INT100497

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 11.78
Pain Relevance 7.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocyte 1
paw 1
neurons 1
spinal cord 1
nasal 1
Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 1107 100.00 Very High Very High Very High
bradykinin 318 100.00 Very High Very High Very High
dorsal root ganglion 162 100.00 Very High Very High Very High
Infliximab 44 99.76 Very High Very High Very High
Hyperalgesia 51 99.52 Very High Very High Very High
Inflammation 296 99.44 Very High Very High Very High
aspirin 7 99.36 Very High Very High Very High
cytokine 90 99.08 Very High Very High Very High
Stimulus evoked pain 4 98.68 Very High Very High Very High
substance P 315 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 1182 100.00 Very High Very High Very High
Ganglion Cysts 165 100.00 Very High Very High Very High
Asthma 10 100.00 Very High Very High Very High
Polyps 1 100.00 Very High Very High Very High
Disease 148 99.84 Very High Very High Very High
Hyperalgesia 54 99.52 Very High Very High Very High
Pressure And Volume Under Development 57 99.48 Very High Very High Very High
INFLAMMATION 284 99.44 Very High Very High Very High
Hypersensitivity 8 98.68 Very High Very High Very High
Inflammatory Pain 12 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 2 displays the changes in the receptor expression in the DRG neurons during AIA.
Gene_expression (expression) of AIA in neurons associated with dorsal root ganglion and arthritis
1) Confidence 0.25 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.74 Pain Relevance 1.08
We therefore conclude that the increased expression of BK receptors in AIA is entirely due to an upregulation of the B2 receptor.


Gene_expression (expression) of AIA associated with b2 receptor, bradykinin and arthritis
2) Confidence 0.25 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.98 Pain Relevance 1.27
These data show that in both normal animals and animals with AIA, B2 receptors but not B1 receptors were expressed.


Neg (not) Gene_expression (expressed) of AIA associated with arthritis
3) Confidence 0.22 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17819 Disease Relevance 0.71 Pain Relevance 0.92
The degree of BMD reduction is dictated by the extent of leukocyte infiltration as osteoclast recruitment along bony surfaces is induced by numerous proinflammatory cytokines [155]; accordingly, bone dissolution is more severe in AIA (Figure 4), where leukocyte influx is more severe than in CIA or SCW.
Gene_expression (severe) of AIA in leukocyte associated with arthritis and cytokine
4) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 0.81 Pain Relevance 0.31
The degree of hind paw swelling is much greater for both AIA models than it is for CIA (Figure 3) or SCW.
Gene_expression (models) of AIA in paw associated with pressure and volume under development and arthritis
5) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 2.40 Pain Relevance 0.85
This period is usually one week after the onset of clinical disease in our AIA, CIA, and SCW models.


Gene_expression (models) of AIA associated with disease and arthritis
6) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.05 Pain Relevance 0.43
The lower airway lesion and the nasal polyp in AIA are postulated to have common pathogenic features involving aspirin sensitivity that would be reflected in the gene expression profile of AIA polyps.
Gene_expression (expression) of AIA in nasal associated with asthma, aspirin, polyps and nasal polyps
7) Confidence 0.08 Published 2009 Journal Clin. Exp. Allergy Section Abstract Doc Link 19489917 Disease Relevance 1.33 Pain Relevance 0.26
BACKGROUND: Aspirin-intolerant asthma (AIA) occurs in the lower and upper airways through excessive production of leukotrienes upon administration of non-steroidal anti-inflammatory drugs (NSAIDs).
Gene_expression (production) of AIA in upper associated with asthma, aspirin, inflammation and cinod
8) Confidence 0.07 Published 2010 Journal BMC Med. Genet. Section Abstract Doc Link 20860846 Disease Relevance 0.81 Pain Relevance 0.43
Using behavioral test, RT-PCR analysis, enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA), the present study demonstrated that (1) Unilateral intra-articular injection of complete Freund's adjuvant (CFA) produced a constant hyperalgesia and an up-regulation of the prostaglandin E(2) (PGE(2)) level as well as the tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels in the spinal cord; (2) Celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2), at a dose of 2, 10, and 20 mg/kg (twice daily, p.o.), presented a dose-dependent anti-hyperalgesic effect; (3) Repeated EA stimulation of ipsilateral 'Huan-Tiao' (GB30) and 'Yang-Ling-Quan' (GB34) acupoints significantly suppressed CFA-induced hyperalgesia, and markedly inhibited the CFA-induced increase of the level of PGE(2) as well as IL-1beta, IL-6, and TNF-alpha in the spinal cord; (4) EA combined with low dose of celecoxib (2 mg/kg, twice daily, p.o.) greatly enhanced the anti-hyperalgesic effects of EA, with a synergistic reversing effect on CFA-induced up-regulation of spinal PGE(2), but not on the IL-1beta, IL-6, or TNF-alpha.
Gene_expression (produced) of adjuvant in spinal cord associated with necrosis, hyperalgesia, cancer, electroacupuncture and spinal cord
9) Confidence 0.01 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18721668 Disease Relevance 0.94 Pain Relevance 0.95
The presence of AIA during each visit was found to be positive in 19% of the patients.
Gene_expression (presence) of AIA
10) Confidence 0.01 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.12 Pain Relevance 0.18
Injection of complete Freund's adjuvant (CFA) into a hindpaw produced a persistent inflammation and a sustained ERK activation in neurons in the superficial layers (laminae I-IIo) of the dorsal horn.
Gene_expression (produced) of adjuvant in dorsal horn associated with inflammation and dorsal horn
11) Confidence 0.00 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11784793 Disease Relevance 0.89 Pain Relevance 0.82

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