INT10033

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.80
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
Anatomy Link Frequency
saphenous vein 4
smooth muscle cell 2
lower limb 1
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 12 98.00 Very High Very High Very High
COX-2 inhibitor 1 96.56 Very High Very High Very High
cytokine 1 89.56 High High
Inflammation 4 89.16 High High
Pain 9 87.00 High High
cINOD 1 73.76 Quite High
COX2 2 25.00 Low Low
agonist 7 22.16 Low Low
aspirin 1 21.52 Low Low
local anesthetic 2 15.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 32 99.84 Very High Very High Very High
Pre-eclampsia 33 99.74 Very High Very High Very High
Increased Venous Pressure Under Development 47 99.68 Very High Very High Very High
Nicotine Addiction 102 99.54 Very High Very High Very High
Cv Unclassified Under Development 12 98.00 Very High Very High Very High
Insulin Resistance 2 95.92 Very High Very High Very High
Necrosis 1 94.56 High High
Cancer 1 94.20 High High
Adhesions 2 93.76 High High
Disorder Of Lipid Metabolism 2 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, elevated levels of prostacyclin secretion stimulated by TNF-alpha were markedly down-regulated by indomethacin and a selective COX-2 inhibitor.
Localization (secretion) of prostacyclin associated with cox-2 inhibitor
1) Confidence 0.69 Published 2007 Journal Mol. Immunol. Section Abstract Doc Link 17337058 Disease Relevance 0.28 Pain Relevance 0.21
Prostacyclin release from the human saphenous vein in diabetics in lower than in nondiabetics.
Localization (release) of Prostacyclin in saphenous vein associated with diabetes mellitus
2) Confidence 0.57 Published 1992 Journal World J Surg Section Title Doc Link 1455886 Disease Relevance 0.68 Pain Relevance 0.15
In order to investigate prostacyclin and thromboxane release, segments from the human saphenous veins were investigated in 53 patients.
Localization (release) of prostacyclin in saphenous veins
3) Confidence 0.50 Published 1992 Journal World J Surg Section Abstract Doc Link 1455886 Disease Relevance 0.54 Pain Relevance 0.12
Segments from nondiabetic patients with lower limb ischemia did not differ from those of varicectomy patients, but diabetic segments had a significantly lower prostacyclin release than both these groups, 34 +/- 11 pg/mm2/15 min, 1 +/- 1 pg/mm2/15 min, and 7 +/- 5 pg/mm2/15 min, respectively (p < 0.05).
Localization (release) of prostacyclin in lower limb associated with diabetes mellitus and ischemia
4) Confidence 0.44 Published 1992 Journal World J Surg Section Abstract Doc Link 1455886 Disease Relevance 0.87 Pain Relevance 0.16
Saphenous veins from patients with varicose veins had an initial prostacyclin release of 61 +/- 13 pg/mm2/15 min declining to 4 +/- 1 pg/mm2/15 min after 60 min (p < 0.001) and increasing after addition to arachidonic acid to 37 +/- 7 pg/mm2/15 min (p < 0.001).
Localization (release) of prostacyclin in Saphenous veins associated with increased venous pressure under development
5) Confidence 0.44 Published 1992 Journal World J Surg Section Abstract Doc Link 1455886 Disease Relevance 0.82 Pain Relevance 0.17
The addition of arachidonic acid failed to increase the prostacyclin release in diabetics.
Localization (release) of prostacyclin associated with diabetes mellitus
6) Confidence 0.44 Published 1992 Journal World J Surg Section Abstract Doc Link 1455886 Disease Relevance 0.83 Pain Relevance 0.14
These findings suggest that diabetics have a lowered prostacyclin release from the saphenous vein and that the deficiency is at the cyclo-oxygenase level.
Localization (release) of prostacyclin in saphenous vein associated with diabetes mellitus
7) Confidence 0.44 Published 1992 Journal World J Surg Section Abstract Doc Link 1455886 Disease Relevance 0.77 Pain Relevance 0.12
In women with severe preeclampsia the urinary excretion of the prostacyclin metabolites is lower than in normotensive women during the last trimester of pregnancy, while thromboxane levels are unchanged, shifting the balance to the debit of the vasoconstrictor and procoagulant TXA2.
Localization (excretion) of prostacyclin associated with pre-eclampsia
8) Confidence 0.08 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.29 Pain Relevance 0
However, in vitro studies have shown that the smoking particles have many effects on endothelial and smooth muscle cells; eg, reduce prostacyclin release and eNOS expression in endothelial cells (Sun et al 1998), induce smooth muscle cell proliferation (Xu et al 1994) and enhance expression of vascular cell adhesion molecular (Chen et al 2004).
Localization (release) of prostacyclin in smooth muscle cell associated with nicotine addiction and adhesions
9) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.75 Pain Relevance 0
The combination of LDL with lipid soluble smoking particles reduces the release of prostacyclin from arterial endothelial cells and enhances arterial smooth muscle cell proliferation (Xu et al 1994).
Localization (release) of prostacyclin in smooth muscle cell associated with nicotine addiction
10) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515430 Disease Relevance 0.97 Pain Relevance 0

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