GO:0072358

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Name cardiovascular system development
Categary Process
Go Slim No
Go Link GO:0072358
Unique Molecular Interactions 84
Total Molecular Interactions 126
Total Single Events 936
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cardiovascular system development. They are ordered first by their pain relevance and then by number of times they were reported for cardiovascular system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
2 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
3 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
4 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
5 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
6 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
7 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
8 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
9 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
10 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
11 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
12 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
13 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
14 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
15 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
16 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
17 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
18 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
19 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
20 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
21 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
22 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
23 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
24 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
25 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
26 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
27 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
28 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
29 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
30 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
31 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
32 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
33 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
34 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
35 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
36 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
37 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
38 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1
39 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
40 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
41 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
42 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
43 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07
44 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07
45 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
46 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
47 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
48 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
49 INT208356 Hdl1 Positive_regulation of Apoe 1 0.12 1.25 0.04
50 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
51 INT208357 Hdl1 Positive_regulation of Localization of Apoe 1 0.12 1.26 0.04
52 INT208350 Positive_regulation of Hdl1 Positive_regulation of Apoe 1 0.12 1.27 0.04
53 INT290181 Binding of APOE and PLTP 1 0.17 1.61 0.04
54 INT194483 Binding of Apoe and Chol1 1 0.24 0.51 0.03
55 INT208352 Apoe Regulation of Localization of Em 1 0.04 1.15 0.03
56 INT194481 Binding of Apoe and Apob 1 0.07 0.51 0.03
57 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03
58 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0
59 INT326065 APOE Positive_regulation of LCAT 1 0.53 0.84 0
60 INT209987 Binding of APOE and LDLR 1 0.24 0 0
61 INT208349 Regulation of Binding of Apoc3 and Apoe 1 0.01 0.38 0
62 INT90283 Binding of APOE and Il1a 1 0.01 0 0
63 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
64 INT353802 Binding of APOE and Apob 1 0.05 0.83 0
65 INT208355 Binding of Apoc3 and Apoe 1 0.01 0.76 0
66 INT198933 Binding of Apoe and App 1 0.33 0.19 0
67 INT353801 Binding of APOE and Cd320 1 0.22 0.83 0
68 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
69 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
70 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
71 INT353804 Binding of APOE and Ldlr 1 0.16 0.84 0
72 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0
73 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
74 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
75 INT284093 VWF Negative_regulation of APOE 1 0.40 2.32 0
76 INT312769 Binding of Apoe and Pon1 1 0.04 0.86 0
77 INT353803 Binding of APOE and Hdl1 1 0.01 0.83 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cardiovascular system development. They are ordered first by their pain relevance and then by number of times they were reported in cardiovascular system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
2 INT197493 Localization of Apoe 61 0.79 27.48 7.06
3 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
4 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
5 INT63042 Binding of Apoe 59 0.48 31.23 5.88
6 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
7 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
8 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
9 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
10 INT72141 Binding of Apoe 11 0.37 10.91 3.27
11 INT97710 Localization of Apoe 1 0.79 7.18 3.2
12 INT50080 Binding of APOE 38 0.45 29.61 2.67
13 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
14 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
15 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
16 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
17 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
18 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
19 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
20 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
21 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
22 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
23 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
24 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
25 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
26 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
27 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
28 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
29 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
30 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
31 INT175580 Localization of APOE 10 0.76 18.84 0.65
32 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
33 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
34 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
35 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
36 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
37 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
38 INT96816 Regulation of APOE 8 0.45 6.62 0.44
39 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
40 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
41 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
42 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
43 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
44 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
45 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
46 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
47 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
48 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
49 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
50 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
51 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
52 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
53 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
54 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
55 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
56 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
57 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
58 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
59 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
60 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
61 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
62 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
63 INT205147 Regulation of Phosphorylation of APOE 1 0.06 0.34 0.07
64 INT97709 Positive_regulation of Localization of Apoe 1 0.68 1.02 0.07
65 INT208336 Positive_regulation of Binding of Apoe 1 0.48 0.7 0.05
66 INT208333 Positive_regulation of Positive_regulation of Apoe 1 0.48 0.65 0.05
67 INT326070 Regulation of Localization of APOE 1 0.58 1.21 0.03
68 INT191285 Positive_regulation of Localization of APOE 3 0.66 3.06 0
69 INT326073 Transcription of APOE 2 0.51 1.94 0
70 INT50081 Positive_regulation of Positive_regulation of APOE 2 0.49 0.18 0
71 INT326524 Negative_regulation of Transcription of APOE 1 0.30 1.71 0
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