GO:0051927

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Name negative regulation of calcium ion transport via voltage-gated calcium channel activity
Categary Process
Go Slim No
Go Link GO:0051927
Unique Molecular Interactions 558
Total Molecular Interactions 733
Total Single Events 6781
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of calcium ion transport via voltage-gated calcium channel activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of calcium ion transport via voltage-gated calcium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
2 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
3 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
4 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
5 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
6 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
7 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
8 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
9 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
10 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
11 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
12 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
13 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
14 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
15 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
16 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
17 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
18 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
19 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
20 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
21 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
22 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
23 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
24 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
25 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
26 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
27 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
28 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
29 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
30 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
31 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
32 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
33 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
34 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
35 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
36 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
37 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
38 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
39 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
40 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
41 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
42 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
43 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
44 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
45 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
46 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
47 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
48 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
49 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
50 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
51 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
52 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
53 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
54 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
55 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
56 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
57 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
58 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
59 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
60 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
61 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
62 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
63 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
64 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
65 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
66 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
67 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
68 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
69 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
70 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
71 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
72 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29
73 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
74 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
75 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
76 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
77 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26
78 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
79 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
80 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
81 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
82 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
83 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
84 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
85 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
86 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
87 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
88 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
89 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
90 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
91 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
92 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
93 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15
94 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
95 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12
96 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
97 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
98 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
99 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09
100 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
101 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
102 INT145407 Oprd1 Regulation of Positive_regulation of Dbi 1 0.17 0 1.07
103 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
104 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
105 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
106 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
107 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
108 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04
109 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
110 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
111 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
112 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
113 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
114 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
115 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
116 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
117 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
118 INT18890 Penk Regulation of Oprd1 1 0.25 0.45 0.97
119 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96
120 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
121 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
122 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
123 INT65463 Bri3 Negative_regulation of Oprd1 1 0.10 0.39 0.94
124 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
125 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
126 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93
127 INT82124 IK Positive_regulation of Gene_expression of Oprd1 1 0.00 0 0.92
128 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
129 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 0.01 0 0.91
130 INT34273 WAS Regulation of Oprd1 1 0.00 0 0.91
131 INT61317 Positive_regulation of Oprd1 Positive_regulation of Gene_expression of Coq10a 1 0.01 0.39 0.91
132 INT34272 WAS Positive_regulation of Oprd1 1 0.01 0 0.91
133 INT54196 Binding of Oprd1 and Agp2 1 0.00 0.18 0.91
134 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91
135 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
136 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
137 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
138 INT52759 Oprd1 Regulation of Sptan1 1 0.03 0 0.9
139 INT86589 Oprd1 Regulation of Localization of Pomc 1 0.18 0 0.9
140 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
141 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
142 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
143 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
144 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
145 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
146 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
147 INT54194 Binding of Oprd1 and Pag1 1 0.01 0.18 0.89
148 INT82125 IK Regulation of Gene_expression of Oprd1 1 0.00 0 0.88
149 INT80792 Prkcg Regulation of Oprd1 1 0.19 0.2 0.86
150 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
151 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
152 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
153 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
154 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
155 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
156 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
157 INT21534 Binding of Oprd1 and Il1 1 0.00 0 0.84
158 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
159 INT84414 Folr2 Regulation of Binding of Oprd1 1 0.03 0.18 0.84
160 INT113972 Regulation of Binding of Oprd1 and Smu1 1 0.00 0.45 0.84
161 INT113971 Binding of Oprd1 and Smu1 1 0.00 0.45 0.84
162 INT97012 Binding of CALM1 and OPRM1 1 0.18 0 0.82
163 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
164 INT89529 OPRM1 Regulation of CALM1 1 0.27 0 0.81
165 INT150348 Oprd1 Regulation of Pat 1 0.01 0.38 0.81
166 INT112842 Positive_regulation of Binding of Pdyn and Oprd1 1 0.00 0 0.81
167 INT112841 Binding of Pdyn and Oprd1 1 0.00 0 0.81
168 INT50793 Oprd1 Regulation of Phosphorylation of Oprd1 1 0.00 0 0.8
169 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8
170 INT151807 Binding of NFATC1 and OPRM1 1 0.19 0 0.79
171 INT21543 Binding of Oprd1 and Cish 2 0.09 0.15 0.78
172 INT77526 Oprd1 Regulation of Positive_regulation of Odc1 1 0.01 0.12 0.78
173 INT90750 Oprd1 Regulation of Positive_regulation of Gpd1 1 0.10 0.25 0.78
174 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
175 INT102841 Pdcl Regulation of Oprd1 1 0.02 0.12 0.77
176 INT133074 CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.77
177 INT151808 NFATC1 Positive_regulation of Positive_regulation of OPRM1 1 0.20 0 0.76
178 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
179 INT74829 Oprd1 Regulation of Slc1a2 1 0.17 0 0.76
180 INT15344 Oprd1 Regulation of Localization of Tacr3 1 0.00 0 0.76
181 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
182 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
183 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
184 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
185 INT83868 Oprd1 Positive_regulation of Gene_expression of Fos 1 0.01 0 0.75
186 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 0.26 0 0.74
187 INT75399 Regulation of Binding of Dll1 and Oprd1 1 0.08 0 0.74
188 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
189 INT133070 Positive_regulation of CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.74
190 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
191 INT75398 Binding of Dll1 and Oprd1 1 0.11 0 0.74
192 INT114281 Binding of Oprd1 and Nacc1 1 0.03 0 0.74
193 INT151806 TRAF3IP2 Positive_regulation of Positive_regulation of OPRM1 1 0.06 0 0.74
194 INT93709 Positive_regulation of Oprd1 Regulation of Calm3 1 0.01 0 0.74
195 INT61050 Oprd1 Positive_regulation of Odc1 1 0.25 0 0.74
196 INT93708 Oprd1 Regulation of Calm3 1 0.01 0 0.73
197 INT133940 Binding of OPRD1 and ARFGEF1 1 0.02 0 0.73
198 INT7049 Binding of YY1 and Oprd1 1 0.01 0 0.73
199 INT133934 Binding of OPRD1 and PDYN 1 0.02 0 0.73
200 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of calcium ion transport via voltage-gated calcium channel activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of calcium ion transport via voltage-gated calcium channel activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
2 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
3 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
4 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
5 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
6 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
7 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
8 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
9 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
10 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
11 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
12 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
13 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
14 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
15 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
16 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
17 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
18 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
19 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
20 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
21 INT13501 Binding of Drd2 65 0.48 23.76 35.6
22 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
23 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
24 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
25 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
26 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
27 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
28 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
29 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
30 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
31 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
32 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
33 INT12484 Binding of Drd2 45 0.48 15.17 24.72
34 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
35 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
36 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
37 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
38 INT49774 Binding of DRD2 48 0.48 17.42 20.73
39 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
40 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
41 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
42 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
43 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
44 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97
45 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
46 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6
47 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
48 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
49 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
50 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
51 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
52 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
53 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
54 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
55 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
56 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
57 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
58 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
59 INT31394 Negative_regulation of Localization of Oprd1 3 0.39 2.38 7.89
60 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
61 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
62 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
63 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
64 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
65 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
66 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33
67 INT6239 Regulation of Regulation of Oprd1 7 0.45 0.34 7.26
68 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23
69 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
70 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
71 INT54062 Transcription of Oprd1 11 0.68 1.05 6.65
72 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
73 INT24460 Localization of Drd2 12 0.73 2.96 6.46
74 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
75 INT54747 Localization of OPRD1 7 0.73 0.69 6.27
76 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
77 INT86772 Localization of Drd2 14 0.80 1.93 6.17
78 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07
79 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
80 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
81 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
82 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76
83 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
84 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
85 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
86 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
87 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
88 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
89 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
90 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
91 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
92 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
93 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3
94 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1
95 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
96 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
97 INT29671 Regulation of Localization of Oprd1 4 0.24 1.04 3.92
98 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87
99 INT71322 Positive_regulation of Binding of Oprd1 4 0.33 0.97 3.87
100 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
101 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
102 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48
103 INT60646 Regulation of Gene_expression of Oprd1 4 0.60 1.76 3.46
104 INT52392 Positive_regulation of Gene_expression of OPRD1 6 0.64 0.23 3.43
105 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
106 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
107 INT74962 Phosphorylation of OPRD1 5 0.82 0.18 3.26
108 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
109 INT109095 Binding of Drd4 7 0.40 3.6 3.18
110 INT54060 Regulation of Transcription of Oprd1 3 0.57 0.59 3.18
111 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
112 INT82035 Negative_regulation of Phosphorylation of Oprd1 3 0.13 0 3.16
113 INT31912 Regulation of Binding of OPRD1 3 0.25 0.93 3.11
114 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01
115 INT59455 Localization of Oprd1 3 0.20 0.22 3.01
116 INT57145 Transcription of OPRD1 6 0.61 0.34 2.99
117 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
118 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
119 INT54632 Negative_regulation of Gene_expression of Oprd1 5 0.58 2.22 2.9
120 INT28729 Negative_regulation of Negative_regulation of Oprd1 3 0.43 0.33 2.79
121 INT147412 Binding of DRD4 11 0.47 7.57 2.77
122 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
123 INT34501 Positive_regulation of Positive_regulation of Oprd1 4 0.43 0.31 2.77
124 INT16715 Positive_regulation of Transcription of Oprd1 3 0.66 0.6 2.74
125 INT234111 Gene_expression of NCS1 3 0.74 15.23 2.68
126 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66
127 INT317124 Positive_regulation of Gene_expression of Ncs1 1 0.69 10.64 2.66
128 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
129 INT317117 Gene_expression of Ncs1 1 0.77 13.85 2.58
130 INT88272 Gene_expression of Drd4 5 0.66 1.07 2.53
131 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
132 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
133 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
134 INT72013 Negative_regulation of Gnai2 5 0.35 0.09 2.44
135 INT59710 Positive_regulation of Negative_regulation of OPRD1 1 0.36 0.21 2.41
136 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
137 INT54748 Positive_regulation of Localization of OPRD1 2 0.08 0.18 2.3
138 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28
139 INT53605 Regulation of Binding of Oprd1 2 0.42 0 2.26
140 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
141 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
142 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
143 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
144 INT50782 Positive_regulation of Phosphorylation of Oprd1 1 0.16 0 2.07
145 INT118701 Positive_regulation of Ncs1 2 0.69 4.13 2.03
146 INT67982 Positive_regulation of Positive_regulation of OPRD1 3 0.04 0.33 2.02
147 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
148 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
149 INT7829 Negative_regulation of Positive_regulation of Oprd1 2 0.30 0.41 1.95
150 INT7003 Negative_regulation of Binding of OPRD1 4 0.13 0.83 1.9
151 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
152 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
153 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
154 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
155 INT142684 Protein_catabolism of OPRM1 2 0.66 0.48 1.81
156 INT67522 Negative_regulation of Negative_regulation of OPRD1 2 0.37 0.24 1.63
157 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55
158 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
159 INT50777 Phosphorylation of Oprd1 2 0.32 0 1.51
160 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
161 INT72008 Gene_expression of Gnai2 4 0.38 0.42 1.49
162 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
163 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36
164 INT115804 Regulation of Localization of OPRM1 2 0.33 0.12 1.33
165 INT29416 Positive_regulation of Binding of OPRD1 2 0.47 0.52 1.31
166 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3
167 INT50776 Regulation of Phosphorylation of Oprd1 1 0.01 0 1.3
168 INT67450 Negative_regulation of Localization of OPRM1 2 0.06 0.24 1.26
169 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
170 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
171 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
172 INT77216 Localization of DRD2 3 0.75 0 1.19
173 INT67523 Protein_catabolism of OPRD1 2 0.63 0.31 1.19
174 INT95374 Negative_regulation of Transcription of Oprd1 1 0.10 0 1.17
175 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
176 INT35786 Negative_regulation of Negative_regulation of OPRM1 2 0.33 0.91 1.1
177 INT74958 Positive_regulation of Phosphorylation of OPRD1 2 0.70 0 1.07
178 INT80966 Negative_regulation of Transcription of Oprd1 1 0.59 0 1.07
179 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
180 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
181 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
182 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
183 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
184 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
185 INT52391 Regulation of Gene_expression of OPRD1 2 0.26 0.28 0.98
186 INT119214 Transcription of Gnai2 1 0.44 0.06 0.96
187 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
188 INT90072 Regulation of Regulation of Oprd1 1 0.41 0 0.9
189 INT119213 Positive_regulation of Gnai2 1 0.42 0.06 0.88
190 INT109658 Gene_expression of IL1RAPL1 3 0.67 1.8 0.87
191 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
192 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
193 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
194 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
195 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
196 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
197 INT88271 Positive_regulation of Drd4 2 0.19 0.5 0.82
198 INT32418 Binding of NCS1 10 0.40 8.93 0.81
199 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
200 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
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