GO:0071901

From wiki-pain
Revision as of 00:15, 25 January 2013 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Name negative regulation of protein serine/threonine kinase activity
Categary Process
Go Slim No
Go Link GO:0071901
Unique Molecular Interactions 58
Total Molecular Interactions 80
Total Single Events 731
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
2 INT120870 Binding of Wnk1 and Sptlc1 1 0.14 1.24 0.56
3 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45
4 INT263433 Abl1 Regulation of Abl1 1 0.04 0.28 0.38
5 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
6 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
7 INT263383 Abl1 Regulation of Trib3 1 0.01 0.28 0.35
8 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21
9 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
10 INT349855 Atf3 Regulation of Hspb1 1 0.37 0.77 0.19
11 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
12 INT86429 Binding of Hspb1 and Esr1 1 0.19 0.26 0.13
13 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
14 INT263429 Pdgfb Positive_regulation of Localization of Abl1 1 0.01 0 0.12
15 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11
16 INT15902 PKIA Negative_regulation of Positive_regulation of Prkaca 1 0.10 0 0.1
17 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09
18 INT110855 Pkia Negative_regulation of Egf 1 0.15 1.2 0.08
19 INT270659 Wnk1 Regulation of Napg 1 0.04 1.12 0.04
20 INT263377 Abl1 Regulation of Src 1 0.15 0 0.04
21 INT270661 Regulation of Wnk1 Regulation of Napg 1 0.04 1.13 0.04
22 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
23 INT263432 Trib3 Regulation of Abl1 1 0.00 0 0.04
24 INT263379 Abl1 Regulation of Bmx 1 0.04 0 0.04
25 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03
26 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03
27 INT286767 Binding of Abl1 and Tusc2 1 0.54 1.04 0.03
28 INT167565 Binding of ERG and LRP5 1 0.02 0.94 0.03
29 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0
30 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0
31 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0
32 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0
33 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0
34 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0
35 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0
36 INT349174 Mapk14 Positive_regulation of Phosphorylation of Hspb1 1 0.35 0.2 0
37 INT205388 Binding of HSPB1 and MME 1 0.22 1.36 0
38 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0
39 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0
40 INT349173 Positive_regulation of Stzid Positive_regulation of Positive_regulation of Hspb1 1 0.03 0.3 0
41 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0
42 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0
43 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0
44 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
45 INT267215 Binding of Cryab and Hspb1 1 0.25 7.19 0
46 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0
47 INT285582 Binding of ABL1 and S100A8 1 0.02 0.2 0
48 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
49 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0
50 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0
51 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0
52 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0
53 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0
54 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein serine/threonine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein serine/threonine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
2 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86
3 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
4 INT24068 Localization of Hspb1 6 0.78 6.11 2.75
5 INT86426 Gene_expression of Hspb1 16 0.78 10.86 2.26
6 INT26415 Regulation of Phosphorylation of PKIA 1 0.01 0.06 2.04
7 INT26417 Phosphorylation of PKIA 1 0.02 0.06 2.04
8 INT263398 Positive_regulation of Abl1 1 0.60 1.44 1.66
9 INT24069 Negative_regulation of Localization of Hspb1 3 0.14 3.93 1.3
10 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
11 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17
12 INT76303 Negative_regulation of Positive_regulation of Hspb1 1 0.42 0.49 1.17
13 INT102758 Negative_regulation of Abl1 2 0.51 1.13 1.1
14 INT71498 Binding of Hspb1 7 0.42 7.38 1.05
15 INT71499 Localization of Hspb1 4 0.72 1.38 1.05
16 INT123962 Phosphorylation of Hspb1 8 0.82 2.08 1.04
17 INT125892 Regulation of Hspb1 2 0.48 4.28 0.98
18 INT24067 Negative_regulation of Hspb1 1 0.11 0.67 0.95
19 INT263387 Binding of Abl1 8 0.42 0.86 0.91
20 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87
21 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
22 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75
23 INT241499 Binding of Abl1 23 0.47 8.86 0.75
24 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
25 INT109983 Positive_regulation of Hspb1 7 0.66 6.66 0.72
26 INT125890 Negative_regulation of Regulation of Hspb1 2 0.42 1.39 0.69
27 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
28 INT234928 Phosphorylation of Hspb1 3 0.72 17.04 0.65
29 INT70216 Gene_expression of HSPB1 8 0.78 4.81 0.64
30 INT62688 Binding of Wnk1 2 0.17 2.83 0.63
31 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
32 INT263404 Regulation of Abl1 1 0.53 0.66 0.52
33 INT123963 Positive_regulation of Gene_expression of Hspb1 7 0.70 3.39 0.51
34 INT123960 Negative_regulation of Phosphorylation of Hspb1 2 0.43 0.48 0.42
35 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39
36 INT123964 Transcription of Hspb1 2 0.53 0.67 0.37
37 INT73854 Transcription of ABL1 4 0.52 2.26 0.34
38 INT263408 Gene_expression of Abl1 4 0.58 0.28 0.33
39 INT349820 Regulation of Regulation of Hspb1 1 0.35 2.99 0.32
40 INT105142 Positive_regulation of HSPB1 3 0.70 1.08 0.3
41 INT110852 Binding of Pkia 1 0.12 1.04 0.3
42 INT90168 Regulation of Wnk1 2 0.04 0.63 0.29
43 INT86428 Binding of Hspb1 1 0.36 0.53 0.29
44 INT258689 Regulation of Gene_expression of Hspb1 1 0.36 0.34 0.29
45 INT15899 Gene_expression of PKIA 1 0.61 0 0.28
46 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
47 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
48 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
49 INT263399 Positive_regulation of Gene_expression of Abl1 1 0.43 0 0.25
50 INT334543 Negative_regulation of Positive_regulation of LRP5 1 0.23 1.81 0.25
51 INT171685 Phosphorylation of HSPB1 2 0.69 0.39 0.24
52 INT173655 Binding of LRP5 10 0.39 3.06 0.22
53 INT241498 Regulation of Abl1 8 0.32 6.46 0.22
54 INT263396 Localization of Abl1 1 0.61 0 0.21
55 INT239412 Binding of ABL1 8 0.28 5.39 0.18
56 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
57 INT263405 Phosphorylation of Abl1 1 0.71 0.05 0.18
58 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
59 INT105143 Binding of HSPB1 1 0.36 0.54 0.17
60 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16
61 INT70215 Positive_regulation of Gene_expression of HSPB1 2 0.68 0.65 0.15
62 INT163461 Regulation of ABL1 8 0.32 5.98 0.14
63 INT105141 Regulation of Gene_expression of HSPB1 1 0.45 0.36 0.14
64 INT258688 Regulation of Transcription of Hspb1 1 0.22 0.17 0.14
65 INT263392 Positive_regulation of Phosphorylation of Abl1 1 0.60 0 0.13
66 INT349165 Positive_regulation of Phosphorylation of Hspb1 1 0.61 4.56 0.13
67 INT263411 Negative_regulation of Positive_regulation of Abl1 1 0.37 0.42 0.13
68 INT24239 Positive_regulation of Pkia 1 0.18 0.31 0.12
69 INT24243 Phosphorylation of Pkia 1 0.22 0.33 0.12
70 INT263386 Negative_regulation of Binding of Abl1 1 0.51 0.05 0.1
71 INT135432 Regulation of Hspb1 1 0.10 0.35 0.1
72 INT241512 Phosphorylation of Abl1 4 0.59 2.68 0.09
73 INT241515 Negative_regulation of Phosphorylation of Abl1 3 0.30 1.36 0.09
74 INT349153 Negative_regulation of Hspb1 1 0.45 3.14 0.09
75 INT263421 Regulation of Localization of Abl1 1 0.23 0 0.08
76 INT123961 Positive_regulation of Transcription of Hspb1 1 0.47 0.34 0.08
77 INT110853 Negative_regulation of Pkia 1 0.14 1.19 0.08
78 INT263389 Regulation of Regulation of Abl1 1 0.39 0.06 0.07
79 INT131835 Positive_regulation of Wnk1 1 0.07 1.28 0.07
80 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06
81 INT163462 Negative_regulation of Regulation of ABL1 1 0.11 1.17 0.06
82 INT349147 Negative_regulation of Phosphorylation of Hspb1 1 0.51 0.57 0.06
83 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05
84 INT241507 Positive_regulation of Abl1 5 0.40 2.69 0.05
85 INT273554 Positive_regulation of Binding of Abl1 2 0.40 2.05 0.05
86 INT315848 Positive_regulation of Negative_regulation of Abl1 1 0.20 0.61 0.05
87 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
88 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
89 INT263406 Protein_catabolism of Abl1 1 0.86 0 0.05
90 INT267197 Positive_regulation of Gene_expression of Hspb1 2 0.45 1.43 0.04
91 INT241506 Localization of Abl1 2 0.54 2.37 0.04
92 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04
93 INT242172 Protein_catabolism of LRP5 1 0.64 0.06 0.04
94 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03
95 INT267205 Positive_regulation of Positive_regulation of Hspb1 2 0.45 1.69 0.03
96 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03
97 INT315842 Regulation of Gene_expression of Abl1 1 0.11 0.94 0.03
98 INT297757 Transcription of Lrp5 2 0.68 0.82 0
99 INT297820 Regulation of Transcription of Lrp5 2 0.44 0.83 0
100 INT273548 Negative_regulation of Binding of Abl1 2 0.34 0.88 0
101 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0
102 INT307613 Phosphorylation of LRP5 1 0.08 0.1 0
103 INT144997 Negative_regulation of Wnk1 1 0.08 0 0
104 INT173644 Negative_regulation of Gene_expression of LRP5 1 0.15 0.59 0
105 INT267190 Regulation of Gene_expression of Hspb1 1 0.40 1.74 0
106 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
107 INT213938 Negative_regulation of Gene_expression of HSPB1 1 0.57 0.38 0
108 INT263393 Regulation of Binding of Abl1 1 0.39 0 0
109 INT350510 Localization of ABL1 1 0.40 2.51 0
110 INT292711 Regulation of Gene_expression of ABL1 1 0.06 1.02 0
111 INT349148 Negative_regulation of Gene_expression of Hspb1 1 0.37 0 0
112 INT350521 Negative_regulation of Negative_regulation of ABL1 1 0.23 0.55 0
113 INT349145 Negative_regulation of Negative_regulation of Hspb1 1 0.37 1.47 0
114 INT342375 Positive_regulation of Binding of Lrp5 1 0.46 0.85 0
115 INT156466 Regulation of Negative_regulation of ABL1 1 0.44 0.63 0
116 INT350517 Negative_regulation of Gene_expression of ABL1 1 0.23 0.53 0
117 INT302465 Localization of LRP5 1 0.61 0 0
118 INT165179 Regulation of Positive_regulation of ABL1 1 0.15 0.95 0
119 INT283069 Negative_regulation of Gene_expression of Abl1 1 0.17 0.69 0
120 INT349154 Regulation of Phosphorylation of Hspb1 1 0.35 0 0
121 INT273558 Transcription of Abl1 1 0.57 0.3 0
122 INT347117 Negative_regulation of Binding of Lrp6 1 0.28 0.5 0
123 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0
124 INT273546 Negative_regulation of Transcription of Abl1 1 0.46 0.3 0
125 INT263391 Negative_regulation of Gene_expression of Abl1 1 0.37 0 0
126 INT350512 Positive_regulation of Phosphorylation of ABL1 1 0.27 0.75 0
127 INT307611 Positive_regulation of Phosphorylation of LRP5 1 0.05 0.1 0
128 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0
129 INT351489 Regulation of Transcription of ABL1 1 0.28 0.08 0
130 INT350508 Protein_catabolism of ABL1 1 0.54 0.5 0
131 INT335873 Transcription of Lrp6 1 0.64 0.25 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox