GO:0051537

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Name 2 iron, 2 sulfur cluster binding
Categary Function
Go Slim No
Go Link GO:0051537
Unique Molecular Interactions 27
Total Molecular Interactions 32
Total Single Events 532
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 2 iron, 2 sulfur cluster binding. They are ordered first by their pain relevance and then by number of times they were reported for 2 iron, 2 sulfur cluster binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37555 FDX1 Positive_regulation of Regulation of Avp 1 0.04 0 0.61
2 INT208910 Ubl4 Regulation of Regulation of FDX1 1 0.01 0.85 0.45
3 INT37554 Avp Regulation of FDX1 1 0.01 0 0.34
4 INT37553 Crh Regulation of FDX1 1 0.03 0 0.34
5 INT241742 Negative_regulation of Sdhb Regulation of Rapgef5 1 0.02 0.39 0.33
6 INT171678 PPY Regulation of CISD1 1 0.00 0.33 0.33
7 INT171677 PRKCA Regulation of CISD1 1 0.00 0 0.33
8 INT263090 Negative_regulation of Binding of FDX1 and LH 1 0.02 0.95 0.32
9 INT263091 Binding of FDX1 and LH 1 0.02 0.95 0.32
10 INT241740 Sdhb Regulation of Rapgef5 1 0.02 0.34 0.32
11 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
12 INT156661 Binding of Pgls and Sdhb 1 0.01 1.43 0.25
13 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2
14 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2
15 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08
16 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
17 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06
18 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03
19 INT240867 Binding of Ros1 and Xdh 1 0.02 0.07 0
20 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0
21 INT295921 Mir761 Positive_regulation of Gene_expression of Ndufv2 1 0.00 0.64 0
22 INT295919 Mir761 Regulation of Gene_expression of Ndufv2 1 0.00 0.64 0
23 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0
24 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0
25 INT331117 EPO Positive_regulation of FXN 1 0.29 1.09 0
26 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0
27 INT354469 Binding of SDHC and Sdhb 1 0.08 1.82 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 2 iron, 2 sulfur cluster binding. They are ordered first by their pain relevance and then by number of times they were reported in 2 iron, 2 sulfur cluster binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67
2 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8
3 INT134460 Positive_regulation of CISD1 5 0.04 1.23 4.8
4 INT22223 Positive_regulation of Xdh 18 0.67 5.87 3.84
5 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08
6 INT24309 Binding of Sdhb 2 0.36 0.98 3.03
7 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86
8 INT22194 Gene_expression of Xdh 20 0.75 10.03 2.83
9 INT208898 Gene_expression of FDX1 8 0.10 5.58 2.39
10 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34
11 INT24307 Transcription of Sdhb 1 0.26 0 2.11
12 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82
13 INT19626 Regulation of Xdh 4 0.22 2.69 1.7
14 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5
15 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34
16 INT121561 Negative_regulation of Binding of Sdhb 1 0.41 0.74 1.2
17 INT158469 Regulation of FECH 3 0.36 1.76 1.13
18 INT115264 Binding of FECH 9 0.41 7.93 1.1
19 INT208896 Regulation of FDX1 1 0.09 1.2 0.99
20 INT22224 Positive_regulation of Positive_regulation of Xdh 3 0.42 0.87 0.92
21 INT134459 Negative_regulation of Positive_regulation of CISD1 1 0.03 0.25 0.89
22 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74
23 INT169779 Positive_regulation of Sdhb 4 0.67 1.2 0.64
24 INT104632 Negative_regulation of Positive_regulation of Xdh 2 0.14 0.9 0.61
25 INT245633 Negative_regulation of FDX1 3 0.10 1.39 0.6
26 INT179373 Localization of XDH 3 0.20 1.97 0.54
27 INT169780 Gene_expression of Sdhb 2 0.65 0.69 0.54
28 INT260596 Positive_regulation of Gene_expression of FDX1 2 0.05 1.75 0.54
29 INT227331 Binding of Xdh 5 0.29 1.83 0.49
30 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43
31 INT241723 Positive_regulation of Gene_expression of Sdhb 1 0.06 0.51 0.38
32 INT111388 Negative_regulation of Gene_expression of Xdh 1 0.13 0.51 0.38
33 INT212657 Positive_regulation of FDX1 2 0.05 1.09 0.37
34 INT261239 Binding of XDH 10 0.34 3.16 0.31
35 INT156656 Gene_expression of Sdhb 1 0.05 1.57 0.3
36 INT169777 Positive_regulation of Positive_regulation of Sdhb 1 0.58 0.24 0.26
37 INT282679 Localization of FECH 1 0.12 9.57 0.23
38 INT113024 Regulation of Gene_expression of Xdh 1 0.03 0.1 0.16
39 INT255793 Positive_regulation of Gene_expression of Xdh 1 0.12 0.27 0.16
40 INT267995 Negative_regulation of Negative_regulation of XDH 2 0.30 0.77 0.15
41 INT223026 Regulation of XDH 2 0.32 2.38 0.15
42 INT324856 Localization of Xdh 1 0.04 0.61 0.15
43 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14
44 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14
45 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11
46 INT108344 Regulation of Sdhb 1 0.29 1.34 0.11
47 INT263205 Negative_regulation of Gene_expression of XDH 2 0.41 0.63 0.1
48 INT320095 Negative_regulation of Binding of XDH 1 0.16 0.46 0.1
49 INT315643 Negative_regulation of Gene_expression of FECH 1 0.29 0.71 0.1
50 INT110568 Positive_regulation of Gene_expression of XDH 7 0.49 5.14 0.09
51 INT199646 Transcription of Fxn 2 0.67 4.78 0.08
52 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08
53 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07
54 INT121075 Positive_regulation of Negative_regulation of Xdh 1 0.11 0 0.07
55 INT315622 Protein_catabolism of FECH 1 0.77 0.49 0.07
56 INT267994 Positive_regulation of Negative_regulation of XDH 1 0.33 0.37 0.07
57 INT315598 Localization of FXN 1 0.43 1.04 0.07
58 INT241727 Positive_regulation of Transcription of Sdhb 1 0.06 0.28 0.06
59 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05
60 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05
61 INT241732 Transcription of Sdhb 1 0.08 0.28 0.05
62 INT239361 Negative_regulation of Ndufv2 1 0.01 0.25 0.05
63 INT53568 Positive_regulation of Negative_regulation of FECH 1 0.47 0.78 0.05
64 INT239376 Localization of CISD1 1 0.22 0.29 0.04
65 INT239372 Regulation of Localization of CISD1 1 0.13 0.29 0.04
66 INT241718 Binding of Sdhb 1 0.05 0 0.04
67 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04
68 INT241731 Localization of Sdhb 1 0.09 0 0.04
69 INT241729 Positive_regulation of Localization of Sdhb 1 0.06 0 0.04
70 INT269499 Regulation of Negative_regulation of Xdh 1 0.32 0.38 0.04
71 INT199648 Regulation of Fxn 1 0.29 2.14 0.04
72 INT199651 Binding of Fxn 3 0.30 1.45 0.03
73 INT291518 Positive_regulation of Negative_regulation of Fxn 1 0.47 1.1 0.03
74 INT267997 Positive_regulation of Positive_regulation of XDH 1 0.35 0.83 0.03
75 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0
76 INT110570 Regulation of Gene_expression of XDH 3 0.32 1.36 0
77 INT315635 Positive_regulation of FXN 2 0.41 5.76 0
78 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0
79 INT291511 Positive_regulation of Transcription of Fxn 1 0.47 0.09 0
80 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0
81 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0
82 INT331131 Regulation of Gene_expression of FXN 1 0.37 1.49 0
83 INT291516 Negative_regulation of Transcription of Fxn 1 0.54 0.77 0
84 INT53569 Negative_regulation of Positive_regulation of FECH 1 0.40 0.52 0
85 INT315620 Regulation of Gene_expression of GLRX5 1 0.40 0.5 0
86 INT315550 Transcription of GLRX5 1 0.53 0.66 0
87 INT315637 Transcription of FXN 1 0.40 1.44 0
88 INT315627 Binding of GLRX5 1 0.33 0 0
89 INT315555 Binding of FXN 1 0.28 1.29 0
90 INT110572 Transcription of XDH 1 0.52 0.15 0
91 INT110571 Positive_regulation of Transcription of XDH 1 0.45 0 0
92 INT295902 Gene_expression of Ndufv2 1 0.04 0.63 0
93 INT315607 Positive_regulation of Gene_expression of GLRX5 1 0.61 2.28 0
94 INT291507 Regulation of Negative_regulation of Fxn 1 0.37 0.87 0
95 INT315552 Negative_regulation of GLRX5 1 0.38 2.17 0
96 INT291512 Regulation of Gene_expression of Fxn 1 0.37 0.06 0
97 INT315553 Positive_regulation of GLRX5 1 0.44 0.68 0
98 INT331130 Negative_regulation of FXN 1 0.48 4.93 0
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