GO:0060591

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Name chondroblast differentiation
Categary Process
Go Slim No
Go Link GO:0060591
Unique Molecular Interactions 114
Total Molecular Interactions 146
Total Single Events 1187
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for chondroblast differentiation. They are ordered first by their pain relevance and then by number of times they were reported for chondroblast differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13282 Fgf2 Regulation of Ngf 1 0.66 0.21 0.91
2 INT66334 Fgf2 Regulation of Fgf1 1 0.37 0.17 0.9
3 INT13280 Ngf Regulation of Fgf2 1 0.48 0.2 0.9
4 INT66333 Fgf2 Negative_regulation of Positive_regulation of Npy 1 0.20 0.17 0.85
5 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
6 INT224726 Negative_regulation of Binding of Fgf2 and Cia1 1 0.01 0.92 0.62
7 INT224727 Binding of Fgf2 and Cia1 1 0.01 0.91 0.61
8 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
9 INT66336 Fgf2 Regulation of Gene_expression of Npy 1 0.12 0.09 0.5
10 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
11 INT66335 Fgf1 Regulation of Fgf2 1 0.10 0.08 0.45
12 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
13 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
14 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
15 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
16 INT295755 Fgf2 Regulation of MMP9 1 0.07 0.99 0.33
17 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
18 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
19 INT56091 FGF2 Positive_regulation of Transcription of SERPINE1 1 0.43 0.41 0.28
20 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
21 INT339535 FGF2 Positive_regulation of Gene_expression of CYP4A11 1 0.00 0.55 0.22
22 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
23 INT174861 Binding of FGF2 and VEGFA 1 0.34 0.59 0.2
24 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
25 INT201212 FGF2 Regulation of FGFR1 2 0.09 1.01 0.18
26 INT337697 FGF2 Regulation of VEGFA 1 0.03 0.51 0.18
27 INT152024 Ptgs1 Regulation of Fgf2 1 0.04 0.9 0.17
28 INT224730 Fgf2 Positive_regulation of Gm2458 1 0.01 0.39 0.17
29 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
30 INT24667 Binding of COL7A1 and FGF2 1 0.13 0.25 0.16
31 INT345999 Binding of Fgf2 and Gfap 1 0.37 0.09 0.16
32 INT298717 Fgf2 Positive_regulation of Gene_expression of PDGFA 1 0.01 0.23 0.15
33 INT172903 Fgf2 Positive_regulation of Gene_expression of Tbxa2r 1 0.03 0.58 0.15
34 INT345996 Fgf2 Positive_regulation of Gene_expression of Gfap 1 0.71 0.13 0.15
35 INT249849 Ufm1 Positive_regulation of Fgf2 1 0.01 0.56 0.14
36 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14
37 INT274472 IL12A Negative_regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
38 INT274473 IL12A Regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
39 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
40 INT345998 Fgf2 Positive_regulation of Gfap 1 0.48 0.09 0.13
41 INT170991 FGF2 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.72 0.13
42 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
43 INT300853 Ngf Positive_regulation of Fgf2 1 0.14 0.18 0.12
44 INT300860 Bdnf Positive_regulation of Fgf2 1 0.08 0.18 0.12
45 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
46 INT351545 FGF2 Positive_regulation of CDH16 1 0.01 0.19 0.1
47 INT351546 FGF2 Positive_regulation of L1CAM 1 0.34 0.19 0.1
48 INT351543 FGF2 Positive_regulation of NCAM1 1 0.03 0.14 0.1
49 INT122546 FGF2 Regulation of Localization of IL6 1 0.55 0.1 0.1
50 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1
51 INT122542 FGF2 Positive_regulation of Localization of IL6 1 0.62 0.09 0.09
52 INT117838 FGFR1 Regulation of FGF2 1 0.33 0.17 0.09
53 INT301921 UCK2 Regulation of Gene_expression of FGF2 1 0.01 1.22 0.08
54 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
55 INT222139 Binding of Egf and Fgf2 1 0.12 0 0.07
56 INT343479 Epo Positive_regulation of Fgf2 1 0.33 0.3 0.06
57 INT24666 Binding of EGF and FGF2 1 0.35 0 0.06
58 INT282552 POU5F1 Positive_regulation of FGF4 1 0.29 0.29 0.05
59 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
60 INT348690 Atp9a Positive_regulation of Gene_expression of Fgf2 1 0.00 0.21 0.05
61 INT295715 PTGER2 Regulation of Localization of FGF2 1 0.02 0.6 0.05
62 INT295723 VEGFA Regulation of Localization of FGF2 1 0.07 0.6 0.05
63 INT185270 Binding of Fgf2 and Ifaprc2 1 0.08 0.4 0.04
64 INT253017 PTTG1IP Regulation of Regulation of Fgf2 1 0.03 0.49 0.04
65 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
66 INT253010 Binding of PTTG1 and Fgf2 1 0.07 0.51 0.03
67 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
68 INT182918 Binding of DR1 and RARA 2 0.08 0 0
69 INT351155 AKT1 Positive_regulation of Positive_regulation of FGF2 1 0.03 0.81 0
70 INT182949 Binding of RARA and VDR 1 0.20 0 0
71 INT260268 Binding of FGF2 and FGFR1 1 0.46 0.94 0
72 INT348687 Fgf2 Regulation of Gene_expression of Plau 1 0.14 0 0
73 INT348688 Fgf2 Regulation of Plau 1 0.14 0 0
74 INT245078 FGF2 Positive_regulation of CXCR4 1 0.07 1.36 0
75 INT183090 Gene_expression of SULF1 Positive_regulation of Phosphorylation of FGF2 1 0.19 0.42 0
76 INT348693 Atp9a Positive_regulation of Fgf2 1 0.00 0.07 0
77 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0
78 INT183091 Binding of FGF2 and FGFR2 1 0.03 0.79 0
79 INT175076 Binding of Fgf2 and Klk1c9 1 0.02 0.38 0
80 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
81 INT150378 Fgf2 Positive_regulation of Mcpt1 1 0.67 1.79 0
82 INT150379 Fgf2 Positive_regulation of Gene_expression of Mcpt1 1 0.45 0.89 0
83 INT183093 SULF1 Negative_regulation of Binding of FGF2 1 0.17 0.41 0
84 INT180856 FGF2 Positive_regulation of Transcription of MT1L 1 0.30 1.06 0
85 INT299130 Cxcl12 Positive_regulation of Gene_expression of Fgf2 1 0.15 0.38 0
86 INT122541 FGF2 Positive_regulation of Transcription of IL6 1 0.42 0 0
87 INT331700 Fgf4 Positive_regulation of Gene_expression of Mmp9 1 0.30 0.41 0
88 INT122544 FGF2 Positive_regulation of Positive_regulation of GRAP2 1 0.20 0 0
89 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
90 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
91 INT182961 Binding of RARA and KCNIP3 1 0.21 0.76 0
92 INT249454 us Positive_regulation of Gene_expression of FGF2 1 0.01 0.13 0
93 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0
94 INT342559 FGF2 Positive_regulation of MAPK1 1 0.08 1.22 0
95 INT122539 FGF2 Regulation of Transcription of IL6 1 0.24 0 0
96 INT299129 Cxcl12 Positive_regulation of Transcription of Fgf2 1 0.16 0.38 0
97 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0
98 INT260266 Binding of FGF2 and FGFBP1 1 0.48 0.94 0
99 INT185268 Binding of Fgf2 and Sox1 1 0.19 0 0
100 INT122537 FGF2 Positive_regulation of Gene_expression of IL6 1 0.45 0 0
101 INT234440 Binding of PROC and RARA 1 0.00 0.73 0
102 INT222481 Fgf2 Positive_regulation of Gene_expression of Prl 1 0.10 0 0
103 INT122536 FGF2 Positive_regulation of Positive_regulation of SGSM3 1 0.73 0 0
104 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
105 INT122540 FGF2 Positive_regulation of Binding of JUN 1 0.24 0 0
106 INT225504 Binding of gr and Rara 1 0.02 0 0
107 INT122543 FGF2 Positive_regulation of JUN 1 0.36 0 0
108 INT122545 FGF2 Positive_regulation of Positive_regulation of MAPK3 1 0.53 0 0
109 INT182948 KCNIP3 Regulation of Transcription of RARA 1 0.23 0.55 0
110 INT342557 FGF2 Positive_regulation of MAPK3 1 0.03 1.21 0
111 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0
112 INT183089 Positive_regulation of Binding of FGF2 and FGFR2 1 0.04 0.4 0
113 INT130851 Acan Positive_regulation of Gene_expression of Bgn 1 0.02 0.07 0
114 INT331701 Fgf4 Positive_regulation of Gene_expression of Kdr 1 0.11 0.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for chondroblast differentiation. They are ordered first by their pain relevance and then by number of times they were reported in chondroblast differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
2 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
3 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
4 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49
5 INT68133 Localization of Fgf2 36 0.81 15.37 9.14
6 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12
7 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
8 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2
9 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18
10 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
11 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
12 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
13 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
14 INT168003 Localization of Fgf2 24 0.80 12.52 3.31
15 INT61547 Regulation of Fgf2 21 0.47 7.23 3.24
16 INT101083 Binding of Fgf2 14 0.42 4.12 3.14
17 INT115317 Transcription of FGF2 14 0.62 12.79 3
18 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3
19 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98
20 INT65033 Negative_regulation of Fgf2 21 0.59 12.36 2.94
21 INT64688 Negative_regulation of Gene_expression of Fgf2 5 0.59 5.07 2.56
22 INT24672 Localization of FGF2 27 0.71 14.59 2.48
23 INT97898 Regulation of FGF2 8 0.60 3.85 2.09
24 INT65207 Positive_regulation of Positive_regulation of Fgf2 10 0.70 3.5 2.08
25 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03
26 INT99636 Negative_regulation of Localization of Fgf2 4 0.41 1.32 1.97
27 INT64687 Regulation of Gene_expression of Fgf2 7 0.62 2.29 1.89
28 INT101707 Gene_expression of FGF4 9 0.78 3.99 1.73
29 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68
30 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
31 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
32 INT122547 Positive_regulation of Positive_regulation of FGF2 3 0.44 3.1 1.49
33 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48
34 INT67457 Binding of Rara 12 0.24 8.28 1.45
35 INT24671 Binding of FGF2 14 0.35 8.73 1.43
36 INT81400 Binding of RARA 25 0.36 12.93 1.27
37 INT174866 Regulation of Gene_expression of FGF2 4 0.39 7.13 1.2
38 INT182985 Transcription of RARA 9 0.60 3.52 1.12
39 INT147407 Protein_catabolism of FGF2 1 0.91 0.33 1.06
40 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
41 INT184236 Positive_regulation of Localization of Fgf2 1 0.27 2.23 0.95
42 INT192090 Localization of Rara 6 0.46 4.15 0.89
43 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
44 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
45 INT178498 Negative_regulation of Fgf2 11 0.42 4.21 0.84
46 INT48250 Regulation of Rara 3 0.29 2.47 0.83
47 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
48 INT212109 Localization of RARA 5 0.65 3.17 0.79
49 INT101886 Transcription of Fgf2 8 0.65 4.46 0.78
50 INT91398 Regulation of RARA 7 0.59 5.84 0.67
51 INT76142 Positive_regulation of Regulation of Fgf2 2 0.47 0.34 0.64
52 INT185240 Binding of Fgf2 14 0.37 7.39 0.59
53 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
54 INT142907 Regulation of Localization of Fgf2 1 0.44 1.16 0.53
55 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
56 INT71274 Gene_expression of Acan 3 0.12 0.99 0.5
57 INT249843 Positive_regulation of Transcription of Fgf2 3 0.59 2.26 0.5
58 INT92683 Transcription of Fgf2 3 0.51 1.83 0.49
59 INT142906 Positive_regulation of Localization of Fgf2 2 0.43 1.82 0.49
60 INT337348 Regulation of Gene_expression of Fgf2 2 0.45 0.54 0.44
61 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
62 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
63 INT300851 Negative_regulation of Positive_regulation of Fgf2 3 0.42 1.01 0.4
64 INT174870 Negative_regulation of Transcription of FGF2 1 0.37 1.66 0.38
65 INT114473 Regulation of Gene_expression of FGF4 1 0.45 0.81 0.32
66 INT345995 Negative_regulation of Gene_expression of Fgf2 1 0.43 0.43 0.29
67 INT114474 Binding of FGF4 1 0.32 0.66 0.28
68 INT71271 Positive_regulation of Acan 2 0.09 0.55 0.27
69 INT71275 Positive_regulation of Localization of Acan 1 0.05 0.48 0.27
70 INT71272 Localization of Acan 1 0.08 0.48 0.26
71 INT122548 Negative_regulation of Localization of FGF2 3 0.41 1.01 0.22
72 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
73 INT174869 Regulation of Negative_regulation of FGF2 1 0.39 1.59 0.22
74 INT175919 Negative_regulation of Positive_regulation of FGF2 1 0.22 0.96 0.22
75 INT345990 Regulation of Positive_regulation of Fgf2 1 0.45 0.14 0.21
76 INT289335 Negative_regulation of Binding of Fgf2 1 0.28 0.33 0.21
77 INT331725 Regulation of Localization of FGF2 2 0.17 0.52 0.19
78 INT130849 Transcription of Acan 1 0.10 0.46 0.19
79 INT295673 Regulation of FGF4 1 0.05 0.83 0.17
80 INT293714 Regulation of Localization of Fgf2 2 0.45 0.1 0.14
81 INT345994 Regulation of Binding of Fgf2 1 0.45 0 0.14
82 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
83 INT326978 Regulation of Binding of FGF2 1 0.21 0.06 0.13
84 INT174865 Regulation of Transcription of FGF2 1 0.39 0.72 0.11
85 INT183123 Phosphorylation of FGF2 3 0.30 1.2 0.08
86 INT281762 Negative_regulation of Localization of Fgf2 1 0.16 1 0.08
87 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
88 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
89 INT240518 Negative_regulation of Positive_regulation of Fgf2 2 0.35 0.66 0.07
90 INT67143 Binding of Acan 1 0.36 0 0.07
91 INT185253 Positive_regulation of Binding of Fgf2 1 0.28 0 0.05
92 INT65032 Positive_regulation of Negative_regulation of Fgf2 2 0.47 0.63 0.04
93 INT301929 Positive_regulation of Localization of FGF2 1 0.23 1.05 0.04
94 INT282588 Positive_regulation of Gene_expression of FGF4 1 0.30 0.25 0.04
95 INT331697 Gene_expression of Fgf4 6 0.58 1.57 0
96 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
97 INT144612 Positive_regulation of Binding of FGF2 2 0.28 0.93 0
98 INT331699 Positive_regulation of Fgf4 2 0.45 0.69 0
99 INT183130 Positive_regulation of Phosphorylation of FGF2 1 0.18 0.2 0
100 INT355397 Regulation of Transcription of Fgf2 1 0.37 0.24 0
101 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
102 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
103 INT331696 Localization of Fgf4 1 0.68 1.38 0
104 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
105 INT183115 Negative_regulation of Phosphorylation of FGF2 1 0.15 0.25 0
106 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
107 INT335001 Positive_regulation of Gene_expression of Fgf4 1 0.13 0 0
108 INT130844 Positive_regulation of Gene_expression of Acan 1 0.09 0 0
109 INT343455 Phosphorylation of Fgf2 1 0.39 0.1 0
110 INT286717 Regulation of Fgf4 1 0.26 0 0
111 INT130848 Positive_regulation of Transcription of Acan 1 0.09 0 0
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