INT100594

Context Info Confidence 0.03 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.24 Pain Relevance 0.41

extracellular space (IL6) aging (IL6) extracellular region (IL6) plasma membrane (DCSTAMP)

Anatomy Link Frequency PGE2 2 DCSTAMP (Homo sapiens) IL6 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 4 95.52 cytokine 5 75.00 Inflammatory mediators 1 48.80 glial activation 1 37.56 COX2 1 25.00

Disease Link Frequency Relevance Heat Creutzfeldt Jakob Disease 3 86.64 Neurodegenerative Disease 2 78.60 INFLAMMATION 2 75.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated.

IL-1beta-induced Positive_regulation (induced) of Gene_expression (synthesis) of IL-6 in PGE2

1) Confidence 0.03 Published 2002 Journal Brain Res. Section Abstract Doc Link 11792368 Disease Relevance 0.24 Pain Relevance 0.41

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