GO:0048861

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Name leukemia inhibitory factor signaling pathway
Categary Process
Go Slim No
Go Link GO:0048861
Unique Molecular Interactions 92
Total Molecular Interactions 123
Total Single Events 520
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leukemia inhibitory factor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for leukemia inhibitory factor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
2 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
3 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
4 INT8415 LIF Regulation of VIP 1 0.13 0.36 1.04
5 INT56743 LIF Positive_regulation of Cck 1 0.08 0.18 1.02
6 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
7 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
8 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
9 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
10 INT98479 Lif Regulation of Gene_expression of Grin1 1 0.04 0.35 0.82
11 INT149597 Lif Regulation of Regulation of Gal 1 0.30 0.69 0.73
12 INT149596 Lif Negative_regulation of Negative_regulation of Gal 1 0.10 0.5 0.7
13 INT82267 Lif Regulation of Gene_expression of Gal 1 0.40 2.76 0.62
14 INT149595 Lif Negative_regulation of Negative_regulation of Trpv1 1 0.34 0.44 0.61
15 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
16 INT98480 Lif Positive_regulation of Pnoc 1 0.18 0.2 0.49
17 INT98484 Lif Regulation of Gene_expression of Gal 1 0.04 0.16 0.47
18 INT98482 Lif Positive_regulation of Gene_expression of Pnoc 1 0.16 0.17 0.46
19 INT98481 Lif Regulation of Regulation of Oprl1 1 0.04 0.16 0.45
20 INT188205 OSM Regulation of LIF 1 0.09 1.12 0.43
21 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43
22 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
23 INT91719 Binding of BDNF and LIF 1 0.09 1.65 0.38
24 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
25 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
26 INT328824 Binding of Il6st and TYK2 1 0.02 0 0.38
27 INT188200 IL6ST Positive_regulation of STAT3 1 0.25 0.38 0.23
28 INT171903 Binding of TNF and Lifr 1 0.01 0.35 0.22
29 INT82268 Lif Regulation of Gene_expression of Iapp 1 0.06 0.9 0.2
30 INT294694 REM1 Positive_regulation of LIFR 1 0.01 0.24 0.18
31 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18
32 INT128221 Binding of IL6ST and Il6 2 0.00 0.73 0.17
33 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17
34 INT222426 Lif Positive_regulation of Localization of Pomc 1 0.02 0.75 0.17
35 INT32211 POMC Positive_regulation of Gene_expression of Lif 1 0.01 0.61 0.15
36 INT188197 LIF Positive_regulation of STAT3 1 0.35 0.27 0.12
37 INT294440 KLK4 Negative_regulation of LIF 1 0.00 0 0.1
38 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1
39 INT299538 Lifr Positive_regulation of Ak5 1 0.07 0.23 0.09
40 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
41 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08
42 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08
43 INT299539 Lif Positive_regulation of Phosphorylation of Stat3 1 0.08 0 0.08
44 INT355020 Lif Positive_regulation of SOAT1 1 0.02 0.7 0.08
45 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08
46 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
47 INT12987 LIF Regulation of Localization of Prl 1 0.09 0 0.07
48 INT299535 Binding of Egf and Lif 1 0.07 0 0.07
49 INT198923 Gene_expression of Lrp8 Positive_regulation of Gene_expression of Lifr 1 0.01 0 0.04
50 INT268652 Binding of CLDN4 and LIF 1 0.35 0.44 0.04
51 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04
52 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03
53 INT266075 LIF Regulation of Gene_expression of PAEP 1 0.19 0.43 0.03
54 INT266070 LIF Regulation of Gene_expression of PAPPA 1 0.35 0.49 0.03
55 INT266072 LGALS1 Regulation of Gene_expression of LIF 1 0.17 0.43 0.03
56 INT266067 PAPPA Regulation of Gene_expression of LIF 1 0.35 0.49 0.03
57 INT266076 LIF Regulation of Gene_expression of LGALS1 1 0.17 0.43 0.03
58 INT66341 LIF Positive_regulation of Gene_expression of FOS 1 0.11 1.07 0
59 INT66339 LIF Positive_regulation of Phosphorylation of CLIP2 1 0.45 1.57 0
60 INT268651 NUPL2 Positive_regulation of Gene_expression of LIF 1 0.66 0.07 0
61 INT66342 LIF Positive_regulation of Phosphorylation of CLIP1 1 0.60 1.57 0
62 INT235594 Binding of LIFR and Rem1 1 0.02 0.36 0
63 INT294316 IL6ST Positive_regulation of Gene_expression of IL11 1 0.22 0 0
64 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0
65 INT66353 LIF Regulation of Ctf2p 1 0.02 0.47 0
66 INT294693 LPA Regulation of LIFR 1 0.00 0 0
67 INT66340 LIF Positive_regulation of C1orf61 1 0.12 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leukemia inhibitory factor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in leukemia inhibitory factor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76
2 INT32208 Gene_expression of Lif 23 0.74 6.23 3.7
3 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4
4 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
5 INT76240 Positive_regulation of Lif 6 0.69 6.04 3.13
6 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9
7 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
8 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48
9 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34
10 INT44027 Positive_regulation of Lif 7 0.40 2.76 1.9
11 INT143983 Gene_expression of Lifr 9 0.47 6.26 1.79
12 INT253751 Localization of Lif 3 0.73 3.94 1.58
13 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
14 INT50437 Regulation of LIF 6 0.44 2.12 1.53
15 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
16 INT50436 Negative_regulation of Positive_regulation of LIF 1 0.37 0.33 1.42
17 INT159009 Regulation of Il6st 2 0.18 2 1.41
18 INT34933 Positive_regulation of Gene_expression of LIF 6 0.67 3.41 1.38
19 INT131255 Positive_regulation of Transcription of Lifr 1 0.01 0.99 1.28
20 INT131252 Transcription of Lifr 1 0.02 0.99 1.28
21 INT75923 Positive_regulation of IL6ST 5 0.45 2.49 1.21
22 INT149594 Positive_regulation of Gene_expression of Lif 2 0.47 0.89 1
23 INT85963 Gene_expression of LIFR 23 0.75 9 0.98
24 INT102819 Regulation of Lif 8 0.53 2.05 0.87
25 INT162783 Binding of LIFR 1 0.36 1.52 0.86
26 INT98478 Negative_regulation of Lif 3 0.42 1.29 0.84
27 INT178455 Localization of LIFR 6 0.61 2.24 0.83
28 INT82262 Regulation of Lif 3 0.31 1.67 0.83
29 INT354449 Positive_regulation of Localization of Lif 1 0.33 1.24 0.83
30 INT68794 Negative_regulation of LIF 6 0.41 1.38 0.7
31 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67
32 INT2109 Negative_regulation of Gene_expression of LIF 4 0.41 0.89 0.66
33 INT333965 Binding of Il6st 1 0.08 0.9 0.65
34 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54
35 INT216834 Localization of Lif 2 0.34 0.23 0.46
36 INT299516 Phosphorylation of Lif 1 0.26 0.56 0.46
37 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45
38 INT2110 Localization of LIF 5 0.73 1.59 0.44
39 INT32207 Regulation of Gene_expression of Lif 3 0.19 1.01 0.42
40 INT182014 Positive_regulation of Lifr 1 0.06 0.47 0.38
41 INT136518 Regulation of IL6ST 2 0.29 0.31 0.36
42 INT171885 Binding of Lifr 2 0.34 2.27 0.3
43 INT299519 Binding of Lif 2 0.21 0.67 0.29
44 INT126195 Transcription of Il6st 1 0.39 0.2 0.28
45 INT188235 Phosphorylation of LIF 1 0.53 0.48 0.23
46 INT216455 Negative_regulation of Gene_expression of Lifr 1 0.36 1.71 0.2
47 INT318610 Positive_regulation of Binding of Lif 1 0.28 0.67 0.19
48 INT148637 Gene_expression of Lifr 5 0.75 0.92 0.18
49 INT188224 Regulation of Gene_expression of LIF 1 0.23 0.53 0.18
50 INT216452 Negative_regulation of Lifr 1 0.36 1.73 0.18
51 INT188216 Positive_regulation of Regulation of LIF 1 0.39 1.13 0.17
52 INT338147 Negative_regulation of Gene_expression of Lif 1 0.38 0.29 0.15
53 INT216451 Negative_regulation of Lif 1 0.36 0.77 0.15
54 INT136520 Positive_regulation of Regulation of IL6ST 1 0.09 0.08 0.13
55 INT299517 Positive_regulation of Gene_expression of Il6st 1 0.06 0.23 0.09
56 INT299520 Positive_regulation of Gene_expression of Lifr 1 0.18 0.23 0.09
57 INT333440 Protein_catabolism of Lif 1 0.23 0.2 0.08
58 INT216454 Binding of Lif 2 0.27 0.85 0.07
59 INT206151 Positive_regulation of Gene_expression of IL6ST 2 0.24 0.35 0.06
60 INT299524 Positive_regulation of Localization of Lif 1 0.21 0 0.06
61 INT294329 Regulation of Gene_expression of IL6ST 1 0.22 0 0.05
62 INT253389 Positive_regulation of Positive_regulation of Il6st 1 0.28 0.07 0.05
63 INT333439 Positive_regulation of Gene_expression of Lif 1 0.18 0.18 0.04
64 INT294344 Localization of IL6ST 1 0.39 0 0.04
65 INT188226 Regulation of Gene_expression of LIFR 1 0.44 0.73 0.04
66 INT178453 Regulation of LIFR 3 0.50 0.31 0.03
67 INT266088 Positive_regulation of Localization of LIF 1 0.34 0.45 0.03
68 INT66346 Binding of LIF 7 0.47 0.9 0
69 INT159329 Transcription of Lif 1 0.36 0.15 0
70 INT235585 Negative_regulation of Negative_regulation of LIFR 1 0.16 0.35 0
71 INT178454 Regulation of Positive_regulation of LIFR 1 0.37 0.19 0
72 INT300189 Negative_regulation of Localization of Lif 1 0.41 0.47 0
73 INT268657 Regulation of Localization of LIF 1 0.38 0.07 0
74 INT148636 Regulation of Lifr 1 0.20 0.27 0
75 INT299513 Regulation of Gene_expression of Lifr 1 0.23 0.14 0
76 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0
77 INT178452 Negative_regulation of Positive_regulation of LIFR 1 0.35 0.19 0
78 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0
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