GO:0071141

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Latest revision as of 09:28, 28 January 2013

Name SMAD protein complex
Categary Component
Go Slim No
Go Link GO:0071141
Unique Molecular Interactions 68
Total Molecular Interactions 104
Total Single Events 575
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

[edit] Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for SMAD protein complex. They are ordered first by their pain relevance and then by number of times they were reported for SMAD protein complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
2 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
3 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
4 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
5 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
6 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
7 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
8 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
9 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
10 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
11 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
12 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
13 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
14 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
15 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
16 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
17 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
18 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
19 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03
20 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
21 INT277927 WIF1 Negative_regulation of SMAD4 1 0.23 0.37 0
22 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
23 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
24 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
25 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
26 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
27 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
28 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
29 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
30 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
31 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
32 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
33 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
34 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
35 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
36 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0
37 INT254857 Tgfb1 Positive_regulation of Phosphorylation of Smad3 1 0.03 0.44 0
38 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0
39 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
40 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
41 INT269942 Sox17 Regulation of Smad3 1 0.37 0.12 0
42 INT218665 Olr811 Negative_regulation of Phosphorylation of Smad3 1 0.01 0.33 0
43 INT269929 Binding of Cdkn2b and Smad3 1 0.18 0.89 0
44 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
45 INT269935 Binding of Smad3 and Scn5a 1 0.13 0 0
46 INT269930 Binding of Smad3 and Sox17 1 0.40 1.16 0
47 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
48 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
49 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
50 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
51 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0
52 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
53 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
54 INT218670 Olr811 Regulation of Phosphorylation of Smad2 1 0.00 0.33 0
55 INT269938 Smad2 Positive_regulation of Tpt1 1 0.14 0.07 0
56 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
57 INT269946 Binding of Smad3 and Gopc 1 0.08 0 0
58 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0
59 INT172981 PAN3 Negative_regulation of SMAD4 1 0.01 0.98 0

[edit] Single Events

The table below shows the top 100 pain related interactions that have been reported for SMAD protein complex. They are ordered first by their pain relevance and then by number of times they were reported in SMAD protein complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
2 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
3 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
4 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
5 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
6 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
7 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
8 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
9 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
10 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
11 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
12 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
13 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
14 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
15 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
16 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
17 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
18 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
19 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
20 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
21 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
22 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
23 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
24 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
25 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
26 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
27 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
28 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
29 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
30 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
31 INT92100 Binding of Smad4 5 0.31 2.23 0.3
32 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
33 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
34 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
35 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
36 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
37 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
38 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
39 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
40 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
41 INT265311 Localization of Smad2 5 0.50 1.57 0.21
42 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2
43 INT277935 Binding of SMAD4 4 0.28 1.12 0.17
44 INT157797 Negative_regulation of Phosphorylation of Smad3 3 0.40 0.95 0.17
45 INT268365 Binding of SMAD2 2 0.47 0.56 0.17
46 INT139977 Regulation of Smad4 1 0.16 1.41 0.15
47 INT135490 Localization of Smad2 1 0.51 0.08 0.14
48 INT158903 Gene_expression of Smad3 2 0.56 0.54 0.13
49 INT158890 Negative_regulation of Gene_expression of Smad3 1 0.42 0.13 0.13
50 INT158893 Negative_regulation of Gene_expression of Smad2 1 0.30 0.13 0.13
51 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12
52 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12
53 INT325505 Transcription of Smad2 1 0.67 0.16 0.09
54 INT325510 Transcription of Smad4 1 0.67 0.16 0.09
55 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
56 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
57 INT254790 Localization of Smad4 2 0.37 0.54 0.06
58 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06
59 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
60 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
61 INT254814 Positive_regulation of Phosphorylation of Smad2 7 0.33 3.74 0.04
62 INT262799 Localization of Smad3 6 0.56 2.09 0.04
63 INT337908 Binding of Smad2 3 0.24 1.06 0.04
64 INT353261 Negative_regulation of Localization of Smad2 1 0.33 0 0.04
65 INT334291 Positive_regulation of Gene_expression of SMAD4 1 0.18 0 0.04
66 INT353263 Positive_regulation of Localization of Smad2 1 0.33 0.15 0.04
67 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03
68 INT184722 Positive_regulation of Smad3 3 0.47 1.22 0.03
69 INT271419 Localization of SMAD3 2 0.11 0.13 0.03
70 INT254799 Transcription of Smad2 1 0.19 0.52 0.03
71 INT353266 Negative_regulation of Negative_regulation of Smad2 1 0.28 0 0.03
72 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03
73 INT254812 Positive_regulation of Phosphorylation of Smad3 1 0.25 0.94 0.03
74 INT254805 Transcription of Smad3 1 0.28 0.76 0.03
75 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
76 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0
77 INT268378 Positive_regulation of Phosphorylation of SMAD2 3 0.67 1.22 0
78 INT271411 Positive_regulation of Positive_regulation of Smad2 2 0.45 0.9 0
79 INT334327 Regulation of SMAD4 2 0.35 1.73 0
80 INT265337 Binding of Smad3 2 0.35 1 0
81 INT269913 Positive_regulation of Binding of Smad3 1 0.34 0.3 0
82 INT218693 Negative_regulation of Phosphorylation of Smad3 1 0.19 0.32 0
83 INT268368 Transcription of SMAD4 1 0.54 1.7 0
84 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
85 INT329784 Gene_expression of SMAD3 1 0.31 0.41 0
86 INT196923 Binding of Hmga2 1 0.47 2.5 0
87 INT268384 Positive_regulation of Phosphorylation of SMAD3 1 0.29 1.22 0
88 INT300344 Localization of HMGA2 1 0.42 1.75 0
89 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
90 INT296615 Positive_regulation of Smad2 1 0.50 1.51 0
91 INT173000 Negative_regulation of Localization of SMAD4 1 0.22 0.98 0
92 INT173008 Localization of SMAD4 1 0.38 0.97 0
93 INT269873 Positive_regulation of Negative_regulation of Smad3 1 0.34 0.31 0
94 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
95 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
96 INT268382 Phosphorylation of SMAD3 1 0.34 0.6 0
97 INT334289 Regulation of Binding of SMAD4 1 0.16 0 0
98 INT268581 Regulation of HMGA2 1 0.18 0.72 0
99 INT334288 Regulation of Negative_regulation of SMAD4 1 0.16 0 0
100 INT228250 Positive_regulation of Smad4 1 0.45 1.93 0
101 INT254809 Positive_regulation of Transcription of Smad3 1 0.25 0.24 0
102 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
103 INT295579 Negative_regulation of Phosphorylation of SMAD2 1 0.42 0.08 0
104 INT196921 Localization of Hmga2 1 0.74 0.44 0
105 INT228247 Regulation of Positive_regulation of Smad4 1 0.26 0.97 0
106 INT268363 Binding of SMAD3 1 0.20 0.56 0
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