GO:0072593

Name reactive oxygen species metabolic process Categary Process Go Slim No Go Link GO:0072593

Unique Molecular Interactions 398 Total Molecular Interactions 497 Total Single Events 5156 Pain Genes Associated 23

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for reactive oxygen species metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for reactive oxygen species metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT156008	Bcl2 Regulation of Localization of Aifm1	1	0.17	1.92	1.47
2	INT225019	PDGFB Positive_regulation of Gene_expression of Cxcl1	1	0.27	0.54	1.4
3	INT145930	ecs Positive_regulation of Gene_expression of Bcl2	1	0.01	2.06	1.34
4	INT142202	FL Positive_regulation of Bcl2	1	0.05	0.39	0.99
5	INT285561	Il23a Positive_regulation of Gene_expression of Il22	2	0.06	2.45	0.93
6	INT112765	Binding of Nfkb1 and Bcl2	1	0.00	1.37	0.91
7	INT151779	Calca Positive_regulation of Transcription of P2rx7	1	0.02	0.54	0.87
8	INT166634	Binding of Bcl2 and Becn1	1	0.20	0.5	0.86
9	INT150864	RYBP Positive_regulation of Positive_regulation of Bcl2	1	0.01	0.66	0.86
10	INT215598	Positive_regulation of P2rx7 Positive_regulation of Localization of TNF	1	0.22	1.44	0.85
11	INT218935	Cyp3a23/3a1 Regulation of Bcl2	1	0.00	1.08	0.74
12	INT205706	P2rx7 Regulation of Gene_expression of Il18	1	0.21	1.35	0.7
13	INT320633	Positive_regulation of MAPK1 Regulation of BCL2	1	0.04	1.21	0.7
14	INT246335	Fig4 Regulation of Localization of P2rx7	1	0.01	0	0.67
15	INT205702	P2rx7 Regulation of Gene_expression of Il1	1	0.04	1.38	0.67
16	INT296785	Tlr9 Regulation of Bcl2	1	0.19	0.76	0.65
17	INT316674	Binding of CRP and SFTPD	1	0.16	2.02	0.59
18	INT205705	Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6	1	0.07	1.42	0.58
19	INT308174	Binding of TNF and P2rx7	1	0.02	0.84	0.56
20	INT226517	Binding of IL19 and Il20ra	1	0.00	0.69	0.53
21	INT185490	Atp5o Negative_regulation of Gene_expression of P2rx7	1	0.01	0.87	0.53
22	INT216941	P2rx7 Regulation of Ryr1	1	0.01	0.55	0.52
23	INT278122	Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7	1	0.03	0	0.51
24	INT228449	PMAIP1 Negative_regulation of Fgf2	1	0.00	0.07	0.49
25	INT228448	PMAIP1 Negative_regulation of Cntf	1	0.00	0.07	0.49
26	INT228447	Negative_regulation of PMAIP1 Negative_regulation of Cntf	1	0.00	0.07	0.49
27	INT302839	MIR15A Negative_regulation of Bcl2	1	0.15	1.41	0.47
28	INT300544	Il22 Positive_regulation of Gene_expression of Mcpt1	1	0.02	1.15	0.47
29	INT306731	Il22 Positive_regulation of Gene_expression of Il2	1	0.12	1.07	0.46
30	INT238639	Cd86 Negative_regulation of Negative_regulation of Bcl2	1	0.01	0.97	0.46
31	INT112772	Binding of Bcl2 and SGSM3	1	0.02	0.69	0.45
32	INT116609	Lnpep Negative_regulation of Bcl2	1	0.05	0.62	0.43
33	INT116606	Lnpep Regulation of Gene_expression of Bcl2	1	0.07	0.62	0.43
34	INT169859	P2rx7 Regulation of Gene_expression of Grin1	1	0.17	0	0.43
35	INT116607	Lnpep Negative_regulation of Gene_expression of Bcl2	1	0.10	0.62	0.43
36	INT309143	Dlat Positive_regulation of Bcl2	1	0.06	1.04	0.42
37	INT332248	Ccl2 Positive_regulation of Ctgf	1	0.04	1.13	0.42
38	INT309152	Dlat Positive_regulation of Gene_expression of Bcl2	1	0.04	1.05	0.42
39	INT235878	Creb1 Positive_regulation of Gene_expression of Bcl2	1	0.05	0.17	0.38
40	INT316675	Binding of CALR and SFTPD	1	0.35	0.96	0.37
41	INT316672	Binding of LRP1 and SFTPD	1	0.35	0.96	0.37
42	INT155062	Csf2 Positive_regulation of Transcription of Bcl2	1	0.31	2.91	0.36
43	INT264555	IL15 Positive_regulation of Gene_expression of BCL2	1	0.02	0.92	0.35
44	INT205704	P2rx7 Regulation of Localization of Il18	1	0.09	0.67	0.35
45	INT228446	PMAIP1 Regulation of Transcription of Mtpn	1	0.00	0	0.34
46	INT269962	Bcl2 Negative_regulation of Bcl2l11	1	0.15	2.14	0.34
47	INT205713	Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8	1	0.03	0.77	0.33
48	INT217025	P2rx7 Regulation of Gene_expression of Ik	1	0.00	0.25	0.33
49	INT155060	Stat3 Negative_regulation of Bcl2	1	0.21	3.7	0.33
50	INT316676	Binding of CRX and SFTPD	1	0.05	0.65	0.33
51	INT217024	Regulation of P2rx7 Regulation of Gene_expression of Ik	1	0.00	0.25	0.33
52	INT205703	P2rx7 Regulation of Positive_regulation of Casp1	1	0.11	0.66	0.33
53	INT205711	P2rx7 Regulation of Localization of IL8	1	0.02	0.92	0.33
54	INT316488	Il22 Positive_regulation of Il10	1	0.29	0.63	0.32
55	INT145682	Binding of P2rx4 and P2rx7	2	0.25	0.36	0.31
56	INT258763	Binding of Drd5 and ADHD1	1	0.07	1.11	0.31
57	INT309366	Pax2 Negative_regulation of Transcription of Slc6a5	1	0.03	0	0.31
58	INT316487	Il22 Regulation of Il22ra1	1	0.12	0.61	0.31
59	INT309369	Ptf1a Positive_regulation of Pax2	1	0.10	0	0.3
60	INT242398	Cyp19a1 Positive_regulation of Bcl2	1	0.00	1.28	0.3
61	INT225021	PDGFB Positive_regulation of Ccl21	1	0.10	0.07	0.3
62	INT225026	PDGFB Positive_regulation of Gene_expression of Ccl21	1	0.10	0.07	0.3
63	INT202313	Gene_expression of PDGFB Positive_regulation of Positive_regulation of Pdgfrb	1	0.14	1	0.29
64	INT215789	Fig4 Positive_regulation of Localization of P2rx7	1	0.03	0.53	0.29
65	INT202314	Gene_expression of PDGFB Positive_regulation of Phosphorylation of Pdgfrb	1	0.14	1	0.29
66	INT218928	Cyp3a23/3a1 Regulation of Transcription of Bcl2	1	0.00	0.56	0.28
67	INT260837	NRP2 Negative_regulation of Negative_regulation of Bcl2	1	0.00	0.9	0.28
68	INT172905	Binding of Bad and Bcl2	3	0.08	6.46	0.27
69	INT355734	Pdgfb Regulation of Bdnf	1	0.22	1.5	0.27
70	INT237927	BCL2 Positive_regulation of BAX	2	0.24	2.22	0.26
71	INT237928	BCL2 Positive_regulation of FAS	1	0.02	1.41	0.26
72	INT272157	Gh1 Negative_regulation of Bcl2	1	0.23	1.2	0.26
73	INT272158	Gh1 Regulation of Bcl2	1	0.15	1.2	0.26
74	INT237925	BCL2 Positive_regulation of Protein_catabolism of PARP1	1	0.02	1.42	0.26
75	INT205701	P2rx7 Positive_regulation of Il1	1	0.04	0.8	0.25
76	INT260840	NRP2 Positive_regulation of Gene_expression of Bcl2	1	0.00	0.85	0.24
77	INT185489	Atp5o Negative_regulation of P2rx7	1	0.01	0.29	0.24
78	INT316815	Ctgf Negative_regulation of Gene_expression of Sparc	1	0.47	0.64	0.24
79	INT306795	Binding of LEP and SFTPD	1	0.08	1.13	0.23
80	INT216911	Positive_regulation of P2rx7 Positive_regulation of Localization of Plg	1	0.02	0.13	0.23
81	INT302170	PTGER2 Positive_regulation of Gene_expression of BCL2	1	0.04	3.76	0.23
82	INT107219	Binding of P2rx7 and Atp5o	1	0.03	0.07	0.21
83	INT216946	P2rx7 Regulation of Il10	1	0.28	0.17	0.21
84	INT107223	APEH Negative_regulation of P2rx7	1	0.00	0.13	0.21
85	INT226373	IL19 Positive_regulation of Gene_expression of IL5	1	0.02	0.56	0.2
86	INT226336	IL19 Positive_regulation of Gene_expression of IL13	1	0.01	0.56	0.2
87	INT226379	IL19 Positive_regulation of IL5	1	0.02	0.55	0.2
88	INT226377	IL19 Positive_regulation of IL13	1	0.01	0.56	0.2
89	INT226384	INCENP Positive_regulation of IL19	1	0.00	0.58	0.2
90	INT92691	Tgfb1 Positive_regulation of Ctgf	1	0.16	0.91	0.2
91	INT226338	IL19 Positive_regulation of Gene_expression of IL10	1	0.01	0.56	0.2
92	INT226542	Negative_regulation of Adora2b Positive_regulation of IL19	1	0.08	0.58	0.2
93	INT226369	IL19 Positive_regulation of IL4	1	0.03	0.55	0.2
94	INT226525	Adora2b Positive_regulation of IL19	1	0.03	0.58	0.2
95	INT226351	IL19 Positive_regulation of IL10	1	0.01	0.55	0.2
96	INT226353	IL19 Positive_regulation of Gene_expression of IL4	1	0.03	0.56	0.2
97	INT153457	Tgfb1 Positive_regulation of Gene_expression of Ctgf	1	0.13	1.15	0.19
98	INT153460	Inhba Positive_regulation of Gene_expression of Ctgf	1	0.77	1.14	0.19
99	INT153461	Tnf Positive_regulation of Gene_expression of Ctgf	1	0.48	1.13	0.19
100	INT205710	CAMP Positive_regulation of P2rx7	1	0.02	0.47	0.19
101	INT300563	Binding of Drd5 and ADHD1	1	0.01	1.13	0.19
102	INT226349	Binding of IL19 and IL20RA	1	0.00	0.24	0.19
103	INT355733	Pdgfb Regulation of Transcription of Bdnf	1	0.10	0.86	0.19
104	INT236307	SFTPD Positive_regulation of IGKV2D-38	1	0.03	0.57	0.18
105	INT176133	AKT1 Regulation of BCL2	2	0.12	1.84	0.17
106	INT226521	IL19 Positive_regulation of Gene_expression of Il6	1	0.01	0.41	0.17
107	INT300305	Mapk14 Positive_regulation of Gene_expression of Ctgf	1	0.19	1.25	0.17
108	INT285026	Bak1 Regulation of Bcl2	1	0.09	0.71	0.17
109	INT285022	Regulation of Bak1 Regulation of Bcl2	1	0.09	0.71	0.17
110	INT349475	Regulation of Bax Regulation of Bcl2	1	0.07	1.35	0.17
111	INT155233	TXNIP Regulation of BCL2	1	0.23	0.15	0.17
112	INT285024	Bcl2 Regulation of Bak1	1	0.09	0.71	0.17
113	INT229203	Binding of Bcl2 and Cyp2c11	1	0.36	1.2	0.17
114	INT155068	Csf2 Negative_regulation of Bcl2	1	0.12	1.88	0.17
115	INT226364	IL19 Positive_regulation of Gene_expression of TNF	1	0.11	0.41	0.17
116	INT355732	Pdgfb Negative_regulation of Bdnf	1	0.13	0.87	0.17
117	INT226357	Binding of IL24 and IL19	1	0.01	0.23	0.16
118	INT347445	CD99 Positive_regulation of BCL2	1	0.17	0.95	0.16
119	INT202312	PDGFB Positive_regulation of Gene_expression of Col7a1	1	0.01	0.7	0.16
120	INT202311	PDGFB Positive_regulation of Gene_expression of Fn1	1	0.02	0.7	0.16
121	INT292750	Akt1 Positive_regulation of Bcl2	1	0.01	1.67	0.15
122	INT349476	Bax Regulation of Bcl2	1	0.07	1.33	0.15
123	INT153458	Ctgf Positive_regulation of Gene_expression of Il6	1	0.34	1.03	0.15
124	INT311666	Binding of BCL2 and TP53	1	0.19	1.26	0.14
125	INT95104	TGFBR2 Positive_regulation of BCL2	1	0.08	0.61	0.14
126	INT294106	Binding of DNASE1L3 and DRD5	1	0.02	0	0.14
127	INT223084	Binding of Pdgfa and Pdgfb	2	0.17	0.83	0.13
128	INT309139	Edc4 Positive_regulation of Bcl2	1	0.03	0.12	0.13
129	INT148594	Binding of BCL2 and CD34	1	0.39	1.17	0.13
130	INT309142	Edc4 Regulation of Bcl2	1	0.02	0.12	0.13
131	INT246016	Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2	1	0.03	1.07	0.13
132	INT270827	P2rx7 Positive_regulation of Localization of Panx1	1	0.41	0.18	0.13
133	INT225024	PDGFB Positive_regulation of Gene_expression of Cxcl5	1	0.16	0.08	0.13
134	INT342311	Binding of Tp53 and Positive_regulation of Gene_expression of BCL2	1	0.08	1.25	0.13
135	INT348542	BCL2 Negative_regulation of NLRP1	1	0.07	2.02	0.13
136	INT246017	Timp1 Negative_regulation of Gene_expression of Bcl2	1	0.03	1.07	0.13
137	INT172899	Binding of Bcl2 and Bcl2l1	3	0.02	5.54	0.12
138	INT178101	EDN1 Negative_regulation of Phosphorylation of BCL2	1	0.03	1	0.12
139	INT305194	Bcl2 Positive_regulation of Epo	1	0.06	0.29	0.12
140	INT216945	Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1	1	0.14	0.18	0.12
141	INT263429	Pdgfb Positive_regulation of Localization of Abl1	1	0.01	0	0.12
142	INT273063	Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2	1	0.01	0.72	0.11
143	INT309371	Lhx1 Positive_regulation of Gene_expression of Pax2	1	0.08	0.07	0.11
144	INT74504	Binding of P2rx7 and Rp2	1	0.02	0.19	0.11
145	INT309372	Lhx5 Positive_regulation of Gene_expression of Pax2	1	0.09	0.07	0.11
146	INT221684	Binding of Bcl2 and FRTS	1	0.01	1.19	0.11
147	INT265888	BCL2 Regulation of Gene_expression of BAD	1	0.04	1.08	0.1
148	INT265890	BCL2 Regulation of Gene_expression of BAX	1	0.04	1.08	0.1
149	INT239643	Binding of BCL2 and BCL2L11	3	0.16	2.26	0.09
150	INT282094	Apoa2 Negative_regulation of BCL2	1	0.06	1.15	0.09
151	INT205708	Binding of Icam1 and P2rx7	1	0.08	1.03	0.09
152	INT275183	Bad Positive_regulation of Gene_expression of Bcl2	1	0.08	0.63	0.09
153	INT265887	IGF1 Negative_regulation of BCL2	1	0.09	1.02	0.09
154	INT48194	Pdgfb Positive_regulation of Setd1a	1	0.23	0	0.09
155	INT294637	Bcl2a1a Positive_regulation of Gene_expression of Bcl2	1	0.15	0.97	0.09
156	INT217036	IRF6 Positive_regulation of Gene_expression of P2rx7	1	0.02	0	0.09
157	INT270824	Binding of P2rx7 and Panx1	1	0.34	0.15	0.09
158	INT204300	Bcl2 Negative_regulation of Positive_regulation of Bak1	1	0.02	1.13	0.09
159	INT304464	Binding of P2rx7 and P2rx6	1	0.05	0	0.09
160	INT257342	Mapk4 Positive_regulation of Gene_expression of Ctgf	1	0.01	0.39	0.08
161	INT314011	VEGFA Regulation of IL19	1	0.04	1.11	0.08
162	INT243156	Positive_regulation of P2rx7 Positive_regulation of NOS1	1	0.00	0.08	0.08
163	INT350908	Binding of Bcl2 and Twist1	1	0.04	1.9	0.08
164	INT258756	Binding of Drd5 and Lmo1	1	0.03	0.64	0.08
165	INT270829	P2rx7 Positive_regulation of Panx1	1	0.66	0.08	0.08
166	INT201456	Hmox1 Positive_regulation of Gene_expression of Bcl2	1	0.06	0.74	0.08
167	INT340420	Hmmr Regulation of P2rx7	1	0.01	1.12	0.08
168	INT285025	Bnip3 Positive_regulation of Bak1	1	0.11	0.78	0.07
169	INT204299	Bcl2 Negative_regulation of Localization of Aifm1	1	0.06	1.22	0.07
170	INT285032	Bnip3 Positive_regulation of Bax	1	0.28	0.77	0.07
171	INT223085	Binding of Pdgfb and Insrr	1	0.01	0.91	0.07
172	INT270835	Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1	1	0.04	0.08	0.07
173	INT297733	Cbr1 Regulation of Gene_expression of Bcl2	1	0.05	0.94	0.07
174	INT279280	Binding of PDGFA and PDGFB	1	0.06	0.9	0.06
175	INT343477	Epo Positive_regulation of Pdgfb	1	0.11	0.31	0.06
176	INT225023	PDGFB Regulation of Transcription of Ccl21	1	0.11	0	0.06
177	INT302177	PTGER2 Positive_regulation of BCL2	1	0.04	2.08	0.06
178	INT94852	PDGFB Regulation of Gene_expression of COL7A1	1	0.09	0.06	0.06
179	INT316819	Sparc Negative_regulation of Gene_expression of Ctgf	1	0.41	0.24	0.06
180	INT225022	PDGFB Regulation of Ccl21	1	0.11	0	0.06
181	INT316822	Sparc Regulation of Gene_expression of Ctgf	1	0.68	0.48	0.06
182	INT352299	Regulation of Binding of BCL2 and VIM	1	0.10	1.07	0.06
183	INT343471	Epo Positive_regulation of Gene_expression of Pdgfb	1	0.11	0.31	0.06
184	INT352298	Binding of BCL2 and VIM	1	0.09	1.06	0.06
185	INT341375	Sod2 Regulation of Bcl2	1	0.08	1.96	0.05
186	INT340427	Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1	1	0.01	1	0.05
187	INT190824	Binding of Cl and Bcl2	1	0.02	1.4	0.05
188	INT333252	Positive_regulation of Binding of Bcl2 and Mcl1	1	0.03	0.88	0.04
189	INT202310	Binding of PDGFB and Pdgfrb	1	0.11	0.39	0.04
190	INT270825	P2rx7 Positive_regulation of Slc37a4	1	0.01	0	0.04
191	INT268664	Ptger2 Positive_regulation of Bcl2	1	0.02	0.9	0.04
192	INT263427	Pdgfb Positive_regulation of Phosphorylation of Rock1	1	0.00	0	0.04
193	INT333245	Binding of Bcl2 and Bcl2l11	1	0.03	0.87	0.04
194	INT268666	Ptger2 Positive_regulation of Gene_expression of Bcl2	1	0.02	0.9	0.04
195	INT223086	Binding of Pdgfb and Pdgfrb	1	0.33	0.46	0.04
196	INT348881	Atpif1 Positive_regulation of If3	1	0.01	0.08	0.04
197	INT348885	Atpif1 Positive_regulation of EIF5B	1	0.01	0.08	0.04
198	INT350905	Binding of Bcl2 and Pcsk4	1	0.03	0.96	0.04
199	INT333253	Binding of Bcl2 and Mcl1	1	0.02	2.14	0.04
200	INT250025	Map3k1 Positive_regulation of Regulation of Bcl2	1	0.01	1.1	0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for reactive oxygen species metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in reactive oxygen species metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT82650	Gene_expression of Bcl2	312	0.78	211.71	55.03
2	INT77307	Gene_expression of Bcl2	399	0.77	319.77	38
3	INT49519	Gene_expression of P2rx7	84	0.76	36.88	34.69
4	INT65960	Gene_expression of BCL2	352	0.78	312.03	30.73
5	INT88327	Gene_expression of P2rx7	109	0.77	48.86	22.41
6	INT160564	Gene_expression of Il22	64	0.55	59.29	20.9
7	INT23787	Positive_regulation of P2rx7	36	0.68	23.54	19.45
8	INT93734	Positive_regulation of Gene_expression of Bcl2	76	0.70	61.95	18.46
9	INT86673	Positive_regulation of Bcl2	77	0.70	57.74	17.37
10	INT121241	Positive_regulation of P2rx7	65	0.69	40.94	13.59
11	INT80222	Negative_regulation of Bcl2	82	0.58	69.16	13.18
12	INT92686	Gene_expression of Ctgf	51	0.77	34.4	11.93
13	INT81640	Positive_regulation of Gene_expression of Bcl2	106	0.69	84.58	11.63
14	INT73427	Localization of P2rx7	24	0.79	8.65	9.87
15	INT70017	Positive_regulation of BCL2	87	0.67	66.62	8.68
16	INT48257	Negative_regulation of P2rx7	18	0.41	7.82	8.42
17	INT70896	Gene_expression of PDGFB	48	0.65	33.55	8.39
18	INT86672	Negative_regulation of Bcl2	50	0.53	34.16	8.37
19	INT65959	Positive_regulation of Gene_expression of BCL2	75	0.70	77.3	8.27
20	INT80220	Positive_regulation of Bcl2	71	0.58	57.73	7.86
21	INT77306	Negative_regulation of Gene_expression of Bcl2	46	0.58	38.05	7.71
22	INT91445	Regulation of Bcl2	50	0.56	38.8	7.41
23	INT93101	Regulation of Gene_expression of Bcl2	26	0.62	18.45	6.71
24	INT84685	Regulation of BCL2	67	0.60	72.96	6.65
25	INT88326	Negative_regulation of P2rx7	16	0.58	8.77	6.25
26	INT94608	Regulation of P2rx7	19	0.23	8.06	6.19
27	INT68882	Binding of P2rx7	16	0.23	4.33	6.17
28	INT100422	Negative_regulation of Gene_expression of Bcl2	46	0.58	28.86	5.7
29	INT145680	Regulation of P2rx7	22	0.61	11.92	5.42
30	INT70613	Negative_regulation of Gene_expression of BCL2	48	0.59	38.91	5.22
31	INT73262	Negative_regulation of BCL2	67	0.57	61.01	5.07
32	INT236335	Gene_expression of SFTPD	26	0.75	15.92	4.59
33	INT92682	Positive_regulation of Gene_expression of Ctgf	17	0.69	12.16	4.51
34	INT74531	Regulation of PDGFB	14	0.26	7.57	4.38
35	INT101957	Transcription of Bcl2	30	0.69	16.57	4.3
36	INT185484	Positive_regulation of Gene_expression of P2rx7	8	0.31	7.44	4.28
37	INT296054	Positive_regulation of Il22	13	0.33	17.97	4.06
38	INT144830	Positive_regulation of Gene_expression of P2rx7	22	0.68	9.78	3.92
39	INT105882	Phosphorylation of Bcl2	11	0.59	8.15	3.73
40	INT285489	Positive_regulation of Gene_expression of Il22	9	0.32	10.97	3.63
41	INT70897	Positive_regulation of Gene_expression of PDGFB	15	0.57	13.04	3.52
42	INT92681	Positive_regulation of Ctgf	13	0.69	9.78	3.47
43	INT113604	Negative_regulation of Gene_expression of Ctgf	19	0.58	9.37	3.43
44	INT109403	Regulation of Gene_expression of BCL2	31	0.60	31.22	3.4
45	INT70895	Localization of PDGFB	20	0.52	8.98	3.4
46	INT129441	Regulation of Gene_expression of P2rx7	8	0.24	4.29	3.32
47	INT162372	Positive_regulation of SFTPD	15	0.67	11.8	3.21
48	INT70885	Gene_expression of Pdgfb	48	0.67	42.27	3.19
49	INT81642	Regulation of Gene_expression of Bcl2	20	0.44	16.93	3.19
50	INT64234	Regulation of Bcl2	41	0.54	31.88	3.16
51	INT144828	Binding of P2rx7	19	0.47	7.84	3.16
52	INT105884	Binding of Bcl2	19	0.35	15.67	3
53	INT107216	Negative_regulation of Gene_expression of P2rx7	10	0.56	3.39	2.61
54	INT306726	Localization of Il22	4	0.57	5.52	2.57
55	INT74527	Positive_regulation of PDGFB	14	0.38	13.31	2.54
56	INT105694	Binding of SFTPD	11	0.46	8.47	2.45
57	INT140091	Gene_expression of Ctgf	26	0.78	14.21	2.39
58	INT147349	Localization of Bcl2	13	0.65	7.83	2.31
59	INT63394	Gene_expression of Drd5	7	0.76	1.85	2.3
60	INT142677	Negative_regulation of Positive_regulation of Bcl2	4	0.36	3.09	2.24
61	INT144829	Localization of P2rx7	12	0.79	2.92	2.12
62	INT63392	Positive_regulation of Drd5	5	0.46	1.73	2.08
63	INT86671	Negative_regulation of Positive_regulation of Bcl2	6	0.57	3.83	2.03
64	INT69702	Positive_regulation of PMAIP1	7	0.35	8.81	1.98
65	INT101108	Localization of Bcl2	16	0.72	11.68	1.86
66	INT105883	Positive_regulation of Phosphorylation of Bcl2	8	0.32	5.67	1.86
67	INT245577	Localization of SFTPD	7	0.63	10.43	1.84
68	INT216936	Negative_regulation of Gene_expression of P2rx7	5	0.42	2.59	1.84
69	INT101958	Positive_regulation of Transcription of Bcl2	4	0.50	2.22	1.65
70	INT137513	Negative_regulation of Positive_regulation of BCL2	6	0.35	5.3	1.62
71	INT212048	Negative_regulation of SFTPD	3	0.42	5.45	1.61
72	INT23786	Positive_regulation of Positive_regulation of P2rx7	5	0.44	2.21	1.58
73	INT125735	Transcription of P2rx7	3	0.62	1.34	1.58
74	INT74528	Negative_regulation of PDGFB	11	0.40	10.34	1.48
75	INT74530	Transcription of PDGFB	7	0.65	4.56	1.47
76	INT215757	Transcription of P2rx7	3	0.21	1.84	1.45
77	INT92685	Transcription of Ctgf	7	0.72	3.92	1.44
78	INT205691	Regulation of Gene_expression of P2rx7	5	0.44	3.25	1.42
79	INT336571	Gene_expression of DRD5	1	0.06	0.73	1.41
80	INT285482	Negative_regulation of Il22	3	0.30	3.02	1.37
81	INT44529	Positive_regulation of Pdgfb	11	0.43	7.98	1.36
82	INT205690	Positive_regulation of Positive_regulation of P2rx7	14	0.68	6.26	1.3
83	INT101107	Positive_regulation of Localization of Bcl2	3	0.48	3.13	1.28
84	INT192349	Negative_regulation of Gene_expression of PDGFB	5	0.31	2.64	1.25
85	INT285470	Regulation of Il22	4	0.11	4.18	1.21
86	INT70886	Positive_regulation of Gene_expression of Pdgfb	13	0.45	12.57	1.17
87	INT158565	Regulation of Ctgf	3	0.61	3.93	1.14
88	INT103859	Positive_regulation of Drd5	2	0.49	0.81	1.14
89	INT180975	Gene_expression of IL19	20	0.75	9.12	1.13
90	INT158563	Negative_regulation of Ctgf	6	0.56	4.31	1.12
91	INT172855	Binding of Bcl2	37	0.32	23.41	1.09
92	INT70021	Localization of BCL2	23	0.74	21.6	1.09
93	INT103857	Gene_expression of Drd5	2	0.23	0.92	1.08
94	INT63393	Positive_regulation of Gene_expression of Drd5	3	0.49	1.21	1.02
95	INT105986	Positive_regulation of Transcription of Ctgf	2	0.69	2.43	1.01
96	INT216661	Regulation of Positive_regulation of P2rx7	1	0.07	0	1
97	INT306723	Binding of Il22	3	0.11	2.44	0.97
98	INT346123	Negative_regulation of Gene_expression of Il22	3	0.30	1.97	0.97
99	INT113887	Positive_regulation of Negative_regulation of P2rx7	1	0.22	1.02	0.96
100	INT85999	Binding of Drd5	2	0.27	0.84	0.94
101	INT151115	Regulation of Regulation of Bcl2	4	0.21	4.12	0.88
102	INT92117	Phosphorylation of BCL2	26	0.80	9.93	0.86
103	INT151776	Positive_regulation of Transcription of P2rx7	1	0.03	0.53	0.86
104	INT236328	Regulation of SFTPD	6	0.38	3.04	0.85
105	INT70019	Binding of BCL2	25	0.47	17.55	0.79
106	INT271589	Regulation of Transcription of P2rx7	1	0.05	0.5	0.78
107	INT109404	Transcription of BCL2	6	0.69	4.49	0.77
108	INT124844	Regulation of Positive_regulation of Bcl2	3	0.43	2.55	0.75
109	INT155392	Negative_regulation of Negative_regulation of Bcl2	3	0.21	1.64	0.74
110	INT226464	Localization of IL19	3	0.73	1.69	0.72
111	INT134444	Positive_regulation of Binding of Bcl2	3	0.47	2.67	0.72
112	INT25663	Localization of PMAIP1	3	0.38	2.47	0.71
113	INT202307	Regulation of Gene_expression of PDGFB	2	0.26	1.24	0.71
114	INT300588	Regulation of Drd5	1	0.32	0.67	0.69
115	INT306800	Positive_regulation of Localization of SFTPD	1	0.16	2.1	0.68
116	INT184846	Negative_regulation of Drd5	1	0.19	2.28	0.68
117	INT125734	Negative_regulation of Transcription of P2rx7	1	0.38	0.81	0.67
118	INT25664	Negative_regulation of Localization of PMAIP1	1	0.09	0.09	0.66
119	INT236330	Regulation of Gene_expression of SFTPD	2	0.59	1.55	0.65
120	INT74529	Binding of PDGFB	13	0.36	7.41	0.62
121	INT306730	Regulation of Gene_expression of Il22	1	0.06	1.04	0.62
122	INT185485	Negative_regulation of Localization of P2rx7	1	0.26	0.95	0.62
123	INT164585	Regulation of PMAIP1	2	0.20	2.07	0.61
124	INT277699	Gene_expression of Pdgfb	5	0.20	4.84	0.59
125	INT70025	Positive_regulation of Positive_regulation of BCL2	3	0.27	0.96	0.58
126	INT103858	Regulation of Gene_expression of Drd5	1	0.08	0.92	0.58
127	INT178128	Negative_regulation of Phosphorylation of BCL2	7	0.27	3.94	0.56
128	INT202306	Negative_regulation of Localization of PDGFB	2	0.25	0.76	0.55
129	INT155090	Regulation of Positive_regulation of BCL2	3	0.26	1.78	0.54
130	INT192946	Gene_expression of PMAIP1	2	0.27	1.77	0.52
131	INT157718	Binding of DRD5	1	0.33	0.57	0.52
132	INT164584	Positive_regulation of Positive_regulation of PMAIP1	1	0.20	0.9	0.52
133	INT144696	Regulation of Transcription of Bcl2	5	0.44	2.96	0.51
134	INT153099	Negative_regulation of Positive_regulation of P2rx7	1	0.42	0.25	0.5
135	INT180974	Positive_regulation of Gene_expression of IL19	4	0.49	2.66	0.49
136	INT134445	Positive_regulation of Positive_regulation of Bcl2	3	0.47	2.43	0.49
137	INT215732	Negative_regulation of Binding of P2rx7	1	0.11	0.74	0.49
138	INT202309	Regulation of Localization of PDGFB	1	0.36	0.92	0.49
139	INT221676	Protein_catabolism of Bcl2	4	0.24	2.77	0.48
140	INT167377	Regulation of Gene_expression of Ctgf	2	0.25	1.35	0.48
141	INT27543	Positive_regulation of ALOX12	1	0.09	2.09	0.48
142	INT158296	Positive_regulation of Gene_expression of Ctgf	5	0.47	4.82	0.47
143	INT223081	Negative_regulation of Gene_expression of Pdgfb	2	0.37	3.07	0.47
144	INT313617	Positive_regulation of Pdgfb	4	0.35	1.53	0.46
145	INT204052	Transcription of Bcl2	5	0.51	3.25	0.45
146	INT278114	Negative_regulation of Negative_regulation of P2rx7	1	0.21	0	0.45
147	INT140090	Negative_regulation of Gene_expression of Ctgf	5	0.58	1.77	0.44
148	INT140295	Protein_catabolism of BCL2	4	0.64	5.7	0.44
149	INT220424	Positive_regulation of Negative_regulation of Bcl2	2	0.14	1.81	0.44
150	INT314034	Negative_regulation of Localization of IL19	1	0.41	0.86	0.44
151	INT353938	Positive_regulation of Negative_regulation of Il22	1	0.36	0.9	0.44
152	INT215741	Positive_regulation of Transcription of P2rx7	1	0.15	1.15	0.43
153	INT70884	Localization of Pdgfb	8	0.35	6.22	0.42
154	INT220436	Binding of IL19	4	0.36	1.92	0.41
155	INT199078	Gene_expression of Nox4	3	0.59	3.83	0.41
156	INT76143	Positive_regulation of Regulation of PDGFB	1	0.01	0.08	0.4
157	INT74532	Positive_regulation of Transcription of PDGFB	1	0.57	0.73	0.4
158	INT155724	Negative_regulation of Transcription of Bcl2	6	0.53	2.35	0.37
159	INT285496	Regulation of Negative_regulation of Il22	1	0.10	1.13	0.37
160	INT344086	Binding of Drd5	1	0.36	0.06	0.37
161	INT317875	Binding of Pdgfb	3	0.10	1.15	0.36
162	INT153261	Positive_regulation of Localization of PDGFB	2	0.37	1.98	0.36
163	INT119248	Binding of Ctgf	1	0.35	1.5	0.35
164	INT213507	Gene_expression of Pax2	10	0.67	1.41	0.34
165	INT225264	Positive_regulation of IL19	4	0.49	1.58	0.34
166	INT316678	Regulation of Positive_regulation of SFTPD	1	0.38	0.96	0.34
167	INT153465	Regulation of Gene_expression of Ctgf	3	0.61	2.5	0.33
168	INT121239	Regulation of Positive_regulation of P2rx7	2	0.61	1.32	0.32
169	INT236323	Positive_regulation of Transcription of SFTPD	1	0.12	0.47	0.32
170	INT236324	Transcription of SFTPD	1	0.17	0.47	0.32
171	INT236327	Positive_regulation of Gene_expression of SFTPD	1	0.12	0.47	0.32
172	INT253424	Protein_catabolism of SFTPD	2	0.74	1.12	0.31
173	INT306727	Positive_regulation of Positive_regulation of Il22	1	0.12	1.26	0.3
174	INT285014	Gene_expression of Bnip3	4	0.61	10.38	0.29
175	INT168140	Regulation of Ctgf	2	0.60	2.15	0.29
176	INT309354	Regulation of Pax2	1	0.10	0	0.29
177	INT216937	Regulation of Binding of P2rx7	1	0.44	0.08	0.29
178	INT178114	Positive_regulation of Phosphorylation of BCL2	11	0.49	4.44	0.28
179	INT309339	Negative_regulation of Localization of Pax2	1	0.15	0	0.28
180	INT300593	Regulation of Gene_expression of Drd5	1	0.33	0.13	0.28
181	INT224441	Negative_regulation of Pdgfb	2	0.33	1.61	0.27
182	INT136840	Positive_regulation of Ctgf	2	0.35	1.34	0.27
183	INT292743	Negative_regulation of Binding of Bcl2	1	0.05	1.97	0.24
184	INT216938	Negative_regulation of Localization of P2rx7	1	0.37	0.25	0.24
185	INT285003	Positive_regulation of Regulation of Bcl2	1	0.46	0.68	0.23
186	INT349702	Positive_regulation of Transcription of Pdgfb	1	0.35	0	0.23
187	INT277701	Localization of Pdgfb	3	0.23	1.49	0.22
188	INT349701	Transcription of Pdgfb	1	0.40	0	0.22
189	INT108563	Negative_regulation of Regulation of Bcl2	1	0.32	0.74	0.22
190	INT133762	Gene_expression of Atpif1	3	0.17	0.34	0.21
191	INT226485	Regulation of IL19	1	0.07	0.56	0.21
192	INT216940	Negative_regulation of Binding of P2rx7	1	0.37	0.15	0.2
193	INT158567	Negative_regulation of Transcription of Ctgf	1	0.43	0.73	0.2
194	INT220426	Regulation of Negative_regulation of Bcl2	1	0.05	0.81	0.18
195	INT216889	Phosphorylation of P2rx7	1	0.23	0	0.18
196	INT220437	Negative_regulation of IL19	1	0.41	0.68	0.18
197	INT238507	Regulation of Regulation of BCL2	3	0.44	5.14	0.16
198	INT101109	Negative_regulation of Localization of Bcl2	1	0.03	0.62	0.16
199	INT307467	Regulation of Binding of P2rx7	1	0.08	0	0.16
200	INT229235	Regulation of Localization of BCL2	2	0.29	3.7	0.15