GOS:enzyme regulator activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for enzyme regulator activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enzyme regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for enzyme regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Genes linked to enzyme regulator activity Documents TM Confidence Disease Relevance Pain Relevance
1 INT249566 Binding of Oprd1 and Psmd1 1 1 0.01 0.82 3.8
2 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 1 0.01 0.66 2.5
3 INT231967 Binding of Psmd1 and Cpn1 1 1 0.06 1.39 2.25
4 INT353630 Binding of Psmd1 and Shbdp1 1 1 0.02 0 0.76
5 INT297335 Binding of Apoc3 and Hdl1 1 1 0.00 0.92 0.29
6 INT334669 Negative_regulation of Car1 Negative_regulation of Positive_regulation of Psmd1 1 1 0.13 1.17 0.27
7 INT334664 Negative_regulation of Gria2 Negative_regulation of Positive_regulation of Psmd1 1 1 0.19 1.17 0.27
8 INT8309 Rgn Positive_regulation of LH 1 1 0.02 0 0.27
9 INT191504 CPN2 Positive_regulation of NLRP3 1 1 0.00 0.37 0.27
10 INT8313 Rgn Regulation of Regulation of LH 1 1 0.01 0 0.25
11 INT8323 Rgn Regulation of Localization of LH 1 1 0.01 0 0.24
12 INT8322 Fshr Regulation of Rgn 1 1 0.01 0 0.23
13 INT8316 Rgn Regulation of LH 1 1 0.01 0 0.2
14 INT8301 Gnrh1 Regulation of Rgn 1 1 0.01 0 0.2
15 INT8306 LH Regulation of Rgn 1 1 0.02 0 0.2
16 INT8305 Grp Regulation of Rgn 1 1 0.01 0 0.2
17 INT8314 Rgn Regulation of Grp 1 1 0.01 0 0.2
18 INT8324 Grpr Regulation of Rgn 1 1 0.00 0 0.19
19 INT329850 APOA5 Negative_regulation of Transcription of APOC3 1 1 0.24 0.85 0.15
20 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 1 0.01 0.42 0.08
21 INT298356 PSMD1 Regulation of Gene_expression of Cd14 1 1 0.04 0.42 0.08
22 INT166784 Binding of PSMD1 and Nkx6-2 1 1 0.21 0.5 0.08
23 INT208363 Binding of Apoc3 and Positive_regulation of Binding of Apoe Apoe 1 1 0.02 0.72 0.05
24 INT208353 Binding of Apoc4 and Apoc3 1 1 0.00 2.56 0.04
25 INT325027 Apoc3 Negative_regulation of Pnlip 1 1 0.01 1.02 0.04
26 INT231605 Binding of PSMD1 and SGCG 1 1 0.02 0.34 0.04
27 INT325026 Apoc3 Negative_regulation of Lpl 1 1 0.03 1.01 0.04
28 INT332978 ACOX1 Negative_regulation of Transcription of Apoc3 1 1 0.00 0.98 0
29 INT209454 Binding of PSMD1 and PSMD2 2 1 0.15 0 0
30 INT28371 CPN2 Regulation of GHRL 1 1 0.00 0 0
31 INT247441 Binding of APOC3 and SNRNP70 1 1 0.04 0.26 0
32 INT165318 Binding of PSMD1 and CHPT1 1 1 0.23 0.57 0
33 INT247444 Binding of APOA1 and APOC3 1 1 0.28 0.39 0
34 INT208349 Regulation of Binding of Apoc3 and Apoe 1 1 0.01 0.38 0
35 INT171599 Binding of APOC3 and Sst1 1 1 0.01 0.68 0
36 INT276607 Binding of DBT and PSMD1 1 1 0.00 0.08 0
37 INT209452 Binding of PSMD2 and PSMD3 2 1 0.07 0.2 0
38 INT185269 Nes Regulation of Psmd1 1 1 0.01 0 0
39 INT185274 Ifaprc2 Regulation of Psmd1 1 1 0.02 0 0
40 INT208365 Apoc3 Positive_regulation of Localization of PROC 1 1 0.00 1.13 0
41 INT332962 Acaa1a Negative_regulation of Transcription of Apoc3 1 1 0.01 0.93 0
42 INT208355 Binding of Apoc3 and Apoe 1 1 0.01 0.76 0
43 INT185271 Pax6 Regulation of Psmd1 1 1 0.02 0 0
44 INT209453 Binding of PSMD1 and PSMD3 2 1 0.08 0.2 0
45 INT171602 APOC3 Negative_regulation of Lipg 1 1 0.04 0.38 0
46 INT171603 APOC3 Negative_regulation of Lpl 1 1 0.48 0.38 0
47 INT185273 Vim Regulation of Psmd1 1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for enzyme regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in enzyme regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
2 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
3 INT197447 Negative_regulation of Psmd1 12 0.33 4.33 7.66
4 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
5 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
6 INT249561 Positive_regulation of Psmd1 12 0.37 7.32 5.06
7 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
8 INT205954 Regulation of Psmd1 8 0.33 3.72 4.52
9 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
10 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73
11 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
12 INT197446 Localization of Psmd1 10 0.56 3.78 2.79
13 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
14 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
15 INT249562 Regulation of Positive_regulation of Psmd1 1 0.33 1.2 2.09
16 INT190883 Gene_expression of Apoc3 16 0.38 14.18 1.93
17 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
18 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
19 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
20 INT32040 Positive_regulation of CPN2 6 0.35 0.67 1.53
21 INT249558 Binding of Psmd1 1 0.28 0.49 1.35
22 INT249556 Regulation of Localization of Psmd1 1 0.33 0.44 1.29
23 INT12108 Regulation of Sln 2 0.39 0.27 1.15
24 INT16157 Gene_expression of CPN2 4 0.26 0 1.14
25 INT166261 Localization of SLN 2 0.66 1.23 1.07
26 INT263912 Positive_regulation of SLN 6 0.39 0.66 0.99
27 INT5423 Protein_catabolism of CPN2 4 0.72 0 0.94
28 INT263905 Gene_expression of SLN 33 0.63 23.21 0.74
29 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58
30 INT5422 Negative_regulation of CPN2 2 0.31 0 0.53
31 INT5420 Binding of CPN2 3 0.35 0.08 0.51
32 INT210 Positive_regulation of Sln 10 0.43 4.06 0.49
33 INT263904 Negative_regulation of Gene_expression of SLN 1 0.14 7.18 0.47
34 INT197765 Gene_expression of Sln 26 0.58 12.11 0.45
35 INT350879 Negative_regulation of Localization of PSMD1 1 0.05 0.43 0.43
36 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42
37 INT335112 Regulation of Localization of APOC3 1 0.13 0.73 0.4
38 INT335117 Localization of APOC3 1 0.40 0.73 0.4
39 INT336330 Regulation of Transcription of Apoc3 1 0.00 0.68 0.35
40 INT336332 Negative_regulation of Transcription of Apoc3 1 0.01 0.68 0.35
41 INT336328 Negative_regulation of Apoc3 1 0.01 0.67 0.35
42 INT336326 Transcription of Apoc3 1 0.01 0.62 0.35
43 INT335718 Regulation of Gene_expression of PSMD2 1 0.09 0.07 0.35
44 INT336324 Regulation of Negative_regulation of Apoc3 1 0.00 0.68 0.35
45 INT52346 Localization of Sln 18 0.69 2.56 0.34
46 INT11689 Binding of PSMD2 16 0.36 2.77 0.34
47 INT48780 Regulation of CPN2 1 0.29 0.38 0.34
48 INT142804 Transcription of Sln 2 0.59 0.72 0.33
49 INT15968 Negative_regulation of Sln 6 0.37 3.03 0.32
50 INT32707 Positive_regulation of Sln 2 0.49 1.3 0.32
51 INT352261 Gene_expression of Rgn 1 0.28 1.5 0.32
52 INT190878 Positive_regulation of Gene_expression of Apoc3 3 0.29 2.76 0.3
53 INT11688 Binding of PSMD3 5 0.36 1.17 0.28
54 INT197766 Binding of Sln 5 0.32 1.6 0.25
55 INT322282 Localization of PSMD2 2 0.20 1.42 0.22
56 INT171597 Gene_expression of APOC3 9 0.77 3.18 0.2
57 INT268903 Protein_catabolism of Sln 5 0.75 0.83 0.2
58 INT335113 Negative_regulation of Gene_expression of APOC3 1 0.24 0.34 0.2
59 INT5421 Localization of CPN2 1 0.58 0 0.2
60 INT128910 Positive_regulation of Positive_regulation of Sln 1 0.04 0.17 0.19
61 INT208335 Binding of Apoc3 3 0.01 2.11 0.18
62 INT190876 Negative_regulation of Apoc3 2 0.15 1.43 0.17
63 INT171595 Negative_regulation of APOC3 3 0.43 1.99 0.15
64 INT171589 Transcription of APOC3 2 0.71 1.25 0.15
65 INT46438 Negative_regulation of RAB3GAP2 1 0.00 0.58 0.15
66 INT352256 Negative_regulation of Rgn 1 0.20 1.32 0.15
67 INT263532 Negative_regulation of Gene_expression of Sln 4 0.37 1.01 0.13
68 INT190877 Regulation of Gene_expression of Apoc3 2 0.11 2.09 0.13
69 INT314749 Positive_regulation of Gene_expression of Psmd1 1 0.17 2.83 0.13
70 INT15564 Regulation of PSMD2 1 0.00 0 0.12
71 INT263908 Positive_regulation of Gene_expression of SLN 1 0.16 1.4 0.12
72 INT165320 Protein_catabolism of PSMD1 1 0.61 1.37 0.11
73 INT312870 Phosphorylation of Psmd1 1 0.02 0 0.11
74 INT165319 Regulation of Protein_catabolism of PSMD1 1 0.31 1.37 0.11
75 INT208332 Positive_regulation of Apoc3 4 0.29 3.3 0.1
76 INT334958 Positive_regulation of Localization of PSMD1 1 0.10 0.87 0.1
77 INT332577 Negative_regulation of SLN 1 0.35 0.08 0.1
78 INT285256 Positive_regulation of Negative_regulation of PSMD2 1 0.04 0 0.08
79 INT263184 Positive_regulation of Eif2b1 1 0.02 0.19 0.07
80 INT202765 Positive_regulation of PSMD3 1 0.12 0.51 0.05
81 INT230602 Localization of ATP6V1H 1 0.17 0.19 0.05
82 INT268895 Protein_catabolism of Sln 1 0.54 0 0.04
83 INT268902 Negative_regulation of Protein_catabolism of Sln 1 0.32 0.08 0.03
84 INT268901 Negative_regulation of Binding of Sln 1 0.28 0.1 0.03
85 INT171594 Binding of APOC3 5 0.37 3.97 0
86 INT227884 Positive_regulation of Gene_expression of PSMD1 2 0.06 0.4 0
87 INT298024 Positive_regulation of Gene_expression of Sln 2 0.26 1.44 0
88 INT116722 Gene_expression of Apoc3 2 0.09 1.04 0
89 INT263915 Binding of SLN 2 0.12 0.81 0
90 INT116723 Positive_regulation of Apoc3 1 0.03 0.23 0
91 INT229895 Gene_expression of RAB3GAP2 1 0.01 0.13 0
92 INT248587 Positive_regulation of Gene_expression of PSMD3 1 0.04 0.16 0
93 INT283786 Transcription of Psmd1 1 0.27 0 0
94 INT222070 Localization of PSMD3 1 0.04 0.09 0
95 INT327868 Protein_catabolism of Psmd1 1 0.02 0.68 0
96 INT171590 Regulation of Gene_expression of APOC3 1 0.61 0.41 0
97 INT332950 Negative_regulation of Transcription of Apoc3 1 0.03 0.92 0
98 INT209457 Negative_regulation of Gene_expression of PSMD1 1 0.27 0.2 0
99 INT268892 Transcription of Sln 1 0.38 0 0
100 INT171592 Positive_regulation of APOC3 1 0.46 0.63 0
101 INT229013 Regulation of Apoc3 1 0.01 0.16 0
102 INT332957 Transcription of Apoc3 1 0.06 0.91 0
103 INT245611 Positive_regulation of Binding of PSMD2 1 0.43 0.1 0
104 INT263531 Phosphorylation of Sln 1 0.70 0 0
105 INT329717 Negative_regulation of Psmd1 1 0.04 0.69 0
106 INT263910 Regulation of SLN 1 0.15 1.01 0
107 INT346858 Regulation of Gene_expression of SLN 1 0.25 0.08 0
108 INT287280 Positive_regulation of Negative_regulation of PSMD1 1 0.10 0 0
109 INT268894 Localization of Sln 1 0.44 0 0
110 INT268896 Binding of Sln 1 0.23 0 0
111 INT332948 Negative_regulation of Gene_expression of Apoc3 1 0.05 0.93 0
112 INT105672 Regulation of Localization of Sln 1 0.36 0 0
113 INT209458 Negative_regulation of Gene_expression of PSMD2 1 0.23 0.2 0
114 INT346861 Positive_regulation of Positive_regulation of SLN 1 0.28 0 0
115 INT171596 Negative_regulation of Transcription of APOC3 1 0.58 0.42 0
116 INT229012 Localization of Apoc3 1 0.01 0.16 0
117 INT327857 Positive_regulation of Protein_catabolism of Psmd1 1 0.01 0.68 0
118 INT263533 Negative_regulation of Positive_regulation of Sln 1 0.37 0 0
119 INT171593 Positive_regulation of Gene_expression of APOC3 1 0.69 0.55 0
120 INT268893 Regulation of Sln 1 0.25 0 0
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