INT100286

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Context Info
Confidence 0.73
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 5.13
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) cell-cell signaling (TXN) cytoplasm (TXN)
Anatomy Link Frequency
plasma 4
lymphocytes 3
macrophages 1
HeLa 1
dendritic cells 1
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 19 99.72 Very High Very High Very High
Inflammation 152 99.00 Very High Very High Very High
cytokine 58 98.60 Very High Very High Very High
rheumatoid arthritis 19 93.80 High High
diclofenac 80 85.84 High High
melanocortin 1 receptor 2 75.00 Quite High
Neuropeptide 1 25.00 Low Low
member 8 38 22.32 Low Low
agonist 19 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 63 99.96 Very High Very High Very High
INFLAMMATION 173 99.36 Very High Very High Very High
Viral Infection 57 98.56 Very High Very High Very High
Apoptosis 120 98.40 Very High Very High Very High
Eczema 19 94.68 High High
Rheumatoid Arthritis 19 93.80 High High
Systemic Lupus Erythematosus 19 92.92 High High
Hypersensitivity 19 91.24 High High
Epstein-barr Virus 38 90.96 High High
Autoimmune Disease 19 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both Trx1 secretion and CD30 expression have been associated with virally transformed lymphocytes.
Localization (secretion) of Trx1 in lymphocytes
1) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 1.12 Pain Relevance 0.21
Human Trx1 was first identified as an autocrine factor secreted by and acting on virally transformed lymphoid cell lines.
Localization (secreted) of Trx1
2) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.09 Pain Relevance 0
On the other hand, Trx1 may be regenerated by co-secreted reductants, as Trx1 secretion in DC-T co-culture is accompanied by the release of reduced cysteine and the creation of a reducing microenvironment between interacting cells (Angelini et al, 2002).
Localization (secretion) of Trx1
3) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.06 Pain Relevance 0.03
Under conditions of oxidative stress, Trx1 is released by cells and accumulates at sites of inflammation (Nordberg and Arner, 2001).
Localization (released) of Trx1 associated with stress and inflammation
4) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.39 Pain Relevance 0.05
Likewise, viral infection leads to elevated Trx1 plasma levels and several studies indicate that secreted Trx1 modulates the antiviral inflammatory process (Nakamura et al, 2001b, 2002).
Localization (secreted) of Trx1 in plasma associated with inflammation and viral infection
5) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 1.14 Pain Relevance 0.21
However, plasma Trx1 is oxidized and appears to represent systemic dilution of Trx1 previously released within tissues.
Localization (released) of Trx1 in plasma
6) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0.05
In addition, Trx1 is released to the extracellular environment by a variety of normal and neoplastic cells (Rubartelli et al, 1992).
Localization (released) of Trx1
7) Confidence 0.73 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.46 Pain Relevance 0.07
Certain Trx1-secreting cell types, including macrophages and dendritic cells, distinctly upregulate expression of Trx1 upon activation (Angelini et al, 2002).
Localization (secreting) of Trx1 in dendritic cells
8) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
As expected, we did not detect trapping of peroxiredoxins (or other Trx1-interacting proteins) by Grx1(CSAAA), neither on silver gels (Figure 1E, lanes 3 and 4) nor by immunoblotting (data not shown).
Neg (neither) Localization (trapping) of Trx1
9) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
While mock-transfected HeLa cells did not capture Trx1(CSAAA) on their surface (Figure 4C, lower row), expression of CD30 led to a strong Trx1 surface association and colocalization of both proteins (Figure 4C, upper row).
Neg (not) Localization (capture) of Trx1 in HeLa
10) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
However, plasma Trx1 is oxidized and appears to represent systemic dilution of Trx1 previously released within tissues.
Localization (dilution) of Trx1 in plasma
11) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0.05
In this study, we addressed the question regarding which lymphocyte surface receptors are targeted and regulated by the redox activity of extracellular Trx1.
Localization (targeted) of Trx1 in lymphocyte
12) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.33 Pain Relevance 0.04
In vitro studies of Trx1 secretion suggest that a substantial fraction of intracellular Trx1 can be released within a few hours (Rubartelli et al, 1992).
Localization (released) of Trx1
13) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.13 Pain Relevance 0.04
However, plasma Trx1 is oxidized and appears to represent systemic dilution of Trx1 previously released within tissues.
Localization (released) of Trx1 in plasma
14) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.10 Pain Relevance 0.05
In vitro studies of Trx1 secretion suggest that a substantial fraction of intracellular Trx1 can be released within a few hours (Rubartelli et al, 1992).
Localization (secretion) of Trx1
15) Confidence 0.68 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.08 Pain Relevance 0.04
We have previously reported that TRX released from UVB-irradiated keratinocytes stimulates melanogenesis by upregulating MSH receptor expression and its binding activity in melanocytes.
Localization (released) of TRX in melanocytes
16) Confidence 0.66 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0 Pain Relevance 0.18
More recently, Trx1 was found to be secreted by dendritic cells upon cognate T-cell recognition and to contribute to subsequent T-cell activation (Angelini et al, 2002).
Localization (secreted) of Trx1 in T-cell
17) Confidence 0.64 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.42 Pain Relevance 0.13
Numerous studies have reported that secretory Trx1 influences effector functions and proliferation of lymphocytes (Nakamura et al, 1997).
Localization (secretory) of Trx1 in lymphocytes
18) Confidence 0.60 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.38 Pain Relevance 0.05
However, in contrast to Trx1, Grx1 is specialized in the recognition and reduction of protein–glutathione mixed disulfide bonds and forms mixed disulfide intermediates with glutathione rather than with proteins (Yang et al, 1998; Peltoniemi et al, 2006).
Localization (specialized) of Trx1
19) Confidence 0.30 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0
The crucial antioxidant power of Trx also takes advantage of its ability to cross the cellular membrane; in fact, evidences have been reported that Trx can be released from cells [26–28] and even enter a living cell [29, 30].
Localization (released) of Trx
20) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.09 Pain Relevance 0.20

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