24 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
25 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
26 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
27 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
28 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
29 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
30 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
31 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
32 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
33 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
34 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
35 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
36 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
37 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
38 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
39 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
40 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
41 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
42 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
43 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
44 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
45 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
46 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
47 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
48 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
49 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
50 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
51 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
52 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
53 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
54 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
55 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
56 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
57 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
58 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
59 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
60 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
61 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
62 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
63 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
64 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
65 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
66 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
67 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
68 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
69 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
70 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
71 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
72 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
73 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
74 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
75 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
76 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
77 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
78 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
79 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
80 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
81 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
82 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
83 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
84 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
85 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
86 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
87 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
88 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
89 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
90 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
91 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
92 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
93 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
94 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
95 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
96 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
97 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
98 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
99 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
100 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
101 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
102 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
103 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
104 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
105 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
106 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
107 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
108 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
109 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
110 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
111 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
112 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
113 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
114 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
115 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
116 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
117 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
118 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
119 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
120 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
121 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
122 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
123 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
124 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
125 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
126 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
127 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
128 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
129 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
130 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
131 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
132 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
133 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
134 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
135 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
136 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
137 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
138 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
139 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
140 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
141 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
142 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
143 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
144 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
145 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
146 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
147 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
148 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
149 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
150 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
151 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
152 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
153 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
154 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
155 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
156 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
157 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
158 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
159 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
160 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
161 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
162 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
163 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
164 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
165 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
166 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
167 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
168 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
169 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
170 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
171 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
172 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
173 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
174 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
175 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
176 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
177 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
178 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
179 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
180 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
181 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
182 INT222988 TNF Positive_regulation of Protein_catabolism of COL1A1 1 0.01 1.66 0.9
183 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9
184 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9
185 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
186 INT80132 Binding of HLA-B and TNF 1 0.04 1.15 0.89
187 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
188 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
189 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
190 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
191 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
192 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
193 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
194 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
195 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
196 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
197 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
198 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85
199 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
200 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported in regulation of I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
7 INT6481 Binding of TNF 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
13 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
14 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
15 INT10166 Localization of Tnf 237 0.81 153.95 88.64
16 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
17 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
18 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
19 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
20 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
21 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
22 INT6849 Localization of IL1B 229 0.81 112.56 69.63
23 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
24 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
25 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
26 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
27 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
28 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
29 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
30 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
31 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
32 INT13354 Transcription of TNF 108 0.72 85.81 42.32
33 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
34 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
35 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
36 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
37 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
38 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
39 INT6484 Binding of IL1B 122 0.47 75.84 35.07
40 INT35406 Localization of Tnf 94 0.81 64.63 31.65
41 INT9347 Localization of Il1b 58 0.81 26.13 31.53
42 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
43 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
44 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
45 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
46 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
47 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
48 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
49 INT48081 Localization of Il1b 46 0.80 21.59 22.4
50 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
51 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
52 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
53 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
54 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
55 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
56 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
57 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
58 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
59 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
60 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
61 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
62 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
63 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
64 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
65 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
66 INT10173 Binding of Tnf 45 0.48 35.6 14.32
67 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
68 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
69 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
70 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
71 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
72 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
73 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
74 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
75 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
76 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
77 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
78 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
79 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
80 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
81 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
82 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
83 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
84 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
85 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
86 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
87 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
88 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
89 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
90 INT68299 Binding of Tnf 17 0.39 12.55 7.49
91 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
92 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
93 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
94 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
95 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86
96 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
97 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
98 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
99 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
100 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
101 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
102 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
103 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
104 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
105 INT80750 Binding of Il1b 11 0.47 7.97 5.95
106 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
107 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78
108 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
109 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
110 INT10705 Binding of Il1b 9 0.36 2.8 5.53
111 INT68465 Positive_regulation of Gene_expression of Pdpk1 7 0.19 2.35 5.49
112 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
113 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
114 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
115 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
116 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
117 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74
118 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
119 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
120 INT1231 Negative_regulation of Positive_regulation of Pdpk1 6 0.35 1.88 4.13
121 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
122 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
123 INT117075 Negative_regulation of Ikbkb 3 0.26 9.51 3.91
124 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
125 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
126 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79
127 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
128 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
129 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
130 INT54749 Binding of BTRC 7 0.09 0.88 2.9
131 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
132 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
133 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
134 INT24068 Localization of Hspb1 6 0.78 6.11 2.75
135 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75
136 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
137 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
138 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
139 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
140 INT96763 Positive_regulation of Localization of Pdpk1 1 0.39 2.08 2.65
141 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
142 INT111017 Regulation of F2rl1 3 0.22 0 2.61
143 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
144 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56
145 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
146 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
147 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
148 INT86426 Gene_expression of Hspb1 16 0.78 10.86 2.26
149 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
150 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
151 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
152 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18
153 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
154 INT13243 Gene_expression of Sqstm1 4 0.30 2.07 2.06
155 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
156 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
157 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
158 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
159 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
160 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
161 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
162 INT26735 Regulation of Gene_expression of Pdpk1 2 0.24 0.56 1.84
163 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
164 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
165 INT104014 Negative_regulation of Phosphorylation of Pdpk1 2 0.23 0.59 1.72
166 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
167 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
168 INT21565 Binding of Ikbkb 4 0.17 1.89 1.64
169 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
170 INT183791 Positive_regulation of Phosphorylation of TNF 6 0.49 4.72 1.56
171 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
172 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
173 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
174 INT67464 Positive_regulation of Negative_regulation of Pdpk1 1 0.19 0.15 1.41
175 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
176 INT68774 Positive_regulation of Ikbkb 2 0.21 0.99 1.39
177 INT118927 Positive_regulation of Phosphorylation of Pdpk1 2 0.04 0.76 1.38
178 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
179 INT24069 Negative_regulation of Localization of Hspb1 3 0.14 3.93 1.3
180 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
181 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
182 INT221206 Phosphorylation of Pdpk1 3 0.53 0.13 1.25
183 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
184 INT104011 Transcription of Pdpk1 1 0.28 0 1.2
185 INT104012 Regulation of Transcription of Pdpk1 1 0.14 0 1.2
186 INT26734 Binding of Pdpk1 4 0.29 1.01 1.19
187 INT76303 Negative_regulation of Positive_regulation of Hspb1 1 0.42 0.49 1.17
188 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
189 INT71370 Regulation of Ikbkb 3 0.12 1.69 1.08
190 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
191 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
192 INT71498 Binding of Hspb1 7 0.42 7.38 1.05
193 INT71499 Localization of Hspb1 4 0.72 1.38 1.05
194 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
195 INT123962 Phosphorylation of Hspb1 8 0.82 2.08 1.04
196 INT9348 Regulation of Localization of Il1b 2 0.27 0.14 1.04
197 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02
198 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02
199 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
200 INT346201 Negative_regulation of Phosphorylation of IL1B 1 0.20 1.69 1.01
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