GO:2000774

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Name positive regulation of cellular senescence
Categary Process
Go Slim No
Go Link GO:2000774
Unique Molecular Interactions 111
Total Molecular Interactions 160
Total Single Events 1171
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cellular senescence. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cellular senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
3 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
4 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
5 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
6 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
7 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
8 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
9 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
10 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
11 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
12 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
13 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
14 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
15 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
16 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
17 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
18 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
19 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
20 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
21 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
22 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
23 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
24 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
25 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
26 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
27 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
28 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
29 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
30 INT223536 Binding of HAND1 and Hmga1 1 0.26 0.57 0.07
31 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
32 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
33 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
34 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
35 INT223531 Binding of Hmga1 and Tcf3 1 0.26 0.57 0.07
36 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
37 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
38 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
39 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
40 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
41 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
42 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
43 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
44 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
45 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
46 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
47 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
48 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
49 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
50 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
51 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
52 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
53 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
54 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
55 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
56 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
57 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
58 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
59 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
60 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
61 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
62 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
63 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
64 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
65 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
66 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
67 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
68 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
69 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
70 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
71 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
72 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
73 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
74 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
75 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
76 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
77 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
78 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
79 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
80 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
81 INT223523 Positive_regulation of Hmga1 Positive_regulation of Erv4 1 0.21 0.95 0
82 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
83 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
84 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
85 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
86 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
87 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
88 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
89 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
90 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
91 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
92 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
93 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
94 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
95 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
96 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
97 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
98 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
99 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
100 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
101 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
102 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
103 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
104 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
105 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
106 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
107 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0
108 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
109 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cellular senescence. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cellular senescence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
2 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
3 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
4 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
5 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
6 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
7 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
8 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
9 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
10 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
11 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
12 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
13 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
14 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
15 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
16 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
17 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
18 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
19 INT168167 Gene_expression of Hmga1 3 0.60 3.48 1.09
20 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
21 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
22 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
23 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
24 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
25 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
26 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
27 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
28 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
29 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
30 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
31 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
32 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
33 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
34 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
35 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
36 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
37 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
38 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
39 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
40 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
41 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
42 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
43 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
44 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
45 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
46 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
47 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
48 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
49 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
50 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
51 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
52 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
53 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
54 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
55 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
56 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
57 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
58 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
59 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
60 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
61 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
62 INT223502 Binding of Hmga1 1 0.27 0.96 0.13
63 INT223509 Positive_regulation of Gene_expression of Hmga1 1 0.38 0.96 0.13
64 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
65 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
66 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
67 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
68 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
69 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
70 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
71 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
72 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
73 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
74 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
75 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
76 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
77 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
78 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
79 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
80 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
81 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
82 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
83 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
84 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
85 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
86 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
87 INT204349 Regulation of SIRT1 8 0.61 1.99 0
88 INT256134 Localization of Sirt1 5 0.50 2.99 0
89 INT204353 Transcription of SIRT1 3 0.68 0.67 0
90 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
91 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
92 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
93 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
94 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
95 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
96 INT196923 Binding of Hmga2 1 0.47 2.5 0
97 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
98 INT289569 Transcription of Sirt1 1 0.71 0.25 0
99 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
100 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
101 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
102 INT300344 Localization of HMGA2 1 0.42 1.75 0
103 INT300287 Localization of Sirt1 1 0.66 1.46 0
104 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
105 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
106 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
107 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
108 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
109 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
110 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0
111 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
112 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
113 INT223519 Positive_regulation of Hmga1 1 0.35 0.87 0
114 INT268581 Regulation of HMGA2 1 0.18 0.72 0
115 INT184623 Positive_regulation of Localization of CDKN2A 1 0.04 0.86 0
116 INT247424 Transcription of Cdkn2a 1 0.47 0.82 0
117 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
118 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
119 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
120 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
121 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0
122 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
123 INT204331 Binding of SIRT1 1 0.47 0.39 0
124 INT247425 Regulation of Transcription of Cdkn2a 1 0.18 0.82 0
125 INT196921 Localization of Hmga2 1 0.74 0.44 0
126 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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