GO:0050786

Name RAGE receptor binding Categary Function Go Slim No Go Link GO:0050786

Unique Molecular Interactions 127 Total Molecular Interactions 192 Total Single Events 1707 Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for RAGE receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for RAGE receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT184262	Binding of AGER and HMGB1	1	0.34	4.49	2.17
2	INT215100	Binding of Hmgb1 and Tlr4	5	0.29	3.21	1.68
3	INT215096	Binding of Hmgb1 and Tlr2	9	0.38	11.61	1.61
4	INT130839	Gfap Positive_regulation of S100B	1	0.51	1.9	1.56
5	INT114364	Hmgb1 Positive_regulation of Gene_expression of TNF	2	0.05	1.85	1.06
6	INT219154	Binding of HMGB1 and TLR4	2	0.17	4.45	0.93
7	INT106312	NFKB1 Regulation of S100A4	1	0.14	1.1	0.83
8	INT274785	S100B Positive_regulation of Ngf	1	0.05	0.61	0.8
9	INT266408	Binding of HMGB1 and Ager	1	0.01	2.57	0.76
10	INT152867	HTR1A Negative_regulation of Localization of S100b	1	0.46	0	0.75
11	INT274786	Ngf Positive_regulation of Gene_expression of S100B	1	0.05	0.63	0.71
12	INT253759	Hmgb1 Positive_regulation of Apex1	1	0.09	4.53	0.69
13	INT215093	Tlr4 Positive_regulation of Localization of Hmgb1	1	0.32	2.9	0.68
14	INT253760	Hmgb1 Positive_regulation of Gene_expression of Apex1	1	0.10	3.53	0.58
15	INT290594	BDNF Positive_regulation of Localization of S100B	1	0.08	0.6	0.57
16	INT323611	Il1 Regulation of Hmgb1	1	0.17	2.36	0.55
17	INT215101	Hmgb1 Positive_regulation of Localization of Il6	4	0.16	1.18	0.54
18	INT128431	SLC6A4 Regulation of S100A4	1	0.48	0.65	0.53
19	INT253767	Binding of Hmgb1 and Tlr9	2	0.12	1.78	0.52
20	INT253770	Hmgb1 Positive_regulation of Localization of Apex1	1	0.08	0.71	0.49
21	INT224675	S100a4 Positive_regulation of Mmp3	1	0.04	0.94	0.48
22	INT224674	S100a4 Positive_regulation of Gene_expression of Mmp9	1	0.03	0.85	0.45
23	INT224686	S100a4 Positive_regulation of Gene_expression of Mmp13	1	0.05	0.85	0.45
24	INT224692	S100a4 Positive_regulation of Gene_expression of Mmp1a	1	0.02	0.85	0.45
25	INT266419	HMGB1 Positive_regulation of Ager	1	0.01	1.37	0.37
26	INT129769	Binding of LYZ and S100B	1	0.33	0.86	0.37
27	INT324823	Tlr4 Positive_regulation of Gene_expression of Hmgb1	1	0.21	0.51	0.37
28	INT324803	Hmgb1 Positive_regulation of Gene_expression of Bad	1	0.02	0.44	0.37
29	INT324818	Hmgb1 Positive_regulation of Gene_expression of Tlr4	1	0.21	0.51	0.37
30	INT324819	Hmgb1 Positive_regulation of Gene_expression of Maob	1	0.09	0.44	0.37
31	INT324827	Hmgb1 Positive_regulation of Bad	1	0.02	0.43	0.36
32	INT266383	Binding of Ager and S100b	1	0.01	3.48	0.33
33	INT253762	Binding of Apex1 and Hmgb1	1	0.09	1.29	0.32
34	INT266375	S100b Positive_regulation of Ager	1	0.02	1.8	0.31
35	INT323612	Negative_regulation of Tlr4 Positive_regulation of Hmgb1	1	0.23	0.2	0.25
36	INT323610	Tlr4 Positive_regulation of Hmgb1	1	0.25	0.2	0.25
37	INT253765	Apex1 Positive_regulation of Hmgb1	1	0.09	1.27	0.24
38	INT343914	Hmgb1 Positive_regulation of Gene_expression of IL12A	1	0.01	0.41	0.24
39	INT128432	HTR1B Regulation of S100A4	1	0.49	0.28	0.24
40	INT253771	Gopc Positive_regulation of Hmgb1	1	0.03	1.27	0.24
41	INT343906	Hmgb1 Positive_regulation of Gene_expression of Cd40	1	0.05	0.41	0.24
42	INT266421	Binding of HMGB1 and Il1	1	0.02	0.37	0.24
43	INT253773	TNF Positive_regulation of Hmgb1	1	0.09	1.21	0.23
44	INT266418	Binding of HMGB1 and Tlr4	1	0.09	0.37	0.23
45	INT344833	Binding of Ager and Hmgb1	1	0.08	0.72	0.22
46	INT266405	S100b Positive_regulation of Gene_expression of TFAM	1	0.00	1.02	0.21
47	INT266423	Binding of HMGB1 and Mapk3	1	0.04	0.9	0.2
48	INT266410	Binding of HMGB1 and Mapk14	1	0.03	0.91	0.2
49	INT266416	Binding of HMGB1 and Mapk1	1	0.06	0.9	0.2
50	INT266414	Binding of HMGB1 and Mapk8	1	0.03	0.91	0.2
51	INT266404	Binding of HMGB1 and Thbd	1	0.06	0.3	0.2
52	INT258289	Hmgb1 Positive_regulation of Tlr2	4	0.48	3.61	0.19
53	INT324815	Binding of Hmgb1 and Caprin1	1	0.01	0.65	0.19
54	INT154329	Binding of S100A8 and S100A12	1	0.41	0.5	0.19
55	INT324797	Binding of Cd24a and Hmgb1	1	0.19	0.66	0.19
56	INT323613	Il1 Regulation of Localization of Hmgb1	1	0.10	0.75	0.19
57	INT135974	S100a4 Negative_regulation of Nos2	1	0.00	0.26	0.17
58	INT135971	S100a4 Negative_regulation of Gene_expression of Nos2	1	0.00	0.26	0.17
59	INT215094	Il6 Positive_regulation of Hmgb1	1	0.18	1.84	0.17
60	INT344832	Hmgb1 Positive_regulation of Gene_expression of Nos2	1	0.12	0.82	0.17
61	INT266422	HMGB1 Positive_regulation of Binding of Ager	1	0.01	0.92	0.16
62	INT122529	Apoe Regulation of S100B	1	0.18	0.29	0.16
63	INT347335	Binding of S100a4 and S100a9	1	0.39	0.51	0.15
64	INT266412	Binding of S100A12 and Ager	1	0.01	1.03	0.15
65	INT347336	Binding of S100a4 and S100a8	1	0.40	0.51	0.15
66	INT266413	Positive_regulation of Binding of HMGB1 and Col4a1	1	0.02	1.05	0.14
67	INT266411	Binding of HMGB1 and Col4a1	1	0.01	1.05	0.14
68	INT290444	S100A4 Regulation of TIMP1	1	0.00	1.3	0.14
69	INT343920	Binding of TLR4 and Hmgb1	1	0.39	0.97	0.13
70	INT324866	Hmgb1 Positive_regulation of Tlr4	1	0.16	1.29	0.13
71	INT96590	Mog Regulation of S100B	1	0.32	0.97	0.13
72	INT261381	Nsdhl Regulation of Gene_expression of S100b	1	0.06	0.82	0.13
73	INT343917	Binding of IRF6 and Hmgb1	1	0.05	0.98	0.13
74	INT237442	Ass1 Positive_regulation of S100b	1	0.00	0.18	0.13
75	INT330800	Binding of S100A1 and S100B	1	0.32	0.5	0.13
76	INT96589	Mbp Regulation of S100B	1	0.34	0.97	0.13
77	INT253761	Hmgb1 Positive_regulation of Gene_expression of Gopc	1	0.03	0.73	0.12
78	INT253772	Binding of THBD and Hmgb1	1	0.05	0.95	0.12
79	INT253775	Negative_regulation of Binding of THBD and Hmgb1	1	0.06	0.69	0.12
80	INT266396	Binding of Ager and S100a4	1	0.01	0.59	0.1
81	INT215095	Negative_regulation of Il6 Positive_regulation of Hmgb1	1	0.13	1.03	0.09
82	INT137395	Binding of CD99 and S100B	1	0.17	1.04	0.09
83	INT250730	Hmgb1 Positive_regulation of Localization of TNF	1	0.08	0.92	0.09
84	INT316112	Binding of S100B and SAE1	1	0.05	1.5	0.08
85	INT266394	Binding of S100a4 and Trp53	1	0.03	0.59	0.08
86	INT266398	Binding of S100b and Trp53	1	0.06	0.92	0.07
87	INT258290	Hmgb1 Regulation of Positive_regulation of Tlr2	1	0.46	1.04	0.05
88	INT316109	TEAD1 Regulation of S100B	1	0.00	1.16	0.04
89	INT198639	S100A12 Positive_regulation of TNF	1	0.15	1.49	0.04
90	INT198646	S100A12 Positive_regulation of IL1B	1	0.01	1.49	0.04
91	INT266372	Binding of S100a1 and S100a4	1	0.11	0.15	0.04
92	INT198651	Positive_regulation of S100A12 Positive_regulation of TNF	1	0.15	1.5	0.04
93	INT204247	S100B Regulation of CD68	1	0.03	1.05	0.04
94	INT198650	Positive_regulation of S100A12 Positive_regulation of IL1B	1	0.01	1.5	0.04
95	INT324859	Hmgb1 Positive_regulation of ecs	1	0.03	0.74	0.03
96	INT324798	Hmgb1 Positive_regulation of Positive_regulation of Mthfd1	1	0.04	0.16	0.03
97	INT244656	Binding of S100B and SLC4A1	1	0.14	1.72	0.03
98	INT324561	Hmgb1 Positive_regulation of Gene_expression of Arc	1	0.18	0.65	0
99	INT292882	Binding of S100A12 and TP63	1	0.06	0.51	0
100	INT299709	S100A12 Regulation of CFB	1	0.00	0.05	0
101	INT283183	Binding of S100A4 and ZAK	1	0.06	0	0
102	INT301246	Binding of HMGB1 and Hbp1	1	0.03	0.74	0
103	INT180294	Positive_regulation of Binding of CPB1 and S100B	1	0.09	0	0
104	INT249185	Binding of S100B and Positive_regulation of CYBB	1	0.11	0	0
105	INT249195	Binding of CA2 and S100B	1	0.07	0	0
106	INT190137	Binding of S100A12 and Gfap	1	0.00	0.65	0
107	INT253769	Binding of Hmgb1 and Il1	1	0.01	0.27	0
108	INT180295	Binding of CPB1 and S100B	1	0.08	0	0
109	INT180302	Positive_regulation of Binding of S100B and Tg(EGFR)0Jlj	1	0.05	0	0
110	INT249180	Binding of NCF2 and S100B	1	0.05	0	0
111	INT180303	Binding of S100B and Tg(EGFR)0Jlj	1	0.03	0	0
112	INT235486	S100B Positive_regulation of Binding of CA2	1	0.13	0.08	0
113	INT249155	Binding of CYBA and S100B	1	0.06	0	0
114	INT324558	Hmgb1 Positive_regulation of Gene_expression of Kiss1	1	0.24	0.65	0
115	INT249174	Binding of AKT1 and S100B	1	0.02	0	0
116	INT249194	S100B Positive_regulation of CYBA	1	0.06	0	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for RAGE receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in RAGE receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT17739	Gene_expression of S100B	226	0.78	132.7	26.4
2	INT114362	Localization of Hmgb1	127	0.78	120.28	23.26
3	INT39553	Gene_expression of Hmgb1	50	0.75	51.18	12.21
4	INT27651	Gene_expression of S100A12	45	0.76	52.25	10.51
5	INT64346	Positive_regulation of S100B	95	0.70	63.11	9.17
6	INT114363	Positive_regulation of Hmgb1	50	0.67	48.92	8.15
7	INT212758	Binding of Hmgb1	40	0.44	35.6	7.41
8	INT112986	Positive_regulation of S100b	19	0.70	17.61	6.86
9	INT117299	Localization of S100b	19	0.78	1.58	6.8
10	INT23465	Gene_expression of S100b	31	0.76	15.09	6.2
11	INT190520	Negative_regulation of Hmgb1	24	0.53	20.08	5.6
12	INT17742	Localization of S100B	44	0.80	17.14	4.65
13	INT184269	Gene_expression of HMGB1	51	0.77	42.96	4.55
14	INT215071	Positive_regulation of Localization of Hmgb1	34	0.63	22.03	4.15
15	INT215085	Positive_regulation of Gene_expression of Hmgb1	17	0.63	16.81	4.13
16	INT215074	Negative_regulation of Localization of Hmgb1	28	0.57	15.09	4
17	INT184288	Localization of HMGB1	20	0.61	14.5	3.84
18	INT25356	Positive_regulation of S100A12	18	0.69	17.62	3.38
19	INT106318	Gene_expression of S100A4	21	0.75	12.13	3.23
20	INT82168	Positive_regulation of S100b	20	0.68	9.72	3.08
21	INT222742	Regulation of S100A12	4	0.53	12.09	3.03
22	INT15584	Binding of S100A12	14	0.48	15.14	3
23	INT154334	Localization of S100A12	9	0.80	9.32	2.89
24	INT131929	Positive_regulation of Gene_expression of S100B	25	0.67	12.61	2.83
25	INT23775	Regulation of S100B	24	0.62	16.75	2.57
26	INT152865	Positive_regulation of Localization of S100b	3	0.68	0	2.53
27	INT184272	Binding of HMGB1	14	0.37	8.78	2.49
28	INT195085	Gene_expression of S100b	12	0.56	12.26	2.33
29	INT106317	Negative_regulation of Gene_expression of S100A4	6	0.41	2.86	2.11
30	INT128453	Positive_regulation of S100A4	8	0.67	3.24	1.84
31	INT253755	Regulation of Hmgb1	7	0.55	6.23	1.8
32	INT135969	Gene_expression of S100a4	9	0.58	5.32	1.79
33	INT58563	Negative_regulation of S100B	13	0.51	11.75	1.77
34	INT152864	Regulation of Localization of S100b	2	0.52	0	1.66
35	INT198663	Positive_regulation of HMGB1	14	0.52	11.41	1.58
36	INT184271	Positive_regulation of Gene_expression of HMGB1	7	0.41	6.17	1.53
37	INT125767	Positive_regulation of Gene_expression of S100b	6	0.49	4.08	1.52
38	INT992	Regulation of S100A4	21	0.60	1.47	1.46
39	INT126199	Negative_regulation of S100a4	1	0.08	1.45	1.38
40	INT112988	Positive_regulation of Transcription of S100b	2	0.47	1.62	1.36
41	INT112987	Transcription of S100b	2	0.53	1.61	1.35
42	INT51064	Regulation of Gene_expression of S100B	13	0.60	5.02	1.34
43	INT125766	Regulation of S100b	7	0.38	4.31	1.33
44	INT154333	Positive_regulation of Localization of S100A12	4	0.69	3.9	1.19
45	INT219168	Positive_regulation of Localization of HMGB1	5	0.36	4	1.16
46	INT161706	Negative_regulation of Gene_expression of S100B	8	0.43	2.69	1.06
47	INT215077	Negative_regulation of Positive_regulation of Hmgb1	3	0.42	5.09	1.05
48	INT51066	Binding of S100B	24	0.48	13.5	0.97
49	INT215078	Negative_regulation of Gene_expression of Hmgb1	4	0.41	4.3	0.96
50	INT106319	Negative_regulation of S100A4	2	0.41	0.89	0.82
51	INT180300	Positive_regulation of Positive_regulation of S100B	3	0.50	2.07	0.79
52	INT128447	Positive_regulation of Localization of S100B	2	0.67	0.9	0.79
53	INT190522	Regulation of Gene_expression of Hmgb1	1	0.39	1.47	0.77
54	INT152863	Negative_regulation of Localization of S100b	1	0.42	0	0.75
55	INT147008	Negative_regulation of Gene_expression of S100b	2	0.27	0.55	0.74
56	INT195107	Localization of S100b	3	0.51	2.63	0.73
57	INT106320	Positive_regulation of Gene_expression of S100A4	2	0.48	0.84	0.65
58	INT195095	Positive_regulation of Gene_expression of S100b	4	0.36	5.37	0.61
59	INT184277	Regulation of Localization of HMGB1	1	0.37	1.15	0.58
60	INT195094	Binding of S100b	2	0.35	3.49	0.51
61	INT343799	Negative_regulation of Transcription of HMGB1	1	0.32	0.37	0.5
62	INT215070	Regulation of Localization of Hmgb1	4	0.26	2.23	0.49
63	INT220339	Transcription of HMGB1	2	0.53	2.03	0.49
64	INT266326	Positive_regulation of S100a4	4	0.65	1.67	0.46
65	INT219178	Negative_regulation of Localization of HMGB1	1	0.22	1.26	0.45
66	INT352592	Positive_regulation of Negative_regulation of Hmgb1	1	0.44	1.31	0.42
67	INT125765	Negative_regulation of Positive_regulation of S100b	2	0.42	0.06	0.4
68	INT128448	Negative_regulation of Positive_regulation of S100A4	1	0.41	0.29	0.35
69	INT156723	Regulation of Localization of S100B	2	0.44	2.61	0.34
70	INT340345	Positive_regulation of Gene_expression of S100A12	1	0.46	1.94	0.34
71	INT285621	Regulation of S100a4	1	0.39	0.67	0.32
72	INT128450	Transcription of S100A4	2	0.67	0.25	0.31
73	INT128455	Positive_regulation of Transcription of S100A4	1	0.49	0.25	0.31
74	INT128456	Positive_regulation of Positive_regulation of S100A4	1	0.49	0.34	0.31
75	INT258283	Positive_regulation of Positive_regulation of Hmgb1	3	0.44	3.1	0.3
76	INT331591	Transcription of Hmgb1	1	0.28	0.92	0.3
77	INT161705	Positive_regulation of Negative_regulation of S100B	1	0.50	0.56	0.28
78	INT266363	Regulation of Binding of S100A12	1	0.29	0.87	0.26
79	INT165392	Positive_regulation of Regulation of S100B	2	0.50	0.56	0.23
80	INT220336	Negative_regulation of HMGB1	3	0.43	0.97	0.21
81	INT202177	Negative_regulation of Gene_expression of S100A12	1	0.22	0.41	0.21
82	INT266367	Positive_regulation of Binding of HMGB1	1	0.26	0.31	0.21
83	INT93077	Negative_regulation of Localization of S100B	3	0.57	0.58	0.2
84	INT266364	Protein_catabolism of HMGB1	1	0.34	0.29	0.19
85	INT266322	Binding of S100a4	1	0.16	1.17	0.18
86	INT195111	Negative_regulation of Positive_regulation of S100b	1	0.06	1.06	0.18
87	INT51065	Transcription of S100B	3	0.60	0.83	0.17
88	INT266353	Negative_regulation of Binding of HMGB1	1	0.22	0.22	0.17
89	INT258272	Negative_regulation of Binding of Hmgb1	1	0.53	1.82	0.15
90	INT344828	Protein_catabolism of Hmgb1	1	0.48	0.67	0.14
91	INT344810	Positive_regulation of Protein_catabolism of Hmgb1	1	0.27	0.67	0.14
92	INT237441	Positive_regulation of Positive_regulation of S100b	2	0.36	3	0.12
93	INT147009	Regulation of Gene_expression of S100b	2	0.07	0.34	0.1
94	INT237438	Regulation of Gene_expression of S100b	2	0.31	2.45	0.1
95	INT318343	Regulation of Binding of Hmgb1	1	0.11	0.41	0.1
96	INT250773	Positive_regulation of Localization of S100a4	1	0.38	0.49	0.1
97	INT206737	Negative_regulation of Gene_expression of HMGB1	3	0.32	3.48	0.09
98	INT250775	Localization of S100a4	1	0.56	0.49	0.09
99	INT82169	Negative_regulation of S100b	2	0.31	0.69	0.08
100	INT159191	Negative_regulation of S100A12	1	0.05	0.59	0.08
101	INT180298	Regulation of Positive_regulation of S100B	3	0.39	1.09	0.04
102	INT299469	Regulation of HMGB1	2	0.18	2.27	0.03
103	INT266358	Regulation of Binding of HMGB1	1	0.14	0	0.03
104	INT299470	Regulation of Gene_expression of HMGB1	1	0.18	1.58	0
105	INT200568	Negative_regulation of Regulation of S100b	1	0.01	1.03	0
106	INT235488	Negative_regulation of Transcription of S100B	1	0.37	0.09	0
107	INT235487	Regulation of Transcription of S100B	1	0.39	0.09	0
108	INT227019	Regulation of Gene_expression of S100A4	1	0.12	0.4	0
109	INT163587	Positive_regulation of Positive_regulation of S100b	1	0.40	0	0
110	INT283188	Binding of S100A4	1	0.18	0	0
111	INT258279	Positive_regulation of Binding of Hmgb1	1	0.45	0.26	0