GO:0044224

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Name juxtaparanode region of axon
Categary Component
Go Slim No
Go Link GO:0044224
Unique Molecular Interactions 206
Total Molecular Interactions 383
Total Single Events 1003
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for juxtaparanode region of axon. They are ordered first by their pain relevance and then by number of times they were reported for juxtaparanode region of axon. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
2 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
3 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
4 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
5 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
6 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
7 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
8 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
9 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
10 INT212662 KCNA1 Regulation of Localization of Cort 1 0.00 1.36 1.37
11 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
12 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2
13 INT212661 KCNA1 Positive_regulation of Scort1 1 0.00 0.91 1.03
14 INT156380 Regulation of Binding of Grin1 and Dlg4 1 0.29 0.32 0.97
15 INT251153 Dlg2 Positive_regulation of Gene_expression of Grin2a 1 0.40 0.6 0.92
16 INT251152 Dlg2 Positive_regulation of Localization of Grin2b 1 0.43 0.6 0.92
17 INT120820 Binding of ASIC3 and Dlg4 3 0.02 0.11 0.84
18 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
19 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
20 INT152945 Dlg4 Regulation of Cap1 1 0.11 0.18 0.76
21 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76
22 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
23 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75
24 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
25 INT329120 Binding of KCNA1 and CNTNAP2 1 0.09 1.23 0.75
26 INT152944 Dlg4 Regulation of Gpr88 1 0.12 0.18 0.75
27 INT329119 Binding of CNTN2 and CNTNAP2 1 0.08 2.41 0.73
28 INT168205 Binding of Dlg4 and Pik3cd 1 0.11 0.37 0.65
29 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57
30 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56
31 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
32 INT69389 CNTN2 Positive_regulation of PENK 1 0.20 0.53 0.54
33 INT212659 KCNA1 Regulation of Cort 1 0.00 0.41 0.49
34 INT263746 Binding of Dlg4 and Neto1 1 0.27 0 0.48
35 INT198931 Binding of Dlg4 and Lrp8 1 0.06 0.23 0.46
36 INT329116 Binding of LGI1 and CNTNAP2 1 0.38 1.3 0.44
37 INT329122 Binding of KCNA1 and LGI1 1 0.08 0.29 0.43
38 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
39 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42
40 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
41 INT34786 KCNA1 Positive_regulation of Localization of PRL 1 0.05 0 0.4
42 INT179207 KCNAB2 Regulation of Gene_expression of ATP1A4 1 0.00 1.25 0.37
43 INT120821 Dlg4 Positive_regulation of ASIC3 1 0.02 0 0.36
44 INT334632 Binding of Kcna2 and Eae1 1 0.17 0.87 0.35
45 INT272602 Binding of Dlg4 and Gria2 3 0.09 0.19 0.34
46 INT120817 Binding of Dlg4 and Lin7b 1 0.00 0 0.34
47 INT296465 Binding of Dlg4 and Rbm39 1 0.00 0.05 0.34
48 INT283841 Dlg4 Negative_regulation of Insrr 1 0.01 0.95 0.33
49 INT251148 Negative_regulation of Binding of Grin2a and Dlg2 1 0.37 0.45 0.32
50 INT198779 Binding of Dlg4 and Psd 10 0.25 0.09 0.31
51 INT135425 Binding of Dlg4 and Dlg3 1 0.29 0.07 0.28
52 INT274944 Binding of Dlg4 and Pick1 1 0.04 0 0.28
53 INT274939 Binding of Dlg4 and Ephb6 1 0.12 0 0.25
54 INT263787 Binding of GRIN1 and Dlg4 3 0.18 0.05 0.23
55 INT198776 Binding of Dlg4 and Psds1 1 0.11 0.05 0.23
56 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22
57 INT69387 Binding of PENK and CNTN2 1 0.14 0.22 0.21
58 INT69379 CNTN2 Positive_regulation of Gene_expression of PENK 1 0.18 0.19 0.18
59 INT273099 Bdnf Positive_regulation of Localization of Dlg4 1 0.21 0.07 0.18
60 INT149346 Negative_regulation of Kcnab1 Positive_regulation of Kcna1 1 0.01 0.08 0.18
61 INT149345 Kcnab1 Negative_regulation of Kcna1 1 0.01 0.08 0.18
62 INT149344 Kcnab1 Positive_regulation of Kcna1 1 0.01 0.08 0.18
63 INT149343 Negative_regulation of Kcnab1 Negative_regulation of Kcna1 1 0.01 0.08 0.18
64 INT329118 Binding of KCNA1 and CNTN2 1 0.02 0 0.14
65 INT69381 CNTN2 Positive_regulation of FOS 1 0.45 0 0.14
66 INT69380 CNTN2 Positive_regulation of Binding of FOS 1 0.49 0 0.14
67 INT272605 Binding of Dlg4 and Nsf 1 0.36 0.41 0.14
68 INT69377 CNTN2 Positive_regulation of Binding of JUN 1 0.49 0 0.14
69 INT69388 CNTN2 Positive_regulation of Gene_expression of FOS 1 0.49 0 0.14
70 INT354705 Binding of ASIC2 and Dlg4 1 0.00 0.11 0.12
71 INT354698 Binding of Dlg4 and Gopc 1 0.02 0.11 0.12
72 INT354717 Binding of ASIC1 and Dlg4 1 0.02 0 0.11
73 INT272265 Binding of Dlg4 and Grip2 1 0.02 0 0.09
74 INT263764 Dlg4 Regulation of Localization of Grin2a 1 0.16 0.17 0.07
75 INT263741 Grin2b Regulation of Localization of Dlg4 1 0.17 0.17 0.07
76 INT263784 Dlg4 Regulation of Localization of Grin1 1 0.17 0.17 0.07
77 INT272595 Binding of Dlg4 and Dnahc8 1 0.03 0.21 0.07
78 INT263734 Dlg4 Regulation of Localization of Vamp2 1 0.15 0.17 0.07
79 INT263742 Grin1 Regulation of Localization of Dlg4 1 0.19 0.17 0.07
80 INT263771 Grin2a Regulation of Localization of Dlg4 1 0.19 0.17 0.07
81 INT263722 Dlg4 Regulation of Localization of Grin2b 1 0.15 0.17 0.07
82 INT263740 Dlg4 Regulation of Localization of Gria2 1 0.11 0.17 0.07
83 INT263724 Positive_regulation of Binding of Dlg4 and Neto1 1 0.28 0 0.06
84 INT346754 Binding of Dlg4 and Gria2 1 0.02 0 0.06
85 INT263751 Binding of Dlg4 and Spna1 1 0.03 0 0.05
86 INT263778 Localization of Neto1 Regulation of Localization of Dlg4 1 0.26 0.18 0.05
87 INT272598 Dlg4 Positive_regulation of Gene_expression of Gria2 1 0.03 0.53 0.04
88 INT272593 Dlg4 Positive_regulation of Clc 1 0.11 0.54 0.04
89 INT205862 CNTN2 Positive_regulation of TNF 1 0.01 0.08 0.04
90 INT272591 Dlg4 Positive_regulation of Gene_expression of Clybl 1 0.09 0.53 0.04
91 INT272590 Dlg4 Positive_regulation of Clybl 1 0.09 0.52 0.04
92 INT272599 Dlg4 Positive_regulation of Gene_expression of Clc 1 0.11 0.54 0.04
93 INT272603 Binding of Dlg4 and Nlgn2 1 0.23 0 0.03
94 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
95 INT272600 Binding of Dlg4 and Grik5 1 0.20 0 0.03
96 INT272597 Binding of Dlg4 and Kcna4 1 0.17 0 0.03
97 INT263788 Positive_regulation of Binding of GRIN1 and Dlg4 1 0.24 0 0.03
98 INT272596 Binding of Dlg4 and Lrp1 1 0.16 0 0.03
99 INT272606 Binding of Dlg4 and Grin2c 1 0.18 0 0.03
100 INT272604 Binding of Dlg4 and Nlgn3 1 0.17 0 0.03
101 INT272601 Binding of Dlg4 and Grik2 1 0.22 0 0.03
102 INT272594 Binding of Dlg4 and Shank1 1 0.20 0 0.03
103 INT272609 Binding of Cit and Dlg4 1 0.11 0 0.03
104 INT198780 Regulation of Binding of Dlg4 and Psd 1 0.14 0 0.03
105 INT346742 Binding of Cacng2 and Dlg4 1 0.03 0 0
106 INT263791 Binding of DLG3 and Dlg4 1 0.20 0 0
107 INT272592 Binding of Dlg4 and Sh3 1 0.11 0.13 0
108 INT287609 Fmr1 Regulation of Protein_catabolism of Dlg4 1 0.05 0.06 0
109 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
110 INT289099 KCNA1 Positive_regulation of Gene_expression of FZD5 1 0.00 0.84 0
111 INT197713 CNTN2 Positive_regulation of ABCB1 1 0.01 0.34 0
112 INT272610 Binding of NA and Dlg4 1 0.41 0.13 0
113 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0
114 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0
115 INT346747 Binding of Dlg4 and Shisa9 1 0.01 0 0
116 INT272264 Dlg4 Regulation of Psd 1 0.22 0.09 0
117 INT346744 Binding of Dlg4 and Tinagl1 1 0.03 0 0
118 INT186402 Binding of KCNA1 and MKS1 1 0.05 0.07 0
119 INT287619 Fmr1 Regulation of Dlg4 1 0.12 0.06 0
120 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for juxtaparanode region of axon. They are ordered first by their pain relevance and then by number of times they were reported in juxtaparanode region of axon. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97100 Negative_regulation of Dlg4 16 0.58 6.18 14.36
2 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36
3 INT88789 Gene_expression of Dlg4 26 0.78 4.41 12.74
4 INT108643 Gene_expression of Dlg4 61 0.76 8.63 8.58
5 INT112099 Negative_regulation of Dlg2 2 0.40 6.17 8.16
6 INT97099 Positive_regulation of Dlg4 13 0.60 3.04 6.98
7 INT88786 Binding of Dlg4 11 0.46 2.73 6.58
8 INT112101 Gene_expression of Dlg2 9 0.73 5.06 6.5
9 INT251134 Binding of Dlg2 6 0.31 4.26 5.99
10 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66
11 INT88790 Negative_regulation of Gene_expression of Dlg4 6 0.59 1.53 4.66
12 INT77148 Gene_expression of Kcna1 20 0.73 4.08 4.46
13 INT69395 Gene_expression of CNTN2 28 0.68 13.29 4.37
14 INT145532 Localization of Dlg4 25 0.79 1.97 4.36
15 INT35999 Positive_regulation of KCNAB2 6 0.65 5.12 4.31
16 INT88787 Transcription of Dlg4 4 0.69 0.83 4.09
17 INT120810 Binding of Dlg4 38 0.41 3.55 4.03
18 INT34790 Localization of KCNA1 4 0.43 11.34 3.99
19 INT329148 Gene_expression of CNTNAP2 17 0.76 6 2.95
20 INT143551 Binding of KCNA1 13 0.46 8.81 2.81
21 INT251126 Regulation of Dlg2 1 0.40 1.56 2.46
22 INT69481 Negative_regulation of Kcna1 5 0.28 0.38 2.33
23 INT251127 Regulation of Gene_expression of Dlg2 1 0.35 1.49 2.23
24 INT70522 Binding of Kcna1 2 0.36 0.73 2.22
25 INT95128 Positive_regulation of KCNA1 8 0.41 4.28 2.19
26 INT134874 Regulation of Dlg4 3 0.58 0.28 2.12
27 INT251128 Regulation of Negative_regulation of Dlg2 1 0.24 1.97 2.01
28 INT198748 Regulation of Gene_expression of Dlg4 10 0.44 2.16 1.85
29 INT119219 Localization of Dlg4 3 0.64 0.16 1.5
30 INT152939 Regulation of Dlg4 9 0.60 1.09 1.49
31 INT134873 Phosphorylation of Dlg4 3 0.80 0.5 1.42
32 INT13880 Gene_expression of KCNAB2 3 0.27 2.95 1.38
33 INT329143 Binding of CNTNAP2 1 0.47 5.04 1.32
34 INT329140 Localization of CNTNAP2 1 0.73 3.56 1.31
35 INT97098 Regulation of Negative_regulation of Dlg4 3 0.45 0.97 1.3
36 INT86486 Negative_regulation of Gene_expression of Kcna1 4 0.55 1.74 1.21
37 INT218609 Localization of Kcna1 1 0.78 0 1.15
38 INT132334 Negative_regulation of Gene_expression of KCNA1 4 0.43 1.52 1.14
39 INT70521 Regulation of Kcna1 2 0.50 0.54 1.11
40 INT69482 Positive_regulation of Kcna1 4 0.32 0.27 1.06
41 INT86489 Regulation of Gene_expression of Kcna1 1 0.42 0.27 1.03
42 INT198750 Positive_regulation of Gene_expression of Dlg4 5 0.68 0.6 1.02
43 INT134876 Negative_regulation of Phosphorylation of Dlg4 1 0.35 0.27 0.93
44 INT134878 Negative_regulation of Negative_regulation of Dlg4 1 0.35 0.27 0.93
45 INT107970 Positive_regulation of Protein_catabolism of CNTN2 1 0.20 1.22 0.88
46 INT169844 Positive_regulation of Localization of Dlg4 2 0.49 0.07 0.75
47 INT179216 Regulation of Gene_expression of KCNAB2 1 0.03 2.35 0.72
48 INT132333 Negative_regulation of KCNA1 8 0.47 0.87 0.71
49 INT353369 Regulation of Localization of Dlg4 1 0.23 0 0.69
50 INT178590 Regulation of CNTN2 7 0.24 2.91 0.68
51 INT156376 Negative_regulation of Transcription of Dlg4 1 0.56 0.16 0.65
52 INT69392 Positive_regulation of Gene_expression of CNTN2 3 0.44 2.43 0.58
53 INT218605 Negative_regulation of Kcna2 2 0.41 1.68 0.55
54 INT198749 Negative_regulation of Dlg4 8 0.53 2.14 0.54
55 INT198744 Negative_regulation of Gene_expression of Dlg4 6 0.42 1.73 0.54
56 INT153321 Positive_regulation of Gene_expression of Dlg4 3 0.49 0.31 0.53
57 INT179218 Regulation of KCNAB2 1 0.03 2.47 0.52
58 INT156377 Regulation of Binding of Dlg4 1 0.43 0.17 0.51
59 INT329161 Negative_regulation of CNTNAP2 1 0.42 0.73 0.51
60 INT198755 Positive_regulation of Dlg4 7 0.59 0.6 0.5
61 INT69393 Positive_regulation of CNTN2 4 0.45 0.8 0.5
62 INT329156 Regulation of CNTNAP2 1 0.19 2.35 0.48
63 INT178591 Binding of CNTN2 4 0.23 1.56 0.44
64 INT107967 Protein_catabolism of CNTN2 1 0.28 0.61 0.44
65 INT13881 Binding of KCNAB2 1 0.13 0.19 0.41
66 INT334624 Positive_regulation of Gene_expression of Kcna2 1 0.49 0.86 0.35
67 INT334621 Gene_expression of Kcna2 1 0.65 0.86 0.34
68 INT334623 Negative_regulation of Gene_expression of Kcna2 1 0.41 0.86 0.34
69 INT296258 Negative_regulation of Localization of Dlg4 1 0.32 0 0.32
70 INT178585 Regulation of Binding of CNTN2 1 0.21 0.71 0.3
71 INT319268 Positive_regulation of Dlg2 1 0.16 0.42 0.28
72 INT283235 Localization of KCNAB2 1 0.02 0.94 0.26
73 INT329158 Positive_regulation of Gene_expression of CNTNAP2 1 0.49 1.3 0.26
74 INT283232 Negative_regulation of Localization of KCNAB2 1 0.01 0.95 0.26
75 INT149339 Positive_regulation of Positive_regulation of Kcna1 2 0.32 0.17 0.24
76 INT178584 Regulation of Gene_expression of CNTN2 1 0.21 1.39 0.24
77 INT329151 Positive_regulation of Gene_expression of KCNA1 1 0.11 1.18 0.24
78 INT149338 Negative_regulation of Positive_regulation of Kcna1 1 0.27 0.1 0.23
79 INT149341 Negative_regulation of Negative_regulation of Kcna1 1 0.28 0.1 0.23
80 INT34788 Negative_regulation of Localization of KCNA1 1 0.04 0 0.2
81 INT272255 Regulation of Positive_regulation of Dlg4 1 0.39 0.06 0.19
82 INT272253 Negative_regulation of Regulation of Dlg4 1 0.37 0 0.18
83 INT329152 Positive_regulation of CNTNAP2 1 0.49 0.54 0.15
84 INT198738 Protein_catabolism of Dlg4 5 0.97 0.06 0.12
85 INT329160 Regulation of Gene_expression of CNTNAP2 1 0.44 0.87 0.11
86 INT272257 Positive_regulation of Localization of Dlg4 1 0.43 0 0.1
87 INT218607 Regulation of Kcna2 1 0.38 0.29 0.08
88 INT218610 Transcription of Kcna1 1 0.51 1.05 0.07
89 INT218606 Regulation of Transcription of Kcna1 1 0.26 1.05 0.07
90 INT100988 Regulation of Gene_expression of Dlg4 1 0.36 0.06 0.05
91 INT198746 Regulation of Protein_catabolism of Dlg4 1 0.26 0 0.04
92 INT272252 Regulation of Phosphorylation of Dlg4 1 0.44 0 0.04
93 INT263696 Transcription of Dlg4 2 0.68 0.07 0
94 INT205791 Transcription of CNTN2 1 0.25 0.7 0
95 INT204916 Regulation of Gene_expression of KCNA1 1 0.45 0.06 0
96 INT272578 Phosphorylation of Dlg4 1 0.69 0 0
97 INT198741 Negative_regulation of Binding of Dlg4 1 0.36 0 0
98 INT263677 Positive_regulation of Binding of Dlg4 1 0.21 0 0
99 INT198745 Regulation of Binding of Dlg4 1 0.44 0 0
100 INT205792 Negative_regulation of CNTN2 1 0.15 0.07 0
101 INT205798 Localization of CNTN2 1 0.24 0.27 0
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