GO:0070410

From wiki-pain
Revision as of 17:32, 25 January 2013 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Name co-SMAD binding
Categary Function
Go Slim No
Go Link GO:0070410
Unique Molecular Interactions 64
Total Molecular Interactions 89
Total Single Events 489
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for co-SMAD binding. They are ordered first by their pain relevance and then by number of times they were reported for co-SMAD binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
2 INT215543 Negative_regulation of Trim33 Negative_regulation of Gopc 1 0.15 0.35 0.48
3 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
4 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
5 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
6 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
7 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
8 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
9 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12
10 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
11 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
12 INT233278 Binding of LBX1 and Tgif1 1 0.00 0.25 0.06
13 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
14 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
15 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
16 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
17 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
18 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
19 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
20 INT311909 Gene_expression of Smad6 Negative_regulation of Gene_expression of Col10a1 1 0.02 0.54 0.04
21 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
22 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
23 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
24 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
25 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
26 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
27 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
28 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
29 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
30 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
31 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
32 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
33 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
34 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
35 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
36 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
37 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
38 INT233279 Binding of TLX1 and Tgif1 1 0.00 0.05 0
39 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
40 INT329746 ENG Positive_regulation of SMAD1 1 0.15 0.44 0
41 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
42 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
43 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
44 INT185271 Pax6 Regulation of Psmd1 1 0.02 0 0
45 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
46 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
47 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
48 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
49 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
50 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
51 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
52 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
53 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0
54 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0
55 INT218670 Olr811 Regulation of Phosphorylation of Smad2 1 0.00 0.33 0
56 INT269938 Smad2 Positive_regulation of Tpt1 1 0.14 0.07 0
57 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
58 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
59 INT283716 Neurod1 Positive_regulation of Pax6 1 0.23 0.46 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for co-SMAD binding. They are ordered first by their pain relevance and then by number of times they were reported in co-SMAD binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
2 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
3 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
4 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
5 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
6 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
7 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
8 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
9 INT215518 Negative_regulation of Trim33 2 0.57 0.43 0.88
10 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
11 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
12 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
13 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
14 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
15 INT215519 Protein_catabolism of Trim33 1 0.86 0.39 0.69
16 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
17 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
18 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
19 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
20 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41
21 INT311882 Negative_regulation of Smad1 1 0.25 0.99 0.39
22 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
23 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
24 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
25 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
26 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
27 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
28 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
29 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
30 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
31 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
32 INT265311 Localization of Smad2 5 0.50 1.57 0.21
33 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
34 INT272889 Negative_regulation of Smad6 2 0.20 1.31 0.19
35 INT311891 Phosphorylation of Smad1 4 0.51 1.34 0.18
36 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
37 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
38 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
39 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14
40 INT135490 Localization of Smad2 1 0.51 0.08 0.14
41 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
42 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
43 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
44 INT353269 Negative_regulation of Positive_regulation of Tgif1 1 0.11 0.5 0.13
45 INT353275 Positive_regulation of Tgif1 1 0.13 0.5 0.13
46 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
47 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
48 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
49 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
50 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
51 INT262799 Localization of Smad3 6 0.56 2.09 0.04
52 INT337908 Binding of Smad2 3 0.24 1.06 0.04
53 INT311890 Binding of Smad1 2 0.23 0.46 0.04
54 INT172971 Gene_expression of Smad6 2 0.37 1.77 0.04
55 INT311898 Positive_regulation of Gene_expression of Smad6 1 0.33 0.53 0.04
56 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
57 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
58 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
59 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
60 INT206481 Transcription of Pax6 2 0.41 0.19 0.03
61 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
62 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
63 INT353260 Gene_expression of Tgif1 1 0.21 0 0.03
64 INT336419 Negative_regulation of Gene_expression of Pax6 1 0.45 0.12 0.03
65 INT353277 Positive_regulation of Gene_expression of Tgif1 1 0.18 0 0.03
66 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
67 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
68 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
69 INT353279 Phosphorylation of Tgif1 1 0.22 0.06 0.03
70 INT311888 Negative_regulation of Phosphorylation of Smad1 1 0.25 0.48 0.03
71 INT268378 Positive_regulation of Phosphorylation of SMAD2 3 0.67 1.22 0
72 INT271411 Positive_regulation of Positive_regulation of Smad2 2 0.45 0.9 0
73 INT265337 Binding of Smad3 2 0.35 1 0
74 INT291889 Negative_regulation of Pax6 2 0.45 0.39 0
75 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
76 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
77 INT329771 Positive_regulation of SMAD1 1 0.36 2.3 0
78 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
79 INT329780 Negative_regulation of Positive_regulation of SMAD1 1 0.22 0.51 0
80 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
81 INT296615 Positive_regulation of Smad2 1 0.50 1.51 0
82 INT324196 Positive_regulation of Gene_expression of Pax6 1 0.36 0 0
83 INT233252 Binding of Tgif1 1 0.01 0.74 0
84 INT291888 Regulation of Gene_expression of Pax6 1 0.33 0 0
85 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
86 INT233211 Regulation of Binding of Tgif1 1 0.00 0.36 0
87 INT336416 Binding of Pax6 1 0.28 0 0
88 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
89 INT353276 Negative_regulation of Tgif1 1 0.11 0 0
90 INT336420 Positive_regulation of Binding of Pax6 1 0.38 0 0
91 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
92 INT295579 Negative_regulation of Phosphorylation of SMAD2 1 0.42 0.08 0
93 INT291885 Regulation of Pax6 1 0.15 0 0
94 INT310173 Binding of Smad6 1 0.05 0 0
95 INT200852 Positive_regulation of Pax6 1 0.11 0 0
96 INT208927 Localization of Pax6 1 0.11 0 0
97 INT268363 Binding of SMAD3 1 0.20 0.56 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox