GOS:aging

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This page displays the top molecular interactions and top single events that were mentioned in the literature for aging. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for aging. They are ordered first by their pain relevance and then by number of times they were reported for aging. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Disease Relevance TM Confidence Documents Genes linked to aging Pain Relevance
1 INT166591 Binding of CALCA and DCLK3 0.69 0.30 4 1 12.18
2 INT145775 Ngf Positive_regulation of Trpv1 7.71 0.72 11 1 11.25
3 INT11250 Cck Positive_regulation of Gene_expression of Fos 0.08 0.78 14 1 7.29
4 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 3.92 0.10 1 1 7.2
5 INT254001 Binding of Cxcr4 and Mif 14.17 0.52 1 1 7.18
6 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 8.19 0.76 6 1 6.66
7 INT98346 Negative_regulation of Binding of CPOX and PTGS1 2.91 0.10 1 1 6.54
8 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 4.31 0.74 8 1 6.1
9 INT95068 Tlr4 Positive_regulation of IL1B 4.54 0.03 1 1 5.6
10 INT69888 Ngf Positive_regulation of Localization of Calca 0.51 0.52 4 2 4.95
11 INT102122 Binding of Calca and RT1-M4 5.83 0.29 7 1 4.94
12 INT11599 Calca Positive_regulation of Npr1 0.3 0.19 5 1 4.8
13 INT24742 Binding of Calca and Vip 0.18 0.37 1 1 4.68
14 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1.36 0.10 1 1 4.52
15 INT128295 IL1B Positive_regulation of Insr 1.36 0.11 1 1 4.5
16 INT186566 Hpcl1 Positive_regulation of Fos 0.38 0.17 1 1 4.49
17 INT64718 IL1B Positive_regulation of Gene_expression of IL6 9.37 0.59 15 2 4.48
18 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 2.97 0.55 1 1 4.23
19 INT143270 Binding of Cnr1 and Gprasp1 0.64 0.54 4 1 4.18
20 INT128998 Cxcl1 Positive_regulation of Localization of Calca 2.96 0.66 1 1 4.15
21 INT13969 Binding of Calca and Sst 0.6 0.32 3 1 4.02
22 INT127128 Binding of CNR1 and CNR2 3.98 0.39 8 1 3.97
23 INT82023 Binding of Ntrk1 and Ngf 3.48 0.53 5 2 3.92
24 INT13966 Calca Positive_regulation of Localization of Sst 0.75 0.49 5 1 3.91
25 INT143946 Binding of Pebp1 and Mastl 2.04 0.00 1 1 3.82
26 INT11252 Cck Positive_regulation of Fos 0 0.78 6 1 3.79
27 INT122349 Ngf Regulation of Trpv1 1.55 0.64 3 1 3.79
28 INT141254 Ngf Regulation of Transcription of Trpv1 1.37 0.53 1 1 3.74
29 INT85541 Ngf Positive_regulation of Gene_expression of Calca 1.84 0.55 2 2 3.71
30 INT132862 Ngf Positive_regulation of Bdnf 4.05 0.46 4 1 3.65
31 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 0.72 0.47 1 1 3.63
32 INT17317 Binding of Jun and Fos 1.03 0.42 7 2 3.5
33 INT24710 Binding of Calca and SUB1P1 2.09 0.01 1 1 3.48
34 INT108471 Binding of CALCA and PNOC 0.64 0.29 1 1 3.25
35 INT74159 Ngf Regulation of Gene_expression of Calca 1.66 0.60 2 2 3.22
36 INT270949 Binding of Slc6a3 and Cpe 0.25 0.28 1 1 3.19
37 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 0.68 0.15 1 1 3.17
38 INT29657 Binding of Calca and Calcb 0 0.26 1 1 3.16
39 INT64719 IL1B Positive_regulation of IL6 6.84 0.41 7 2 3.14
40 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 0.4 0.43 1 1 3.13
41 INT122780 Ngf Regulation of Gene_expression of Trpv1 3.74 0.65 4 1 3.11
42 INT37162 Binding of Calca and Cckar 0.55 0.04 1 1 3.01
43 INT182635 Binding of CCR5 and CCL5 4.19 0.09 2 1 3
44 INT150886 Il1a Regulation of Il1b 3.46 0.02 1 1 2.93
45 INT150888 Il1a Regulation of Il6 3.47 0.10 1 1 2.93
46 INT166592 Binding of CALCA and RAMP1 0.33 0.35 2 1 2.91
47 INT73821 CALCA Positive_regulation of Localization of IL8 2.37 0.25 1 1 2.91
48 INT318996 Binding of CCR3 and CCL5 3.39 0.07 1 1 2.9
49 INT319003 Binding of CCR1 and CCL5 3.38 0.08 1 1 2.89
50 INT264929 Binding of Cnr1 and Gnaz 1.71 0.18 1 1 2.89
51 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2.01 0.06 2 1 2.85
52 INT194409 Binding of CALCA and IGKV1D-8 0 0.15 1 1 2.84
53 INT130085 Crp Positive_regulation of Gene_expression of Vcam1 4.34 0.23 1 1 2.84
54 INT222522 Il1a Positive_regulation of Gene_expression of Il6 1.79 0.06 2 1 2.79
55 INT169134 Binding of Calca and Trpa1 3.37 0.37 1 1 2.79
56 INT190167 Binding of JUN and MMP12 0.82 0.26 1 1 2.76
57 INT317551 Binding of Akt1 and Oprm1 0.21 0.19 1 1 2.74
58 INT127621 Bst1 Regulation of Positive_regulation of Fos 0 0.26 1 1 2.73
59 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 3.07 0.08 1 1 2.71
60 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 3.07 0.76 1 1 2.71
61 INT180779 Bdnf Regulation of Calca 0.23 0.09 1 1 2.71
62 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 0.67 0.49 1 1 2.69
63 INT326585 Binding of GYPA and SLC6A3 0.86 0.13 1 1 2.64
64 INT53648 Acot1 Positive_regulation of Localization of Calca 0 0.23 2 1 2.61
65 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2.75 0.49 2 1 2.61
66 INT67663 Ins1 Positive_regulation of Ntrk2 0.19 0.00 1 1 2.59
67 INT104219 SCD Positive_regulation of Cnr1 2.67 0.00 1 1 2.54
68 INT57624 Calca Regulation of Positive_regulation of Trh 0 0.50 1 1 2.53
69 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 0.16 0.78 1 1 2.53
70 INT253988 Binding of Cd74 and Mif 6.57 0.36 1 1 2.52
71 INT48526 Binding of Calca and Penk 1.03 0.24 1 1 2.51
72 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 0.52 0.19 1 1 2.46
73 INT136129 Calca Positive_regulation of ATP8A2 0.89 0.38 1 1 2.4
74 INT81657 Binding of CPOX and PTGS1 1.9 0.15 5 1 2.37
75 INT115367 Binding of IL6 and IL6R 8.16 0.07 12 1 2.36
76 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 3.22 0.19 1 1 2.35
77 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1.4 0.37 1 2 2.34
78 INT108987 Ngf Regulation of Gene_expression of Sit1 1.46 0.00 1 1 2.32
79 INT54489 Binding of Jun and Rabep2 1.48 0.16 4 1 2.3
80 INT13967 Calca Positive_regulation of Sst 0 0.45 1 1 2.3
81 INT152900 TRPV1 Regulation of Gene_expression of CALCA 0.73 0.69 1 1 2.29
82 INT152901 TRPV1 Regulation of Localization of CALCA 0.73 0.44 1 1 2.29
83 INT124121 IL6 Positive_regulation of CCL2 1.84 0.26 1 2 2.25
84 INT124120 IL6 Regulation of CCL2 1.8 0.15 1 2 2.22
85 INT69887 Ngf Regulation of Calca 0.1 0.49 2 2 2.19
86 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 3.81 0.27 1 2 2.19
87 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 3.81 0.25 1 1 2.19
88 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 3.8 0.30 1 1 2.19
89 INT94494 Il1b Positive_regulation of Gene_expression of Il6 3.81 0.27 1 2 2.19
90 INT146520 Tmem132a Regulation of Gene_expression of Fos 0.5 0.69 1 1 2.18
91 INT209924 IL1B Negative_regulation of PPARA 4.38 0.20 1 1 2.17
92 INT128997 Cxcl1 Positive_regulation of Localization of Ccl2 1.54 0.72 1 1 2.16
93 INT120319 Ghrh Regulation of Ngf 1.89 0.25 1 1 2.11
94 INT79470 Mgat4a Regulation of Localization of Calca 1.72 0.08 1 1 2.1
95 INT89733 Binding of Calca and Nrm 0.71 0.31 1 1 2.09
96 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1.34 0.19 1 1 2.08
97 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 2.11 0.00 1 1 2.08
98 INT161190 CRX Regulation of Gene_expression of Ntrk2 3.05 0.04 1 1 2.06
99 INT161187 NMS Regulation of Gene_expression of Ntrk2 3.05 0.43 1 1 2.06
100 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 0.87 0.39 4 1 2.05
101 INT115042 Gdnf Regulation of Calca 0.25 0.53 1 1 2.03
102 INT70043 IL6 Regulation of IL10 3.59 0.18 3 1 2.01
103 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2.23 0.48 2 1 2
104 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2.23 0.49 2 1 2
105 INT128996 Ccl2 Positive_regulation of Localization of Calca 1.43 0.68 1 2 2
106 INT274372 Phc1 Negative_regulation of Slc6a3 0.47 0.06 1 1 1.99
107 INT117794 Hpcl1 Positive_regulation of Gene_expression of Fos 0.15 0.17 3 1 1.98
108 INT54488 Npepo Regulation of Gene_expression of Jun 0 0.30 1 1 1.98
109 INT87891 Agt Regulation of Cck 0 0.28 1 1 1.97
110 INT278937 LEP Positive_regulation of Gene_expression of IL6 3.42 0.32 1 1 1.97
111 INT156509 Il6 Regulation of Positive_regulation of Grin1 1.93 0.28 1 1 1.93
112 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 0.48 0.51 3 1 1.92
113 INT125348 Decr1 Regulation of Gene_expression of Fos 0.1 0.00 1 1 1.92
114 INT83418 Binding of OPRL1 and Ntrk1 0 0.02 1 1 1.91
115 INT279359 Binding of ADA and TNF 2.61 0.20 1 1 1.91
116 INT51051 IL1B Positive_regulation of Localization of IL6 3.79 0.57 7 2 1.87
117 INT183781 Binding of IL6 and INS 8.97 0.22 6 1 1.87
118 INT276668 Ngf Regulation of Nav1 0.98 0.09 1 1 1.85
119 INT81920 Binding of IL1B and NFKB1 1.54 0.04 1 1 1.85
120 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1.1 0.48 1 1 1.84
121 INT267133 Binding of ICAM1 and VCAM1 25.43 0.32 25 1 1.83
122 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 0.28 0.03 1 1 1.8
123 INT100771 Binding of Itga1 and Vcam1 3.91 0.11 3 1 1.79
124 INT302646 ARSA Positive_regulation of TGFB1 0.52 0.10 1 1 1.76
125 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1.87 0.08 1 1 1.76
126 INT146512 Tmem132a Negative_regulation of Gene_expression of Fos 0 0.23 1 1 1.76
127 INT102160 Binding of Mmp2 and Mmp9 2.87 0.28 3 2 1.75
128 INT139640 Jun Regulation of Gene_expression of Npy 1.98 0.21 1 1 1.75
129 INT24934 Calca Regulation of Nka1 0.43 0.05 3 1 1.73
130 INT37840 Binding of Cyp27b1 and Oprd1 0 0.01 1 1 1.73
131 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 4.29 0.38 3 1 1.71
132 INT264922 Binding of Cnr1 and Mors1 0.1 0.14 1 1 1.71
133 INT148090 Binding of CALCA and NCOR2 0.65 0.00 1 1 1.71
134 INT169464 Akt1 Positive_regulation of Egfr 1.63 0.28 1 1 1.7
135 INT94617 KNG1 Positive_regulation of Localization of Calca 0.75 0.00 1 1 1.7
136 INT89379 TNF Positive_regulation of Gene_expression of IL6 4.37 0.50 5 1 1.69
137 INT10202 Agt Positive_regulation of Avp 0 0.70 3 1 1.69
138 INT213071 IL6 Positive_regulation of Gene_expression of CRP 6.58 0.52 4 1 1.68
139 INT160304 Npy Regulation of Gene_expression of Fos 1.43 0.67 3 1 1.68
140 INT56134 CALCA Positive_regulation of POMC 0.72 0.71 2 1 1.68
141 INT80199 Ngf Regulation of Transcription of Rab38 1.48 0.01 1 1 1.68
142 INT102447 Binding of CALCA and CALCRL 0.33 0.26 2 1 1.67
143 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3.05 0.75 3 1 1.66
144 INT94618 KNG1 Positive_regulation of Calca 0.75 0.00 1 1 1.66
145 INT100274 IL1RN Negative_regulation of IL1B 1.79 0.53 5 1 1.65
146 INT144213 Nppa Positive_regulation of Localization of Calca 2.8 0.71 1 1 1.65
147 INT278223 Binding of NOS3 and ACSM3 6.32 0.41 1 1 1.65
148 INT83093 IL1B Positive_regulation of BDKRB1 0.44 0.51 1 1 1.65
149 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 0 0.01 1 1 1.65
150 INT23889 Calca Positive_regulation of Localization of Tacr1 0.45 0.11 1 1 1.65
151 INT24157 Binding of CALCA and SFTPA1 0.96 0.07 2 1 1.64
152 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 1.01 0.47 4 1 1.63
153 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 2.13 0.46 3 1 1.63
154 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 0.54 0.12 1 1 1.63
155 INT54484 Npepo Positive_regulation of Gene_expression of Fos 0 0.43 1 1 1.63
156 INT160578 Binding of CALCA and TAC1 0.91 0.07 1 1 1.61
157 INT73116 TYMS Negative_regulation of DNMT3B 0 0.24 1 1 1.6
158 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 0 0.24 1 1 1.6
159 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 0.33 0.02 1 1 1.59
160 INT105112 Plat Positive_regulation of JUN 1.55 0.01 1 1 1.58
161 INT158774 Mapk14 Regulation of Il6 0.08 0.11 1 1 1.57
162 INT212660 Nr3c1 Regulation of KCNA1 1.25 0.00 1 1 1.57
163 INT148935 Ramp1 Regulation of Calca 0.69 0.27 1 1 1.56
164 INT315284 PRKG1 Positive_regulation of Nos1 0.85 0.33 1 1 1.56
165 INT74937 IL1B Positive_regulation of CPOX 1.13 0.18 5 1 1.55
166 INT158877 PRS Positive_regulation of Gene_expression of Fos 5.14 0.09 1 1 1.54
167 INT8734 Pebp1 Positive_regulation of Oprd1 0 0.01 1 1 1.54
168 INT170654 Binding of Ntf3 and Ngf 1.66 0.38 1 1 1.54
169 INT13970 Positive_regulation of Calca Positive_regulation of Sst 0 0.37 1 1 1.53
170 INT13965 Calca Positive_regulation of Positive_regulation of Sst 0 0.37 1 1 1.53
171 INT192081 Igkv11-125 Positive_regulation of Cnr1 0.23 0.10 1 1 1.51
172 INT79021 Regulation of Binding of Jun and Fos 0.66 0.50 2 2 1.5
173 INT10276 Il1b Regulation of Gene_expression of Penk 0.85 0.61 1 1 1.5
174 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1.69 0.48 1 1 1.5
175 INT126718 Binding of Il6 and Il6r 2.33 0.09 3 1 1.49
176 INT96784 Binding of CALCA and Calca 0.27 0.23 3 2 1.47
177 INT150885 Il6 Regulation of Il10 1.74 0.22 1 1 1.47
178 INT180791 Negative_regulation of Gdnf Regulation of Calca 0 0.17 1 1 1.47
179 INT158776 Il1b Regulation of Ephb1 0.09 0.15 1 1 1.46
180 INT83416 Binding of OPRK1 and Ntrk1 0 0.02 1 1 1.45
181 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 0 0.17 1 1 1.45
182 INT276681 Calca Regulation of Nav1 0.74 0.07 1 1 1.45
183 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 0.1 0.10 3 1 1.44
184 INT155371 VIP Positive_regulation of Localization of IL6 3.37 0.64 1 1 1.44
185 INT180789 Ngf Regulation of Localization of Trpv1 1.22 0.28 1 1 1.44
186 INT95325 HTR1B Negative_regulation of Calca 0.69 0.47 1 1 1.43
187 INT214372 Ptprq Positive_regulation of Akt1 0.88 0.04 1 1 1.43
188 INT236365 Binding of CD40LG and IL6 4.16 0.20 3 1 1.42
189 INT150069 Cnr1 Regulation of Cnr2 0.83 0.50 2 1 1.42
190 INT100908 Slc6a3 Regulation of Positive_regulation of Etf1 0 0.05 1 1 1.41
191 INT68723 Pomgnt1 Negative_regulation of Gene_expression of Fos 0 0.12 1 1 1.41
192 INT144122 Binding of Calca and P2rx6 0 0.10 1 1 1.4
193 INT180809 Ngf Positive_regulation of Positive_regulation of Sorbs1 0.84 0.03 1 1 1.4
194 INT169163 Binding of Calca and Ctbs 0.51 0.00 1 1 1.4
195 INT134764 Ghrl Regulation of Gene_expression of NOS3 2.66 0.02 1 1 1.4
196 INT180808 Ngf Positive_regulation of Gene_expression of Sorbs1 0.84 0.03 1 1 1.4
197 INT172834 Binding of IL6 and T2dm2 6.4 0.00 1 1 1.4
198 INT197111 Binding of IL1B and MCF2 2.12 0.02 1 1 1.4
199 INT51213 Vip Regulation of Localization of Calca 0 0.38 1 1 1.39
200 INT108583 Binding of Vip and Fos 0 0.36 1 1 1.39

Single Events

The table below shows the top 100 pain related interactions that have been reported for aging. They are ordered first by their pain relevance and then by number of times they were reported in aging. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Disease Relevance TM Confidence Documents Pain Relevance
1 INT5200 Gene_expression of Fos 894.43 0.78 3083 1639.02
2 INT1912 Gene_expression of Calca 453.25 0.78 1152 739.84
3 INT5202 Positive_regulation of Gene_expression of Fos 319.28 0.70 1163 684
4 INT2543 Positive_regulation of Calca 331.13 0.70 787 592.08
5 INT5228 Positive_regulation of Fos 209.8 0.70 934 503.87
6 INT9238 Gene_expression of IL6 1135.66 0.78 1575 424.22
7 INT6056 Negative_regulation of Gene_expression of Fos 193.05 0.59 601 386.84
8 INT2540 Negative_regulation of Calca 172.11 0.59 538 384.38
9 INT6580 Negative_regulation of Ptgs1 381.53 0.59 929 376.26
10 INT2649 Regulation of Calca 146.05 0.62 433 330.95
11 INT5680 Gene_expression of Ngf 264.29 0.78 530 310.56
12 INT5591 Regulation of Gene_expression of Fos 129.06 0.62 425 265.78
13 INT5972 Gene_expression of IL1B 510.91 0.78 948 263.97
14 INT16868 Gene_expression of Il6 499.48 0.78 807 256.57
15 INT4759 Negative_regulation of Localization of Calca 82.62 0.59 294 226.45
16 INT626 Localization of CALCA 125.39 0.81 289 221.15
17 INT6665 Gene_expression of FOS 165.31 0.77 520 217.66
18 INT48955 Gene_expression of Nos2 403.87 0.78 753 208.08
19 INT2391 Negative_regulation of PTGS1 207.62 0.59 501 205.6
20 INT11313 Positive_regulation of Il6 331.27 0.70 526 201.59
21 INT10194 Positive_regulation of IL6 600.62 0.70 702 183.38
22 INT55879 Gene_expression of CCL2 240.74 0.78 421 166.02
23 INT5050 Regulation of Localization of Calca 41.25 0.62 149 148.57
24 INT3300 Positive_regulation of Gene_expression of Calca 77.76 0.70 179 144.2
25 INT2541 Binding of Calca 67.14 0.48 200 134.62
26 INT48953 Positive_regulation of Nos2 239.85 0.70 486 131.87
27 INT65731 Gene_expression of Cnr1 63.82 0.78 234 109.34
28 INT11051 Positive_regulation of Gene_expression of IL6 319.21 0.69 415 109.3
29 INT8413 Gene_expression of Ptgs1 110.17 0.78 248 108.58
30 INT12082 Localization of IL6 241.78 0.81 365 105.78
31 INT10272 Gene_expression of Il1b 121.02 0.78 194 103.03
32 INT82878 Gene_expression of Ccl2 164.95 0.78 201 101.35
33 INT11381 Positive_regulation of IL1B 209.31 0.70 330 100.9
34 INT5587 Regulation of Fos 40.81 0.62 191 99.7
35 INT4860 Positive_regulation of CALCA 73.35 0.00 148 97.61
36 INT17459 Positive_regulation of Gene_expression of FOS 53.45 0.67 182 96.38
37 INT74058 Gene_expression of Nos1 80.04 0.78 260 95.71
38 INT69764 Positive_regulation of Cnr1 67.8 0.70 126 91.49
39 INT74376 Gene_expression of Cnr1 73.43 0.78 173 89.7
40 INT5780 Regulation of Gene_expression of Calca 59.52 0.62 90 85.03
41 INT16254 Positive_regulation of Gene_expression of Ngf 80.61 0.70 144 82.08
42 INT5590 Negative_regulation of Fos 40.94 0.59 144 81.98
43 INT64636 Positive_regulation of Gene_expression of Nos2 147.52 0.70 242 79.53
44 INT2431 Positive_regulation of Mpo 211.99 0.70 275 78.47
45 INT17546 Negative_regulation of Ngf 60.28 0.59 135 77.19
46 INT15769 Gene_expression of Il1b 114.51 0.78 146 75.35
47 INT10274 Positive_regulation of Il1b 79.76 0.70 123 73.56
48 INT3034 Localization of Ngf 50.81 0.81 126 72.84
49 INT11380 Negative_regulation of IL1B 125.62 0.59 215 72.35
50 INT6849 Localization of IL1B 112.56 0.81 229 69.63
51 INT9484 Gene_expression of Jun 34.89 0.78 175 68.54
52 INT19511 Localization of Il6 118.17 0.81 212 67.67
53 INT65733 Positive_regulation of Cnr1 40.27 0.70 125 67.33
54 INT6894 Gene_expression of CNR1 74.07 0.78 168 62.84
55 INT10706 Regulation of Il6 93.23 0.62 150 62.34
56 INT6761 Binding of CALCA 26.71 0.48 100 62.05
57 INT67981 Positive_regulation of CCL2 136.84 0.70 165 61.85
58 INT9196 Gene_expression of PTGS1 96.99 0.77 215 60.5
59 INT4760 Negative_regulation of Gene_expression of Calca 34.19 0.59 93 60.3
60 INT14740 Gene_expression of TGFB1 168.48 0.78 272 60.18
61 INT1759 Gene_expression of TIMP1 133.87 0.77 267 59.29
62 INT48901 Negative_regulation of IL6 136.33 0.57 186 57.87
63 INT6669 Negative_regulation of Positive_regulation of Fos 23.5 0.59 98 56.82
64 INT17458 Negative_regulation of Gene_expression of FOS 36.77 0.57 98 55.69
65 INT82650 Gene_expression of Bcl2 211.71 0.78 312 55.03
66 INT8700 Positive_regulation of Positive_regulation of Calca 21.69 0.67 56 53.66
67 INT9234 Negative_regulation of Gene_expression of IL6 101.61 0.59 171 53.15
68 INT49017 Negative_regulation of Gene_expression of Nos2 80.64 0.59 169 52.67
69 INT83199 Gene_expression of Nos3 100.72 0.78 193 51.57
70 INT62630 Positive_regulation of CNR1 40.34 0.70 86 51.51
71 INT8490 Negative_regulation of CALCA 29.73 0.59 87 51.34
72 INT49028 Positive_regulation of Nos1 34.73 0.70 102 51.05
73 INT6473 Positive_regulation of Gene_expression of IL1B 117.23 0.70 204 50.86
74 INT9210 Regulation of IL6 125.61 0.62 166 49.95
75 INT6796 Positive_regulation of Jun 37.18 0.70 165 49.64
76 INT40777 Positive_regulation of Akt1 59.41 0.69 163 49.43
77 INT106525 Phosphorylation of Akt1 183.81 0.82 436 47.82
78 INT81498 Positive_regulation of Gene_expression of CCL2 53.89 0.70 107 45.22
79 INT63383 Binding of Cnr1 22.28 0.48 77 44.61
80 INT8465 Regulation of Ptgs1 36.03 0.57 100 44.41
81 INT19078 Binding of Ngf 31.03 0.48 78 44.33
82 INT49105 Gene_expression of Vcam1 157.27 0.78 157 43.01
83 INT11406 Positive_regulation of Localization of CALCA 20.64 0.70 49 42.8
84 INT50957 Negative_regulation of Il6 79.08 0.59 134 42.67
85 INT82883 Positive_regulation of Ccl2 84.96 0.69 105 42.27
86 INT9233 Negative_regulation of Gene_expression of IL1B 56.99 0.59 114 41.82
87 INT5973 Regulation of IL1B 66.6 0.62 109 39.88
88 INT68975 Gene_expression of Mmp9 79.57 0.78 111 38.55
89 INT385 Gene_expression of Agt 63.62 0.78 182 37.91
90 INT64558 Negative_regulation of Nos1 26.76 0.58 88 36.78
91 INT390 Positive_regulation of Agt 61.47 0.70 170 36.08
92 INT12608 Regulation of CNR1 24.36 0.60 62 36.02
93 INT6484 Binding of IL1B 75.84 0.47 122 35.07
94 INT66005 Regulation of Cnr1 19.21 0.61 47 34.52
95 INT50308 Binding of Cnr1 14.41 0.48 61 33.52
96 INT8784 Negative_regulation of Positive_regulation of Calca 14.67 0.59 40 33.49
97 INT65698 Localization of CCL2 77.54 0.81 118 32.69
98 INT84170 Positive_regulation of Gene_expression of Ccl2 48.79 0.69 58 32.43
99 INT62830 Gene_expression of VCAM1 125.23 0.78 149 32.4
100 INT6053 Transcription of Fos 20.97 0.72 107 31.88
101 INT114881 Gene_expression of Akt1 102.49 0.78 227 31.81
102 INT29503 Gene_expression of Mmp2 56.92 0.77 95 31.68
103 INT1159 Negative_regulation of Agt 40.14 0.59 133 31.67
104 INT9347 Localization of Il1b 26.13 0.81 58 31.53
105 INT47764 Binding of Jun 22.62 0.48 106 31.39
106 INT8027 Regulation of Gene_expression of Ngf 26.32 0.62 34 31.16
107 INT56290 Negative_regulation of Gene_expression of Il6 47.98 0.59 79 31.07
108 INT6058 Localization of Fos 16.7 0.81 73 30.84
109 INT1158 Regulation of Agt 29.4 0.61 106 30.29
110 INT68973 Positive_regulation of Mmp9 58.56 0.52 89 30.04
111 INT86437 Binding of IL6 121.22 0.48 154 29.3
112 INT651 Positive_regulation of PTGS1 37.27 0.69 93 29.18
113 INT2389 Regulation of PTGS1 31.23 0.61 86 28.95
114 INT23463 Positive_regulation of Gene_expression of CALCA 18.14 0.70 47 28.76
115 INT116737 Localization of Mif 52.97 0.81 63 28.11
116 INT82882 Localization of Ccl2 41.96 0.80 61 28
117 INT112707 Negative_regulation of Akt1 28.85 0.59 89 27.76
118 INT111359 Localization of Cnr1 11.25 0.81 55 27.41
119 INT116861 Gene_expression of Apoe 100.41 0.78 182 27.26
120 INT17331 Positive_regulation of JUN 60.4 0.69 132 27.03
121 INT97 Negative_regulation of Adrb1 32.44 0.59 102 26.9
122 INT5650 Gene_expression of Mpo 80.27 0.77 117 26.42
123 INT48979 Regulation of Gene_expression of FOS 14.4 0.61 52 25.95
124 INT122570 Negative_regulation of Akt1 91.44 0.59 173 25.53
125 INT61953 Transcription of Nos2 46.64 0.72 101 25.49
126 INT5948 Regulation of Il1b 22.8 0.60 44 25.4
127 INT74688 Regulation of Nos1 22.16 0.62 55 25.3
128 INT74377 Regulation of Cnr1 16.93 0.59 38 24.77
129 INT23937 Gene_expression of EDNRA 55.63 0.65 103 24.67
130 INT40776 Gene_expression of Akt1 34.91 0.77 99 24.39
131 INT10349 Negative_regulation of Il1b 25.53 0.58 48 24.24
132 INT117718 Positive_regulation of Phosphorylation of Akt1 39.26 0.69 112 24.09
133 INT70503 Regulation of Gene_expression of Nos2 44 0.62 71 24.01
134 INT37889 Gene_expression of P2ry2 26.01 0.65 75 23.8
135 INT3330 Gene_expression of AGT 98.65 0.76 149 22.73
136 INT48081 Localization of Il1b 21.59 0.80 46 22.4
137 INT21503 Binding of Ptgs1 15.6 0.48 45 22.29
138 INT14731 Positive_regulation of TGFB1 52.57 0.67 78 22.23
139 INT14733 Positive_regulation of Gene_expression of TGFB1 49.89 0.69 71 22.2
140 INT19949 Regulation of Positive_regulation of Fos 6.11 0.60 36 22.05
141 INT3299 Positive_regulation of AGT 79.45 0.68 126 21.91
142 INT74682 Positive_regulation of Mmp2 40.46 0.69 72 21.73
143 INT74059 Positive_regulation of Gene_expression of Nos1 11.5 0.70 55 21.39
144 INT5586 Binding of Fos 12.7 0.48 47 21.33
145 INT61825 Negative_regulation of Slc6a3 6.52 0.59 47 21.27
146 INT54708 Gene_expression of Adrbk1 1.06 0.75 22 20.62
147 INT51474 Binding of Il6 44.99 0.48 55 20.52
148 INT45840 Positive_regulation of Gene_expression of Ptgs1 16.07 0.50 35 20.49
149 INT8765 Positive_regulation of Cyp3a23/3a1 22.28 0.67 63 20.39
150 INT9237 Regulation of Gene_expression of IL1B 30.69 0.62 49 20.34
151 INT40750 Gene_expression of Mif 34.59 0.78 61 20.28
152 INT10442 Negative_regulation of CNR1 20.88 0.59 47 20.2
153 INT65907 Negative_regulation of Gene_expression of Ngf 19.5 0.59 36 20.03
154 INT51055 Positive_regulation of TIMP1 50.07 0.69 103 19.86
155 INT64261 Negative_regulation of Positive_regulation of Ngf 16.28 0.59 21 19.78
156 INT51054 Negative_regulation of Localization of IL6 24.48 0.59 45 18.97
157 INT56239 Positive_regulation of Rtn4 14.05 0.26 20 18.8
158 INT7000 Positive_regulation of Htr2a 9.48 0.67 42 18.7
159 INT89594 Gene_expression of Ccl5 24.08 0.54 44 18.62
160 INT9482 Positive_regulation of Gene_expression of Jun 9.95 0.69 60 18.61
161 INT93734 Positive_regulation of Gene_expression of Bcl2 61.95 0.70 76 18.46
162 INT84171 Negative_regulation of Gene_expression of Ccl2 26.37 0.58 30 18.28
163 INT187513 Positive_regulation of Pla2g4a 34.09 0.62 5 18.22
164 INT55880 Negative_regulation of Gene_expression of CCL2 22.37 0.59 49 18.09
165 INT9246 Positive_regulation of Cat 52.73 0.70 113 18.04
166 INT55878 Regulation of Gene_expression of CCL2 15.71 0.62 34 17.97
167 INT5922 Gene_expression of Rtn4 12.7 0.48 27 17.86
168 INT83198 Positive_regulation of Nos3 35.69 0.64 78 17.71
169 INT12081 Localization of TGFB1 35.4 0.81 64 17.47
170 INT6728 Gene_expression of Ednra 13.41 0.65 43 17.38
171 INT36054 Transcription of IL1B 32.64 0.72 53 17.31
172 INT195831 Phosphorylation of Pla2g4a 34.43 0.74 15 17.14
173 INT1533 Negative_regulation of AGT 46.54 0.42 105 16.92
174 INT65214 Binding of Slc6a3 4.77 0.48 54 16.79
175 INT61949 Regulation of Nos2 34.08 0.58 74 16.7
176 INT2432 Positive_regulation of Cp 31.1 0.67 41 16.68
177 INT77620 Gene_expression of Fas 72.4 0.78 146 16.61
178 INT87932 Positive_regulation of Gene_expression of Cnr1 8.86 0.69 28 16.38
179 INT62629 Localization of CNR1 11.86 0.76 35 16.3
180 INT50932 Positive_regulation of Positive_regulation of Il6 24.9 0.69 36 16.12
181 INT12950 Gene_expression of Cat 35.94 0.75 85 15.76
182 INT116736 Positive_regulation of Mif 31.93 0.70 40 15.37
183 INT54356 Regulation of Slc6a3 5.86 0.58 48 15.24
184 INT71634 Gene_expression of SLC6A3 13.48 0.78 45 15.23
185 INT49532 Regulation of Gene_expression of Il6 25.8 0.61 43 14.99
186 INT32802 Negative_regulation of Ada 4.03 0.57 21 14.87
187 INT74098 Negative_regulation of Gene_expression of Nos1 16.25 0.59 36 14.82
188 INT663 Negative_regulation of Adrb3 15.95 0.59 55 14.68
189 INT61635 Positive_regulation of P2ry2 12.08 0.56 35 14.68
190 INT2843 Gene_expression of Epo 62.01 0.78 100 14.66
191 INT5324 Binding of Htr2a 7.14 0.47 23 14.66
192 INT5904 Localization of MPO 36.37 0.81 62 14.64
193 INT60197 Gene_expression of JUN 42.32 0.78 90 14.61
194 INT95 Positive_regulation of Adrb1 11.95 0.62 34 14.41
195 INT25266 Positive_regulation of Localization of IL1B 15.89 0.69 38 14.35
196 INT17593 Regulation of Jun 5.5 0.60 37 14.35
197 INT20071 Positive_regulation of HTR2A 10.89 0.67 33 14
198 INT22272 Negative_regulation of HTR2A 7.62 0.57 28 13.87
199 INT55740 Gene_expression of Timp1 28.63 0.75 53 13.85
200 INT110 Regulation of Adrb3 8.09 0.60 33 13.84
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