INT10044

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0.99
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1)
Anatomy Link Frequency
plasma 1
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3 99.48 Very High Very High Very High
antidepressant 172 98.88 Very High Very High Very High
agonist 22 98.40 Very High Very High Very High
depression 38 98.18 Very High Very High Very High
fluoxetine 24 97.84 Very High Very High Very High
qutenza 7 96.12 Very High Very High Very High
Desipramine 14 94.48 High High
Endep 2 93.44 High High
Deafferentation 2 90.48 High High
sSRI 16 89.20 High High
Disease Link Frequency Relevance Heat
Cyanosis 2 99.80 Very High Very High Very High
Pain 3 99.48 Very High Very High Very High
Depression 38 98.18 Very High Very High Very High
Eczema 4 97.92 Very High Very High Very High
INFLAMMATION 2 85.36 High High
Injury 1 74.40 Quite High
Erythema 1 30.56 Quite Low
Pressure And Volume Under Development 1 29.76 Quite Low
Keloid Scars 1 25.00 Low Low
Pruritus 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the various CDP-diglycerides tested for the activation of PI synthetase, CDP-dipalmitin was the most active.
Positive_regulation (activation) of PI
1) Confidence 0.69 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2845289 Disease Relevance 0 Pain Relevance 0.25
At low liponucleotide concentrations, PI synthetase activity was significantly enhanced by imipramine (1 mM), whereas the enzyme activity was inhibited at higher liponucleotide concentrations (greater than 0.3 mM).
Positive_regulation (enhanced) of PI
2) Confidence 0.69 Published 1988 Journal Neurochem. Res. Section Abstract Doc Link 2845289 Disease Relevance 0 Pain Relevance 0.29
Nonselective nitric oxide synthase inhibitor L-NAME produced a dose-dependent increase in alpha(1)-antitrypsin activity in intact animals.
Positive_regulation (increase) of antitrypsin
3) Confidence 0.35 Published 2008 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 19240864 Disease Relevance 0 Pain Relevance 0.53
Hence, to the extent that CDP-DG production might be relevant to depression or the mechanism of antidepressant drug action, an antidepressive agent should not merely increase PI hydrolysis, but the CDP-DG produced must exceed and probably precede the production of PI messengers.
Neg (not) Positive_regulation (increase) of PI associated with antidepressant and depression
4) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.15 Pain Relevance 0.72
Numerous agents acting at diverse receptor systems can enhance PI metabolism, but few such pure receptor agonists are known to exhibit an antidepressive effect in humans or animals [67].
Positive_regulation (enhance) of PI associated with agonist
5) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.43
Alpha 1-proteinase inhibitor (alpha 1-PI), a serine protease inhibitor, was tested for its efficacy for the treatment of recalcitrant atopic dermatitis.
Positive_regulation (tested) of Alpha 1-proteinase associated with eczema
6) Confidence 0.02 Published 1992 Journal Ann Allergy Section Abstract Doc Link 1456482 Disease Relevance 0.43 Pain Relevance 0.04
PURPOSE: The purpose of this study was to investigate adverse reaction reports of pain and/or cyanosis attributed to alpha 1-proteinase inhibitor (A1PI), a plasma alpha-globulin protein used to treat A1PI deficiency.
Spec (investigate) Positive_regulation (attributed) of alpha 1-proteinase in plasma associated with pain and cyanosis
7) Confidence 0.02 Published 1992 Journal Am. J. Med. Section Abstract Doc Link 1534964 Disease Relevance 0.35 Pain Relevance 0.17

General Comments

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