GO:0051787

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Name misfolded protein binding
Categary Function
Go Slim No
Go Link GO:0051787
Unique Molecular Interactions 88
Total Molecular Interactions 134
Total Single Events 924
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for misfolded protein binding. They are ordered first by their pain relevance and then by number of times they were reported for misfolded protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
2 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
3 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
4 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
5 INT251166 Clu Positive_regulation of Trpc3 1 0.09 0.75 0.67
6 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
7 INT251188 Clu Positive_regulation of TRPV1 1 0.01 0.23 0.64
8 INT251167 Clu Positive_regulation of Trpc6 1 0.12 0.2 0.6
9 INT251168 Clu Positive_regulation of Trpc7 1 0.15 0.2 0.59
10 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 0.00 1.59 0.5
11 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
12 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
13 INT51341 Binding of Pomc and Clu 1 0.14 0 0.38
14 INT67000 Dnajc3 Negative_regulation of Negative_regulation of Penk 1 0.00 0.54 0.34
15 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
16 INT324830 Hspd1 Positive_regulation of IFNA1 1 0.04 0.46 0.3
17 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
18 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
19 INT333927 GLUL Positive_regulation of HSPA5 1 0.17 0.78 0.24
20 INT324835 Hspd1 Positive_regulation of Gene_expression of IFNA1 1 0.15 0.31 0.23
21 INT192864 Binding of Hspa5 and Mela 1 0.25 1.06 0.22
22 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21
23 INT251162 Clu Positive_regulation of Gene_expression of Trpv1 1 0.20 0.07 0.18
24 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
25 INT250550 Binding of F12 and CHDH 1 0.05 2.26 0.17
26 INT130690 Gene_expression of HSPA5 Negative_regulation of Positive_regulation of DDIT3 1 0.21 0.58 0.17
27 INT324804 Binding of Hspd1 and Tlr4 1 0.14 0.36 0.13
28 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
29 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
30 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12
31 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11
32 INT51344 Binding of Clu and Vtn 1 0.06 0 0.1
33 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09
34 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
35 INT215880 Car2 Regulation of Hspa5 1 0.09 0.66 0.08
36 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
37 INT306510 INCENP Regulation of Gene_expression of Clu 1 0.00 1.92 0.05
38 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05
39 INT276951 Hspd1 Positive_regulation of Il10 1 0.05 0.75 0.04
40 INT215876 Atf4 Regulation of Hspa5 1 0.22 0.43 0.04
41 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
42 INT276949 Hspd1 Positive_regulation of Gene_expression of Socs3 1 0.15 0.71 0.04
43 INT306505 Binding of Clu and Tnf 1 0.24 0.4 0.04
44 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04
45 INT276977 Hspd1 Positive_regulation of Gene_expression of Il13 1 0.07 0.75 0.04
46 INT276956 Hspd1 Positive_regulation of Il13 1 0.07 0.75 0.04
47 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
48 INT306501 Negative_regulation of Binding of Clu and Tnf 1 0.29 0.4 0.04
49 INT276954 Hspd1 Positive_regulation of Stat3 1 0.31 0.65 0.04
50 INT276967 Hspd1 Regulation of Gene_expression of Socs3 1 0.14 0.71 0.04
51 INT276970 Hspd1 Positive_regulation of Gene_expression of Il10 1 0.10 0.69 0.03
52 INT350792 Binding of Hspd1 and Lsr1 1 0.00 0.25 0
53 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
54 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
55 INT306509 Binding of XRCC6 and Clu 1 0.37 0.27 0
56 INT206943 Hspa5 Positive_regulation of Atf4 1 0.47 0.62 0
57 INT320632 Ptger2 Regulation of Gene_expression of Hspd1 1 0.00 0.41 0
58 INT146131 Binding of Gnrh1 and Hspd1 1 0.02 0.88 0
59 INT243635 Positive_regulation of Binding of Nfatc2 and Stub1 1 0.09 0 0
60 INT263584 Hspa5 Positive_regulation of Myo1b 1 0.00 1.02 0
61 INT346743 Atf6 Positive_regulation of Hspa5 1 0.00 0 0
62 INT243628 Binding of Nfatc2 and Stub1 1 0.06 0 0
63 INT263586 Hspa5 Positive_regulation of Esr1 1 0.15 1.01 0
64 INT350796 Binding of CEBPB and Hspd1 1 0.00 0.25 0
65 INT307156 Esr1 Positive_regulation of Hspa5 1 0.04 0.79 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for misfolded protein binding. They are ordered first by their pain relevance and then by number of times they were reported in misfolded protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61
2 INT117621 Positive_regulation of HSPA5 17 0.59 13.26 6.06
3 INT51337 Binding of Clu 3 0.12 0.05 5.45
4 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
5 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31
6 INT130700 Gene_expression of HSPA5 16 0.75 11.55 2.81
7 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73
8 INT130702 Positive_regulation of Gene_expression of HSPA5 7 0.59 7.53 2.68
9 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8
10 INT49347 Negative_regulation of Clu 4 0.58 1.63 1.79
11 INT77164 Binding of F12 8 0.47 2.66 1.48
12 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45
13 INT53775 Gene_expression of Hspd1 21 0.78 31.25 1.38
14 INT35944 Regulation of Clu 4 0.20 0.15 1.3
15 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27
16 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23
17 INT73176 Positive_regulation of Hspd1 5 0.35 3.96 1.22
18 INT251180 Phosphorylation of Clu 1 0.29 0.79 1.22
19 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
20 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
21 INT233561 Gene_expression of Clu 14 0.66 45.63 1.07
22 INT100273 Localization of Clu 4 0.61 0.49 0.88
23 INT159015 Positive_regulation of Localization of HSPA5 1 0.36 0.33 0.88
24 INT159013 Localization of HSPA5 2 0.42 0.32 0.87
25 INT99156 Binding of HSPA5 3 0.38 0.57 0.84
26 INT70666 Positive_regulation of CLU 16 0.45 12.95 0.74
27 INT94233 Positive_regulation of Gene_expression of Clu 3 0.69 2.64 0.71
28 INT188347 Localization of Hspd1 2 0.41 4.53 0.71
29 INT94232 Negative_regulation of Gene_expression of Clu 2 0.43 1.17 0.63
30 INT116838 Regulation of Gene_expression of Hspd1 1 0.18 0.19 0.62
31 INT53774 Positive_regulation of Gene_expression of Hspd1 7 0.70 6.99 0.6
32 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
33 INT135294 Negative_regulation of Positive_regulation of Clu 1 0.37 0.35 0.59
34 INT53778 Regulation of Gene_expression of Hspd1 2 0.58 3.61 0.52
35 INT251182 Regulation of Phosphorylation of Clu 1 0.16 0.13 0.52
36 INT221932 Gene_expression of F12 4 0.66 2.61 0.5
37 INT207614 Binding of Hspd1 4 0.18 1.16 0.5
38 INT89258 Localization of STUB1 3 0.14 0.67 0.49
39 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
40 INT233552 Positive_regulation of Gene_expression of Clu 3 0.59 9.31 0.45
41 INT154748 Positive_regulation of Gene_expression of Hspa5 11 0.44 7.66 0.44
42 INT100082 Negative_regulation of Hspd1 3 0.54 1.91 0.42
43 INT130698 Negative_regulation of Positive_regulation of HSPA5 2 0.36 1.58 0.42
44 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36
45 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
46 INT324772 Positive_regulation of Gene_expression of Hspd1 1 0.49 0.41 0.29
47 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28
48 INT122985 Negative_regulation of Gene_expression of CLU 4 0.57 4.58 0.27
49 INT333957 Regulation of HSPA5 3 0.52 0.61 0.27
50 INT145259 Binding of CLU 1 0.03 0.84 0.27
51 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
52 INT77165 Regulation of Positive_regulation of F12 1 0.38 0.28 0.23
53 INT77160 Positive_regulation of Binding of F12 1 0.42 0.28 0.23
54 INT142482 Positive_regulation of Positive_regulation of HSPA5 1 0.28 1.17 0.22
55 INT122987 Negative_regulation of CLU 5 0.42 4.58 0.21
56 INT203471 Localization of Stub1 1 0.23 0.5 0.21
57 INT172021 Localization of Hspa5 2 0.18 0.93 0.2
58 INT35945 Positive_regulation of Regulation of Clu 1 0.35 0 0.2
59 INT144676 Gene_expression of Hspa5 1 0.06 1.12 0.19
60 INT207611 Regulation of Hspd1 1 0.20 0.19 0.17
61 INT58589 Regulation of F12 3 0.39 1.9 0.16
62 INT192842 Binding of Hspa5 3 0.33 1.48 0.16
63 INT122984 Localization of CLU 2 0.78 2.46 0.16
64 INT122989 Positive_regulation of Localization of CLU 2 0.45 1.81 0.16
65 INT154746 Regulation of Positive_regulation of Hspa5 1 0.40 0.18 0.16
66 INT122986 Positive_regulation of Gene_expression of CLU 3 0.67 2.37 0.14
67 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12
68 INT53777 Negative_regulation of Positive_regulation of Hspd1 1 0.59 0.58 0.12
69 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11
70 INT109025 Negative_regulation of Hspd1 2 0.55 1.48 0.1
71 INT144677 Positive_regulation of Gene_expression of Hspa5 1 0.04 0.59 0.1
72 INT109020 Positive_regulation of Negative_regulation of Hspd1 1 0.39 0.76 0.1
73 INT233567 Positive_regulation of Clu 3 0.59 2.91 0.09
74 INT123574 Localization of F12 1 0.15 0.25 0.09
75 INT144668 Positive_regulation of Hspa5 1 0.03 0.53 0.09
76 INT184167 Binding of STUB1 5 0.07 0.72 0.08
77 INT192840 Transcription of Hspa5 4 0.47 1.93 0.08
78 INT243617 Binding of Stub1 3 0.09 0.16 0.08
79 INT263572 Regulation of Hspa5 3 0.41 4.15 0.07
80 INT333944 Regulation of Regulation of HSPA5 1 0.38 0.14 0.07
81 INT221986 Localization of Hspd1 1 0.52 1.8 0.06
82 INT233554 Negative_regulation of Gene_expression of Clu 2 0.39 1.96 0.05
83 INT233550 Localization of Clu 2 0.69 4.52 0.05
84 INT337002 Positive_regulation of Binding of HSPA5 1 0.14 0.05 0.05
85 INT130701 Negative_regulation of Gene_expression of HSPA5 1 0.50 0.5 0.05
86 INT258395 Positive_regulation of Positive_regulation of Hspd1 5 0.25 2.79 0.04
87 INT269823 Transcription of Hspd1 1 0.30 1.66 0.04
88 INT161524 Regulation of Clu 4 0.38 3.18 0.03
89 INT182999 Negative_regulation of Gene_expression of STUB1 1 0.08 0.31 0.03
90 INT289783 Negative_regulation of Hspa5 2 0.22 0.7 0
91 INT263569 Phosphorylation of Hspa5 2 0.42 1.63 0
92 INT200277 Positive_regulation of Gene_expression of Stub1 2 0.06 0 0
93 INT196230 Regulation of STUB1 2 0.05 0.8 0
94 INT233556 Regulation of Gene_expression of Clu 2 0.33 1.45 0
95 INT230477 Binding of Hspd1 2 0.34 1.09 0
96 INT209699 Negative_regulation of STUB1 1 0.07 0.41 0
97 INT49344 Negative_regulation of Transcription of Clu 1 0.35 0.07 0
98 INT49345 Transcription of Clu 1 0.58 0.2 0
99 INT233564 Regulation of Positive_regulation of Clu 1 0.38 0.98 0
100 INT342089 Regulation of Gene_expression of Stub1 1 0.02 0.16 0
101 INT320629 Regulation of Hspd1 1 0.58 0.68 0
102 INT276945 Negative_regulation of Positive_regulation of Hspd1 1 0.22 0.9 0
103 INT263577 Positive_regulation of Transcription of Hspa5 1 0.33 0.95 0
104 INT206738 Regulation of CLU 1 0.44 1.15 0
105 INT307137 Regulation of Gene_expression of Hspa5 1 0.16 0.93 0
106 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0
107 INT354842 Protein_catabolism of CLU 1 0.28 1.6 0
108 INT327365 Negative_regulation of Positive_regulation of Hspa5 1 0.21 0.68 0
109 INT306487 Binding of Clu 1 0.24 0.27 0
110 INT49348 Regulation of Transcription of Clu 1 0.50 0.13 0
111 INT313091 Negative_regulation of Stub1 1 0.07 0.25 0
112 INT318803 Regulation of Gene_expression of CLU 1 0.21 0.9 0
113 INT250579 Transcription of F12 1 0.62 0.77 0
114 INT320630 Negative_regulation of Gene_expression of Hspd1 1 0.55 1.3 0
115 INT233557 Transcription of Clu 1 0.45 0.77 0
116 INT174710 Regulation of Hspa5 1 0.01 0.14 0
117 INT337007 Negative_regulation of Binding of HSPA5 1 0.14 0 0
118 INT318804 Negative_regulation of Localization of CLU 1 0.18 1.33 0
119 INT174711 Transcription of Hspa5 1 0.02 0.7 0
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