INT100026

From wiki-pain
Revision as of 07:13, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 73
Total Number 73
Disease Relevance 43.26
Pain Relevance 23.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Tnfrsf1b) nucleus (Tnfrsf1b)
Anatomy Link Frequency
neuronal 7
neurons 4
liver 3
DRG 3
monocyte 2
Tnfrsf1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 1250 99.98 Very High Very High Very High
Arthritis 643 99.96 Very High Very High Very High
Inflammation 1449 99.92 Very High Very High Very High
nociceptor 6 98.84 Very High Very High Very High
Trigeminal ganglion neurons 1 98.24 Very High Very High Very High
allodynia 81 96.96 Very High Very High Very High
rheumatoid arthritis 176 96.92 Very High Very High Very High
Hyperalgesia 653 96.88 Very High Very High Very High
Spinal nerve ligature 4 96.16 Very High Very High Very High
Bile 660 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 273 100.00 Very High Very High Very High
Cancer 257 100.00 Very High Very High Very High
Ganglion Cysts 1252 99.98 Very High Very High Very High
Arthritis 779 99.96 Very High Very High Very High
Cold Sores 9 99.96 Very High Very High Very High
INFLAMMATION 1437 99.92 Very High Very High Very High
Sprains And Strains 43 99.58 Very High Very High Very High
Apoptosis 124 99.40 Very High Very High Very High
Nervous System Injury 268 99.32 Very High Very High Very High
Nociception 301 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of TNFR2 mRNA measured by real-time RT-PCR was increased after the induction of inflammation (Fig. 3a), rising to four times the initial level by 7 days after induction of inflammation.
Gene_expression (Expression) of TNFR2 mRNA associated with inflammation
1) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.33 Pain Relevance 0.91
In order to investigate changes in TNF receptor expression in response to inflammation, we performed real-time RT-PCR and in situ mRNA hybridisation using gene-specific primers on DRG tissues taken from normal animals and at 3- and 7-day time points after induction of CFA arthritis.
Gene_expression (expression) of TNF receptor associated with dorsal root ganglion, inflammation and arthritis
2) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.48 Pain Relevance 1.32
An anti-His-FITC antibody was used to detect cells expressing the TNFR2 (Fig. 4b), and colocalisation was shown by double immunohistochemistry using the ScFv and an anti myc-CY-3 antibody (Fig. 4c).


Gene_expression (expressing) of TNFR2
3) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.53 Pain Relevance 0.23
After induction of CFA arthritis, expression of both TNFR1 and TNFR2 within the DRG tissues was markedly increased.
Gene_expression (expression) of TNFR2 associated with dorsal root ganglion and arthritis
4) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.26 Pain Relevance 0.90
One well per plate was transfected with TNFR2, while two were left untransfected.
Gene_expression (transfected) of TNFR2
5) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.08 Pain Relevance 0
TNFR2 was, however, shown to be expressed by non-neuronal cells of macrophage–monocyte lineage.
Gene_expression (expressed) of TNFR2 in monocyte
6) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.00 Pain Relevance 0.43
Seven days after CFA injection, TNFR2 protein was detected in small DRG cells (Fig. 4d).
Gene_expression (detected) of TNFR2 protein associated with dorsal root ganglion
7) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.56 Pain Relevance 0.23
It is also consistent with the present finding of relatively low-grade TNF receptor expression in both neuronal and non-neuronal DRG cells taken from animals without inflammation.
Gene_expression (expression) of TNF receptor in neuronal associated with dorsal root ganglion and inflammation
8) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.46 Pain Relevance 1.03
The expression of TNFR2 increased significantly during the time course of CFA arthritis as a result of increased numbers of ED1-positive cells in the DRG following inflammation.
Gene_expression (expression) of TNFR2 associated with dorsal root ganglion, inflammation and arthritis
9) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.00 Pain Relevance 0.39
Neuronal expression of TNFR2 has been reported by some investigators [12,14,15] but not others [13].
Gene_expression (expression) of TNFR2 in Neuronal
10) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.14 Pain Relevance 0.64
In situ hybridisation did not detect TNFR2 mRNA in the DRGs of naive animals (Fig. 3b) but identified ipsilateral expression of TNFR2 mRNA in small, non-neuronal cells 3 and 7 days after induction of inflammation (Fig. 3c,d).


Gene_expression (expression) of TNFR2 mRNA in neuronal associated with inflammation
11) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 1.07 Pain Relevance 0.59
In our study, we used a highly specific antibody to TNFR2 protein, and although low-grade neuronal TNFR2 expression may have been below the detection threshold for the immunocytochemical technique used, it seems unlikely that functionally important expression was present.
Gene_expression (expression) of TNFR2 in neuronal
12) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.88 Pain Relevance 0.50
In contrast to TNFR1, we found no evidence for neuronal expression of TNFR2.
Gene_expression (expression) of TNFR2 in neuronal
13) Confidence 0.72 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.85 Pain Relevance 0.57
However, the precise cellular sites of TNFalpha and TNF receptor synthesis are still a matter of controversy.
Gene_expression (synthesis) of TNF receptor
14) Confidence 0.72 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 0.81 Pain Relevance 0.24
TNFR2 was exclusively expressed and regulated in non-neuronal cells.
Gene_expression (expressed) of TNFR2 in neuronal
15) Confidence 0.72 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15509749 Disease Relevance 1.00 Pain Relevance 0.45
CTS inhibited the IL-1beta-stimulated synthesis of TNF-alpha, TNFR2, and iNOS.
Gene_expression (synthesis) of TNFR2 associated with sprains and strains
16) Confidence 0.70 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 1.29 Pain Relevance 0.14
These findings are the first to show that biomechanical signals regulate the expression of TNFR2 but not TNFR1 under inflammatory conditions.
Gene_expression (expression) of TNFR2 associated with inflammation
17) Confidence 0.70 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 0.98 Pain Relevance 0.13
Stable transfectants were selected by culturing in a medium containing Geneticin (G418, Sigma) and selected clones were used for TNFR2-Fc protein production.
Gene_expression (production) of TNFR2
18) Confidence 0.69 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816690 Disease Relevance 0.09 Pain Relevance 0.03
Expression of TNF receptor subtypes (TNFR1 and TNFR2) on sensory neurones was identified using immunohistochemistry, fluorescence-activated cell sorting analysis and RT-PCR.
Gene_expression (Expression) of TNF receptor
19) Confidence 0.68 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11750919 Disease Relevance 0.73 Pain Relevance 0.29
We conclude that distinct receptors TNFR1 and TNFR2 are expressed on cultured DRG neurones and that they are functionally linked to intracellular Ca2+ mobilisation, a response that may involve sphingolipid signalling.
Gene_expression (expressed) of TNFR2 in DRG associated with dorsal root ganglion
20) Confidence 0.68 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 11750919 Disease Relevance 0.60 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox