GO:0050732

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Name negative regulation of peptidyl-tyrosine phosphorylation
Categary Process
Go Slim No
Go Link GO:0050732
Unique Molecular Interactions 97
Total Molecular Interactions 121
Total Single Events 901
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of peptidyl-tyrosine phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of peptidyl-tyrosine phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
3 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
4 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
5 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
6 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
7 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
8 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
9 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
10 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
11 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
12 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
13 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
14 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
15 INT165637 Ptpn6 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.57 0.23
16 INT165636 Ptpn6 Regulation of Nfkb1 1 0.01 0.36 0.2
17 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
18 INT301615 Binding of Cyp2e1 and Samsn1 1 0.02 2.42 0.18
19 INT254497 GOPC Regulation of Transcription of HNF4A 1 0.02 0.72 0.16
20 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
21 INT348012 Samsn1 Positive_regulation of Vps54 1 0.00 1.93 0.15
22 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
23 INT348011 Binding of Samsn1 and Vps54 1 0.00 1.35 0.11
24 INT338901 Binding of PECAM1 and PTPN6 1 0.03 0.18 0.1
25 INT253300 Itgam Positive_regulation of Gene_expression of Ptprc 1 0.19 0.11 0.09
26 INT254496 Binding of HNF4A and GOPC 1 0.10 0.34 0.08
27 INT232897 Binding of Rab27a and SAMSN1 1 0.00 0.73 0.08
28 INT231507 Binding of Ptprc and Tlr4 2 0.21 1.22 0.06
29 INT236363 Regulation of Binding of Ptprc and Tlr4 1 0.25 1.23 0.06
30 INT260728 Binding of Samsn1 and NAFLD2 1 0.00 1.15 0.05
31 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04
32 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
33 INT288199 Binding of Ptprc and Trav6-3 1 0.00 0.05 0.03
34 INT181079 Binding of Akt1 and Errfi1 1 0.00 0.8 0.03
35 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03
36 INT314397 Binding of Ptpn6 and Slc17a7 1 0.05 0 0
37 INT322546 Negative_regulation of PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
38 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0
39 INT314393 Ptpn6 Regulation of 1190002H23Rik 1 0.01 0 0
40 INT219416 CCNA2 Regulation of HNF4A 1 0.00 0.11 0
41 INT235596 HNF4A Regulation of Gene_expression of TPI1 1 0.00 0.25 0
42 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
43 INT182952 KCNIP3 Positive_regulation of HNF4A 1 0.02 0.45 0
44 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0
45 INT296211 Binding of Ptprc and Tg(CAG-EGFP)D4Nagy 1 0.01 0.13 0
46 INT314402 Positive_regulation of Ptpn6 Regulation of 1190002H23Rik 1 0.02 0 0
47 INT182922 FRA8E Positive_regulation of HNF4A 1 0.00 0.2 0
48 INT194924 CD22 Positive_regulation of PTPN6 1 0.05 0.08 0
49 INT181078 Binding of Errfi1 and Cdc42ep3 1 0.00 0.73 0
50 INT307214 Hnf4a Regulation of Ppara 1 0.18 0.35 0
51 INT314403 Ptpn6 Positive_regulation of Gpsm2 1 0.12 0.07 0
52 INT182926 VDR Positive_regulation of HNF4A 1 0.02 0.09 0
53 INT326836 Binding of HNF4A and PLD2 1 0.03 0.35 0
54 INT142932 Binding of Arid1a and Samsn1 1 0.01 1.55 0
55 INT219410 CCNF Regulation of HNF4A 1 0.01 0.11 0
56 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0
57 INT182938 Binding of HNF4A and KCNIP3 1 0.01 0.2 0
58 INT314398 Ptpn6 Regulation of Gene_expression of Ctbs 1 0.03 0 0
59 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
60 INT219420 CCNE2 Regulation of HNF4A 1 0.00 0.11 0
61 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
62 INT173123 Binding of HNF4A and PPARA 1 0.10 0.19 0
63 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0
64 INT322545 PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
65 INT183018 Dre Positive_regulation of HNF4A 1 0.00 0.09 0
66 INT228285 Binding of Ptprc and Nt5e 1 0.06 0.25 0
67 INT182957 CDKN1A Negative_regulation of HNF4A 1 0.02 0.11 0
68 INT182927 Binding of HNF4A and HRES1 1 0.00 0 0
69 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
70 INT245865 Binding of Cd34 and Ptprc 1 0.04 0 0
71 INT314396 Binding of Ptpn6 and Slc17a6 1 0.05 0 0
72 INT326902 Binding of HNF4A and Tcf4 1 0.02 0.35 0
73 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
74 INT231510 Binding of Ptprc and Gopc 1 0.07 0.17 0
75 INT314400 Binding of Ptpn6 and Gpsm2 1 0.07 0 0
76 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
77 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0
78 INT181085 Binding of Cdc42 and Errfi1 1 0.08 0.67 0
79 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of peptidyl-tyrosine phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of peptidyl-tyrosine phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
2 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
3 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
4 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
5 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
6 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
7 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
8 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
9 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
10 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68
11 INT187454 Binding of Ptprc 34 0.38 9.66 2.54
12 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
13 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
14 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1
15 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
16 INT199222 Gene_expression of SAMSN1 14 0.57 18.97 1.61
17 INT206528 Negative_regulation of Gene_expression of Ptprc 8 0.34 3.91 1.61
18 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59
19 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
20 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
21 INT128478 Positive_regulation of Ptprc 26 0.44 8.1 1.45
22 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
23 INT90771 Positive_regulation of Ptprc 20 0.48 8.43 1.27
24 INT172630 Binding of HNF4A 16 0.05 7.78 1.22
25 INT206515 Regulation of Gene_expression of Ptprc 6 0.39 3.4 1.22
26 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
27 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
28 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
29 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
30 INT172616 Regulation of HNF4A 9 0.06 4.25 1.02
31 INT147464 Binding of Ptprc 13 0.36 15.18 0.98
32 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
33 INT199226 Positive_regulation of SAMSN1 6 0.57 10.2 0.9
34 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
35 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86
36 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
37 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
38 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
39 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
40 INT117031 Binding of Samsn1 6 0.21 6.82 0.76
41 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
42 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
43 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
44 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
45 INT109505 Regulation of Ptprc 3 0.32 2.45 0.58
46 INT199225 Localization of SAMSN1 1 0.62 6.07 0.57
47 INT143131 Regulation of Ptprc 4 0.27 2.56 0.5
48 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
49 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
50 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
51 INT110477 Positive_regulation of Localization of PRKCZ 1 0.20 0.07 0.45
52 INT275642 Negative_regulation of HNF4A 4 0.05 2.08 0.44
53 INT163361 Negative_regulation of SAMSN1 2 0.42 6.6 0.43
54 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
55 INT110479 Localization of PRKCZ 1 0.35 0.07 0.43
56 INT187463 Positive_regulation of Gene_expression of Ptprc 9 0.44 2.8 0.42
57 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
58 INT321429 Positive_regulation of Gene_expression of PTPN6 1 0.03 1.78 0.41
59 INT110478 Regulation of PRKCZ 1 0.20 0.1 0.37
60 INT106253 Positive_regulation of HNF4A 14 0.29 3.88 0.34
61 INT120391 Negative_regulation of Localization of PRKCD 1 0.22 0 0.34
62 INT157416 Positive_regulation of Samsn1 6 0.53 4.28 0.33
63 INT231497 Negative_regulation of Binding of Ptprc 2 0.34 0.99 0.33
64 INT120398 Positive_regulation of Positive_regulation of PRKCD 1 0.26 0 0.33
65 INT147463 Positive_regulation of Binding of Ptprc 2 0.35 0.95 0.3
66 INT183208 Transcription of HNF4A 7 0.11 3.15 0.28
67 INT85329 Regulation of Errfi1 1 0.01 0.39 0.28
68 INT170860 Localization of Samsn1 2 0.23 1.16 0.27
69 INT80059 Negative_regulation of Ptprc 8 0.41 1.85 0.25
70 INT187465 Localization of Ptprc 8 0.62 3.71 0.25
71 INT252757 Negative_regulation of PTPN6 4 0.10 0.74 0.25
72 INT199224 Negative_regulation of Positive_regulation of SAMSN1 3 0.48 4.77 0.25
73 INT187460 Transcription of Ptprc 2 0.44 0.51 0.25
74 INT199221 Binding of SAMSN1 2 0.29 2.36 0.24
75 INT252717 Positive_regulation of Gene_expression of SAMSN1 1 0.03 1.53 0.24
76 INT275639 Positive_regulation of Binding of HNF4A 2 0.04 0.87 0.21
77 INT321425 Gene_expression of PTPN6 1 0.03 0.89 0.2
78 INT60751 Positive_regulation of Gene_expression of HNF4A 2 0.49 3.5 0.19
79 INT280906 Negative_regulation of Ptprc 2 0.15 2.26 0.16
80 INT164022 Regulation of Gene_expression of HNF4A 1 0.03 0.82 0.16
81 INT187456 Regulation of Binding of Ptprc 1 0.29 0.51 0.15
82 INT323231 Positive_regulation of Binding of Samsn1 1 0.18 0.55 0.14
83 INT175046 Negative_regulation of Gene_expression of Ptprc 2 0.30 0.8 0.13
84 INT287917 Phosphorylation of HNF4A 1 0.08 0.07 0.13
85 INT209698 Gene_expression of PRKCD 1 0.33 1.78 0.12
86 INT231491 Regulation of Positive_regulation of Ptprc 1 0.35 0.18 0.1
87 INT199228 Regulation of Gene_expression of SAMSN1 1 0.37 1.48 0.1
88 INT175042 Localization of Ptprc 2 0.53 1.41 0.09
89 INT231493 Positive_regulation of Binding of Ptprc 1 0.39 0.19 0.09
90 INT252729 Phosphorylation of PTPN6 2 0.03 0.67 0.08
91 INT194938 Regulation of PTPN6 2 0.29 0.48 0.08
92 INT126667 Localization of HNF4A 2 0.06 0.45 0.08
93 INT209688 Negative_regulation of Positive_regulation of PRKCD 1 0.18 1.1 0.08
94 INT276339 Localization of PTPN6 1 0.10 1.31 0.08
95 INT231501 Negative_regulation of Positive_regulation of Ptprc 1 0.34 0.38 0.06
96 INT175044 Positive_regulation of Gene_expression of Ptprc 1 0.35 3.61 0.06
97 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
98 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
99 INT287925 Regulation of Binding of HNF4A 1 0.06 1.1 0.05
100 INT267192 Localization of Prkcd 1 0.78 0.96 0.03
101 INT267186 Positive_regulation of Localization of Prkcd 1 0.49 0.97 0.03
102 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
103 INT231500 Phosphorylation of Ptprc 2 0.33 0.16 0
104 INT282314 Negative_regulation of Gene_expression of Ptpn6 2 0.09 0.63 0
105 INT314379 Regulation of Localization of Ptpn6 1 0.10 0.08 0
106 INT175043 Regulation of Gene_expression of Ptprc 1 0.36 0.27 0
107 INT326868 Positive_regulation of Transcription of HNF4A 1 0.04 0.08 0
108 INT231492 Protein_catabolism of Ptprc 1 0.52 0.1 0
109 INT230666 Regulation of Binding of Prkcd 1 0.44 0 0
110 INT315189 Binding of SFRP1 1 0.15 2.96 0
111 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
112 INT157415 Regulation of Positive_regulation of Samsn1 1 0.35 0 0
113 INT259807 Transcription of Ptprc 1 0.04 0.67 0
114 INT218006 Regulation of Regulation of Ptpn6 1 0.05 0.25 0
115 INT194944 Positive_regulation of PTPN6 1 0.06 0.46 0
116 INT326878 Negative_regulation of Gene_expression of HNF4A 1 0.03 0.43 0
117 INT175045 Positive_regulation of Positive_regulation of Ptprc 1 0.35 1.35 0
118 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
119 INT230673 Binding of Prkcd 1 0.36 0 0
120 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
121 INT287915 Positive_regulation of Positive_regulation of HNF4A 1 0.06 0.37 0
122 INT209686 Negative_regulation of Gene_expression of PRKCD 1 0.18 0 0
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