GOS:neurological system process

This page displays the top molecular interactions and top single events that were mentioned in the literature for neurological system process. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neurological system process. They are ordered first by their pain relevance and then by number of times they were reported for neurological system process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Disease Relevance	TM Confidence	Documents	Genes linked to neurological system process	Pain Relevance
1	INT276678	Nkx1-1 Regulation of Nav1	0.88	0.15	1	1	3.31
2	INT276679	Prkcg Positive_regulation of Positive_regulation of Nkx1-1	0.94	0.07	1	1	3.08
3	INT355251	Cacna1a Regulation of Gene_expression of Gabrg1	0.06	0.01	1	1	1.86
4	INT276674	Negative_regulation of Nkx1-1 Regulation of Nav1	0.68	0.11	1	1	1.81
5	INT276680	Binding of Prkcg and Nkx1-1	0.18	0.05	1	1	1.66
6	INT355254	Ltp Regulation of Cacna1a	0	0.04	1	1	1.58
7	INT74843	Binding of Cacna1a and Ea2	3.29	0.13	3	1	1.55
8	INT276687	Pax3 Positive_regulation of Nkx1-1	0.59	0.00	1	1	1.47
9	INT276688	Positive_regulation of Prkcg Positive_regulation of Nkx1-1 Regulation of Trpv1	0.16	0.05	1	1	1.46
10	INT276673	Nkx1-1 Regulation of Trpv1	0.16	0.05	1	1	1.37
11	INT355253	Ltp Positive_regulation of Cacna1a	0	0.05	1	1	1.34
12	INT355252	Binding of Cacna1a and Cnr1	0	0.04	1	1	1.31
13	INT154203	Binding of Pick1 and Grm7	1.64	0.41	1	1	1.28
14	INT74841	Binding of Cacna1a and Ea2	2.33	0.01	2	1	1.27
15	INT206766	Positive_regulation of Ltp Positive_regulation of Positive_regulation of Nkx1-1	0.22	0.01	1	1	1.16
16	INT73679	Nkx1-1 Positive_regulation of Tacr3	0.26	0.22	1	1	1.12
17	INT108729	Binding of CACNA1A and Cacna1a	1.21	0.13	3	1	0.95
18	INT31416	Cacna1a Positive_regulation of Gene_expression of Gcg	0	0.03	1	1	0.65
19	INT88080	Binding of Chrna4 and Psmb6	0.56	0.03	1	2	0.46
20	INT12678	Sepp1 Regulation of Nkx1-1	0.1	0.03	1	1	0.45
21	INT12675	Nka1 Regulation of Nkx1-1	0.1	0.03	1	1	0.45
22	INT354981	Cacna1a Negative_regulation of Gene_expression of Nos2	0.99	0.01	1	1	0.45
23	INT296477	Binding of Cacng2 and Dlg4	0.22	0.04	1	1	0.42
24	INT160971	Gm2111 Positive_regulation of Grm7	0.16	0.01	1	1	0.41
25	INT354984	Binding of Cacna1a and Tnf	0.83	0.01	1	1	0.4
26	INT158355	Cacna1a Regulation of Alox5	0.7	0.01	1	1	0.37
27	INT354985	Cacna1a Regulation of Nos2	0.73	0.01	1	1	0.34
28	INT354982	Cacna1a Regulation of Tnf	0.73	0.00	1	1	0.34
29	INT198566	Ddit4l Regulation of Axin1	1	0.03	1	2	0.31
30	INT151258	Binding of Cacna1a and FCMTE1	0.57	0.00	1	1	0.3
31	INT281797	Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA	0.43	0.01	1	2	0.3
32	INT349951	Grm7 Regulation of pcp	0.56	0.00	1	1	0.28
33	INT208499	Positive_regulation of Nkx1-1 Positive_regulation of Npr1	0	0.00	1	1	0.27
34	INT142003	Binding of Cacna1a and Etax2	1.02	0.00	1	1	0.26
35	INT296450	Cacng2 Regulation of Gria2	0.24	0.13	1	1	0.26
36	INT142004	Binding of Cacna1a and TGM6	1.02	0.00	1	1	0.26
37	INT346745	Binding of Cacng2 and Grip2	0	0.01	1	1	0.25
38	INT70660	Binding of Hrasls and Nkx1-1	0	0.01	1	1	0.24
39	INT281798	CFD Regulation of Positive_regulation of Chrna4	0.24	0.01	1	2	0.24
40	INT296467	Binding of Cacng2 and Gria1	0.25	0.12	1	1	0.23
41	INT296464	Binding of Cacng2 and Tinagl1	0.25	0.06	1	1	0.23
42	INT87169	Creb1 Positive_regulation of Gene_expression of Nkx1-1	0.17	0.11	1	1	0.21
43	INT256706	Binding of Hsp90b1 and Wfs1	5.02	0.43	1	1	0.2
44	INT217074	Binding of Acsm3 and Axin1	5.37	0.00	1	2	0.17
45	INT296469	Gene_expression of Cacng2 Positive_regulation of Gria2	0	0.15	1	1	0.16
46	INT296461	Gene_expression of Cacng2 Positive_regulation of Rbm39	0	0.00	1	1	0.16
47	INT241967	Binding of Grm7 and Acpt	0	0.17	1	1	0.16
48	INT71329	Cacna1a Regulation of Ea2	0.71	0.01	1	1	0.15
49	INT71328	Cacna1a Regulation of Atxn2	0.71	0.00	1	1	0.15
50	INT296468	Cacng2 Regulation of Regulation of Gria2	0	0.10	1	1	0.11
51	INT139558	Chrna4 Regulation of Neurod1	0	0.17	1	2	0.1
52	INT139557	Chrna4 Regulation of Gene_expression of Neurod1	0	0.17	1	2	0.1
53	INT120559	Binding of Cacna1a and FCMTE1	0.25	0.02	1	1	0.1
54	INT163473	Binding of GM2A and GRDX	0.35	0.27	1	1	0.08
55	INT354983	Cacna1a Regulation of Mpo	0.41	0.02	1	1	0.04
56	INT354987	Cacna1a Regulation of Localization of LDHA	0.23	0.00	1	1	0.03
57	INT256707	Eif2ak3 Regulation of Gene_expression of Wfs1	0.78	0.10	1	1	0.03
58	INT346742	Binding of Cacng2 and Dlg4	0	0.03	1	1	0
59	INT256703	Negative_regulation of Hsp90b1 Positive_regulation of Wfs1	0.24	0.42	1	1	0
60	INT256700	Negative_regulation of Binding of Hsp90b1 and Wfs1	0	0.52	1	1	0
61	INT261963	Binding of Cacna1a and Tgm2	1.19	0.08	1	1	0
62	INT287885	Binding of DVL1 and AXIN1	0	0.02	1	1	0
63	INT346746	Binding of Cacng2 and Gria2	0.18	0.21	1	1	0
64	INT250496	Gopc Regulation of Positive_regulation of Cacna1a	0	0.37	1	1	0
65	INT236724	Binding of AXIN1 and Ctnnd2	1.03	0.39	1	1	0
66	INT256705	Binding of Wfs1 and Xbp1	0.39	0.19	1	1	0
67	INT256704	Xbp1 Positive_regulation of Positive_regulation of Wfs1	0.4	0.26	1	1	0
68	INT256702	Binding of Wfs1 and Tmed4	0.61	0.01	1	1	0
69	INT246649	Binding of Kcnj11 and Krt23	0.53	0.01	1	1	0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neurological system process. They are ordered first by their pain relevance and then by number of times they were reported in neurological system process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Disease Relevance	TM Confidence	Documents	Pain Relevance
1	INT26698	Positive_regulation of Cacna1a	26.33	0.67	37	39.1
2	INT41487	Negative_regulation of Cacna1a	9.42	0.57	16	25.2
3	INT7039	Regulation of Nkx1-1	10.51	0.44	22	20.89
4	INT15370	Binding of Nkx1-1	5.84	0.29	24	18.16
5	INT31136	Binding of Cacna1a	30.76	0.45	28	17.35
6	INT58596	Positive_regulation of Gene_expression of Nkx1-1	14.05	0.49	21	13.53
7	INT30101	Regulation of Cacna1a	14.38	0.45	25	12.43
8	INT75765	Positive_regulation of Gene_expression of Cacna1a	17.51	0.70	17	10.91
9	INT12663	Localization of Nkx1-1	3.77	0.74	16	8.74
10	INT73544	Gene_expression of Grm7	31.28	0.64	34	8.04
11	INT104508	Regulation of Gene_expression of Nkx1-1	4.55	0.30	9	7.36
12	INT88079	Gene_expression of Chrna4	8.52	0.76	20	6.98
13	INT91821	Binding of Cacna1a	13.1	0.48	16	6.37
14	INT129508	Localization of Cacna1a	6.47	0.74	7	5.13
15	INT84676	Regulation of Positive_regulation of Nkx1-1	1.58	0.12	1	5.1
16	INT110796	Positive_regulation of Positive_regulation of Cacna1a	0.51	0.49	1	4.84
17	INT79682	Gene_expression of Grm7	4.74	0.75	6	4.5
18	INT82731	Transcription of Cacna1a	3.41	0.56	5	4.27
19	INT79680	Binding of Grm7	2.83	0.47	6	3.58
20	INT58595	Transcription of Nkx1-1	2.53	0.47	7	3.54
21	INT24959	Negative_regulation of Gene_expression of Nkx1-1	2.64	0.20	4	3.4
22	INT94045	Regulation of Cacna1a	3.56	0.42	5	3.33
23	INT91979	Positive_regulation of Positive_regulation of Nkx1-1	2.06	0.23	3	3.06
24	INT355244	Negative_regulation of Negative_regulation of Cacna1a	0	0.04	1	2.67
25	INT276682	Negative_regulation of Positive_regulation of Nkx1-1	1.07	0.11	1	2
26	INT123253	Localization of Chrna4	1.31	0.44	4	1.99
27	INT106869	Positive_regulation of Binding of Nkx1-1	0.21	0.13	2	1.85
28	INT122435	Positive_regulation of Grm7	1.89	0.00	3	1.79
29	INT354979	Positive_regulation of Localization of Cacna1a	0.86	0.05	2	1.79
30	INT355239	Negative_regulation of Positive_regulation of Cacna1a	0	0.04	1	1.79
31	INT79683	Negative_regulation of Grm7	2.22	0.41	3	1.75
32	INT71327	Localization of Cacna1a	2.51	0.60	3	1.7
33	INT276684	Regulation of Binding of Nkx1-1	0.18	0.11	1	1.61
34	INT287528	Gene_expression of WFS1	2.74	0.75	1	1.55
35	INT106865	Negative_regulation of Binding of Nkx1-1	0.14	0.11	3	1.48
36	INT90740	Negative_regulation of Cacna1a	1.43	0.23	3	1.38
37	INT79681	Localization of Grm7	2.57	0.78	5	1.34
38	INT74927	Gene_expression of Cacna1e	0.7	0.51	4	1.25
39	INT267107	Binding of CHRNB2	1.33	0.07	2	1.25
40	INT82727	Positive_regulation of Transcription of Cacna1a	1.07	0.01	1	1.25
41	INT130323	Regulation of Grm7	1.9	0.26	3	1.21
42	INT81768	Negative_regulation of Chrna4	1.97	0.42	5	1.2
43	INT85571	Positive_regulation of Cacna1a	2.06	0.50	3	1.18
44	INT355243	Negative_regulation of Regulation of Cacna1a	0	0.04	1	1.16
45	INT218977	Negative_regulation of Localization of Nkx1-1	0.84	0.03	1	1.09
46	INT321650	Negative_regulation of Gene_expression of Cacna1a	0.13	0.04	2	0.95
47	INT87768	Binding of Chrnb1	0.18	0.26	4	0.94
48	INT94046	Protein_catabolism of Cacna1a	0.83	0.70	1	0.9
49	INT287524	Regulation of WFS1	1.34	0.40	1	0.78
50	INT123254	Regulation of Chrna4	0.84	0.27	3	0.76
51	INT146019	Regulation of Transcription of Nkx1-1	0.41	0.18	1	0.72
52	INT146018	Positive_regulation of Transcription of Nkx1-1	0.41	0.31	1	0.72
53	INT91056	Negative_regulation of Gene_expression of Grm7	1.21	0.18	2	0.69
54	INT103336	Transcription of Cacna1a	1.17	0.69	2	0.68
55	INT123251	Regulation of Gene_expression of Chrna4	0.36	0.27	2	0.67
56	INT154199	Regulation of Localization of Grm7	0.92	0.60	1	0.62
57	INT99329	Binding of Chrna4	0.45	0.37	3	0.6
58	INT272575	Binding of Cacng2	0.54	0.36	3	0.58
59	INT123256	Regulation of Localization of Chrna4	0.28	0.27	1	0.58
60	INT120995	Positive_regulation of Gene_expression of Grm7	0.57	0.00	1	0.57
61	INT296850	Positive_regulation of Gene_expression of Atg7	4.41	0.40	1	0.54
62	INT135449	Transcription of Kcnj11	0.64	0.06	1	0.53
63	INT90479	Negative_regulation of CHRNA4	0.37	0.57	2	0.51
64	INT55538	Positive_regulation of Gm2a	0	0.22	1	0.48
65	INT95695	Transcription of Chrnb1	0.8	0.19	2	0.47
66	INT77748	Localization of Chrna4	0	0.15	1	0.46
67	INT96576	Transcription of Cacna1e	0.28	0.58	1	0.42
68	INT256681	Regulation of Wfs1	4.72	0.43	8	0.36
69	INT90497	Positive_regulation of Gene_expression of Cacna1e	0.17	0.01	1	0.36
70	INT90498	Positive_regulation of Cacna1e	0.17	0.01	1	0.35
71	INT99962	Positive_regulation of Gene_expression of Cacna1a	1.1	0.01	1	0.34
72	INT254881	Negative_regulation of Atg7	5.69	0.34	9	0.32
73	INT190521	Regulation of Positive_regulation of Chrnb1	0.35	0.09	1	0.31
74	INT264110	Regulation of Chrnb1	0.82	0.03	1	0.31
75	INT264108	Positive_regulation of Gene_expression of Chrnb1	1.06	0.03	1	0.31
76	INT264112	Regulation of Gene_expression of Chrnb1	1.07	0.04	1	0.31
77	INT268029	Gene_expression of Kcnj11	0.23	0.02	1	0.29
78	INT311615	Binding of CHRNB1	0.24	0.01	1	0.28
79	INT256682	Gene_expression of Wfs1	6.63	0.74	1	0.25
80	INT296852	Negative_regulation of Gene_expression of Atg7	4.67	0.47	1	0.19
81	INT296853	Positive_regulation of Atg7	1.45	0.37	4	0.18
82	INT256696	Positive_regulation of Wfs1	9.14	0.66	1	0.17
83	INT210123	Localization of Axin1	0.84	0.04	1	0.17
84	INT66933	Binding of AXIN1	1.8	0.32	6	0.16
85	INT296433	Positive_regulation of Gene_expression of Cacng2	0	0.18	1	0.16
86	INT256684	Positive_regulation of Gene_expression of Wfs1	3.62	0.66	1	0.16
87	INT241959	Binding of Grm7	0	0.23	1	0.15
88	INT246309	Negative_regulation of Chrnb1	0.09	0.09	2	0.14
89	INT296851	Localization of Atg7	0.82	0.60	1	0.14
90	INT263410	Negative_regulation of Axin1	0	0.01	1	0.14
91	INT260482	Localization of Grm7	0.11	0.18	1	0.13
92	INT250219	Positive_regulation of KCNJ11	2.5	0.68	3	0.12
93	INT139554	Positive_regulation of Gene_expression of Chrna4	0	0.25	2	0.1
94	INT139553	Transcription of Chrna4	0	0.27	1	0.1
95	INT168525	Localization of GPR98	0.17	0.21	1	0.1
96	INT139555	Positive_regulation of Positive_regulation of Chrna4	0	0.25	1	0.1
97	INT338884	Regulation of Grm7	0.42	0.13	1	0.09
98	INT338883	Positive_regulation of Regulation of Grm7	0.42	0.22	1	0.09
99	INT256675	Regulation of Gene_expression of Wfs1	2.33	0.43	1	0.09
100	INT256687	Positive_regulation of Transcription of Wfs1	1.95	0.44	1	0.09
101	INT145364	Negative_regulation of AXIN1	0.52	0.33	2	0.08
102	INT347113	Protein_catabolism of Axin1	0.68	0.43	1	0.08
103	INT256693	Transcription of Wfs1	2.44	0.68	1	0.08
104	INT58644	Negative_regulation of KCNJ11	0	0.24	1	0.08
105	INT204808	Binding of Kcnj11	3.28	0.04	3	0.07
106	INT207818	Positive_regulation of Kcnj11	1.67	0.48	2	0.07
107	INT300139	Positive_regulation of WFS1	1.32	0.36	1	0.07
108	INT296861	Regulation of Atg7	0.43	0.19	1	0.07
109	INT346730	Positive_regulation of Cacng2	0	0.49	1	0.06
110	INT244699	Positive_regulation of AXIN1	0	0.02	1	0.05
111	INT309389	Phosphorylation of Cacna1a	0.54	0.01	1	0.05
112	INT309386	Positive_regulation of Phosphorylation of Cacna1a	0.54	0.01	1	0.05
113	INT346727	Regulation of Cacng2	0	0.26	1	0.03
114	INT268030	Positive_regulation of Gene_expression of Kcnj11	0	0.02	1	0.03
115	INT204807	Negative_regulation of Binding of Kcnj11	1.9	0.03	1	0.03
116	INT268039	Positive_regulation of Kcnj11	0.07	0.02	1	0.03
117	INT207834	Negative_regulation of Localization of KCNJ11	0	0.41	1	0.03
118	INT105164	Negative_regulation of Axin1	0.17	0.14	2	0
119	INT256676	Regulation of Binding of Wfs1	0.35	0.43	1	0
120	INT246313	Localization of Chrnb1	0.28	0.17	1	0
121	INT268034	Regulation of Kcnj11	0.08	0.00	1	0
122	INT287932	Negative_regulation of Binding of AXIN1	0	0.12	1	0
123	INT256692	Negative_regulation of Wfs1	0	0.41	1	0
124	INT256671	Regulation of Positive_regulation of Wfs1	1.77	0.59	1	0
125	INT329212	Phosphorylation of KCNJ11	1.07	0.80	1	0
126	INT246320	Regulation of Localization of Chrnb1	0.19	0.10	1	0
127	INT256686	Binding of Wfs1	0.91	0.46	1	0
128	INT235673	Positive_regulation of Gene_expression of Axin1	0	0.16	1	0
129	INT256677	Regulation of Transcription of Wfs1	0.5	0.59	1	0
130	INT347116	Localization of Axin1	0.53	0.28	1	0
131	INT339052	Binding of KCNJ11	1.16	0.34	1	0
132	INT329213	Positive_regulation of Phosphorylation of KCNJ11	1.14	0.45	1	0