GO:0051612

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Name negative regulation of serotonin uptake
Categary Process
Go Slim No
Go Link GO:0051612
Unique Molecular Interactions 88
Total Molecular Interactions 117
Total Single Events 1920
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of serotonin uptake. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of serotonin uptake. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
5 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
6 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
7 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
8 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
9 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
10 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
11 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
12 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
13 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
14 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
15 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
16 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
17 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
18 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
19 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
20 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
21 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
22 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
23 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
24 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
25 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
26 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
27 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
28 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
29 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
30 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
31 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
32 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
33 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
34 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
35 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
36 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
37 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
38 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
39 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
40 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
41 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
42 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
43 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
44 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
45 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
46 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
47 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
48 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
49 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
50 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
51 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
52 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 1 0.07 0.31 0.29
53 INT328410 Nlrp1a Negative_regulation of Snca 1 0.07 0.31 0.29
54 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
55 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
56 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
57 INT328707 Trat1 Negative_regulation of Nos1 1 0.02 2.32 0.24
58 INT257223 Ltp Positive_regulation of Gene_expression of Nos1 1 0.03 0.07 0.24
59 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
60 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
61 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
62 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
63 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18
64 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
65 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
66 INT71383 Vip Positive_regulation of Nos1 1 0.01 0.09 0.16
67 INT257230 Binding of CALM1 and Nos1 1 0.00 0 0.15
68 INT304496 Mknk1 Positive_regulation of Gene_expression of Nos1 1 0.19 0.18 0.15
69 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
70 INT195896 Egf Positive_regulation of Nos1 1 0.10 0.57 0.12
71 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
72 INT304502 Mknk1 Positive_regulation of Phosphorylation of Nos1 1 0.19 0.16 0.11
73 INT328413 Binding of Snca and Nlrp1a 1 0.06 0.75 0.1
74 INT301144 Nos1 Regulation of Gene_expression of TNF 1 0.11 0.55 0.09
75 INT83270 Snca Regulation of Napepld 1 0.14 0 0.09
76 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06
77 INT269501 Nos1 Regulation of Lta 1 0.28 0.26 0.05
78 INT317313 Atp13a2 Negative_regulation of Snca 1 0.13 0.59 0
79 INT117647 Agt Regulation of Nos1 1 0.19 0.13 0
80 INT315669 Binding of Nes and Nos1 1 0.20 0 0
81 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
82 INT317315 Gene_expression of Snca Negative_regulation of Psmb10 1 0.00 0.52 0
83 INT317320 Binding of Snca and Atp13a2 1 0.08 0.58 0
84 INT231168 Binding of Dmd and Nos1 1 0.11 0.06 0
85 INT269500 Lta Positive_regulation of Protein_catabolism of Nos1 1 0.29 0.65 0
86 INT249934 Nos1 Regulation of Nos2 1 0.20 0.19 0
87 INT269503 Lta Regulation of Nos1 1 0.44 1.3 0
88 INT168246 Pomgnt1 Positive_regulation of Transcription of Nos1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of serotonin uptake. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of serotonin uptake. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
2 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
3 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
4 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
5 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
6 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
7 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
8 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
9 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
10 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
11 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
12 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
13 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
14 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
15 INT80251 Binding of Nos1 21 0.30 8.24 11.31
16 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
17 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
18 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
19 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
20 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
21 INT71381 Localization of Nos1 33 0.79 11.46 8.05
22 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
23 INT69499 Binding of Nos1 15 0.36 2.56 6.23
24 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
25 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
26 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
27 INT84673 Localization of Nos1 19 0.80 5.01 5.62
28 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
29 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
30 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
31 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
32 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36
33 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
34 INT123595 Regulation of Snca 7 0.62 4.3 3.06
35 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
36 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
37 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
38 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
39 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
40 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
41 INT127125 Localization of Snca 6 0.81 8.24 1.88
42 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74
43 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
44 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
45 INT201271 Phosphorylation of Snca 3 0.82 4.22 1.45
46 INT124247 Negative_regulation of Gene_expression of Snca 12 0.59 3.87 1.39
47 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
48 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19
49 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
50 INT151753 Transcription of Snca 6 0.69 1.99 1.11
51 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
52 INT292945 Positive_regulation of Positive_regulation of Snca 4 0.69 2.42 1.05
53 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
54 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
55 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
56 INT151752 Positive_regulation of Transcription of Snca 2 0.50 0.99 0.92
57 INT124246 Binding of Snca 10 0.37 6.53 0.9
58 INT216258 Positive_regulation of Regulation of Nos1 2 0.40 1.45 0.74
59 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7
60 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
61 INT201270 Regulation of Positive_regulation of Nos1 2 0.38 2.27 0.63
62 INT144447 Regulation of Regulation of Nos1 1 0.43 0.1 0.59
63 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
64 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53
65 INT92549 Negative_regulation of Localization of Nos1 1 0.37 0.26 0.5
66 INT148264 Transcription of SNCA 1 0.40 0.25 0.42
67 INT343972 Negative_regulation of Binding of SNCA 1 0.36 0.2 0.39
68 INT104414 Negative_regulation of Transcription of Nos1 1 0.42 0.96 0.38
69 INT169628 Binding of SNCA 4 0.47 3.53 0.36
70 INT343973 Localization of SNCA 1 0.63 0.07 0.3
71 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29
72 INT107757 Regulation of Negative_regulation of Nos1 2 0.39 0 0.27
73 INT112278 Positive_regulation of Regulation of Nos1 4 0.38 0.99 0.25
74 INT142052 Binding of Snca 4 0.47 1.02 0.22
75 INT105900 Regulation of Binding of Nos1 1 0.35 0.52 0.22
76 INT292944 Regulation of Positive_regulation of Snca 1 0.45 0.36 0.21
77 INT133634 Positive_regulation of Negative_regulation of Nos1 1 0.47 0.57 0.2
78 INT257418 Negative_regulation of Transcription of Snca 1 0.43 0.93 0.19
79 INT257203 Regulation of Phosphorylation of Nos1 1 0.15 0 0.17
80 INT166361 Phosphorylation of SNCA 1 0.70 0.72 0.17
81 INT157084 Localization of Snca 1 0.51 0.17 0.16
82 INT343974 Negative_regulation of Gene_expression of SNCA 1 0.31 0.09 0.16
83 INT319289 Protein_catabolism of Snca 1 0.35 0.93 0.15
84 INT286343 Negative_regulation of Gene_expression of Snca 1 0.26 0.65 0.15
85 INT288642 Negative_regulation of Positive_regulation of Snca 1 0.07 0.93 0.09
86 INT292946 Positive_regulation of Localization of Snca 1 0.50 0.52 0.06
87 INT100487 Negative_regulation of Binding of Nos1 1 0.28 0 0.04
88 INT112277 Negative_regulation of Regulation of Nos1 1 0.35 0.33 0.03
89 INT109984 Positive_regulation of Localization of Nos1 2 0.39 0.86 0
90 INT317275 Positive_regulation of Binding of Snca 1 0.37 0.53 0
91 INT139479 Protein_catabolism of Nos1 1 0.58 0.05 0
92 INT269497 Protein_catabolism of Nos1 1 0.57 0.64 0
93 INT343971 Positive_regulation of Positive_regulation of SNCA 1 0.42 0.35 0
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