GO:0071404

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Name cellular response to low-density lipoprotein particle stimulus
Categary Process
Go Slim No
Go Link GO:0071404
Unique Molecular Interactions 103
Total Molecular Interactions 153
Total Single Events 1433
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to low-density lipoprotein particle stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to low-density lipoprotein particle stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
2 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
3 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
4 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
5 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
6 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
7 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
8 INT196525 Binding of MMP2 and MMP9 2 0.32 2.49 0.78
9 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78
10 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74
11 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7
12 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69
13 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66
14 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66
15 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65
16 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
17 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
18 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
19 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
20 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
21 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6
22 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
23 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57
24 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56
25 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56
26 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52
27 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52
28 INT196524 Binding of MMP1 and MMP9 1 0.31 0.74 0.51
29 INT196519 Positive_regulation of Binding of MMP1 and MMP9 1 0.42 0.74 0.51
30 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
31 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
32 INT127664 Negative_regulation of PDE4A Negative_regulation of MMP9 1 0.37 0.76 0.48
33 INT127665 Negative_regulation of PDE4A Negative_regulation of Transcription of MMP9 1 0.37 0.76 0.48
34 INT303445 Mmp3 Positive_regulation of Mmp9 1 0.01 1.19 0.47
35 INT226070 Binding of CRP and MMP9 1 0.51 1.13 0.42
36 INT226072 Binding of MMP9 and SHBG 1 0.15 1.02 0.39
37 INT302466 Positive_regulation of F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.1 0.35
38 INT295755 Fgf2 Regulation of MMP9 1 0.07 0.99 0.33
39 INT295717 VEGFA Regulation of MMP9 1 0.01 0.98 0.33
40 INT340616 COL4A4 Regulation of MMP9 1 0.12 0.95 0.32
41 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3
42 INT213062 PTGS1 Regulation of Gene_expression of MMP9 1 0.04 0.25 0.3
43 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3
44 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
45 INT187113 Binding of IGHG3 and MMP9 1 0.01 0.63 0.3
46 INT260896 CRH Positive_regulation of Localization of MMP9 1 0.15 0.15 0.3
47 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29
48 INT275548 Il10 Regulation of Mmp9 1 0.00 0.86 0.28
49 INT302468 INCENP Positive_regulation of Gene_expression of MMP9 1 0.01 0.72 0.26
50 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
51 INT205155 Negative_regulation of Binding of CD44 and MMP9 1 0.32 1.98 0.23
52 INT213061 PTGER2 Regulation of Gene_expression of MMP9 1 0.03 0.25 0.23
53 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22
54 INT325470 MMP3 Positive_regulation of MMP9 1 0.17 0.9 0.2
55 INT335298 IRF6 Positive_regulation of MMP9 1 0.01 0.21 0.19
56 INT226071 Binding of HSD11B1 and MMP9 1 0.09 0.47 0.19
57 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
58 INT169117 PLAU Regulation of Gene_expression of MMP9 1 0.47 0.49 0.17
59 INT179934 Mapk8 Regulation of Gene_expression of Mmp9 1 0.06 0.48 0.15
60 INT179931 Ephb1 Regulation of Gene_expression of Mmp9 1 0.04 0.48 0.15
61 INT195443 MMP2 Positive_regulation of Protein_catabolism of Mmp9 1 0.15 0.95 0.14
62 INT264397 MMP9 Regulation of Positive_regulation of MMP13 1 0.20 0.06 0.12
63 INT275462 Negative_regulation of JUN Positive_regulation of Gene_expression of MMP9 1 0.04 0.27 0.12
64 INT266660 PTGER2 Positive_regulation of Gene_expression of MMP9 1 0.06 0.08 0.12
65 INT264395 MMP9 Regulation of Positive_regulation of MMP1 1 0.13 0.06 0.12
66 INT264400 MMP9 Regulation of MMP14 1 0.08 0.06 0.11
67 INT264398 MMP9 Regulation of MMP2 1 0.07 0.06 0.11
68 INT264388 MMP9 Regulation of MMP3 1 0.06 0.06 0.11
69 INT294449 KLK4 Negative_regulation of MMP9 1 0.01 0 0.1
70 INT236467 MMP9 Negative_regulation of SNRPB 1 0.01 0.45 0.1
71 INT311725 Binding of Plat and Mmp9 1 0.36 0.64 0.1
72 INT183796 IL17A Positive_regulation of MMP9 1 0.28 0.24 0.1
73 INT183795 IL17A Positive_regulation of Positive_regulation of MMP9 1 0.30 0.24 0.1
74 INT266655 TIMP1 Regulation of Gene_expression of MMP9 1 0.18 0.11 0.06
75 INT179932 Trib3 Negative_regulation of Positive_regulation of Mmp9 1 0.01 0.41 0.05
76 INT205154 Binding of MMP9 and SPP1 1 0.25 0.45 0.05
77 INT209155 MMP9 Negative_regulation of TIMP1 1 0.01 0.17 0.05
78 INT179933 Trib3 Negative_regulation of Gene_expression of Mmp9 1 0.01 0.41 0.05
79 INT209157 MMP9 Negative_regulation of MMP2 1 0.00 0.16 0.05
80 INT175625 PAR1 Regulation of Gene_expression of MMP9 1 0.02 1.25 0.05
81 INT311729 Plat Positive_regulation of Positive_regulation of Mmp9 1 0.34 0.71 0.04
82 INT317417 Binding of CFH and MMP9 1 0.10 1.27 0.04
83 INT348685 Positive_regulation of Mmp9 Positive_regulation of Protein_catabolism of Plau 1 0.10 0.27 0.03
84 INT340614 Binding of ENG and MMP9 1 0.16 0.14 0
85 INT245111 MMP9 Positive_regulation of Localization of Gtf3a 1 0.00 0.99 0
86 INT337677 Scrib Positive_regulation of Gene_expression of MMP9 1 0.03 1.12 0
87 INT245110 Binding of MMP9 and Mmp9 1 0.08 1.53 0
88 INT335295 SLC15A4 Negative_regulation of MMP9 1 0.00 0.07 0
89 INT184952 NLRP1 Negative_regulation of Positive_regulation of MMP9 1 0.12 0.34 0
90 INT341310 Binding of Npc1 and Chdh 1 0.11 7.04 0
91 INT341308 Negative_regulation of Npc1 Positive_regulation of Gene_expression of Srebf1 1 0.31 1.48 0
92 INT348692 Atp9a Positive_regulation of Gene_expression of Mmp9 1 0.00 0.07 0
93 INT205153 Gene_expression of SPP1 Regulation of Localization of MMP9 1 0.14 0.57 0
94 INT348695 Atp9a Positive_regulation of Mmp9 1 0.00 0.07 0
95 INT205150 SPP1 Positive_regulation of Positive_regulation of MMP9 1 0.21 0 0
96 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0
97 INT337681 Scrib Positive_regulation of MMP9 1 0.01 1.12 0
98 INT341309 Binding of Npc1 and Sugt1 1 0.01 1.04 0
99 INT266657 TIMP1 Regulation of Localization of MMP9 1 0.18 0 0
100 INT205156 CD44 Positive_regulation of MMP9 1 0.51 0.24 0
101 INT319026 Binding of Npc1 and Ruvbl1 1 0.00 0.08 0
102 INT339217 MMP9 Negative_regulation of VEGFA 1 0.05 0.38 0
103 INT335294 IRF6 Positive_regulation of Gene_expression of MMP9 1 0.01 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to low-density lipoprotein particle stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to low-density lipoprotein particle stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
2 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
3 INT99610 Localization of MMP9 126 0.79 48.46 32.67
4 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
5 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
6 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
7 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
8 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
9 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
10 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
11 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
12 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
13 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01
14 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47
15 INT3476 Phosphorylation of Npc1 7 0.48 0 4.84
16 INT125896 Negative_regulation of Gene_expression of Mmp9 15 0.43 13.73 4.18
17 INT99608 Transcription of MMP9 18 0.65 9.67 4.11
18 INT133312 Binding of MMP9 25 0.42 16.79 3.83
19 INT68974 Localization of Mmp9 10 0.80 4.84 3.35
20 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73
21 INT183810 Positive_regulation of Positive_regulation of MMP9 9 0.52 4.15 2.46
22 INT3475 Regulation of Phosphorylation of Npc1 3 0.36 0 2.45
23 INT152286 Regulation of Gene_expression of Mmp9 5 0.36 3.95 2.15
24 INT125246 Negative_regulation of Positive_regulation of Mmp9 5 0.27 5.34 2.09
25 INT103244 Protein_catabolism of MMP9 12 0.72 11.81 2.01
26 INT102158 Protein_catabolism of Mmp9 7 0.65 5.43 1.91
27 INT42585 Positive_regulation of Phosphorylation of Npc1 3 0.19 0 1.59
28 INT186724 Negative_regulation of Transcription of MMP9 5 0.37 1.59 1.57
29 INT295688 Positive_regulation of Regulation of MMP9 1 0.14 0.67 1.51
30 INT125897 Binding of Mmp9 3 0.36 2.36 1.32
31 INT187123 Negative_regulation of Positive_regulation of MMP9 7 0.42 2.54 1.17
32 INT86063 Positive_regulation of Positive_regulation of Mmp9 4 0.35 2.34 1.17
33 INT143956 Regulation of Positive_regulation of MMP9 5 0.40 2.61 1.11
34 INT96579 Negative_regulation of Negative_regulation of MMP9 5 0.40 4.55 1.04
35 INT187135 Positive_regulation of Negative_regulation of MMP9 3 0.43 1.87 0.92
36 INT79941 Negative_regulation of Npc1 9 0.59 3.97 0.82
37 INT191101 Regulation of Localization of MMP9 6 0.38 2.49 0.81
38 INT187132 Negative_regulation of Binding of MMP9 5 0.36 3.15 0.81
39 INT290922 Regulation of Protein_catabolism of Mmp9 2 0.28 0.78 0.75
40 INT263047 Transcription of Mmp9 7 0.53 3.61 0.65
41 INT205724 Regulation of Positive_regulation of Mmp9 1 0.32 0.25 0.65
42 INT263044 Negative_regulation of Regulation of Mmp9 1 0.31 0.12 0.65
43 INT170346 Gene_expression of Npc1 18 0.78 7.69 0.48
44 INT3477 Regulation of Npc1 6 0.45 1.87 0.47
45 INT125895 Negative_regulation of Binding of Mmp9 1 0.43 1.15 0.39
46 INT97859 Localization of Npc1 12 0.75 6.66 0.35
47 INT187022 Positive_regulation of Transcription of MMP9 3 0.45 3.27 0.34
48 INT4133 Binding of Npc1 14 0.47 8.24 0.33
49 INT32509 Positive_regulation of Npc1 6 0.50 2.24 0.33
50 INT295690 Negative_regulation of Regulation of MMP9 1 0.11 0.99 0.33
51 INT68972 Positive_regulation of Localization of Mmp9 1 0.50 0.38 0.3
52 INT166099 Phosphorylation of MMP9 2 0.41 0.52 0.29
53 INT32508 Positive_regulation of Positive_regulation of Npc1 2 0.47 0.67 0.23
54 INT291078 Negative_regulation of Protein_catabolism of Mmp9 1 0.26 0.96 0.2
55 INT291079 Positive_regulation of Protein_catabolism of Mmp9 1 0.31 0.96 0.2
56 INT335331 Regulation of Negative_regulation of MMP9 1 0.11 0.18 0.17
57 INT170340 Regulation of Gene_expression of Npc1 2 0.17 0.38 0.14
58 INT325474 Regulation of Regulation of MMP9 1 0.53 0.96 0.14
59 INT185014 Regulation of Transcription of MMP9 2 0.43 0.56 0.11
60 INT320843 Negative_regulation of Gene_expression of Npc1 2 0.59 5.82 0.07
61 INT349349 Positive_regulation of Transcription of Mmp9 1 0.11 0.31 0.06
62 INT187440 Positive_regulation of Binding of MMP9 1 0.16 0.45 0.05
63 INT319022 Positive_regulation of Binding of Npc1 2 0.50 0.24 0.03
64 INT205170 Positive_regulation of Phosphorylation of MMP9 1 0.30 0.25 0.03
65 INT205166 Regulation of Binding of MMP9 1 0.34 0.26 0.03
66 INT319021 Negative_regulation of Transcription of Npc1 2 0.38 1.44 0
67 INT319023 Transcription of Npc1 2 0.63 1.44 0
68 INT319016 Positive_regulation of Gene_expression of Npc1 1 0.17 0 0
69 INT320845 Regulation of Localization of Npc1 1 0.39 0.71 0
70 INT319015 Regulation of Binding of Npc1 1 0.16 0 0
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