INT100373

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 10.00
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
retinas 6
endothelial cells 6
ECM 2
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 16 98.76 Very High Very High Very High
palliative 1 91.04 High High
metalloproteinase 28 89.44 High High
corticosteroid 21 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
analgesia 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 8 100.00 Very High Very High Very High
Diabetes Mellitus 165 99.84 Very High Very High Very High
Cancer 312 99.20 Very High Very High Very High
Hypoxia 14 99.08 Very High Very High Very High
Glioma 168 98.84 Very High Very High Very High
Reprotox - General 1 4 92.32 High High
Neuroblastoma 7 90.04 High High
Atopic Dermatitis 1 86.68 High High
Chills 1 85.88 High High
Fever 1 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, Flt-1 expression was decreased in early diabetic retinas but was upregulated following IVTA treatment.
Negative_regulation (decreased) of Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
1) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.70 Pain Relevance 0
From the present study it may be suggested that the marked reduction in Flt1 and VEGF expression caused by GLA treatment could cause a reduction in angiogenesis as seen by reduced MVD most likely through reduced endothelial cell proliferation, although this was not quantified directly.
Negative_regulation (reduction) of Gene_expression (expression) of Flt1 in endothelial cell
2) Confidence 0.40 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.55 Pain Relevance 0
The decrease in Flt1 expression seen in the presence of GLA may reduce the degree of protection of VEGF from degradation in the ECM thereby compounding the effect of decreased VEGF expression.
Negative_regulation (decrease) of Gene_expression (expression) of Flt1 in ECM
3) Confidence 0.40 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.44 Pain Relevance 0
In contrast to the elevated levels of VEGF and FLK-1, FLT-1 expression was reduced by 37.5% in diabetic retinas (16.94 ± 0.76 vs. 27.09 ± 0.56 positive cells/mm, P < 0.0001) (Fig. 2C).
Negative_regulation (reduced) of Gene_expression (expression) of FLT-1 in retinas associated with diabetes mellitus
4) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.87 Pain Relevance 0
The expression of another VEGF receptor, FLT-1, was unexpectedly decreased in diabetic retinas and increased following IVTA treatment.
Negative_regulation (decreased) of Gene_expression (expression) of FLT-1 in retinas associated with diabetes mellitus
5) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.49 Pain Relevance 0
The decrease in ERK1 and ERK2 expression may be involved in the decrease in VEGF and Flt1 expression in the GLA treated tumours.
Negative_regulation (decrease) of Gene_expression (expression) of Flt1 associated with cancer
6) Confidence 0.29 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.67 Pain Relevance 0
The presence of GLA caused inhibition of mRNA expression of VEGF, Flt1, ERK1/2 and MMP2 but not Flk1.
Negative_regulation (inhibition) of Gene_expression (expression) of Flt1
7) Confidence 0.29 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.80 Pain Relevance 0
Immunohistochemical quantification confirmed the decrease in VEGF and Flt1 protein expression and found a lack of change in Flk1 protein content.
Negative_regulation (decrease) of Gene_expression (expression) of Flt1 protein
8) Confidence 0.29 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.78 Pain Relevance 0
The mRNA expression of Flt1 was reduced by 77 ± 16% in the presence of 5 mM GLA while the protein expression was reduced by 57 ± 5.8% (Figure 1F, 1G).
Negative_regulation (reduced) of Gene_expression (expression) of Flt1
9) Confidence 0.29 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.50 Pain Relevance 0
These changes were associated with reduced expression of vascular endothelial growth factor (VEGF) (71 ± 16%) and the VEGF receptor Flt1 (57 ± 5.8%) but not Flk1.
Negative_regulation (reduced) of Gene_expression (expression) of Flt1
10) Confidence 0.25 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.66 Pain Relevance 0.04
Here we demonstrate that both nonselective (indomethacin) and COX-2-selective (NS-398) NSAIDs inhibit hypoxia-induced in vitro angiogenesis in gastric microvascular endothelial cells via coordinated sequential events: 1) increased expression of the von Hippel-Lindau (VHL) tumor suppressor, which targets proteins for ubiquitination leading to 2) reduced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) and, as a result, 3) reduced expression of vascular endothelial growth factor (VEGF) and its specific receptor Flt-1.
Negative_regulation (reduced) of Gene_expression (expression) of Flt-1 in endothelial cells associated with cancer, hypoxia and cinod
11) Confidence 0.08 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 1.00 Pain Relevance 0.61
Taken together, these results indicate that NSAIDs inhibit hypoxia-induced angiogenesis in endothelial cells by inhibiting VEGF and Flt-1 expression through increased VHL expression and the resulting ubiquitination and degradation of HIF-1alpha.
Negative_regulation (inhibiting) of Gene_expression (expression) of Flt-1 in endothelial cells associated with hypoxia and cinod
12) Confidence 0.08 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.90 Pain Relevance 0.62
During therapy TNF-alpha concentrations raised markedly in the ascites fluid whereas VEGF and sFLT-1 ascites levels declined.
Negative_regulation (declined) of Gene_expression (levels) of sFLT-1 associated with pressure and volume under development
13) Confidence 0.00 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12209996 Disease Relevance 1.64 Pain Relevance 0.09

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