GO:0070493

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Name thrombin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0070493
Unique Molecular Interactions 172
Total Molecular Interactions 265
Total Single Events 1299
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thrombin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for thrombin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
2 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
3 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
4 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
5 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
6 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
7 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
8 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
9 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
10 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
11 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
12 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
13 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
14 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
15 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
16 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
17 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
18 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
19 INT167907 Binding of F2r and ITS 1 0.01 0.7 0.55
20 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
21 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
22 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5
23 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
24 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
25 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
26 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41
27 INT338044 F2 Positive_regulation of Pard3 1 0.08 0.38 0.4
28 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
29 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
30 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
31 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
32 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
33 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
34 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
35 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
36 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
37 INT338051 Ngf Positive_regulation of Localization of F2 1 0.11 0 0.32
38 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
39 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3
40 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
41 INT338039 F2 Positive_regulation of Positive_regulation of Prkca 1 0.04 0.52 0.27
42 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
43 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
44 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
45 INT305686 Binding of Gfap and F2r 1 0.01 0 0.25
46 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24
47 INT123660 F2R Positive_regulation of PAR1 2 0.10 1.96 0.22
48 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
49 INT338043 F2 Positive_regulation of Localization of Prkca 1 0.04 0.1 0.2
50 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
51 INT123664 F2R Positive_regulation of PAR4 1 0.03 0.51 0.19
52 INT338050 Ngf Positive_regulation of F2 1 0.11 0.25 0.18
53 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
54 INT253776 Binding of THBD and F2 1 0.00 1.15 0.18
55 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
56 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18
57 INT338061 Nrtn Positive_regulation of F2 1 0.07 0.25 0.18
58 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
59 INT63511 F2 Negative_regulation of SERPINE2 1 0.15 0.97 0.16
60 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
61 INT207117 Binding of VEGFA and F2r 1 0.02 0.56 0.15
62 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
63 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
64 INT338040 Ctsg Positive_regulation of F2r 1 0.29 0 0.15
65 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
66 INT338052 F2r Positive_regulation of F2rl3 1 0.12 0 0.15
67 INT338056 Ctsg Positive_regulation of F2rl3 1 0.30 0 0.15
68 INT338055 F2 Positive_regulation of Par2 1 0.08 0.22 0.13
69 INT207109 F2 Positive_regulation of Phosphorylation of Akt2 1 0.08 0.25 0.12
70 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
71 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
72 INT347515 Binding of GP1BA and Vwf 1 0.01 0.19 0.11
73 INT338048 F2rl3 Positive_regulation of Pard3 1 0.11 0.05 0.11
74 INT262255 Binding of APC and F2R 1 0.05 3 0.1
75 INT298502 F10 Positive_regulation of F2 1 0.00 0.12 0.09
76 INT289711 Binding of F2 and Spp1 1 0.08 0.21 0.08
77 INT289710 F2 Regulation of Spp1 1 0.04 0 0.08
78 INT253774 THBD Regulation of F2 1 0.00 0.61 0.08
79 INT61385 FANCB Negative_regulation of PLEK 1 0.42 0.13 0.07
80 INT37547 Binding of GP1BA and F8 1 0.03 0.15 0.07
81 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05
82 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
83 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04
84 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
85 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
86 INT331881 F2 Positive_regulation of F8 1 0.10 0.53 0.03
87 INT231862 F2 Positive_regulation of INCENP 1 0.00 0.86 0.03
88 INT261729 COL5A2 Regulation of Gene_expression of F2R 1 0.18 0 0
89 INT308131 PLEK Positive_regulation of F2 1 0.12 0.08 0
90 INT325904 Binding of F2 and Wbp5 1 0.01 1.22 0
91 INT325898 Negative_regulation of Binding of F2 and Gopc 1 0.03 0.14 0
92 INT325910 Wbp5 Positive_regulation of Positive_regulation of F2 1 0.01 0.67 0
93 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0
94 INT308132 Binding of RRM1 and F2 1 0.01 0 0
95 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0
96 INT325902 Binding of F2 and Fgg 1 0.01 0 0
97 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
98 INT286682 Maob Positive_regulation of Positive_regulation of PLEK 1 0.51 0.89 0
99 INT354487 Binding of F9 and PLEK 1 0.52 0.14 0
100 INT325903 Binding of F2 and Gopc 1 0.02 0.26 0
101 INT275985 Binding of PLEK and Gp6 1 0.29 0 0
102 INT261732 F2 Positive_regulation of F2R 1 0.14 0 0
103 INT338047 Binding of F2r and Pard3 1 0.11 0 0
104 INT325901 Binding of Dio1 and F2 1 0.01 0.63 0
105 INT270084 Binding of PLEK and PSMG1 1 0.09 0.26 0
106 INT325897 Negative_regulation of Binding of F2 and Wbp5 1 0.01 0.96 0
107 INT142143 F2r Regulation of Plcg1 1 0.02 0.07 0
108 INT289708 Tnxa Positive_regulation of F2 1 0.00 0 0
109 INT325905 Wbp5 Positive_regulation of F2 1 0.01 0.37 0
110 INT289709 Gopc Positive_regulation of F2 1 0.05 0 0
111 INT261730 ROCK1 Positive_regulation of Positive_regulation of F2R 1 0.37 0 0
112 INT325899 Binding of Hps3 and F2 1 0.12 2.43 0
113 INT142142 F2r Positive_regulation of Phosphorylation of Plcg1 1 0.03 0.08 0
114 INT353337 F2r Positive_regulation of Gene_expression of Mif 1 0.46 0 0
115 INT261735 Positive_regulation of F2 Positive_regulation of F2R 1 0.14 0 0
116 INT325907 Positive_regulation of Binding of F2 and Gopc 1 0.03 0.12 0
117 INT308130 Binding of F13A1 and F2 1 0.01 0.49 0
118 INT231837 F2 Regulation of Akt1 1 0.02 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thrombin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in thrombin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
2 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
3 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
4 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
5 INT18412 Binding of PLEK 49 0.47 17.82 10.72
6 INT3366 Localization of PLEK 44 0.78 15.83 9.55
7 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
8 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
9 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
10 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
11 INT22839 Gene_expression of F2 31 0.74 15.53 5.56
12 INT159819 Gene_expression of F2rl3 5 0.45 5.53 5.24
13 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08
14 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
15 INT63506 Localization of F2 21 0.77 7.53 3.41
16 INT46754 Localization of F2r 7 0.78 2.36 3.24
17 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
18 INT82653 Regulation of F2r 8 0.36 3.78 2.62
19 INT111017 Regulation of F2rl1 3 0.22 0 2.61
20 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
21 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
22 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
23 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
24 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2
25 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
26 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
27 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
28 INT156231 Binding of F2r 9 0.23 3.78 1.57
29 INT22836 Regulation of F2 9 0.59 2.3 1.49
30 INT158311 Positive_regulation of F2rl3 7 0.51 1.77 1.44
31 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
32 INT117498 Regulation of Positive_regulation of F2r 1 0.18 0.91 1.24
33 INT98976 Regulation of F2r 7 0.60 0.71 1.22
34 INT338033 Localization of F2r 1 0.41 0.62 1.2
35 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
36 INT195105 Negative_regulation of Gene_expression of F2r 3 0.37 1.41 0.91
37 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
38 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
39 INT196322 Binding of F2 18 0.15 7.74 0.83
40 INT79181 Negative_regulation of GP1BA 2 0.06 2.23 0.8
41 INT195099 Positive_regulation of Gene_expression of F2r 7 0.57 5.31 0.78
42 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
43 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
44 INT353325 Positive_regulation of Localization of F2r 1 0.49 1.31 0.76
45 INT62192 Regulation of Localization of F2r 2 0.60 0.59 0.7
46 INT207089 Regulation of Negative_regulation of F2r 1 0.17 1.49 0.62
47 INT353321 Regulation of Positive_regulation of F2r 1 0.60 0.6 0.62
48 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
49 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
50 INT123672 Positive_regulation of F2R 9 0.47 0.77 0.58
51 INT69098 Positive_regulation of Gene_expression of F2 5 0.66 3.79 0.58
52 INT191777 Binding of F2r 2 0.02 0.89 0.54
53 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
54 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
55 INT338026 Regulation of Localization of F2r 1 0.25 0.05 0.52
56 INT99615 Gene_expression of GP1BA 12 0.75 2.98 0.5
57 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
58 INT195092 Protein_catabolism of F2 4 0.26 2.75 0.47
59 INT213786 Positive_regulation of Positive_regulation of F2rl3 1 0.27 0.92 0.46
60 INT113641 Negative_regulation of Gene_expression of GP1BA 4 0.57 2.2 0.44
61 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
62 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
63 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
64 INT69104 Positive_regulation of Localization of F2 2 0.66 0.06 0.39
65 INT69103 Negative_regulation of Localization of F2 2 0.56 0.48 0.37
66 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
67 INT144981 Binding of F2R 3 0.36 1.66 0.35
68 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
69 INT353324 Negative_regulation of Positive_regulation of F2r 1 0.41 0.24 0.35
70 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
71 INT161343 Negative_regulation of Positive_regulation of F2rl3 1 0.31 0 0.29
72 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
73 INT62191 Negative_regulation of Localization of F2r 1 0.35 0 0.26
74 INT195091 Negative_regulation of Positive_regulation of F2r 1 0.48 1.69 0.25
75 INT158312 Negative_regulation of F2rl3 3 0.52 1.8 0.24
76 INT305682 Positive_regulation of Positive_regulation of F2r 1 0.03 0 0.24
77 INT42592 Negative_regulation of Transcription of PLEK 1 0.41 0 0.21
78 INT42593 Transcription of PLEK 1 0.67 0 0.2
79 INT69101 Regulation of Gene_expression of F2 1 0.43 0 0.2
80 INT17010 Regulation of GP1BA 2 0.03 0.93 0.18
81 INT195112 Positive_regulation of Positive_regulation of F2r 1 0.41 0.97 0.18
82 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
83 INT160255 Negative_regulation of Negative_regulation of F2rl3 1 0.38 1.8 0.18
84 INT108192 Regulation of Binding of PLEK 1 0.60 0.17 0.17
85 INT261745 Regulation of F2R 1 0.43 0.22 0.16
86 INT261739 Regulation of Gene_expression of F2R 1 0.26 0.22 0.16
87 INT98700 Regulation of Gene_expression of F2r 1 0.45 0 0.15
88 INT207087 Negative_regulation of Binding of F2r 1 0.27 0.06 0.14
89 INT16719 Positive_regulation of Positive_regulation of PLEK 1 0.45 0.13 0.14
90 INT213764 Binding of F2rl3 2 0.21 0.37 0.11
91 INT307530 Negative_regulation of Binding of F2R 1 0.03 0 0.09
92 INT200604 Positive_regulation of Binding of F2 1 0.07 0.91 0.08
93 INT145503 Protein_catabolism of F2r 1 0.66 0.46 0.07
94 INT195082 Regulation of Gene_expression of F2r 1 0.37 0.67 0.07
95 INT261737 Transcription of F2R 1 0.50 0.31 0.05
96 INT196321 Negative_regulation of Gene_expression of F2 2 0.17 1.48 0.04
97 INT353327 Transcription of F2r 1 0.67 0.21 0.03
98 INT191771 Positive_regulation of Gene_expression of F2r 1 0.01 0.31 0.03
99 INT231815 Positive_regulation of Positive_regulation of F2 1 0.10 0 0
100 INT338031 Transcription of F2r 1 0.39 0 0
101 INT338028 Positive_regulation of Gene_expression of F2rl3 1 0.20 0 0
102 INT80131 Negative_regulation of Regulation of F2 1 0.05 0 0
103 INT149028 Positive_regulation of Gene_expression of F2rl1 1 0.43 0 0
104 INT180099 Binding of Plek 1 0.02 0 0
105 INT149032 Regulation of Gene_expression of F2rl1 1 0.23 0 0
106 INT306376 Positive_regulation of GP1BA 1 0.05 0 0
107 INT353323 Negative_regulation of Gene_expression of F2r 1 0.41 0 0
108 INT261741 Negative_regulation of Positive_regulation of F2R 1 0.40 0 0
109 INT261743 Positive_regulation of Positive_regulation of F2R 1 0.44 0 0
110 INT338034 Transcription of F2rl3 1 0.28 0 0
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