INT100275

Context Info Confidence 0.25 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 19 Total Number 24 Disease Relevance 6.99 Pain Relevance 1.33

nucleoplasm (TBL1XR1) small molecule metabolic process (TBL1XR1) histone binding (TBL1XR1) nucleolus (TBL1XR1) nucleus (TBL1XR1) DNA binding (TBL1XR1)

Anatomy Link Frequency Skin 3 bulb 2 chondrocytes 1 band 1 PGE2 1 TBL1XR1 (Homo sapiens)

Pain Link Frequency Relevance Heat Fibrositis 6 99.96 Perioperative pain 10 85.00 Pain 588 81.12 Analgesic 78 78.64 nociceptor 10 75.12 psoriasis 6 64.04 imagery 62 54.08 antagonist 4 50.00 Inflammation 116 39.68 visual analogue scale 70 10.60

Disease Link Frequency Relevance Heat Sleep Disorders 6 99.96 Contusions 6 99.68 Wound Healing 538 99.52 Injury 784 98.88 Venous Stasis Ulcers 236 97.68 Disease 6 95.60 Low Back Pain 8 95.20 Ulcers 1080 89.60 Infection 98 88.12 Wound Infection 48 85.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Technically water-filtered infrared-A (wIRA) is produced in special radiators, whose whole incoherent broad-band radiation of a 3000 Kelvin halogen bulb is passed through a cuvette, containing water, which absorbs or decreases the described undesired wavelengths within infrared [1], [2], [4], see Figure 2 (Fig. 2): an example of the resulting spectrum with visible light (VIS) and water-filtered infrared-A (wIRA) is shown in Figure 3 (Fig. 3).

Gene_expression (produced) of wIRA in band

1) Confidence 0.25 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 0.06 Pain Relevance 0

Working mechanisms of wIRA

Gene_expression (mechanisms) of wIRA

2) Confidence 0.25 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 0.07 Pain Relevance 0

Bechterew [77], arthroses, arthritises, contusions; fibromyalgia (preferably wIRA in combination with motion, i.e. wIRA with a small amount of ergometer work) [93], regeneration after sports [78] (wIRA alone or wIRA in combination with motion), postoperative rehabilitation [89], [94], improvement of lipolysis (wIRA in combination with motion) [61].

Gene_expression (preferably) of wIRA associated with contusions and fibrositis

3) Confidence 0.22 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 1.19 Pain Relevance 0.08

Why wIRA?

Gene_expression (Why) of wIRA

4) Confidence 0.22 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 0.10 Pain Relevance 0

Water-filtered infrared-A as a special form of heat radiation with a high tissue penetration and with a low thermal load to the skin surface acts both by thermal (related to heat energy transfer) and thermic (temperature depending, with a relevant change of temperature) as well as by non-thermal (without a relevant transfer of heat energy) and non-thermic (not depending on temperature, without a relevant change of temperature) effects. wIRA produces a therapeutically usable field of heat in the tissue and increases tissue temperature, tissue oxygen partial pressure, and tissue perfusion.

Gene_expression (produces) of wIRA in skin

5) Confidence 0.22 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Abstract Doc Link PMC2831244 Disease Relevance 0.36 Pain Relevance 0

Technically water-filtered infrared-A (wIRA) is produced in special radiators, whose full spectrum of radiation of a halogen bulb is passed through a cuvette, containing water, which absorbs or decreases the described undesired wavelengths of the infrared radiation.

Gene_expression (produced) of wIRA in bulb

6) Confidence 0.19 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Abstract Doc Link PMC2831244 Disease Relevance 0.08 Pain Relevance 0

A typical image of the stratum corneum after application of the fluorescein sodium containing formulation, without wIRA irradiation, is presented in Figure 6a (Fig. 6).

Gene_expression (irradiation) of wIRA

7) Confidence 0.17 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703260 Disease Relevance 0 Pain Relevance 0

Skin hydration (in relative (arbitrary) units) rose from 67 before wIRA to 87 after wIRA irradiation (medians) (Figure 9 (Fig. 9)).

Gene_expression (irradiation) of wIRA in Skin

8) Confidence 0.17 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703260 Disease Relevance 0 Pain Relevance 0

Thermal effects of wIRA and production of a therapeutically usable field of heat

Gene_expression (production) of wIRA

9) Confidence 0.06 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.41 Pain Relevance 0

Technically water-filtered infrared-A (wIRA) is produced in special radiators, in which the complete incoherent radiation of a 3000-Kelvin halogen bulb passes a water containing cuvette, so that the undesired portions of radiation are absorbed or decreased [17], [18], [19], [20].

Gene_expression (produced) of wIRA in bulb

10) Confidence 0.06 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.18 Pain Relevance 0

Clinical use and advantages of wIRA

Gene_expression (advantages) of wIRA

11) Confidence 0.06 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.66 Pain Relevance 0.05

Working mechanisms of wIRA

Gene_expression (mechanisms) of wIRA

12) Confidence 0.06 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.64 Pain Relevance 0.16

To assess the irradiation characteristics of the wIRA radiators, emitting wIRA(+VIS), a porous rubber mat was heated at a distance of 25 cm for a period of 10 minutes.

Gene_expression (radiators) of wIRA

13) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.41 Pain Relevance 0

How can the beneficial effects of wIRA be explained?

Gene_expression (effects) of wIRA

14) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.66 Pain Relevance 0.17

Skin heating patterns during treatment with a wIRA radiator

Gene_expression (radiator) of wIRA in Skin

15) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.15 Pain Relevance 0

Previous clinical studies with wIRA concerning wound healing

Gene_expression (studies) of wIRA associated with wound healing

16) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 1.30 Pain Relevance 0.86

To assess the irradiation characteristics of the wIRA radiators, emitting wIRA(+VIS), a porous rubber mat was heated at a distance of 25 cm for a period of 10 minutes.

Gene_expression (radiators) of wIRA

17) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.41 Pain Relevance 0

Non-thermal effects of wIRA

Gene_expression (effects) of wIRA

18) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.06 Pain Relevance 0

Aceclofenac may modulate PGE2 production by increasing IL-IRa production and decreasing NO synthesis.

Gene_expression (production) of IL-IRa in PGE2

19) Confidence 0.04 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0 Pain Relevance 0

CONCLUSION: Proinflammatory stimuli induce IL-IRa synthesis in human articular chondrocytes.

Gene_expression (synthesis) of IL-IRa in chondrocytes

20) Confidence 0.04 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0 Pain Relevance 0

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