INT100603

Context Info Confidence 0.22 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 3.05 Pain Relevance 2.25

plasma membrane (DCSTAMP)

Anatomy Link Frequency chondrocytes 1 HASM 1 mast cells 1 PGE2 1 DCSTAMP (Homo sapiens)

Pain Link Frequency Relevance Heat COX2 5 99.56 COX-2 inhibitor 2 98.90 qutenza 6 97.54 cINOD 22 95.52 Inflammation 114 94.68 Central nervous system 1 93.32 cytokine 54 88.92 dexamethasone 9 61.84 intrathecal 1 58.76 fibrosis 2 53.28

Disease Link Frequency Relevance Heat Skin Cancer 9 99.84 African Trypanosomiasis 23 97.76 INFLAMMATION 148 94.68 Asthma 41 94.56 Necrosis 3 88.08 Cancer 5 87.72 Creutzfeldt Jakob Disease 3 86.64 Eosinophilia 3 83.40 Occupational Lung Diseases 3 81.04 Neurodegenerative Disease 2 78.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

What are the roles of FIND and WHO in the development of new diagnostic tools for HAT?

Gene_expression (roles) of FIND associated with african trypanosomiasis

1) Confidence 0.22 Published 2006 Journal Kinetoplastid Biol Dis Section Body Doc Link PMC1464096 Disease Relevance 0.35 Pain Relevance 0.13

We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells.

Gene_expression (expression) of IL-1beta-induced in HASM associated with cox-2 inhibitor

2) Confidence 0.12 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.16 Pain Relevance 0.36

Indeed, PGE(2) also induced and enhanced IL-1beta-induced COX-2 expression.

Gene_expression (expression) of IL-1beta-induced

3) Confidence 0.12 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.15 Pain Relevance 0.39

Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.

Gene_expression (expression) of IL-1beta-induced associated with qutenza and skin cancer

4) Confidence 0.07 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.65 Pain Relevance 0.39

We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated.

Gene_expression (synthesis) of IL-1beta-induced in PGE2

5) Confidence 0.04 Published 2002 Journal Brain Res. Section Abstract Doc Link 11792368 Disease Relevance 0.24 Pain Relevance 0.41

Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro Several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo.

Gene_expression (production) of IL-1beta-induced in chondrocytes associated with inflammation and cox2

6) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Title Doc Link PMC2438359 Disease Relevance 0.09 Pain Relevance 0.10

These properties include mucus hypersecretion, the terminal differentiation of B cells into antibody-producing cells, upregulation of IL-4-dependent IgE production and stimulation of cytotoxic T-cell differentiation, as well as differentiation of immature mast cells.

Gene_expression (production) of IL-4-dependent in mast cells

7) Confidence 0.02 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.40 Pain Relevance 0.47

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