GOS:peptidase activity

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This page displays the top molecular interactions and top single events that were mentioned in the literature for peptidase activity. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported for peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Disease Relevance TM Confidence Documents Genes linked to peptidase activity Pain Relevance
1 INT32444 Binding of Cpe and Pomc 0 0.22 2 1 4.47
2 INT36536 PRSS1 Positive_regulation of PENK 0.86 0.24 1 1 4.39
3 INT220623 Binding of Stat1 and Bace1 10.33 0.25 11 2 3.81
4 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 0.17 0.27 1 4 3.48
5 INT73071 Binding of Cpe and Insrr 0.33 0.01 3 1 3.38
6 INT215943 Binding of Mmp14 and Timp2 1.59 0.21 1 1 3.33
7 INT17300 Prss12 Positive_regulation of Localization of Acot1 0 0.11 4 1 3.28
8 INT7190 Syt17 Positive_regulation of Ctsb 0 0.16 1 2 3.23
9 INT270949 Binding of Slc6a3 and Cpe 0.25 0.28 1 1 3.19
10 INT36535 PRSS1 Positive_regulation of Regulation of PENK 0.54 0.23 1 1 3.06
11 INT190167 Binding of JUN and MMP12 0.82 0.26 1 1 2.76
12 INT23280 PRSS1 Positive_regulation of Penk 1.53 0.05 1 1 2.74
13 INT69059 Klkb1 Regulation of H2-M3 Regulation of Klkb1 0.42 0.00 1 1 2.71
14 INT69057 H2-M3 Regulation of Klkb1 0.42 0.00 1 1 2.71
15 INT150455 Binding of Prss12 and Nts 1.42 0.24 3 1 2.66
16 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 0.5 0.06 1 1 2.6
17 INT231968 Binding of Cpn1 and Rvm 1.57 0.11 1 1 2.45
18 INT231970 Binding of Cpn1 and Pag1 1.56 0.07 1 1 2.44
19 INT255317 Binding of Dpep1 and Nav1 0 0.01 1 1 2.42
20 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 0 0.23 3 2 2.35
21 INT139723 PROC Positive_regulation of MAPK8 2.98 0.01 1 1 2.33
22 INT247601 Binding of PEPD and SCN9A 2.26 0.15 1 1 2.27
23 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 0 0.01 1 2 2.26
24 INT231971 Binding of Cpn1 and Shbdp1 1.39 0.04 1 1 2.26
25 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 0 0.10 1 2 2.25
26 INT231967 Binding of Psmd1 and Cpn1 1.39 0.06 1 1 2.25
27 INT85251 Chi3l1 Positive_regulation of Casp3 0 0.01 1 2 2.25
28 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 0 0.12 2 2 2.19
29 INT255318 Binding of Dpep1 and Nrcam 0 0.00 1 1 2.16
30 INT45376 Binding of Cpe and Mme 0.32 0.07 1 2 2.13
31 INT17299 Prss12 Regulation of Localization of Acot1 0 0.05 3 1 2.07
32 INT54488 Npepo Regulation of Gene_expression of Jun 0 0.30 1 1 1.98
33 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 0.18 0.05 1 2 1.92
34 INT146586 Npff Negative_regulation of Gene_expression of Casp3 0.18 0.06 1 2 1.92
35 INT243043 Binding of Mmp9 and Timp1 0.25 0.05 1 1 1.86
36 INT205152 Binding of CD44 and MMP9 17.13 0.35 23 1 1.85
37 INT82867 Cck Regulation of Localization of Pgc 0 0.05 1 1 1.83
38 INT192161 Mmp14 Positive_regulation of Mmp2 1.23 0.19 2 3 1.81
39 INT167319 Binding of OPRM1 and PCSK2 0.63 0.22 1 1 1.77
40 INT266764 TPSD1 Positive_regulation of F2RL1 Positive_regulation of Localization of SFTPA1 1.55 0.00 1 1 1.76
41 INT102160 Binding of Mmp2 and Mmp9 2.87 0.28 3 3 1.75
42 INT185143 Elane Positive_regulation of Pik3r1 0 0.01 1 1 1.72
43 INT30134 Binding of TPP1 and S100A9 0.74 0.13 1 1 1.69
44 INT24689 Binding of PLAT and Serpine1 3.77 0.00 1 1 1.64
45 INT54484 Npepo Positive_regulation of Gene_expression of Fos 0 0.43 1 1 1.63
46 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 0.45 0.23 1 1 1.62
47 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 0.45 0.23 1 1 1.61
48 INT326509 Binding of ACE and VWF 2.07 0.05 1 1 1.59
49 INT111076 Psen1 Regulation of Psenen 0.76 0.17 1 2 1.58
50 INT105112 Plat Positive_regulation of JUN 1.55 0.01 1 1 1.58
51 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 2.84 0.00 1 1 1.58
52 INT168609 Binding of Itgb1 and Mmp9 0.41 0.02 1 1 1.58
53 INT237286 Dlat Regulation of Prep 0 0.01 1 1 1.57
54 INT168611 Binding of Mmp9 and Ndor1 0.41 0.29 1 1 1.57
55 INT26985 Cpe Negative_regulation of Localization of Ins1 0 0.02 1 1 1.57
56 INT76651 Cpe Positive_regulation of Gene_expression of Il6 0 0.08 1 1 1.56
57 INT106751 Pes1 Negative_regulation of Casp3 0 0.23 2 2 1.54
58 INT23546 Negative_regulation of CNDP2 Negative_regulation of POMC Positive_regulation of POMC 0 0.04 1 1 1.52
59 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 0 0.03 1 1 1.52
60 INT201950 IFNA1 Positive_regulation of Binding of DPP4 and 2.17 0.12 1 1 1.47
61 INT201946 IFNA1 Positive_regulation of DPP4 2.16 0.17 1 1 1.46
62 INT104975 MITF Regulation of Transcription of PRSS1 0.35 0.68 1 1 1.46
63 INT111760 Dio1 Positive_regulation of Binding of Cpe and 0.34 0.04 1 1 1.44
64 INT111761 Positive_regulation of Binding of Cpe and Insrr 0.33 0.01 1 1 1.43
65 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 0 0.21 1 1 1.43
66 INT111756 Dio1 Positive_regulation of Cpe 0.34 0.04 1 1 1.42
67 INT31391 Binding of PRCP and Abpa 0.16 0.03 1 1 1.42
68 INT111759 Binding of Cpe and Drd2 0.32 0.01 1 1 1.42
69 INT111762 Positive_regulation of Binding of Cpe and Drd2 0.33 0.02 1 1 1.42
70 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1.65 0.05 1 1 1.42
71 INT43814 Binding of Cpe and Oprm1 0 0.08 1 1 1.41
72 INT140314 PCSK7 Positive_regulation of LDHA 1.6 0.07 1 1 1.4
73 INT116827 Binding of UCHL1 and TRPV1 0.88 0.41 1 1 1.39
74 INT777 Prss12 Positive_regulation of Prl 0 0.19 1 1 1.33
75 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 1.2 0.49 3 1 1.3
76 INT341336 Binding of Pepd and Nav1 0.92 0.07 1 1 1.3
77 INT201942 DPP4 Negative_regulation of CXCL10 0.9 0.33 1 1 1.3
78 INT95275 Binding of Edn1 and Ece1 2.09 0.32 1 1 1.3
79 INT139722 PROC Positive_regulation of CDCP1 1.61 0.00 1 1 1.29
80 INT18659 Plat Regulation of ZC3H12D 0.1 0.02 1 1 1.29
81 INT108386 IL1B Positive_regulation of MMP1 1.56 0.27 3 1 1.28
82 INT115985 Cpe Positive_regulation of Binding of Gnas and 0.17 0.00 1 1 1.28
83 INT83707 Acyp2-ps1 Regulation of Casp3 0 0.17 1 2 1.28
84 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 0.69 0.06 1 2 1.28
85 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 1.14 0.49 3 1 1.27
86 INT73598 BAX Positive_regulation of Casp1 0.63 0.06 1 2 1.27
87 INT70181 PRCP Positive_regulation of FOS 0.36 0.58 1 1 1.26
88 INT139724 PROC Positive_regulation of MAPK14 1.57 0.00 1 1 1.25
89 INT43446 Binding of Cpe and H3 0 0.02 1 1 1.25
90 INT202042 CAMK2N2 Negative_regulation of MMP9 0.73 0.01 1 1 1.25
91 INT132465 Ltf Positive_regulation of Nos1 0.05 0.35 1 1 1.24
92 INT145315 D2Mit212 Regulation of Casp3 0 0.00 1 2 1.24
93 INT202039 CAMK2N2 Negative_regulation of MMP1 0.73 0.00 1 1 1.24
94 INT202036 CAMK2N2 Negative_regulation of MMP3 0.73 0.00 1 1 1.24
95 INT20530 Nts Regulation of Prss12 0.74 0.24 5 1 1.23
96 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1.25 0.06 1 1 1.23
97 INT162344 KCNMA1 Positive_regulation of ACE 1.25 0.06 1 1 1.23
98 INT145317 D2Mit212 Positive_regulation of Casp3 0 0.01 1 2 1.22
99 INT7200 Reg3b Negative_regulation of Syt17 Positive_regulation of Ctsb 0 0.01 1 2 1.22
100 INT7198 Magt1 Negative_regulation of Syt17 Positive_regulation of Ctsb 0 0.03 1 2 1.22
101 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 0 0.03 1 2 1.21
102 INT59707 PSENEN Regulation of Negative_regulation of YY1 0.07 0.12 1 1 1.21
103 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 0 0.03 1 2 1.21
104 INT187172 RPS3AP9 Negative_regulation of MMP9 0.89 0.00 1 1 1.2
105 INT93435 Binding of Casp3 and Cckbr 0.15 0.06 1 2 1.18
106 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 2.88 0.05 1 2 1.18
107 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1 1.16
108 INT155892 Nps Negative_regulation of Casp3 0.06 0.27 1 4 1.16
109 INT33605 DFP Positive_regulation of Cpe 0 0.16 1 1 1.16
110 INT165929 Binding of MME and WSN 0.99 0.01 1 1 1.16
111 INT24796 ACE Positive_regulation of Localization of HMMR 0.58 0.00 1 1 1.16
112 INT326665 Cpe Positive_regulation of Oprd1 1.24 0.01 1 1 1.15
113 INT155890 Nps Negative_regulation of Gene_expression of Casp3 0.05 0.27 1 4 1.15
114 INT34422 Cck Positive_regulation of Negative_regulation of Npepo 0 0.31 1 1 1.14
115 INT348398 LPA Positive_regulation of Pik3cb 0.88 0.04 1 1 1.14
116 INT159238 H2-M3 Negative_regulation of Gpm6a Positive_regulation of Casp3 0 0.01 1 4 1.14
117 INT348400 LPA Positive_regulation of Trib3 0.87 0.00 1 1 1.14
118 INT76199 CASP1 Positive_regulation of CEL 0.32 0.06 1 1 1.14
119 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 0 0.06 1 1 1.13
120 INT84487 Binding of Cpe and Mif-ps1 0 0.05 1 1 1.13
121 INT60134 MME Negative_regulation of GRP 0 0.20 1 1 1.12
122 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 0.14 0.03 1 4 1.12
123 INT159235 H2-M3 Negative_regulation of Casp3 0 0.05 1 4 1.12
124 INT59035 Binding of CPB1 and POMC 0 0.00 1 1 1.12
125 INT54486 Npepo Positive_regulation of Gene_expression of Rabep2 0 0.14 1 1 1.08
126 INT172757 Rnpep Positive_regulation of Hps4 0 0.00 1 1 1.08
127 INT187176 Binding of BSG and MMP1 1.18 0.09 1 1 1.08
128 INT161011 Binding of Cpe and St13 0.61 0.03 2 1 1.07
129 INT91395 MMP2 Positive_regulation of CALCA 0.17 0.36 1 1 1.07
130 INT120313 Gnrhr Negative_regulation of Mmp2 0.85 0.03 1 1 1.07
131 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 0.81 0.13 1 1 1.07
132 INT159237 Gpm6a Positive_regulation of Casp3 0 0.03 1 4 1.07
133 INT6415 Binding of Cpe and Oprd1 0 0.00 1 1 1.07
134 INT105113 Plat Positive_regulation of NFKB1 1.06 0.03 1 1 1.06
135 INT116777 Psma5 Positive_regulation of Binding of Fn1 and 1.24 0.01 1 1 1.06
136 INT7199 Syt17 Regulation of Syt17 Positive_regulation of Ctsb 0 0.02 1 2 1.05
137 INT266742 GOPC Regulation of Positive_regulation of ACR 0.36 0.02 1 1 1.05
138 INT312097 ELANE Regulation of ALOX5 1.75 0.08 1 1 1.05
139 INT145906 Elane Regulation of Transcription of Oprm1 0.14 0.10 1 1 1.04
140 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 0 0.13 1 2 1.04
141 INT7201 Syt17 Negative_regulation of Syt17 Positive_regulation of Ctsb 0 0.03 1 2 1.04
142 INT307047 Foxm1 Positive_regulation of Casp3 0.06 0.11 1 4 1.03
143 INT144069 Positive_regulation of TRPV1 Positive_regulation of Gene_expression of MMP1 1.35 0.43 1 1 1.03
144 INT98555 Oprm1 Positive_regulation of Casp8 0.36 0.51 1 2 1.02
145 INT79602 Binding of PSMA5 and Oprd1 1.05 0.19 2 1 1.01
146 INT265070 Reln Positive_regulation of Gene_expression of Fos 0.51 0.02 1 1 1.01
147 INT30135 S100A9 Positive_regulation of REN 0.32 0.32 1 1 1
148 INT45665 Fpr1 Negative_regulation of Mme 0 0.13 1 2 1
149 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 0 0.46 1 1 0.99
150 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1.14 0.01 1 1 0.99
151 INT314037 THL Negative_regulation of Localization of Plau 1.64 0.17 1 1 0.99
152 INT195668 Binding of F2 and THBD 5.67 0.08 7 1 0.98
153 INT238091 Binding of GRIP1 and Mmp24 0 0.00 1 1 0.98
154 INT62017 ELANE Positive_regulation of Localization of ACOT1 0.35 0.05 1 1 0.98
155 INT238092 Binding of SHBG and Mmp24 0 0.04 1 1 0.98
156 INT90385 EXTL3 Regulation of Ctsl 1.1 0.00 1 1 0.98
157 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1.08 0.00 1 2 0.97
158 INT24395 Binding of CALCA and CLPP 0.17 0.03 1 1 0.96
159 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1.39 0.06 1 1 0.96
160 INT195219 Binding of CPB2 and CSRP1 0.99 0.03 1 1 0.96
161 INT227545 Hspa9 Positive_regulation of Prep 0.59 0.18 1 1 0.96
162 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1.39 0.06 1 1 0.96
163 INT171264 TNF Positive_regulation of MMP1 2.05 0.10 2 1 0.95
164 INT147232 Binding of tn and Cpe 1.55 0.03 1 1 0.95
165 INT42482 Binding of Cpe and Pebp1 0 0.02 1 1 0.95
166 INT351311 Has1 Regulation of Gene_expression of MMP3 1.15 0.11 1 1 0.95
167 INT266659 Binding of MMP9 and MOCS1 1.71 0.01 1 1 0.94
168 INT12373 SCN5A Negative_regulation of Cpe 0 0.00 1 1 0.94
169 INT214411 DNAH8 Regulation of CAPN1 1.01 0.00 1 1 0.94
170 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1.73 0.15 1 1 0.93
171 INT118204 ST14 Regulation of YY1 0 0.04 1 1 0.93
172 INT214409 ATP1A4 Regulation of CAPN1 1.01 0.01 1 1 0.93
173 INT145853 Casp1 Positive_regulation of Mapk14 0.68 0.02 1 2 0.93
174 INT107001 F2 Positive_regulation of PAR1 2.15 0.05 4 1 0.92
175 INT13193 FPR1 Positive_regulation of ELANE 1.22 0.44 3 1 0.92
176 INT34837 Maob Regulation of Negative_regulation of Mme 0.15 0.48 1 2 0.92
177 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 0 0.04 1 2 0.92
178 INT159993 App Regulation of Gene_expression of Bace1 0.32 0.46 1 2 0.92
179 INT75200 Umod Positive_regulation of Transcription of Psma4 1.04 0.02 1 1 0.92
180 INT161455 Mmp7 Positive_regulation of Egfr 0.19 0.03 1 1 0.92
181 INT193291 Binding of CAP1 and Cfd 0.13 0.02 1 1 0.91
182 INT243044 Mmp8 Regulation of Mmp9 1.45 0.05 1 2 0.91
183 INT138601 BCL2L2 Positive_regulation of F2 0.66 0.00 1 1 0.91
184 INT193277 Binding of Cfd and Brs3 0.13 0.01 1 1 0.91
185 INT159995 Prkcg Regulation of Gene_expression of Bace1 0.32 0.39 1 2 0.91
186 INT190147 MMP12 Positive_regulation of MMP2 Positive_regulation of Protein_catabolism of MMRN1 0.87 0.03 1 2 0.9
187 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1.29 0.02 1 2 0.9
188 INT121700 IL12RB1 Positive_regulation of Gene_expression of MMP1 0.22 0.06 1 1 0.9
189 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 0.2 0.06 1 1 0.9
190 INT121701 HRAS Negative_regulation of MMP1 0.2 0.06 1 1 0.89
191 INT121704 HRAS Negative_regulation of MMP3 0.19 0.06 1 1 0.89
192 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1.02 0.03 1 4 0.89
193 INT126268 Tpsab1 Positive_regulation of F2rl1 1.65 0.35 2 1 0.88
194 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 0.19 0.06 1 1 0.88
195 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 0 0.13 1 4 0.88
196 INT154258 Binding of Abat and Prss12 0 0.03 1 1 0.87
197 INT277831 Binding of TNFRSF1A and NPEPPS 1.1 0.01 1 1 0.87
198 INT26984 Cpe Regulation of Ins1 0 0.02 1 1 0.87
199 INT14626 Binding of Dpep1 and Pax3 0 0.01 1 1 0.87
200 INT76652 Cpe Positive_regulation of Il6 0 0.08 1 1 0.87

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptidase activity. They are ordered first by their pain relevance and then by number of times they were reported in peptidase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Disease Relevance TM Confidence Documents Pain Relevance
1 INT22548 Positive_regulation of Casp3 258.78 0.70 483 213.07
2 INT5061 Negative_regulation of Mme 51.97 0.59 306 136.9
3 INT14151 Gene_expression of Casp3 140.26 0.78 311 120.68
4 INT1724 Negative_regulation of ACE 315.64 0.59 437 74.48
5 INT8962 Gene_expression of Cpe 39.67 0.71 110 71.67
6 INT46 Localization of Ren 46.15 0.81 233 62.44
7 INT73048 Gene_expression of MMP9 159.75 0.77 268 57.81
8 INT48232 Gene_expression of MMP1 96.31 0.78 245 57.72
9 INT31116 Gene_expression of Casp3 78.21 0.78 192 57.43
10 INT96937 Gene_expression of Mmp9 150.3 0.75 191 56.01
11 INT314 Positive_regulation of Ren 66.68 0.70 212 55.56
12 INT1486 Negative_regulation of Cpe 28.78 0.59 85 54.08
13 INT1487 Regulation of Cpe 10.24 0.62 68 52.91
14 INT72182 Gene_expression of Mcpt1 123.7 0.75 167 52.15
15 INT22546 Positive_regulation of Gene_expression of Casp3 47.89 0.70 97 51.92
16 INT5957 Positive_regulation of Cpe 21.07 0.69 65 51.22
17 INT117598 Regulation of ACR 41.25 0.26 118 48.01
18 INT375 Positive_regulation of REN 152.46 0.70 293 47.55
19 INT26500 Gene_expression of MMP2 110.57 0.78 201 46.9
20 INT20492 Gene_expression of MMP12 81.36 0.76 89 46.12
21 INT49552 Negative_regulation of Positive_regulation of Casp3 36.04 0.55 76 44.78
22 INT27493 Negative_regulation of Casp3 56.89 0.56 114 44.63
23 INT5214 Localization of Cpe 13.3 0.73 49 44.36
24 INT115384 Positive_regulation of Mmp9 94.74 0.68 121 43.02
25 INT5539 Negative_regulation of Mme 28.91 0.59 75 41.84
26 INT29496 Gene_expression of MMP3 49.49 0.75 136 41.78
27 INT11560 Positive_regulation of CASP3 184.33 0.70 236 39.38
28 INT68975 Gene_expression of Mmp9 79.57 0.78 111 38.55
29 INT11292 Gene_expression of Mme 20.98 0.78 77 35.85
30 INT49 Negative_regulation of Ren 37.48 0.59 129 35.62
31 INT223416 Gene_expression of Trhde 64.16 0.48 2 34.21
32 INT2699 Binding of Cpe 7.07 0.48 40 33.64
33 INT7133 Negative_regulation of MME 29.22 0.59 85 33.1
34 INT99610 Localization of MMP9 48.46 0.79 126 32.67
35 INT29503 Gene_expression of Mmp2 56.92 0.77 95 31.68
36 INT124860 Gene_expression of Bace1 157.11 0.78 330 31.65
37 INT1179 Negative_regulation of Ace 67.03 0.59 157 30.46
38 INT68973 Positive_regulation of Mmp9 58.56 0.52 89 30.04
39 INT65597 Negative_regulation of Casp3 39.19 0.59 69 29.32
40 INT9650 Gene_expression of LPA 104.57 0.75 141 29
41 INT5653 Positive_regulation of ELANE 72.78 0.70 136 27.94
42 INT55737 Positive_regulation of MMP2 59.11 0.68 101 27.71
43 INT8362 Localization of Prss12 5.09 0.78 53 27
44 INT129956 Gene_expression of MMP13 60.48 0.72 145 26.98
45 INT90313 Negative_regulation of Gene_expression of Casp3 22.23 0.57 57 26.77
46 INT5232 Negative_regulation of Enpep 3.25 0.57 56 26.7
47 INT73047 Positive_regulation of MMP9 73.22 0.68 133 26.42
48 INT140193 Gene_expression of Mmp3 49.65 0.71 58 25.4
49 INT48235 Negative_regulation of NPEPPS 44.54 0.46 72 25.03
50 INT4877 Gene_expression of MME 122.82 0.78 184 24.78
51 INT2140 Regulation of REN 28.24 0.62 104 24.49
52 INT86295 Gene_expression of Mmp2 73.68 0.76 114 24.25
53 INT22549 Positive_regulation of Positive_regulation of Casp3 29.5 0.56 48 23.7
54 INT34487 Localization of MMP2 31.41 0.81 56 23.61
55 INT29704 Regulation of Casp3 22.13 0.56 51 22.79
56 INT16996 Gene_expression of PRTN3 85.61 0.75 113 22.57
57 INT5905 Negative_regulation of ELANE 47.43 0.59 113 22.09
58 INT8580 Gene_expression of ELANE 62.98 0.75 132 21.79
59 INT74682 Positive_regulation of Mmp2 40.46 0.69 72 21.73
60 INT34488 Negative_regulation of MMP2 41.98 0.59 85 21.72
61 INT170313 Gene_expression of Mmp1a 38.53 0.65 50 21.36
62 INT50814 Positive_regulation of Mmp2 51.37 0.68 72 20.42
63 INT96269 Positive_regulation of Mcpt1 52.38 0.61 71 20.4
64 INT116282 Gene_expression of Mmp13 45.4 0.75 83 20.18
65 INT93663 Positive_regulation of MMP1 33.38 0.67 72 19.86
66 INT78694 Positive_regulation of Gene_expression of Casp3 18.64 0.66 46 19.62
67 INT12243 Positive_regulation of PRSS1 52.87 0.70 91 19.48
68 INT9490 Regulation of Mme 6.69 0.56 44 19.21
69 INT27670 Negative_regulation of Ace 79.21 0.57 122 18.08
70 INT23635 Positive_regulation of MMP12 28.19 0.59 31 17.95
71 INT132997 Localization of Mmp9 45.9 0.80 59 17.61
72 INT84464 Gene_expression of DPP4 56.15 0.78 101 17.53
73 INT1767 Positive_regulation of PROC 54.14 0.67 83 17
74 INT49379 Localization of MMP12 13.07 0.77 26 16.93
75 INT110767 Localization of Mcpt1 24.3 0.68 43 16.74
76 INT15237 Protein_catabolism of Mme 10.26 0.96 31 16.69
77 INT99898 Gene_expression of Mmp14 28.54 0.56 37 16.39
78 INT15166 Positive_regulation of Mme 13.01 0.70 40 16.24
79 INT108588 Gene_expression of CASP3 84.49 0.78 126 16.2
80 INT26314 Positive_regulation of MMP3 22.14 0.67 48 16.17
81 INT78697 Negative_regulation of Gene_expression of Casp3 11.22 0.57 33 16.16
82 INT13400 Negative_regulation of Enpep 4.23 0.50 30 15.86
83 INT111073 Gene_expression of Psen1 78.65 0.76 167 15.83
84 INT103245 Positive_regulation of Gene_expression of MMP9 36.86 0.68 64 15.7
85 INT5333 Gene_expression of NPEPPS 26.34 0.65 45 15.25
86 INT26501 Positive_regulation of Gene_expression of MMP2 39 0.67 51 15.16
87 INT103210 Localization of MMP1 12.15 0.78 43 15.13
88 INT12891 Negative_regulation of MMP3 17.99 0.58 41 15.06
89 INT74587 Gene_expression of MMP8 24.4 0.78 31 14.91
90 INT1284 Negative_regulation of Mmp13 36.21 0.57 20 14.91
91 INT14453 Localization of Mme 2.46 0.80 44 14.75
92 INT92823 Positive_regulation of Gene_expression of MMP1 25.69 0.68 65 14.31
93 INT20665 Gene_expression of ACE 51.71 0.78 87 14.19
94 INT9649 Positive_regulation of LPA 74.75 0.69 105 13.89
95 INT82929 Gene_expression of Plat 26.96 0.78 58 13.85
96 INT190204 Positive_regulation of Gene_expression of MMP12 31.31 0.67 22 13.69
97 INT17938 Binding of Cpe 11.17 0.48 28 13.62
98 INT655 Positive_regulation of Localization of REN 32.41 0.70 86 13.56
99 INT95427 Positive_regulation of Mmp3 15.28 0.70 39 13.36
100 INT101147 Gene_expression of Uchl1 14.73 0.76 31 13.22
101 INT22003 Negative_regulation of Cpe 6.23 0.58 25 12.94
102 INT2673 Negative_regulation of PROC 50.34 0.57 93 12.79
103 INT2129 Positive_regulation of F2 58.95 0.70 83 12.63
104 INT195226 Positive_regulation of ACR 7.85 0.26 23 12.62
105 INT123779 Positive_regulation of MMP13 24.3 0.65 42 12.45
106 INT5959 Protein_catabolism of Cpe 0.98 0.90 17 12.43
107 INT81626 Positive_regulation of Positive_regulation of Casp3 16.75 0.69 34 12.18
108 INT13287 Gene_expression of Cpb2 7.84 0.56 27 11.95
109 INT93715 Negative_regulation of MMP9 36.05 0.55 69 11.73
110 INT1190 Positive_regulation of F2 46.41 0.70 53 11.64
111 INT310842 Gene_expression of Pgpep1 28.03 0.32 1 11.64
112 INT481 Regulation of Localization of Ren 5.95 0.62 37 11.61
113 INT148639 Gene_expression of Uchl1 16.76 0.59 30 11.54
114 INT12372 Negative_regulation of Localization of Cpe 1.85 0.53 12 11.39
115 INT661 Gene_expression of REN 48.21 0.78 100 11.36
116 INT68976 Positive_regulation of Gene_expression of Mmp9 28.21 0.42 34 11.28
117 INT7350 Negative_regulation of Anpep 2.89 0.59 30 11.28
118 INT11208 Gene_expression of Cpe 2.42 0.78 23 11.09
119 INT96271 Positive_regulation of Gene_expression of Mcpt1 21.34 0.53 30 11.06
120 INT4498 Gene_expression of F2 57.4 0.65 83 10.8
121 INT12240 Negative_regulation of PRSS1 29.5 0.57 46 10.77
122 INT86291 Negative_regulation of Mmp2 20.38 0.57 33 10.76
123 INT74681 Positive_regulation of Gene_expression of Mmp2 15.58 0.55 23 10.74
124 INT15054 Gene_expression of Mme 42.52 0.77 48 10.63
125 INT93281 Negative_regulation of Folh1 5.55 0.50 12 10.63
126 INT4806 Localization of TPSAB1 5.05 0.80 29 10.52
127 INT1180 Gene_expression of Ren 27.33 0.77 63 10.51
128 INT34485 Negative_regulation of Localization of MMP2 9.96 0.50 17 10.49
129 INT78695 Regulation of Casp3 9.43 0.44 24 10.48
130 INT29705 Regulation of Positive_regulation of Casp3 5.37 0.48 13 10.45
131 INT11205 Gene_expression of Prep 8.11 0.77 65 10.12
132 INT112969 Negative_regulation of Mcpt1 20.17 0.45 30 10.11
133 INT32344 Localization of LTF 15.28 0.80 30 10.09
134 INT98130 Positive_regulation of CASP8 65.29 0.67 79 10.08
135 INT27937 Gene_expression of Klkb1 1.86 0.55 35 10.08
136 INT10546 Positive_regulation of Prss12 4.57 0.44 12 10.05
137 INT107606 Negative_regulation of MMP1 11.94 0.42 38 10.01
138 INT64054 Positive_regulation of Tmprss11d 9.33 0.67 19 9.99
139 INT95632 Positive_regulation of MMP8 10.06 0.70 26 9.96
140 INT113603 Negative_regulation of Gene_expression of Mcpt1 22.82 0.41 26 9.91
141 INT126031 Negative_regulation of Gene_expression of MMP9 22.71 0.57 40 9.79
142 INT15449 Positive_regulation of Plat 12.76 0.69 32 9.71
143 INT140191 Positive_regulation of Gene_expression of Mmp13 13.47 0.67 25 9.71
144 INT102987 Regulation of MMP3 9.35 0.60 23 9.54
145 INT132036 Negative_regulation of DPP4 63.24 0.59 126 9.51
146 INT72789 Gene_expression of Cpa1 12.36 0.50 29 9.47
147 INT26502 Negative_regulation of Gene_expression of MMP2 21.45 0.58 39 9.42
148 INT18941 Regulation of Enpep 2.56 0.55 17 9.38
149 INT71174 Gene_expression of CASP1 30.3 0.75 44 9.37
150 INT13593 Binding of Prss12 4.35 0.36 13 9.37
151 INT47301 Gene_expression of Ctsl 7.72 0.76 27 9.32
152 INT65390 Positive_regulation of Plat 23.31 0.70 30 9.31
153 INT105103 Regulation of Gene_expression of Casp3 3.15 0.39 11 9.22
154 INT20664 Binding of ACE 35.27 0.48 60 9.16
155 INT20425 Localization of Cpe 5.18 0.81 23 9.14
156 INT48233 Negative_regulation of Gene_expression of MMP1 12.94 0.58 34 9.08
157 INT1168 Binding of PROC 44.15 0.38 62 9.04
158 INT4534 Regulation of PROC 19.81 0.33 38 8.99
159 INT187190 Positive_regulation of Localization of MMP9 8.1 0.68 27 8.93
160 INT9387 Positive_regulation of Cpe 3.99 0.70 27 8.87
161 INT3622 Regulation of CTSB 16.08 0.58 34 8.76
162 INT13432 Positive_regulation of Klkb1 5.36 0.57 23 8.65
163 INT18258 Negative_regulation of Thop1 1.6 0.56 20 8.61
164 INT129962 Positive_regulation of Gene_expression of MMP13 20.74 0.65 41 8.54
165 INT15805 Gene_expression of TFRC 17.44 0.75 35 8.52
166 INT70848 Gene_expression of Casp1 10.97 0.77 24 8.52
167 INT109005 Gene_expression of Proc 37.86 0.75 61 8.49
168 INT91772 Gene_expression of PSEN1 38.12 0.75 115 8.48
169 INT13840 Negative_regulation of CPQ 1.25 0.57 19 8.36
170 INT13085 Positive_regulation of ACE 44.2 0.70 50 8.31
171 INT27050 Positive_regulation of Trhde 14.07 0.43 2 8.23
172 INT4880 Regulation of MME 7.78 0.61 17 8.2
173 INT14033 Negative_regulation of Gene_expression of Cpe 3.47 0.33 10 8.2
174 INT78696 Regulation of Positive_regulation of Casp3 2.93 0.39 9 8.2
175 INT88919 Positive_regulation of Casp9 28.64 0.70 39 8.18
176 INT389 Gene_expression of Ace 10.31 0.67 21 8.1
177 INT94122 Negative_regulation of Mmp23 15.81 0.37 21 8.03
178 INT2271 Gene_expression of F2 30.21 0.76 51 7.97
179 INT1925 Gene_expression of PLAT 34.76 0.75 47 7.88
180 INT113671 Negative_regulation of Mmp3 6.33 0.49 26 7.88
181 INT25958 Regulation of Ace 11.88 0.59 26 7.87
182 INT10627 Positive_regulation of Lnpep 3.36 0.69 24 7.85
183 INT98178 Localization of Casp3 21.01 0.65 32 7.77
184 INT14600 Positive_regulation of Tpsab1 22.1 0.68 51 7.7
185 INT153814 Localization of LPA 18.25 0.65 19 7.68
186 INT8603 Binding of Mme 1.42 0.48 28 7.64
187 INT74629 Gene_expression of Mmp7 12.78 0.55 17 7.58
188 INT7168 Positive_regulation of Ctsb 0.3 0.70 9 7.58
189 INT11441 Negative_regulation of Anpep 3.73 0.59 18 7.51
190 INT1771 Positive_regulation of Ace 10.47 0.68 31 7.46
191 INT81378 Negative_regulation of Dpp4 7.87 0.59 18 7.42
192 INT524 Positive_regulation of Cpa1 4.74 0.39 12 7.38
193 INT22782 Localization of PRSS1 14.44 0.81 25 7.34
194 INT18463 Localization of Pgc 3.74 0.78 31 7.3
195 INT153794 Gene_expression of Ctsk 24.99 0.77 51 7.28
196 INT38466 Positive_regulation of Localization of Cpe 1.36 0.29 7 7.2
197 INT14599 Localization of Tpsab1 14.58 0.79 36 7.18
198 INT43727 Negative_regulation of Gene_expression of MMP3 4.81 0.40 16 7.18
199 INT10513 Gene_expression of Plat 19.49 0.76 44 7.17
200 INT111398 Localization of Mmp2 23.78 0.76 37 7.17
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